SHISHU UNIVERSITY

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Profile of Departments

Department of NeuroHealth Innovation

We focus on the pathologic characterization, prevention, and treatment of intractable neurodegenerative diseases that are the cause of dementia and neuropsychiatric disorders and lifestyle-related diseases through approaches involving amyloidosis, neurosynapses, and sports medicine research.

  • 1. Neuronal and vascular amyloid deposition of a familial amyloid polyneuropathy patient
  • 2. Interval walking training
  • 3. Gene introduction to pyramidal neurons in layer 2/3 of the mouse neocortex.
  •   Red represents the expression of Red fluorescent protein from Discosoma sp., green represents the expression of CASK, a causative gene of a type of neurodevelopemental disorder, and yellow represents neurons expressing both. The nuclei of all the neocortical cells were shown in blue. (Image from Mori et al. Molecular Psychiatry 2019)
  • 4. Disease-model animals

Researchers List

Head of the Department of NeuroHealth Innovation
Academic Assembly Professor (Institute of Health Sciences), Ph. D. in Medicine
Research Professor
Full-time Contributor
Masahide Yazaki
Career
1998 Graduated from Shinshu University Graduate School of Medicine
2004 Assistant Professor, School of Medicine, Shinshu University
2011 Associate Professor in Shinshu University School of Medicine
2017 Professor in Shinshu University School of Medicine
Research Field
Neurology, Protein metabolism
Research Theme
Elucidation of pathophysiology on amyloidoses and establishment of novel therapeutic approaches
Message
We believe that further investigation of pathophysiology of amyloidosis may allow us to transmit new prevention methods of amyloid formation or seeds of new therapeutic approach for amyloidosis to the world. Our aims of the research are to elucidate the pathomechanism of development of amyloidosis and to establish the effective diagnostic procedures for early-stage amyloidosis patients.
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Research Professor
Full-time Contributor
Katsuhiko Tabuchi
Research Field
Neurophysiology
Research Theme
To investigate the mechanisms of synapse formation and functions focusing on synaptic cell adhesion molecules that are also related to neuropsychiatric disorders, such as autism and schizophrenia.
Home Page
http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-2seiri/index.html
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Research Professor
Full-time Contributor
Shizue Masuki
Research Field
Environmental physiology (including physical medicine and nutritional physiology)
Research Theme
Development of an evidence-based exercise training program for preventive medicine
Academic Assembly Associate Professor (Institute of Medicine)
Ph. D. in Medicine
Research Professor
Full-time Contributor
Masayuki Mori
Research Field
Medical Genetics
Research Theme
Elucidation of etiology for hereditary diseases by molecular cloning of the causative genes in animal models.
Home Page
http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/grdkarei/i-byotai/
Academic Assembly Assistant Professor (Institute of Medicine)
Ph. D. in Science
Tabuchi Unit
Full-time Contributor
Takuma Mori
Research Field
Neurobiology
Research Theme
I generate various mouse models of neurodevelopmental disorders and infantile epilepsy and analyze the function and structure of the neuronal circuits using the patch clamp recording and the connectome analysis using viral vectors.
Academic Assembly Assistant Professor (Institute of Medicine)
Ph. D. in Medicine
Masuki Unit
Full-time Contributor
Mayuko Morikawa
Research Field
Environmental physiology (including physical medicine and nutritional physiology)
Research Theme
Development of exercise prescriptions to prevent life-style related diseases and physical disability in middle-aged and older males and females
Assistant Professor (fixed-term)
Ph. D. in Medicine
Mori Unit
Full-time Contributor
Jian Dai
Research Field
Aging biology, Molecular biology
Research Theme
1. Effect of oxidative stress inhibitors on the pathogenesis and progression of amyloidosis.
2. The role of fragmented amyloid precursor protein in the pathogenesis and progression of amyloidosis.
Assistant Professor (fixed-term)
Ph. D. in Medicine
Mori Unit
Full-time Contributor
Hiroki Miyahara
Research Field
Ageing biology, Bioinfomatics
Research Theme
Understanding the pathological mechanism and exploring the treatment strategy of amyloidosis
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Masuki Unit
Part-time Contributor
Mikito Kawamata
Research Field
Anesthesiology, Pain Research
Research Theme
Pain processing in the periphery and spinal cord, mechanisms of acute pain (surgical injury-induced pain), surgery-induced damage and recovery from the damage
Professor (fixed-term)
Ph. D. in Medicine
Masuki Unit
Part-time Contributor
Hiroshi Horiuchi
Research Field
Rehabilitation Medicine, Orthopaedic Surgery
Research Theme
Physical Exercise for rehabilitation, Development surgical technique and rehabilitation for improving the longevity of knee arthroplasty, Development new design of total knee arthroplasty, Acute Phase Rehabilitation
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Yazaki Unit
Part-time Contributor
Yoshiki Sekijima
Research Field
Neurology, Clinical genetics, Amyloidosis
Research Theme
Pathogenesis of and novel therapeutic strategies to ameliorate the transthyretin amyloidoses.
Early Diagnosis of transthyretin-type cerebral amyloid angiopathy
Academic Assembly Professor (Institute of Health Sciences)
Ph. D. in Medicine
Masuki Unit
Part-time Contributor
Kazuyuki Matsuda
Research Field
Pathological Examination
Pathological Medical Chemistry
Research Theme
Pathogenic analysis of fibrogenesis using co-culture system
Pathogenic analysis of juvenile myelomonocytic leukemia using iPS cells
Academic Assembly Assistant Professor (Institute of Medicine)
Ph. D. in Medicine
Yazaki Unit
Part-time Contributor
Tsuenaki Yoshinaga
Research Field
Amyloidosis, General Neurology
Research Theme
Biochemical tissue deposited amyloid from tiny tissue samples using Laser microdissection and LC-MS/MS
Shanghai Jiao Tong University, China
Weidong Li
Research Field
Pathogenesis and therapeutics of neuropsychiatric disorders such as Schizophrenia, Depression, ADHD and NF1; Adult neurogenesis; Molecular cognition; iPS and brain tumor.
Research Theme
Prof. Weidong Li, Deputy Dean, Research Management Division, Shanghai Jiao Tong University, Vice Dean of Bio-X Institutes / Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Assistant Director of Brian Science and Technology Research Center of Shanghai Jiao Tong University. Dr. Li was graduated from China Medical University in 1996 and got his PhD from Shinshu University Schools of Medicine (Japan) in 2001. He did his post-doc researches at UCLA since 2002 and was promoted to the assistant researcher (research assistant professor) in the Department of Neurobiology in 2007. He was a Project Leader of the National Basic Research Program of China (973 Program) after he set up his lab in China since 2009. His lab focus on the mechanism and therapeutic of neuropsychiatric disorders by using animal modeling approaches. Recently, he also initiated a “China Super Brain Research Center” to investigate the brain function of the people with extraordinary abilities. Dr. Li won several prestigious awards, including Young Investigator Awards of National Alliance for Research on Schizophrenia and Depression (NARSAD) and the Children’s Tumor Foundation in US, Shanghai “Shu Guang” Scholar, Shanghai “Pujiang Talent” and Shanghai “Eastern Scholar”. Editor of Molecular Brain.