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Department of NeuroHealth Innovation

We focus on the pathologic characterization, prevention, and treatment of intractable neurodegenerative diseases that are the cause of dementia and neuropsychiatric disorders and lifestyle-related diseases through approaches involving amyloidosis, neurosynapses, and sports medicine research.

  • 1. Neuronal and vascular amyloid deposition of a familial amyloid polyneuropathy patient
  • 2. Interval walking training
  • 3. Gene introduction to pyramidal neurons in layer 2/3 of the mouse neocortex.
  • 　 Red represents the expression of Red fluorescent protein from Discosoma sp., green represents the expression of CASK, a causative gene of a type of neurodevelopemental disorder, and yellow represents neurons expressing both. The nuclei of all the neocortical cells were shown in blue. (Image from Mori et al. Molecular Psychiatry 2019）
  • 4. Disease-model animals

Researchers List

Researcher Directory
Head of the Division of NeuroHealth Innovation
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Research Professor
Katsuhiko Tabuchi
Career
1999: Postdoctoral Fellow, University of Texas Southwestern Medical Center
2008: Research Associate, Stanford University School of Medicine
2009: Associate Professor, Division of Cerebral Structure, National Institute for Physiological Sciences, National Institutes of Natural Sciences
2009–2015: PRESTO Researcher (concurrent position), Japan Science and Technology Agency (JST)
2012–Present: Professor, Department of Molecular and Cellular Physiology (Former Department of Neurophysiology), Shinshu University School of Medicine
Research Field
Neurophysiology
Research Theme
To investigate the mechanisms of synapse formation and functions focusing on synaptic cell adhesion molecules that are also related to neuropsychiatric disorders, such as autism and schizophrenia.
Home Page
http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-2seiri/index.html
Message
We are currently seeking motivated individuals to join our lab. If you are interested in conducting research with us, please contact Katsuhiko Tabuchi at ktabuchi@shinshu-u.ac.jp.
Director of the Institute for Biomedical Sciences
Academic Assembly Professor (Institute of Health Sciences)
Ph. D. in Medicine
Research Professor
Masahide Yazaki
Researcher Directory
Research Field
Neurology, Protein metabolism
Research Theme
Elucidation of pathophysiology on amyloidoses and establishment of novel therapeutic approaches
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Research Professor
Shizue Masuki
Researcher Directory
Research Field
Environmental physiology (including physical medicine and nutritional physiology)
Research Theme
Development of an evidence-based exercise training program for preventive medicine
Academic Assembly Professor (Institute of Health Sciences)
Ph. D. in Engineering
Yazaki Unit
Kazuyoshi Yamauchi
Researcher Directory
Research Field
Laboratory medicine for apolipoprotein E-related diseases
Research Theme
We aim to investigate the pathophysiological roles of post-translational modifications of apoE—especially redox modifications—in the development and progression of atherosclerosis and Alzheimer's disease, and to explore the potential of the apoE redox state as a basis for novel biomarker development.
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Yazaki Unit
Yoshiki Sekijima
Researcher Directory
Research Field
Neurology, Clinical genetics, Amyloidosis
Research Theme
Pathogenesis of and novel therapeutic strategies to ameliorate the transthyretin amyloidoses.
Early Diagnosis of transthyretin-type cerebral amyloid angiopathy
Academic Assembly Professor (Institute of Health Sciences)
Ph. D. in Medicine
Masuki Unit
Kazuyuki Matsuda
Researcher Directory
Research Field
Pathological Examination
Pathological Medical Chemistry
Research Theme
Pathogenic analysis of fibrogenesis using co-culture system
Pathogenic analysis of juvenile myelomonocytic leukemia using iPS cells
Academic Assembly Assistant Professor (Institute of Medicene)
Ph. D. in Science
Tabuchi Unit
Yoshinori Shirai
Researcher Directory
Research Field
Neuroscience, Biochemistry, Molecular Biology
Research Theme
Molecular mechanism of Neuropsychiatric Disease
Home Page
https://www.shinshu-u.ac.jp/faculty/medicine/chair/i-2seiri/index.html
Academic Assembly Assistant Professor (Institute of Medicine)
Ph. D. in Medicine
Yazaki Unit
Tsuneaki Yoshinaga
Researcher Directory
Research Field
Amyloidosis, General Neurology
Research Theme
Biochemical tissue deposited amyloid from tiny tissue samples using Laser microdissection and LC-MS/MS
Assistant Professor (School of Medicine)
Ph. D. in Engineering
Tabuchi Unit
Emi Suzuki-Kouyama
Researcher Directory
Research Field
Neuroscience, Molecular and Cellular Biology
Research Theme
Molecular mechanisms of neural development in animal models of developmental disorders and the development of therapeutic strategies via pharmacological and genetic approaches.
Assistant Professor (Graduate School of Medicine)
Ph. D. in Medicine
Masuki Unit
Mayuko Morikawa
Researcher Directory
Research Field
Environmental physiology (including physical medicine and nutritional physiology)
Research Theme
Development of exercise prescriptions to prevent life-style related diseases and physical disability in middle-aged and older males and females
Specially Appointed Assistant Professor (School of Medicine)
Ph. D. in Medicine
Yazaki Unit
Mitsuto Sato
Researcher Directory
Career

Research Field
ATTR amyloidosis, hereditary spinocerebellar degeneration
Research Theme
1. Elucidation of the pathogenesis of wild-type ATTR amyloidosis and identification of biomarkers applicable to early diagnosis and treatment.
2. Development of nucleic acid-based therapeutics for hereditary spinocerebellar degenerative diseases.