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研究・業績

研究報告

大学院での研究テーマ,臨床研究のテーマなど

写真:研究イメージ

写真:研究イメージ

写真:研究イメージ

写真:研究イメージ
カーボンナノチューブの臨床応用のための基礎研究(運動機能学)

写真:研究イメージ
ナビゲーションを用いたACL再建は先進医療を取得

上肢グループ(加藤教授、林講師)

  • 腱・手指関節のバイオメカニクス
  • 手根管・肘部管症候群の疫学、病態、治療法、予後に関する臨床研究
  • 肩腱板断裂に対する低侵襲手術
  • 筋の加齢(サルコペニア)に関する基礎的研究

下肢グループ(齋藤直人保健学科教授、天正講師)

  • カーボンナノチューブを用いた生体材料開発
  • 低侵襲人工関節手術
  • チャンレー人工股関節の長期成績
  • 下肢関節軟骨再生医療に関する臨床研究

脊椎グループ(高橋准教授、倉石助教、池上助教、二木診療助教)

  • ナビゲーションを用いた脊椎手術
  • 脊柱側弯症に対する臨床研究
  • 脊柱側弯症の矯正手術の有限要素法による応力解析
  • 早期発症側弯症に対する新しい手術法の開発
  • 脊椎低侵襲手術

腫瘍グループ(鬼頭診療助教、岡本診療助教)

  • 転移性軟部腫瘍
  • 骨軟部腫瘍の遺伝子解析
  • 骨軟部欠損後の骨再生医療に関する臨床研究
  • 悪性骨軟部腫瘍に対する四肢温存

骨粗鬆症グループ

【スタッフ】
整形外科・講師:中村幸男、整形外科・医員:上原将志、リハビリテーション科・助教:池上章太
上村幹男 先生(信州大学医学部運動機能学教室特別講師、骨粗鬆症・脊椎疾患センター かみむらクリニック)
内山茂晴 先生(信州大学医学部運動機能学教室特任教授、岡谷市民病院)

日本は世界でも例を見ないほどの超高齢化社会に突入しております。
また、長野県の平均寿命は男女とも第1位ですが、健康で自立して暮らせる健康寿命は、男性6位、女性17位と上位ではありません。
健康寿命を損ない要支援・要介護が必要になる要因は、脳血管障害、認知症、衰弱などをしのいで運動器の障害が第1位です。
中でも、大腿骨近位部骨折(骨盤に近い足のつけ根の骨折)や脊椎圧迫骨折(背骨の骨折)のため、手術や入院が必要になる患者様が、毎年増え続けております。
このような状況は、先進国の中で日本だけであり、原因として骨粗しょう症が最も多い、という認識を持つことが大切です。
我々は、骨折は不注意のため「偶然に」起こるものではなく、いくつかの望ましくない要素が重なった結果、「必然」として起こるものと考えています。
骨粗しょう症グループでは、骨折を未然に防ぐことを目標とし、患者様が重大な骨折を起こす前に必ず発しているはずの信号を見つけ、適切な治療を適切なタイミングで始めるためのベースとなる研究をしています。
骨密度だけでは評価できない骨強度について、多岐にわたる骨粗しょう症の薬について、常に最新の情報を取り入れながら、研究、診断、治療を積極的に行っております。具体的には、骨密度や骨形態計測、骨代謝マーカー、各種ホルモンやビタミンなど、様々なデータと骨折との関係を臨床・基礎科学両面から明らかにする事を目標として、診療、研究を進めております。

腱再生グループ(林講師、大学院生)

腱は筋肉からの力を骨に伝え、関節の動きや角度をコントロールする重要な役割を担っています。しかし、腱組織の分化メカニズムや分子レベルでの機能などは未だ不明な点が数多く残っています。したがって指の腱損傷、ばね指、手根管症候群のような一般的によく知られた手指のけがや病気においても、腱の再生、修復、変性は実はよくわかっていません。
私達は、これらの疾患の新しい治療法の確立のため、最新の分子生物学的手法で腱の再生、修復、変性の基礎研究を進めています。

写真:研究イメージ

プロテオミクスグループ(羽二生久夫講師、高橋淳准教授、加藤博之教授)

生物の遺伝子がその生理作用を発揮するには、タンパク質に翻訳されて初めて機能します。
プロテオミクスは、その機能が発揮されている組織や、細胞における全てのタンパク質の発現情報を網羅的に研究しようという手法です。
この手法を用いて我々は、整形分野における加齢性の病態変化のメカニズムや骨代謝の解明、そして医療応用が期待されるカーボンナノチューブを含むナノマテリアルの、新しい安全性評価法としての利用をするための研究を進めています。

写真:研究イメージ
2次元電気泳動像

骨格筋加齢研究グループ(加藤教授、山田充彦 分子薬理学教授、大学院生)

加齢により筋力が減少することをサルコペニアといい、高齢者が歩けなくなり介護を要するようになる原因の一つとなっています。これを予防することは社会的にも重要であり、ロコモ運動では予防体操などで筋力を増強することを目指しています。
一方、加齢によって筋力が低下する原因についてはまだ解明されておらず、これを明らかにすることで新たな薬物療法の確立につながると考えられます。
分子薬理学教室では関連する遺伝子やタンパク質の発現量をPCR法やWestern blot法によって、イオンチャネルの働きをパッチクランプ法によって解析することができます。加齢によりこれらの分子がどのように変化しているのか、それを治療する方法は何かを、分子薬理学教室と共同で研究しています。

写真:研究イメージ

ロコモ検診グループ(加藤教授、上肢班、脊椎班、病院リハ部)

長野県の平均寿命は男女とも日本一ですが、健康寿命は残念ながら男性6位、女性17位です。健康寿命を損なう最も多い原因は、運動器の加齢による「ロコモーティブシンドローム」です。
本研究は医学部附属病院リハビリテーション部、小布施町の新生病院、小布施町役場との共同研究です。毎週土曜日に、50歳〜80歳の小布施町4人の検診を行っています。検診項目は、骨密度、バランス能力、大腿四頭筋力、握力、歩行能力、骨代謝などです。さらに果樹園などの農業が盛んな小布施における手足の関節の加齢変化を明らかにするために、手、足、指、肘の変形性関節症、脊柱変形、ばね指、肘部管・手根管症候群なども検診しています。
2年間に400人の検診を行い、各年代、性別におけるこれらの有病率を明らかにし、有病率と生活習慣、就労状況、内科的基礎疾患、運動週間との関係を分析していく予定です。

骨関節疾患病態解析ラボ

スタッフ
・整形外科講師 中村幸男
・博士研究員  鈴木孝子
・技能補佐員  高梨祐司
・技能補佐員  北野文江
・整形外科医員 小松雅俊

研究テーマ
  1. 先天性骨系統疾患の原因遺伝子同定と機能解析:
    国内外の多施設共同研究により、特に先天性側弯症、先天性橈尺骨癒合症の研究に力を入れており、次世代シーケンサーを用いた疾患原因遺伝子の絞り込み、Crispr/Cas9システムによる遺伝子改変動物モデルを用いた機能解析を行っております。
  2. 関節リウマチ、骨粗鬆症の病態解明を目指した治療戦略:
    関節リウマチ関連遺伝子の機能解析、JAKシグナルなど新規治療薬の分子メカニズムの解析、骨粗鬆症の最新の治療薬のデータ発信、等を行っております。
  3. 変形性関節症における病態理解

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業績集

2016年度 英文基礎臨床研究業績

  1. Kito M, Yoshimura Y, Isobe K, Aoki K, Suzuki S, Tanaka T, Okamoto M, Sano K, Kato H. Clinical Outcome of Dedifferentiated Liposarcoma in the Extremities: A Retrospective Case Series of 7 Patients. J Orthop Sci. 2016; 21: 673-7.
  2. Uehara M, Tsutsumimoto T, Yui M, Ohta H, Oba H, Misawa H. Single-stage surgery for compressive thoracic myelopathy associated with compressive cervical myelopathy and/or lumbar spinal stenosis. Eur Spine J. 2016; 25: 1904-11.
  3. Itsubo T, Uchiyama S, Yamazaki H, Hayashi M, Nakamura K, Kuniyoshi K, Kato H. Factors affecting extension lag after tendon reconstruction for finger extensor tendon rupture due to distal radioulnar lesion. J Orthop Sci. 2016; 21; 19-23.
  4. Tanaka A, Yoshimura Y, Aoki K, Kito M, Okamoto M, Suzuki S, Momose T, Kato H. Knee extension strength and post-operative functional prediction in quadriceps resection for soft-tissue sarcoma of the thigh. Bone Joint Res. 2016; 5: 232-8.
  5. Yoshida K, Maruyama M, Kasama K, Hashidate H, Kitagawa K. Open reduction by fenestration to the ilium for central acetabular depression fractures: a case report and operative technique. Open Journal of Orthopedics. 2016: 221-6.
  6. Yoshida K, Kasama K, Akahane T. Avulsion fracture of the calcaneus treated with a soft anchor bridge and lag screw technique: a report of two cases. J Foot Ankle Surg. 2016; 55: 310-3.
  7. Kamimura M, Nakamura Y, Sugino N, Uchiyama S, Komatsu M, Ikegami S, Kato H, Taguchi A. Associations of self-reported height loss and kyphosis with vertebral fractures in Japanese women 60 years and older: a cross-sectional survey. Sci Rep. 2016; 6: 29199.
  8. Ikegami S, Kamimura M, Uchiyama S, Nakamura Y, Mukaiyama K, Kato H. Clinical implications of hip flexion in the measurement of spinal bone mineral density. J Clin Densitom. 2016; 19: 270-6.
  9. Takahara K, Kamimura M, Moriya H, Ashizawa R, Koike T, Hidai Y, Ikegami S, Nakamura Y, Kato H. Risk factors of adjacent vertebral collapse after percutaneous vertebroplasty for osteoporotic vertebral fracture in postmenopausal women. BMC Musculoskelet Disord. 2016; 17: 12.
  10. Kuroda C, Haniu H, Ajima K, Tanaka M, Sobajima A, Ishida H, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N. The dispersion state of tangled multi-walled carbon nanotubes affects their cytotoxicity. Nanomaterials-Basel. 2016; 6: 219.
  11. Shimodaira H, Tensho K, Akaoka Y, Takanashi S, Kato H, Saito N. Remnant-preserving tibial tunnel positioning using anatomical landmarks in double-bundle anterior cruciate ligament reconstruction. Arthroscopy. 2016; 32: 1822-30.
  12. Kuroda C, Haniu H, Ajima K, Tanaka M, Sobajima A, Ishida H, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N. The dispersion state of tangled multi-walled carbon nanotubes affects their cytotoxicity. Nanomaterials. 2016; 6: 219
  13. Kuraishi S, Takahashi J, Mukaiyama K, Shimizu M, Ikagami S, Futatsugi T, Hirabayashi H, Ogihara N, Hashidate H, Tateiwa Y, Kinoshita H, Kato H. Comparison of clinical and radiological results of posterolateral fusion and posterior lumbar interbody fusion in the treatment of L4 degenerative lumbar spondylolisthesis. Asian Spine J. 2016; 10: 143-52.
  14. Takahashi J, Hirabayashi H, Hashidate H, Ogihara N, Mukaiyama K, Komatsu M, Inaba Y, Kosho T, Kato H. Challenges of transarticular screw fixation in young children: Report of surgical treatment of a 5-year-old patient’s unstable os-odontoideum. Asian Spine J. 2016; 10: 950-954.
  15. Akaoka Y, Yamazaki H, Kodaira H, Kato H. Risk factors for the effect of anticoagulant and antiplatelet agents on perioperative blood loss following proximal femoral fractures. Medicine (Baltimore). 2016; 95: e4120
  16. Yoshimura Y, Sano K, Isobe KI, Aoki K, Kito M, Kato H.A recurrent solitary fibrous tumor of the thigh with malignant transformation: A case report. Int J Surg Case Rep. 2016; 21: 111-4.
  17. Nakamura Y, Uchiyama S, Kamimura M, Komatsu M, Ikegami S, Kato H. Bone alterations are associated with ankle osteoarthritis joint pain. Sci Rep. 2016; 6: 18717.
  18. Nishimura M, Itsubo T, Horii E, Hayashi M, Uchiyama S, Kato H. Tardy ulnar nerve palsy caused by chronic radial head dislocation after Monteggia fracture: a report of two cases. J Pediatr Orthop B. 2016; 25: 450-3.
  19. Karube T, Uchiyama S, Murai T, Yamazaki H, Kato H. Functional evaluation and DASH scores of a patient treated with second toe-to-thumb transfers for bilateral thumb amputations: A case report. J Orthop Sci. 2016; 21: 97-9.
  20. Kamimura M, Nakamura Y, Ikegami S, Uchiyama S, Kato H. Bisphosphonate Pre-Treatment Diminishes the Therapeutic Benefits of Teriparatide in Japanese Osteoporotic Patients. Tohoku J Exp Med. 2016; 239: 17-24.
  21. Ido Y, Uchiyama S, Nakamura K, Itsubo T, Hayashi M, Hata Y, Imaeda T, Kato H. Postoperative improvements in DASH score, clinical findings, and nerve conduction velocity in patients with cubital tunnel syndrome. Sci Rep. 2016; 6:27497.
  22. Taguchi A, Kamimura M, Sugino N, Uchida K, Kitamura Y, Ikegami S, Nakamura Y, Uchiyama S, Kato H. Association of self-reported height loss and kyphosis with loss of teeth in Japanese elderly. Oral Health and Dental Management. ORAL HEALTH AND DENTAL MANAGEMENT. 2016; 15: 69-74.
  23. Nakamura Y, Ikegami S, Takanashi Y, Kamimura M, Uchiyama S, Kato H. Value changes in bone turnover markers and bone mineral density using ibandronate in Japanese postmenopausal osteoporotic patients. J Nutr Disorders Ther. 2016; 6: 2
  24. Oshiba H, Itsubo T, Ikegami S, Nakamura K, Uchiyama S, Kato H. Results of bone peg grafting for capitellar osteochondritis dissecans in adolescent baseball players. Am J Sports Med. 2016; 44: 3171-8.
  25. Taguchi A, Kamimura M, Nakamura Y, Sugino N, Ichinose A, Maezumi H, Fukuzawa T, Ashizawa R, Takahara K, Gushiken S, Mukaiyama K, Ikegami S, Uchiyama S, Kato H. Delayed wound healing after tooth extraction and self-reported kyphosis in Japanese men and women. Sci Rep. 2016; 6: 36309.
  26. Yamazaki H, Uchiyama S, Hosaka M, Kato H. Closed rupture of the flexor tendon secondary to sclerosis of the hook of the hamate: a report of two cases. J Hand Surg Asian Pac Vol. 2016; 21: 405-9.
  27. Thirukonda GJ, Uehara S, Nakayama T, Yamashita T, Nakamura Y, Mizoguchi T, Takahashi N, Yagami K, Udagawa N, Kobayashi Y. The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts. J Bone Miner Metab. 2016; 34: 395-405.
  28. Isobe F, Nakamura Y, Kamimura M, Uchiyama S, Kato H. Effects of denosumab treatment during early pregnancy - a case report. J Nutr Disorders Ther. 2016; 6: 189.
  29. Kamimura M, Nakamura Y, Ikegami S, Komatsu M, Uchiyama S, Kato H. Monthly minodronate inhibits bone resorption to a greater extent than does monthly risedronate. Osteoporosis Sarcopenia. 2016; 2: 170-4.

2015年度 英文基礎臨床研究業績

  1. Ikegami S, Uchiyama S, Nakamura Y, Mukaiyama K, Hirabayashi H, Kamimura M, Nonaka K, Kato H. Factors that characterize bone health with aging in healthy postmenopausal women. J Bone Miner Metab. 2015; 33: 440-7
  2. Maruyama K, Haniu H, Saito N, Matsuda Y, Tsukahara T, Kobayashi S, Tanaka M, Aoki K, Takanashi S, Okamoto M, Kato H. Endocytosis of multi-walled carbon nanotubes in bronchial epithelial and mesothelial cells. Biomed Res Int. 2015; 2015: 793186.
  3. Tensho K, Akaoka Y, Shimodaira H, Takanashi S, Ikegami S, Kato H, Saito N. What components comprise the measurement of the tibial tuberosity-trochlear groove distance in a patellar dislocation population? J Bone Joint Surg Am. 2015; 97: 1441-8.
  4. Mukaiyama K, Kamimura M, Uchiyama S, Ikagami S, Kato H. Elevation of serum alkaline phosphatase (ALP) level in postmenopausal women is caused by high bone turn over. Aging Clin Exp Res. 2015; 27: 413-8.
  5. Hayashi M, Uchiyama S, Nakamura K, Itsubo T, Momose T, Kato H. Arthrodesis of the carpometacarpal joint of the thumb with plate fixation and bone grafting: a retrospective review. J Orthop Sci. 2015; 20: 302-6
  6. Yamazaki H, Uchiyama S, Komatsu M, Hashimoto S, Kato H. Risk assessment of tendon attrition following treatment of distal radius fractures with volar locking plates using audible crepitus and placement of the plate: A prospective clinical cohort study. J Hand Surg Am. 2015; 40: 1571-81.
  7. Yamazaki H, Uchiyama S, Komatsu M, Hashimoto S, Kobayashi Y, Sakurai T, Kato H. Arthroscopic assistance does not improve the functional or radiographic outcome of unstable intra-articular distal radial fractures treated with a volar locking plate: a randomised controlled trial. Bone Joint J. 2015; 97-B: 957-62.
  8. Kito M, Yoshimura Y, Isobe K, Aoki K, Momose T, Suzuki S, Tanaka A, Sano K, Akahane T, Kato H. Clinical outcome of deep-seated atypical lipomatous tumor of the extremities with median-term follow-up study. Eur J Surg Oncol. 2015; 41: 400-6.
  9. Uchiyama S, Ikegami S, Kamimura M, Mukaiyama K, Nakamura Y, Nonaka K, Kato H. The skeletal muscle cross sectional area in long-term bisphosphonate users is smaller than that of bone mineral density-matched controls with increased serum pentosidine concentrations. Bone. 2015; 75: 84-7.
  10. Hashidate H, Kamimura M, Ikegami S, Mukaiyama K, Uchiyama S, Nakamura Y, Kato H. Serum pentosidine levels after 3 years of bisphosphonate treatment in post-menopausal osteoporotic women. Endocr Res. 2015; 40: 172-6.
  11. Uehara M, Takahashi J, Kuraishi S, Shimizu M, Ikegami S, Futatsugi T, Aoki K, Mukaiyama K, Ogihara N, Hashidate H, Hirabayashi H, Kato H. Mini Open for Cervical Radiculopathy: A comparison of large tubular and trimline retractors. Asian Spine J. 2015; 9: 548-52.
  12. Uehara M, Takahashi J, Kuraishi S, Shimizu M, Ikegami S, Futatsugi T, Kato H. Osteoid osteoma presenting as thoracic scoliosis. Spine J. 2015; 15: e77-81.
  13. Kobayashi Y, Thirukonda GJ, Nakamura Y, Koide M, Yamashita T, Uehara S, Kato H, Udagawa N, Takahashi N. Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a. Biochem Biophys Res Commun. 2015; 463: 1278-83.
  14. Nakamura Y, Kikugawa S, Seki S, Takahata M, Iwasaki N, Terai H, Matsubara M, Fujioka F, Inagaki H, Kobayashi T, Kimura T, Kurahashi H, Kato H. PCSK5 mutation in a patient with the VACTERL association. BMC Res Notes. 2015; 8: 228.
  15. Nakamura Y, Kamimura M, Ikegami S, Mukaiyama K, Komatsu M, Uchiyama S, Kato H. A case series of pregnancy- and lactation-associated osteoporosis and a review of the literature. Ther Clin Risk Manag. 2015; 11: 1361-5
  16. Nakamura Y, Kamimura M, Ikegami S, Mukaiyama K, Uchiyama S, Taguchi A, Kato H. Changes in serum vitamin D and PTH values using denosumab with or without bisphosphonate pre-treatment in osteoporotic patients: a short-term study. BMC Endocr Disord. 2015; 15: 81
  17. Nomura H, Takanashi S, Tanaka M, Haniu H, Aoki K, Okamoto M, Kobayashi S, Takizawa T, Usui Y, Oishi A, Kato H, Saito N. Specific biological responses of the synovial membrane to carbon nanotubes. Sci Rep. 2015; 5:14314.
  18. Kobayashi S, Tsuruoka S, Usui Y, Haniu H, Aoki K, Takanashi S, Okamoto M, Nomura H, Tanaka M, Aiso S, Saito M, Kato H, Saito N. An advanced in situ imaging method using heavy metal-doped hollow tubes to evaluate the biokinetics of carbon nanotubes in vivo. NPG Asia Mater. 2015; 7:e203.
  19. Ikegami S, Takahashi J, Kuraishi S, Shimizu M, Futatsugi T, Uehara M, Horiuchi K, Shimodaira S, Kato H. Efficacy of erythropoietin-beta injections during autologous blood donation before spinal deformity surgery in children and teenagers. Spine. 2015; 40: E1144-9.
  20. Tsukahara T, Tsukahara R, Haniu H, Matsuda Y, Murakami-Murofushi K. Cyclic phosphatidic acid inhibits the secretion of vascular endothelial growth factor from diabetic human coronary artery endothelial cells through peroxisome proliferator-activated receptor gamma. Mol Cell Endocrinol. 2015; 412: 320-9.
  21. Tsukahara T, Haniu H, Matsuda Y. Cyclic phosphatidic acid induces G0/G1 arrest, inhibits AKT phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells. Cell Mol Biol Lett. 2015; 20: 38-47.
  22. Tsukahara T, Haniu H, Matsuda Y. The PTB-associated splicing factor/peroxisome proliferator-activated receptor gamma axis regulates autophagosome formation in human pancreatic cancer cells. Biores Open Access. 2015; 4: 319-25.
  23. Komatsu M, Nakamura Y, Maruyama M, Abe K, Watanapokasin R, Kato H. Expression profiles of human CCN genes in patients with osteoarthritis or rheumatoid arthritis. J Orthop Sci. 2015; 20: 708-16.
  24. Ohe A, Kimura T, Goh AC, Oba A, Takahashi J, Mogami Y. Characteristics of trunk control during crook-lying unilateral leg raising in different types of chronic low back pain patients. Spine. 2015; 40: 550-9.
  25. Komatsu M, Nakamura Y, Kamimura M, Ikegami S, Mukaiyama K, Uchiyama S, Kato H. Bone alterations in painful osteoarthritic shoulder. J Case Rep. 2015; 5: 84-7.
  26. Mukaiyama K, Uchiyama S, Nakamura Y, Ikegami S, Taguchi A, Kamimura M, Kato H. Eldecalcitol, in combination with bisphosphonate, is effective for treatment of Japanese osteoporotic patients. Tohoku J Exp Med. 2015; 237: 339-43.
  27. Aoki T, Tensho K, Akaoka Y, Shimodaira H, Takanashi S, Kato H, Saito N Intrameniscal Goty Tophi in the Knee. J Bone Joint Surg. Case connect. 2015; 26 5(3): e74
  28. Tsuruoka S, Matsumoto H, Koyama K, Akiba E, Yanagisawa T, Cassee FR, Saito N, Usui Y, Kobayashi S, Porter DW, Castranova V, Endo M. Radical scavenging reaction kinetics with multi-walled carbon nanotubes. Carbon. 2015; 83: 232-239.
  29. Tsuruoka S, Matsumoto H, Castranova V, Porter DW, Yanagisawa T, Saito N, Kobayashi S, Endo M. Differentiation of chemical reaction activity of various carbon nanotubes using redox potential: classification by physical and chemical structures. Carbon. 2015; 95: 302-308.
  30. Nishimura N, Takeda S, Teranishi T, Hayashi H, Saito N Kishimoto A. Influence of pmsa-based polymer on the settling velocity of cnt in aqueous media. Mater Trans. 2015; 56: 2006-9.
  31. Yamazaki H, Akaoka Y, Komatsu M. Percutaneous transluminal angioplasty for axillary artery dissection after open reduction of shoulder fracture-dislocation. JBJS Case Connector. 2015; 5: e46.

2014年度 英文基礎臨床研究業績

  1. Kito M, Yoshimura Y, Aoki K, Uchiyama S, Uehara T, Kato H. Locked metacarpophalangeal joint of the middle finger caused by a lipoma in the flexor tenosynovium. a case report. J Bone Joint Surg. Case Connect. 2014; 5: e64.
  2. Tensho K, Aoki T, Morioka S, Narita N, Kato H, Saito N. Snapping pes syndrome after total knee arthroplasty. nee Surg Sports Traumatol Arthrosc. 2014; 22: 192-4
  3. Ikegami S, Kamimura M, Uchiyama S, Mukaiyama K, Kato H. Unilateral vs Bilateral Hip Bone Mineral Density Measurement for the Diagnosis of Osteoporosis. J Clin Densitom. 2014; 17: 84-90.
  4. Okamoto M, Udagawa N, Uehara S, Maeda K, Yamashita T, Nakamichi Y, Kato H, Saito N, Minami Y, Takahashi N, Kobayashi Y. Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis. Sci Rep. 2014: 27; 4: 4493.
  5. Nakamura K, Uchiyama S, Ido Y, Itsubo T, Hayashi M, Murakami H, Sato N, Imaeda T, Kato H. The effect of vascular pedicle preservation on blood flow and clinical outcome following ulnar nerve transposition. J Hand Surg Am. 2014; 39: 291-302.
  6. Haniu H, Saito N, Matsuda Y, Tsukahara T, Usui Y, Maruyama K, Takanashi S, Aoki K, Kobayashi S, Nomura H, Tanaka M, Okamoto M, Kato H. Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells. Int J Nanomedicine. 2014; 9:1979-90.
  7. Hatakenaka T, Uemura K, Itsubo T, Hayashi M, Uchiyama S, Kato H. Septic arthritis of the elbow in a child due to Pseudomonas aeruginosa: a case report. J Pediatr Orthop B. 2014; 23: 285-7.
  8. Itsubo T, Murakami N, Uchiyama S, Nakamura K. Kato H. MRI staging to evaluate the stability of capitellar osteochondritis dissecans lesions. Am J Sport Med. 2014; 42: 1972-7.
  9. Saito N, Haniu H, Usui Y, Aoki K, Hara K, Takanashi S, Shimizu M, Narita N, Okamoto M, Kobayashi S, Nomura H, Kato H, Nishimura N, Taruta S, Endo M. Safe clinical use of carbon nanotubes as innovative biomaterials. Chem Rev. 2014; 114: 6040-79.
  10. Momose T, Uchiyama S, Kobayashi S, Nakagawa H, Kato H. Structural changes of the carpal tunnel, median nerve and flexor tendons in MRI before and after endoscopic carpal tunnel release. Hand Surg. 2014; 19: 193-8.
  11. Nakamura Y, Nojiri K, Yoshihara H, Takahata T, Honda-Takahashi K, Kubo S, Sakatsume K, Kato H, Maruta T, Honda T. Significant differences of brain blood flow in patients with chronic low back pain and acute low back pain detected by brain SPECT. J Orthop Sci, 2014; 19: 384–9.
  12. Shimizu M, Takahashi J, Ikegami S, Kuraishi S, Futatsugi T, Kato H.. Are pedicle screw perforation rates influenced by registered or unregistered vertebrae in multilevel registration using a CT-based navigation system in the setting of scoliosis? Eur Spine J. 2014; 23: 2211-7
  13. Takahashi J, Ikegami S, Kuraishi S, Shimizu M, Futatsugi T, Kato H. Skip pedicle screw fixation combined with Ponte osteotomy for adolescent idiopathic scoliosis. Eur Spine J. 2014: 23: 2689-95..
  14. Uehara M, Takahashi J, Ikegami S, Mukaiyama K, Kuraishi S, Shimizu M, Futatsugi T, Ogihara N, Hashidate H, Hirabayashi H, Kato H.Screw perforation features in 129 consecutive patients performed computer-guided cervical pedicle screw insertion. Eur Spine J. 2014; 23: 2189-95..
  15. Tensho K, Shimodaira H, Aoki T, Narita N, Kato H, Kakegawa A, Fukushima N, Moriizumi T, Fujii M, Fujinaga Y, Saito N. Bony Landmarks of the Anterior Cruciate Ligament Tibial Footprint: A Detailed Analysis Comparing 3-Dimensional Computed Tomography Images to Visual and Histological Evaluations. Am J Sports Med. 2014; 42: 1433-40.
  16. Uchiyama S, Sekijima Y, Tojo K, Sano K, Imaeda T, Moriizumi T, Ikeda SI, Kato H. Effect of synovial transthyretin amyloid deposition on preoperative symptoms and postoperative recovery of median nerve function among patients with idiopathic carpal tunnel syndrome. J Orthop Sci. 2014; 9: 913-9.
  17. Kito M, Yoshimura Y, Isobe K, Aoki K, Momose T, Kato H. Intraosseous neurilemmoma of the proximal ulna. Int J Surg Case Rep. 2014; 23; 5: 914-8.
  18. Nakamura Y, Kamimura M, Ikegami S, Mukaiyama K, Uchiyama S, Kato H. Changes in Bone Turnover Markers and Fracture in Osteo¬porosis: A Review of the Literature. Ann Orthop Rheumatol. 2014; 2: 1023.
  19. Nakamura Y, Kamimura M, Mukaiyama K, Ikegami S, Uchiyama S, Kato H. A Case with Atypical Clinical Course Diagnosed as Osteoarthritis, Osteonecrosis, Subchondral Insufficiency Fracture, or Rapidly Destructive Coxopathy. Open Rheumatol J. 2014; 8: 18-21.
  20. Ito-Amano M, Nakamura Y, Morisaki M, He X, Hayashi M, Watanapokasin R, Kato H. Temporal and Spatial Expression Patterns of Bone Morphogenetic Protein 3 in Developing Zebrafish. Open Rheumatol J. 2014; 8: 22-5.
  21. Kinoshita T, Fukushima K, Abe RT, Ogawa Y, Nakagawa M, Katoh N, Yoshida T, Kato H, Ikeda S. Motor branch biopsy of the pronator teres muscle in a patient with painful forearm neuropathy. Case Rep Neurol. 2014; 6: 202-6.
  22. Kamimura M, Nakamura Y*, Ikegami S, Ichinose A, Uchiyama S, and Kato H. Tramadol/acetaminophen causes constipation more frequently in women with degenerative spinal disorders than in those with degenerative joint disorders. Drugs Ther Perspect. 2014; 30: 149–54.
  23. Komatsu M, Nakamura Y, Kamimura M, Uchiyama S, Mukaiyama K, Ikegami S, Kato H. Knee joint pain potentially due to bone alterations in a knee osteoarthritis patient.. Am J Case Rep. 2014 ; 15: 534-7.
  24. Kamimura M, Nakamura Y, Uchiyama S, Ikegami S, Mukaiyama K, Kato H. The Pathophysiology and Progression of Hip Osteoarthritis Accompanied with Joint Pain are Potentially Due to Bone Alterations - Follow-up Study of Hip OA Patients. Open Rheumatol J. 2014: 2; 8: 46-53.
  25. Tsukahara T, Matsuda Y, Haniu H. The role of autophagy as a mechanism of toxicity induced by multi-walled carbon nanotubes in human lung cells. Int J Mol Sci. 2014; 16: 40-8.
  26. Komatsu M, Kamimura M, Nakamura Y, Mukaiyama K, Ikegami S, Uchiyama S, Kato H. Rapid bone destruction in a patient with knee osteoarthritis -A case report and review of the literature-. Clin Cases Miner Bone Metab. 2014; 11: 239-42.
  27. Akaoka Y、Tensho K, Shimodaira H, Aoki T, Takanashi S, Kato H, Saito N. Early post-operative intra-tunnel migration of the EndoButton after anatomical double-bundle anterior cruciate ligament reconstruction. J Bone Joint S Case Connect. 2014; 4: e111.
  28. Maruyama M, Tensho K, Wakabayashi S, Hisa K. Standing versus supine radiographs to evaluate femoral head penetration in the polyethylene liner after total hip arthroplasty. J Arthroplasty. 2014; 29: 2415-9
  29. Uehara M, Takahashi J, Mukaiyama K, Kuraishi S, Shimizu M, Ikegami S, Futatsugi T, Ogihara N, Hashidate H, Hirabayashi H, Kato H. Mid-Term results of computer-assisted cervical pedicle screw fixation. Asian Spine J. 2014; 8: 759-67.
  30. Uehara M, Takahashi J, Mukaiyama K, Kuraishi S, Shimizu M, Ikegami S, Futatsugi T, Ogihara N, Hashidate H, Hirabayashi H, Kato H. Comparison of spinous process-splitting laminectomy versus conventional laminectomy for lumbar spinal Ssenosis. Asian Spine J. 2014; 8: 768-76.
  31. Uehara M, Takahashi J, Mukaiyama K, Kuraishi S, Shimizu M, Ikegami S, Futatsugi T, Sano K, Hongo K, Kato H. Myxopapillary epemdymoma of the cauda equine in 5-year-old boy. Asian Spine J. 2014; 8: 846-51.
  32. Ikegami S, Tsutsumimoto T, Ohta H, Yui M, Kosaku H, Uehara M, Misawa H. Preoperative spinal cord damage affects the characteristics and prognosis of segmental motor paralysis after cervical decompression surgery. Spine. 2014; 39: 463-8.
  33. Hashidate H, Kamimura M, Ikegami S, Mukaiyama K, Uchiyama S, Nakamura Y, Kato H. Serum pentosidine levels after 3 years of bisphosphonate treatment in post-menopausal osteoporotic women. Endocr Res. 2014 Dec 23:1-5.

2013年度 英文基礎臨床研究業績

  1. Ogihara N, Takahashi J, Hirabayashi H, Mukaiyama K, Kato H. Surgical treatment of Klippel-Feil syndrome with basilar invagination. Eur Spine J. 2013; 22: Suppl 3: S380-7.
  2. Kobayashi S, Takahashi J, Sakashita K, Fukushima M, Kato H. Ewing sarcoma of the thoracic epidural space in a young child. Eur Spine J. 2013; 22: Suppl 3: S373-9.
  3. Kuraishi S, Takahashi J, Hirabayashi H, Hashidate H, Ogihara N, Mukaiyama K, Kato H. Pedicle morphology using computed tomography-based navigation system in adolescent idiopathic scoliosis. J Spinal Disord Tech. 2013; 26: 22-8.
  4. Takahashi J, Kobayashi H, Wakabayashi S, Kato H. e t al. The effect of a prostaglandin E1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis. J Orthop Sci. 2013; 18: 208-15.
  5. Oba H, Takahashi J, Futatsugi T, Mogami Y, Shibata S, Ohji Y, Tanikawa H. Study of dural sac cross-sectional area in early and late phases following lumbar decompression surgery. Spine J. 2013; 13: 1088-94.
  6. Uehara M, Takahashi J, Ogihara N, Hirabayashi H, Mukaiyama K, Kuraishi S, Shimizu M, Futatsugi T, Hashidate H, Kato H. Mid-term results of computer-assisted cervical reconstruction for rheumatoid cervical spines. J Orthop Sci. 2013; 18: 916-25.
  7. Uehara M, Takahashi J, Hirabayashi H, Kitahara J, Kamijyo T, Ebara S, Kato H. Hodgkin's disease of the thoracic vertebrae. Spine J. 2013 ;13: e59-63.
  8. Uehara M, Takahashi J, Hirabayashi H, Ogihara N, Mukaiyama K, Kuraishi S, Shimizu M, Hashidate H, Kato H. Evaluation of clinical results and quality of life after surgical reconstruction for rheumatoid cervical spine. Spine J. 2013; 13: 391-6.
  9. Hirabayashi H, Takahashi J, Hashidate H, Ogihara N, Mukaiyama K, Kuraishi S, Shimizu M, Nakagawa H, Matsue R, Kato H. Spinous process plate fixation for cervical spinal fusion after spinal trauma: two case reports. J Zhejiang Univ Sci B. 2013; 14: 855-8.
  10. Mukaiyama K, Takahashi J, Hirabayashi H, Ogihara N, Kuraishi S, Shimizu M, Kato H. Factors influencing the residual rib hump after posterior spinal fusion for adolescent idiopathic scoliosis with Lenke 1 and 2 curves. J Orthop Sci. 2013; 18: 687-92.
  11. Uchiyama S, Nakamura K, Itsubo T, Murakami H, Hayashi M, Imaeda T, Kato H. Technical Difficulties and Their Prediction in 2-Portal endoscopic Carpal Tunnel Release for Idiopathic Carpal Tunnel Syndrome. Arthroscopy. 2013; 29:860-9
  12. Uchiyama S, Itsubo T, Nakamura K, Fujinaga Y, Sato N, Imaeda T, Kadoya M, Kato H. Effect of early administration of alendronate after surgery for distal radial fragility fracture on radiological fracture healing time. J Bone Joint J. 2013; 95-B: 1544-50.
  13. Hayashi M, Makoto M, Kato H. Carpal tunnel syndrome associated with underlying Kienbock's disease. J Hand Surg Eur 2013 Mar 5 [Epub ahead of print]
  14. Hayashi M, Zhao C, An KN, Amadio PC. The effects of growth and differentiation factor 5 on bone marrow stromal cell transplants in an in vitro tendon healing model. J Hand Surg Eur, 2011; 36: 271-9.
  15. Sasaki J, Itsubo T, Nakamura K, Hayashi M, Uchiyama S, Kato H. Intrasynovial tendon graft for chronic flexor tendon laceration of the finger: a case report. Open Orthop J. 2013; 19; 7: 282-5.
  16. Nakamura K, Uchiyama S, Ido Y, Itsubo T, Hayashi M, Murakami H, Sato N, Imaeda T, Kato H. The Effect of Vascular Pedicle Preservation on Blood Flow and Clinical Outcome Following Ulnar Nerve Transposition. J Hand Surg Am. 2013 Dec 13. [Epub ahead of print]
  17. Tensho K, Aoki T, Morioka S, Narita N, Kato H, Saito N. Snapping pes syndrome after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2012; Dec [Epub ahead of print]
  18. Maruyama M, Wakabayashi S, Tensho K. Less invasive rotational acetabular osteotomy for hip dysplasia. Clin Orthop Relat Res. 2013; 471: 1263-70.
  19. Yoshimura Y, Isobe K, Arai H, Aoki K, Kito M, Kato H. Preoperative radiographic and histopathologic evaluation of central chondrosarcoma. Arch Orthop Trauma Surg. 2013; 133: 1225-31.
  20. Haniu H, Saito N, Matsuda Y, Tsukahara T, Maruyama K, Usui Y, Aoki K, Takanashi S, Kobayashi S, Nomura H, Okamoto M, Shimizu M, Kato H. Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response. Toxicol In Vitro. 2013; 27: 1679-85.
  21. Ikegami S, Kamimura M, Uchiyama S, Mukaiyama K, Kato H. Unilateral vs bilateral hip bone mineral density measurement for the diagnosis of osteoporosis. J Clin Densitom. 2013 May 15. [Epub ahead of print]
  22. Kamimura M, Nakamura Y, Ikegami S, Uchiyama S, Kato H. Joint pain undergoes a transition in accordance with signal changes of bones detected by MRI in hip osteoarthritis. Open Rheumatol J. 2013 Sep 30;7:67-74.
  23. Kamimura M, Nakamura Y, Mukaiyama K, Ikegami S, Uchiyama S, Kato H. The pathophysiology of primary hip osteoarthritis may originate from bone alterations. Open Rheumatol J. 2013; 7:101-107.
  24. Matsunaga D, Akizuki S, Takizawa T, Omae S, Kato H. Compact platelet-rich fibrin scaffold to improve healing of patellar tendon defects and for medial collateral ligament reconstruction. Knee. 2013; 20: 545-50.

2012年度 英文基礎臨床研究業績

  1. Haniu H, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Okamoto M, Takanashi S, Ishigaki N, Nakamura K, Kato H, Saito N. Toxicoproteomic evaluation of carbon nanomaterials in vitro. J Proteomics. 2012; 74: 2703-12.
  2. Yamazaki H, Takeoka M, Kitazawa M, Ehara T, Itano N, Kato H, Taniguchi S. ASC plays a role in the priming phase of the immune response to type II collagen in collagen-induced arthritis. Rheumatol Int. 2012; 32:1625-32.
  3. Nakamura Y, He X, Kato H, Wakitani S, Kobayashi T, Watanabe S, Iida A, Tahara H, Warman ML, Watanapokasin R, Postlethwait JH. Sox9 Is Upstream of MicroRNA-140 in Cartilage. Appl Biochem Biotechnol. 2012; 166: 64-71.
  4. DeLaurier A, Nakamura Y, Braasch I, Khanna V, Kato H, Wakitani S, Postlethwait JH, Kimmel CB. Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton. BMC Dev Biol. 2012; 12:16.
  5. Iwasaki N, Kamishima T, Kato H, Funakoshi T, Minami A. A retrospective evaluation of magnetic resonance imaging effectiveness on capitellar osteochondritis dissecans among overhead athletes. Am J Sports Med. 2012; 40: 624-30.
  6. Shiozawa R, Uchiyama S, Sugimoto Y, Ikegami S, Iwasaki N, Kato H. Comparison of splinting versus nonsplinting in the treatment of pediatric trigger finger. J Hand Surg Am. 2012; 37: 1211-6.
  7. Narita N, Takao M, Innami K, Kato H, Matsushita T. Minimally invasive subtalar arthrodesis with iliac crest autograft through posterior arthroscopic portals: a technical note. Foot Ankle Int. 2012; 33: 803-5.
  8. Itsubo T, Fukushima N, Kakegawa A, Yokouchi K, Kawagishi K, Kato H, Moriizumi T. Effects of repeated crush injuries on motor functional recovery of the sciatic nerve. Neurol Res. 2012; 34: 908-14.
  9. Takanashi S, Hara K, Aoki K, Usui Y, Shimizu M, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Okamoto M, Kobayashi S, Kato H, Sano K, Nishimura N, Tsutsumi H, Machida K, Saito N. Sci Rep. 2012; 2: 498.
  10. Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N. Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts. Adv Mater. 2012; 24: 2176-85.
  11. Ogihara N, Usui Y, Aoki K, Shimizu M, Narita N, Hara K, Nakamura K, Ishigaki N, Takanashi S, Okamoto M, Kato H, Haniu H, Ogiwara N, Nakayama N, Taruta S, Saito N. Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes. Nanomedicine-UK. 2012; 7: 981-93.
  12. Miwa H, Hashimoto Y, Tensho K, Wakitani S, Takagi M. Xeno-free proliferation of human bone marrow mesenchymal stem cells. Cytotechnology. 2012; 64: 301-8.
  13. Uehara M, Takahashi J, Hirabayashi H, Hashidate H, Ogihara N, Mukaiyama K, Kato H. Computer-assisted C1-C2 Transarticular Screw Fixation "Magerl Technique" for Atlantoaxial Instability. Asian Spine J. 2012; 6: 168-77.
  14. Kano S, Tanikawa H, Mogami Y, Shibata S, Takanashi S, Oji Y, Aoki T, Oba H, Ikegami S, Takahashi J. Comparison between continuous and discontinuous multiple vertebral compression fractures. Eur Spine J. 2012; 21: 1867-72.
  15. Ogihara N, Takahashi J, Hirabayashi H, Hashidate H, Kato H. Stable Reconstruction Using Halo-vest for Unstable Upper Cervical Spine and Occipito-cervical Instability. Eur Spine J. 2012; 21: 295-303.
  16. Tanaka A, Takahashi J, Hirabayashi H, Ogihara N, Mukaiyama K, Shimizu M, Hashidate H, Kato H. A case of pyogenic spondylodiscitis caused by Campylobacter fetus for which early diagnosis by MRI was difficult. Asian Spine J. 2012; 6: 274-8.
  17. Uehara M, Takahashi J, Ogihara N, Hirabayashi H, Hashidate H, Mukaiyama K, Shimizu M, Kato H. Cervical pedicle screw fixation combined with laminoplasty for cervical spondylotic myelopathy with instability. Asian Spine J. 2012; 6: 241-8.
  18. Haniu H, Saito N, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Nakamura K, Ishigaki N, Tsukahara T, Kato H. Manufacturing strategy for multi-walled carbon nanotubes as a biocompatible and innovative material. Journal of Nanotechnology. 2012 ID937819: 1-6, 2012.
  19. Ueda N, Yamakami T, Yamaguchi T, Kitajima K, Usui Y, Aoki K, Endo M, Saito N, Taruta S. Microstructure development and fracture toughness of acid-treated carbon nanofibers/alumina composites. J Ceram Soc Jpn. 2012; 120: 560-8.
  20. Usui Y, Haniu H, Tsuruoka S, Saito N. Carbon nanotubes innovate on medical technology. Med Chem. 2012; 2: 1-6.

Book

  1. Yamazaki H, Kato H, Uchiyama S. Tendon rupture after fractures or carpal disorders. Tendon Surgery of the Hand, Tang JB, ed., ELSEVIER, Philadelphia, 2012; 228-32.
  2. Hirabayashi H. Management of lumbar spinal Meningioma: A systematic review. Monleon D, ed., Meningiomas Management and Surgery. InTech, Rijeka, 2012; 35-44.
  3. Takahashi J, Hirabayashi H, Hashidate H, Ogihara N, Mukaiyama K, Kuraishi S, Shimizu M, Uehara M, Kato H. Perforation rates of cervical pedicle screw inserted from C3 to C6 -A retrospective analysis of 78 patients over a period of 14 years-. Spine Surgery; Chung KJ ed., InTech, Croatia, 2012;113-20

2011年度 英文基礎臨床研究業績

  1. Yamazaki H, Kato H, Uchiyama S, Iwasaki N, Ishikura H, Minami A.
    Long term results of early active extension and passive flexion mobilization following one-stage tendon grafting for neglected injuries of the flexor digitorum profundus in children. J Hand Surg Eur Vol. 2011; 36:303-7.
  2. Tensho K, Kodaira H, Yasuda, G, Yoshimura Y, Narita N, Morioka S, Kato H, Saito N.
    Anatomic double-bundle anterior cruciate ligament reconstruction, using CT-based navigation and fiducial markers. Knee Surg Sports Traumatol Arthrosc. 2011;19:378-83.
  3. Yoshimura Y, Isobe K, Koike T, Arai H, Aoki K, Kato H. Metastatic carcinoma to subcutaneous tissue and skeletal   muscle: clinicopathological features in 11 cases. Jpn J Clin Oncol. 2011; 41:358-64.
  4. Yoshimura Y, Lozej JA, Ishii K, Isobe K, Arai H, Kato H. Multifocal periosteal chondromas in the ring finger of an adolescent boy: case report. J Hand Surg Am. 2011;36:101-5.
  5. Takazawa A, Matsuda S, Fujioka F, Uchiyama S, Kato H. Split tibia vascularized fibular graft for congenital pseudarthrosis of the tibia: a preliminary report of 2 cases. J Pediatr Orthop. 2011;31:e20-4.
  6. Hashidate H, Kamimura M, Nakagawa H, Takahara K, Ikegami S, Uchiyama S, Kato H. Early changes in bone specific turnover markers during the healing process after vertebral fracture. Open Orthop J. 2011; 14;5:32-6.
  7. Matsuki H, Ishikawa J, Iwasaki N, Uchiyama S, Minami A, Kato H. Non-vascularized bone graft with Herbert-type screw fixation for proximal pole scaphoid nonunion. J Orthop Sci. 2011; 16:749-55.
  8. Sekijima Y, Uchiyama S, Tojo K, Sano K, Shimizu Y, Imaeda T, Hoshii Y, Kato H, Ikeda SI. High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly. Hum Pathol. 2011 Jul 4. [Epub ahead of print]
  9. Ikegami S, Kamimura M, Uchiyama S, Kato H. Women with insufficient 25-hydroxyvitamin D without secondary hyperparathyroidism have altered bone turnover and greater incidence of vertebral fractures.
    J Orthop Sci. 2011;16:573-80.
  10. Matsuhashi T, Iwasaki N, Kato H, Minami M, Minami A. Clinical outcomes of excision arthroplasty for kienbock's disease. Hand Surg. 2011;16:277-82
  11. Ishigaki N, Kimura T, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogihara N, Nakamura K, Kato H, Ohira M, Yokokawa Y, Miyoshi K, Murakami N, Okada S, Nakamura T, Saito N. Analysis of pelvic movement in the elderly during walking using a posture monitoring system equipped with a triaxial accelerometer and gyroscope. J Biomech. 2011 Jun 3;44:1788-92.
  12. Haniu H, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Okamoto M, Takanashi S, Ishigaki N, Nakamura K, Kato H, Saito N.Toxicoproteomic evaluation of carbon nanomaterials in vitro. J Proteomics. 2011; 74: 2703-12.
  13. Saito N, Aoki K, Usui Y, Shimizu M, Hara K, Narita N, Ogihara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Kim YA, Endo M. Application of carbon fibers to biomaterials: a new era of nano-level control of carbon fibers after 30-years of development. Chem Soc Rev. 2011;40:3824-34.
  14. Takahashi J, Ebara S, Hashidate H, Hirabayashi H, Ogihara N, Mukaiyama K, Kato H. Computer-assisted hemivertebral resection for congenital spinal deformity. J Orthop Sci. 2011;16:503-9.
  15. Takahashi J, Newton PO, Ugrinow VL, Bastrom TP, Harms Study Group. Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis: Factors Influencing the Selection of the Optimal Lowest Instrumented Vertebra.Spine. 2011; 36:1131-41.
  16. Kuraishi S, Takahashi J, Hirabayashi H, Hashidate H, Ogihara N, Mukaiyama K, Kato H. Pedicle Morphology using Computed Tomography-based Navigation System in Adolescent Idiopathic Scoliosis.
    J Spinal Disord Tech. 2011 Sep 28[Epub ahead of print]
  17. Uchiyama S, Itsubo T, Nakamura K, Murakami H, Momose T, and Kato H. MRI-based identification of an appropriate point of needle insertion for patients with idiopathic carpal tunnel syndrome to avoid median nerve injury. ISRN Orthopedics 2011, Article ID 528147
  18. Hara K, Aoki K, Usui Y, Shimizu M, Narita N, Ogihara N, Nakamura K, Ishigaki N, Sano K, Haniu H, Kato H, Nishimura N, Kim YA, Taruta S, Saito N. Evaluation of CNT toxicity in comparison to tattoo ink nanoparticles for use as a biomaterial. Mater Today. 2011; 14: 434-440.
  19. Haniu H, Tsukahara T, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H, Saito N. DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes. Int J Nanomedicine. 2011;6:2689-2695.
  20. Nakamura Y, He X, Kato H, Wakitani S, Kobayashi T, Watanabe S, Iida A, Tahara H, Warman ML, Watanapokasin R, Postlethwait JH. Sox9 Is Upstream of MicroRNA-140 in Cartilage.
    Appl Biochem Biotechnol. 2011[Epub ahead of print]
  21. Hayashi M, Zhao C, An KN, Amadio PC: The effects of growth and differentiation factor 5 on bone marrow stromal cell transplants in an in vitro tendon healing model. J Hand Surg Eur. 2011; 36:271-9.
  22. Ohnishi H, Oda Y, Aoki T, Tadokoro M, Katsube Y, Ohgushi H, Hattori K, Yuba S.
    A comparative study of induced pluripotent stem cells generated from frozen, stocked bone marrow- and adipose tissue-derived mesenchymal stem cells. J Tissue Eng Regen Med. 2011 Jun 27. [Epub ahead of print]
  23. Hagiwara Y, Hattori K, Aoki T, Ohgushi H, Ito H. Autofluorescence assessment of extracellular matrices of a cartilage-like tissue construct using a fluorescent image analyser. J Tissue Eng Regen Med. 2011;5:163-8.
  24. Wakitani S, Okabe T, Horibe S, Mitsuoka T, Saito M, Koyama T, Nawata M, Tensho K, Kato H, Uematsu K, Kuroda R, Kurosaka M, Yoshiya S, Hattori K, Ohgushi H. Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months. J Tissue Eng Regen Med. 2011;5:146-50.
  25. Book

  26. Takahashi J. Computer-assisted spinal surgery. Advances in Electrical Engineering Research, Vol 1:2011; Nova Science Publishers, Inc. New York. 251-266
  27. Saito N, Aoki K, Usui Y, Shimizu M, Hara K, Narita N, Ogihara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Kim C, Taruta S, Kim YA, Endo M: Thin carbon fiber web that functions as a scaffold for tissue regeneration. In: Berhardt LV (ed), Advances in Medicine and Biology, Volume 11: 2011; Nova Science Publishers, Inc.,
    New York. 301-310.

2010年度 英文基礎臨床研究業績

  1. Niwa T, Uchiyama S, Yamazaki H, Kasashima T, Tsuchikane A, Kato H. Closed tendon rupture as a result of Kienbock’s disease.
    Scand J Plast Reconstr Surg Hand Surg. 2010; 44: 59-63.
  2. Itsubo T, Hayashi Mi, Uchiyama S, Hirachi K, Minami A, Kato H. Differential onset patterns and causes of carpal tunnel syndrome after distal radius fracture:
    a retrospective study of 105 wrists. J Orthop Sci. 2010; 15: 518-23.
  3. Uchiyama S, Yasutomi T, Momose T, Nakagawa H, Kamimura M, Kato H. Carpal tunnel pressure measurement during two-portal endoscopic carpal tunnel release. Clin Biomech. 2010; 25: 893-8.
  4. Uchiyama S, Itsubo T, Nakamura K, Kato H, Yasutomi T, Momose T. Current concepts of carpal tunnel syndrome: pathophysiology, treatment, and evaluation. J Orthop Sci. 2010; 15: 1-13.
  5. Takahashi J, Hirabayashi H, Hashidate H, Ogihara N, Kato H. Accuracy of multilevel registration in image-guided pedicle screw insertion for adolescent idiopathic scoliosis. Spine. 2010; 35: 347-52.
  6. Miyake N, Kosho T, Mizumoto S, Furuichi T, Hatamochi A, Nagashima Y, Arai E, Takahashi K, Kawamura R, Wakui K, Takahashi J, Kato H, Yasui H, Ishida T, Ohashi H, Nishimura G, Shiina M, Saitsu H, Tsurusaki Y, Doi H, Fukushima Y, Ikegawa S, Yamada S, Sugahara K, Matsumoto N.
    Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome. Hum Mutat. 2010; 31: 966-74.
  7. Kosho T, Miyake N, Hatamochi A, Takahashi J, Kato H, Miyahara T, Igawa Y, Yasui H, Ishida T, Ono K, Kosuda T, Inoue A, Kohyama M, Hattori T, Ohashi H, Nishimura G, Kawamura R, Wakui K, Fukushima Y, Matsumoto N. A new Ehlers-Danlos syndrome with craniofacial characteristics, multiple congenital contractures, progressive joint and skin laxity, and multisystem fragility-related manifestations.. Am J Med Genet A. 2010; 152A: 1333-46.
  8. Yamazaki M, Kosho T, Kawachi S, Mikoshiba M, Takahashi J, Sano R, Oka K, Yoshida K, Watanabe T, Kato H, Komatsu M, Kawamura R, Wakui K, Knappskog PM, Boman H, Fukushima Y. Cold-induced sweating syndrome with neonatal features of Crisponi syndrome: longitudinal observation of a patient homozygous for a CRLF1 mutation. Am J Med Genet A. 2010; 152A: 764-9.
  9. Uehara M, Yamazaki H, Kato H. Acute plastic bowing of the radius with a distal radioulnar joint injury: a case report. Hand Surg. 2010; 15: 217-220.
  10. Iwasaki N, Terashima T, Minami A, Kato H. Congenital Dorsally Curving Deformity of the Distal Phalanx of the Little Finger: Case Report J Hand Surg. Am. 2010; 35: 1502-05.
  11. Ikegami S, Kamimura M, Uchiyama S, Nakagawa H, Hashidate H, Takahara K, Takahashi J, Kato H. Anti-nociceptive effects of elcatonin injection for postmenopausal women with back pain: a randomized controlled trial. Open Orthop J. 2010; 4: 132-6.
  12. Uehara M, Takahashi J, Hirabayashi H, Hashidate H, Ogihara N, Mukaiyama K, Ikegami S, Kato H. Perforation rates of cervical pedicle screw insertion by disease and vertebral level. Open Orthop J. 2010 ; 4 : 142-6.
  13. Iwasaki N, Kato H, Ishikawa J, Masuko T, Funakoshi T, Minami A. Autologous osteochondral mosaicplasty for osteochondritis dissecans of the elbow in teenage athletes: surgical technique. J Bone Joint Surg Am. 2010; 92 Suppl 1 Pt 2: 208-16.
  14. Aoki T, Ohnishi H, Oda Y, Tadokoro M, Sasao M, Kato H, Hattori K, Ohgushi H. Generation of induced pluripotential stem cells from human adipose-derived stem cells without c-MYC. Tissue Eng Part A. 2010 ; 16: 2197-206.
  15. Ogihara N, Takahashi J, Hirabayashi H, Hashidate H, Kato H. Long-term Results of Computer-assisted Posterior Occipitocervical Reconstruction. World Neurosurg. 2010; 73: 722-8.
  16. Takahashi J, Kamimura M, Yuzawa Y, Kinoshita T, Kato H. Anterior vertebral reconstruction surgery using polymethylmethacrylate and posterior spinal short fusion through the posterior approach for osteoporotic vertebral pseudoarthrosis. The Open Spine Journal. 2010; 2: 29-34.
  17. Yamazaki H, Uchiyama S, Kato H. Snapping Wrist Caused by Tenosynovitis of the Extensor Carpi Radialis Longus Tendon Subsequent to Subcutaneous Muscle Rupture in the Forearm: Case Report. J Hand Surg Am. 2010; 35: 1964-7
  18. Yoshimura Y, Isobe KI, Koike T, Arai H, Aoki K, Kato H. Metastatic Carcinoma to Subcutaneous Tissue and Skeletal Muscle: Clinicopathological Features in 11 Cases. Jpn J Clin Oncol. 2010; Nov 4. [Epub ahead of print]
  19. Wakitani1 S, Okabe T, Horibe S, Mitsuoka T, Saito M, Koyama T, Nawata M, Tensho K, Kato H, Uematsu K, Kuroda R, Krosaka M, Yoshiya S, Hattori K, Ohgushi H. Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45joint followed for up to 11 years and 5months. J. Tissue Eng Reg Med. 2010; 5: 146-50
  20. Tensho K, Kodaira H, Yasuda G, Yoshimura Y, Narita N, Morioka S, Kato H, Saito N. Anatomic double-bundle anterior cruciate ligament reconstruction, using CT-based navigation and fiducial markers. Knee Surg Sports Traumatol Arthrosc. 2010; 19: 378-83.
  21. Ueda N, Yamakami T, Yamaguchi T, Kitajima K, Usui Y, Aoki K, Nakanishi T, Miyaji F, Endo M, Saito N, Taruta S. Fabrication and mechanical properties of high-dispersion-treated carbon nanofiber/alumina composites. J CERAMIC SOCIETY JAPAN. 2010; 118: 847-54.
  22. Imaeda T, Uchiyama S, Wada T, Okinaga S, Sawaizumi T, Omokawa S, Momose T, Moritomo H, Gotani H, Abe Y, Nishida J, and Kanaya F for the clinical Outcomes committee of the Japanese Orthopaedic association and the Impairment evaluation committee of the Japanese Society for Surgery of the hand.
    Reliability, Validity and Responsiveness of Japanese version of the Patient Rated Wrist Evaluation (PRWE-J). J Orthop Sci. 2010;15: 509-17.
  23. Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, EndoM. Chapter X. Application of Carbon Nanotubes on Scaffolds for Bone Tissue Regeneration. Bone regeneration: growth factors, augmentation procedures and tissue engineering applications, Nova Science Publishers, Inc., New York.2010; 275-84

2009年度 英文基礎臨床研究業績

  1. Iwasaki N, Kato H, Ishikawa J, Masuko T, Funakoshi T, Minami A. Autologous osteochondral mosaicplasty for osteochondritis dissecans of the elbow in teenage athletes.
    J Bone Joint Surg Am. 2009; 91:2359-66.
  2. Hara K, Uchiyama S, Kato H. Irreducible simultaneous dislocation of both interphalangeal joints in the little finger: a case report.. Hand Surg. 2009;14:39-42.
  3. Iwasaki N, Kato H, Kamishima T, Minami A. Sequential Alterations in Magnetic Resonance Imaging Findings After Autologous Osteochondral Mosaicplasty for Young Athletes With Osteochondritis Dissecans of the Humeral Capitellum. Am J Sports Med. 2009.
  4. Nakamura K, Hirachi K, Uchiyama S, Iwasaki N, Minami A, Kato H. Long-term Clinical and Radiographic outcomes after open reduction for missed Monteggia fracture in children. J Bone Joint Surg Am. 2009 Jun;91:1394-404.
  5. Matsubara, Uchiyama S, Tanikawa H, Mogami Y, and Kato H. Carpal tunnel syndrome due to fibromatous hamartoma of the median nerve in Klippel-Trenauney syndrome. A case report. J Bone Joint Surg., Am. 2009; 91:1223-7.
  6. Itsubo T, Uchiyama S, Momose T, Yasutomi T, Imaeda T, Kato H. Electrophysiological responsiveness and quality of life (QuickDASH, CTSI) evaluation of surgically treated carpal tunnel syndrome. J Orthop Sci. 2009;14:17-23.
  7. Nonomura Y, Nanki N, Kato H., Goto K, Miyasaka N, Kohsaka H. Hypoxia-induced Abrogation of Contact-dependent Inhibition of Rheumatoid Arthritis Synovial Fibroblast Proliferation. J Rheumatology, 2009; 36:698-705.
  8. Ikegami S, Kamimura M, Uchiyama S, Nakagawa H, Hashidate H, Takahara K, Kato H. Bone Mineral Density Measurement at Both Spine and Hip for Diagnosing Osteoporosis in Japanese Patients J Clin Densitom. 2009; 12:337-344
  9. Ikegami S, Kamimura M, Nakagawa H, Takahara K, Hashidate H, Uchiyama S, Kato H. Comparison in bone turnover markers during early healing of femoral neck fracture and trochanteric fracture in elderly patients. Orthopedic Reviews. 2009; 21:50-55
  10. Hirabayashi H, Takahashi J, Kato H, Ebara S, Takahashi H Surgical resection without dural reconstruction of a lumbar meningioma in an elderly woman Eur Spine J. 2009; 18:232-235
  11. Hirabayashi H, Takahashi J, Hashidate H, Ogihara N, Tashiro A, Misawa H, Ebara S, Mitsui K, Wakabayashi S, Kato H Characteristics of L3 nerve root radiculopathy Surg Neurol. 2009;72:36-40
  12. Aoki K, Usui Y, Narita N, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Sano K, Ogiwara N, Kametani K, Kim C, Kim YA, Taruta S, Endo M, Saito N A Thin Carbon-Fiber Web as a Scaffold for Bone-Tissue Regeneration Small 2009; 5:1540-1546
  13. Narita N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Usui Y, Aoki K, Simizu M, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, Saito N Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function Nano Letters 2009; 9: 1406-1413
  14. Akahane T, Shimizu T, Isobe K, Yoshimura Y, Kato H Serum soluble interleukin-2 receptor levels in patients with malignant lymphoma of bone J Orthop Sci 2009; 14: 248-252
  15. Takahashi J, Aoki K, Ogihara N, Hirabayashi H, Hashidate H, Kato H Mini open foraminotomy (MOF) for cervical radiculopathy The Open Spine Journal. 2009; 1:1-4
  16. Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Taruta S, Endo M Carbon nanotubes: biomaterial applications Chem Soc Rev 2009; 38:1897-1903
  17. Masuko T, Iwasaki N, Ishikawa J, Kato H, Minami A. Radiolunate fusion with distraction using corticocancellous bone graft for minimizing decrease of wrist motion in rheumatoid wrists. Hand Surg. 2009;14:15-21
  18. Matsuhashi T, Iwasaki N, Oizumi N, Kato H, Minami M, Minami A. Radial overgrowth after radial shortening osteotomies for skeletally immature patients with Kienbock's disease. J Hand Surg Am. 2009; 34:1242-7
研修・入局案内

後期研修は、上肢(肩~手指)、下肢(股~足指)、脊椎、骨軟部腫瘍の4つの専門分野別に手術数年間1000例(救急外傷180例)の治療を通じて国際的レベルで鍛えられます。

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