修士課程 医科学専攻
法医学
分野の概要
法医学とは、法律上の案件について医学的判断をくだすことによって社会貢献に寄与する学問で、長野県内における司法解剖とそれに伴う各種検査が中心的業務となります。特に、本教室では個人識別技術と法中毒分析技術を発展すべく研究を行っています。
研究テーマ
DNA型分析を用いた個人識別は、大規模災害やテロ事件における被害者の身元確認手段として大変有効である。また、「死因究明等推進基本法」が施行され、新たな死因究明制度が始まり、死因究明のための薬毒物検査法の確立が急務である。本教室では、個人識別に有用なDNA多型、各種クロマトグラフィーと質量分析を利用した法中毒分析技術について研究し、法医鑑定業務への応用を通じて、社会的貢献を目指しています。
スタッフ
教授 | 浅村英樹 |
---|---|
助教 | 原山雄太、小林寛也 |
その他 | 3名 |
主要な成果/Major Publications
- Otagiri T, Sato N, Shiozaki T, Harayama Y, Hayashi T, Kobayashi K, Asamura H. Mutation analysis for 25 Y-STR markers in Japanese population. Legal Medicine 50:101860,2021.
- Shiozaki T, Sato N, Hayashi T, Kobayashi K, Asamura H. Wild-type ATTR amyloidosis may be associated with unexpected death among the elderly. Legal Medicine 41: 101634,2019.
- Takahashi F, Kobayashi M, Kobayashi A, Kobayashi K, Asamura H. High-Frequency Heating Extraction Method for Sensitive Drug Analysis in Human Nails. Molecules 23(3231): doi:10.3390/Molecules23123231, 2018.
- Development of Multiple Assays using 46 SNPs for Comprehensive mtDNA Haplogrouping and Application to Highly Degraded DNA. Nunotani M, Sato N, Kamei S, Shiozaki T, Hayashi T, Asamura H. J Forensic Sci. 61:472-477.2016.
- Analysis of 30 insertion-deletion polymorphisms in the Japanese population using the Investigator DIPplex® kit. Nunotani M, Shiozaki T, Sato N, Kamei S, Takatsu K, Hayashi T, Ota M, Asamura H. Legal Medicine. 17:467-470.2015.
- Molecular analysis of potassium ion channel genes in sudden death cases among patients administered psychotropic drug therapy: are polymorphisms in LQT genes a potential risk factor? Kamei S, Sato N, Harayama Y, Nunotani M, Takatsu K, Shiozaki T, Hayashi T, Asamura H. J Hum Genet. 59:95-99,2014.
- Analysis of Y chromosome haplogroups in Japanese population using short amplicons and its application in forensic analysis. Harayama Y, Kamei S, Sato N, Hayashi T, Shiozaki T, Ota M, Asamura H. Legal Medicine. 16:20-25,2014.
- Oki T, Hayashi T, Ota M, Asamura H. (2012) Development of multiplex assay with 16 SNPs on X chromosome for degraded samples. Leg Med 14(1): 11-16.
- Asamura H, Shiozaki T, Sato N, Hayashi T. (2012) Trial investigation of post-mortem non-invasive transnasal endoscopy. Forensic Science Int 220: 184-190.
- Asamura H, Oki T, Ota M, Fukushima H. (2010) Unusual body posture after death leading to signs of stangulation. Am J Forensic Med Pathol 31: 195-197.
- Oki T, Asamura T, Hayashi T, Ota M. (2010) Unusual intracranial stab wounds inflicted with mental tent stakes for a case involving a family murder suicide. Forensic Science Int 202: 19-21.
- Kitayama T, Ogawa Y, Fujii K, Nakahara H, Mizuno N, Sekiguchi K, Yurino N, Yokoi T, Fukuma Y, Yamamoto K, Oki T, Asamura H, Fukushima H. (2010) Evaluation of a new experimental kit for the extraction of DNA from bones and teeth using a non-powder method. Leg Med 12: 84-89.
- Asamura H, Hayashi T, Oki T, Ota M, Fukushima H. (2009) An Unusual Case of Shaken Baby Syndrome Involving a Popular Baby Chair. Res.Pract.Forens med 52: 217-220.
- Asamura H, Ito M, Fukushima H. (2009) An Unusual Suicide Case of the Combination of Asphyxia. Am J Forensic Med Pathol 30: 215-217.
- Asamura H, Fujimori S, Ota M, Oki T, Fukushima H. (2008) Evaluation of miniY-STR multiplex PCR systems for extended 16 Y-STR loci. Int J Leg Med 122: 43-49.
- Asamura H, Ota M, Fukushima H. (2008) Population data on 10 non-CODIS STR loci in Japanese population using a newly developed multiplex PCR system. J Forensic Leg Med 15: 519-523.
- Asamura H, Fujimori S, Ota M, Fukushima H. (2007) MiniSTR multiplex systems based on non-CODIS loci for analysis of degraded DNA samples. Forensic Science Int 173: 7-15.
- Asamura H, Sakai H, Kobayashi K, Ota M, Fukushima H. (2006) MiniX-STR multiplex system population study in Japan and application to dengraded DNA analysis. Int J Leg Med 120: 174-181.
- Asamura H, Sakai H, Ota M, Fukushima H. (2006) Japanese population data for eight X-STR loci using two new quadruplex systems. Int J Leg Med 120: 303-309.
- Asamura H, Uchida R. Takayanagi K, Ota M, Fukushima H. (2006) Allele frequencies of the six miniSTR loci in a population from Japan. Int J Leg Med 120: 182-184.