SHISHU UNIVERSITY

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Profile of Departments

Department of Life Innovation

As the social environment and population structure change dramatically, we are developing infrastructure technology and its social implementation to establish strategies for individual life design towards the ideal way for people to contribute to society. We also aim to elucidate the fundamental principles in the formation of life and disease, especially of human transformation with aging.

  • 1. Cultured vascular endothelial cells forming a mesh structure
  • 2. Abnormal findings in an adrenomedullin knockout mouse

Researchers List

Head of the Department of Life Innovation
Academic Assembly Professor (Institute of Medicine), Ph. D. in Medicine
Research Professor
Full-tme Contributor

Tatsuya Sawamura
Career
1992 Graduate School of Medicine, University of Tsukuba (Ph.D.)
1992 Assistant Professor, Department of Pharmacology, Graduate School of Medicine, Kyoto University
1998 Chief, Department of Bioscience, National Cardiovascular Center Research Institute
2003 Director, Department of Vascular Physiology, National Cardiovascular Center Research Institute
2014 Professor, Department of Physiology, Shinshu University School of Medicine
2016 Director, Research Center for Next Generation Medicine, Shinshu University
2019 Head, Department of Life Innovation Institute for Biomedical Sciences, Shinshu University
Research Field
Vascular medicine, Aging science
Research Theme
Our goal is to elucidate the mechanisms of vascular dysregulation and why the disruption occurs during aging, by investigating the biology of vascular endothelial cells. We hope that our findings would open a new avenue for understanding aging-related diseases since the vascular malfunction is closely related to malfunctioning of organs.
Message
Most lifestyle-related diseases are diseases for which prevention is important, and they are actually preventable. It is our pleasure if our study would contribute to medical diagnosis and therapeutics of lifestyle-related diseases, preventing aging of vasculature, hence realizing healthy longevity.
Academic Assembly Professor
(Institute of Medicine)
Ph. D. in Medicine
Research Professor
Full-time Contributor
Takayuki Shindo
Research Field
Cardiovascular Research, Developmental engineering
Research Theme
・Clarification of the mechanism of diseases and development of novel therapies using disease model
・Roles of vasoactive peptides in vascular development, angiogenesis and cancer metastasis 
・Generation and analysis of gene-engineered mice using CRISPR/Cas9
・Regenerative medical research of heart, vasculature and liver
Academic Assembly Associate Professor (Institute of Medicine)
Ph. D. in Science
Shindo Unit
Full-time Contributor
Takayuki Sakurai
Research Field
Developmental Engineering, Genome Editing, Developmental Biology
Research Theme
Generation of novel disease and multifactorial disease model mice
Generation of novel genome editing technology
Study for mammalian embryo development and generation of embryo manipulation technology
Academic Assembly Assistant Professor (Institute of Medicine)
Ph. D. in Medicine
Shindo Unit
Full-time Contributor
Akiko Kamiyoshi
Research Field
Metabolism, Endocrinology
Research Theme
Regulation of energy metabolism of adipocytes by bioactive peptide
Mechanisms of liver protection by bioactive peptide
Academic Assembly Assistant Professor (Institute of Medicine)
Ph. D. in Pharmacy
Sawamura Unit
Full-time Contributor
Akemi Kakino
Research Field
Vascular biology
Research Theme
The regulatory machinery for vascular function
The endogenous protein which controls an action of oxidized LDL
Home Page
http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-1seiri/index.html
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Shindo Unit
Part-time Contributor
Toshinori Murata
Research Field
Ophthalmology especially diabetic retinopathy
Research Theme
Investigation of the pathogenesis of diabetic retinopathy. I have investigated the role of( vascular endothelial growth factor) in diabetic macular edema and traction retinal detachment.
Academic Assembly Professor (Institute of Science)
Ph. D. in Engineering
Sawamura Unit
Part-time Contributor
Jiye Jin
Research Field
Analytical Chemistry(Electroanalytical Chemistry)
Research Theme
We are doing research on developing of new electrochemical sensors for detecting reactive oxygen species (ROS) in order to elucidate the relationship between disease and oxidative stress. The sensors are applied to the evaluation of antioxidant capacity of food and the photocatalytic performance of the photocatalysts.
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Sawamura Unit
Part-time Contributor
Takeji Umemura
Research Field
Gastroenterology
Research Theme
Viral hepatitis
Autoimmune liver diseases
IgG4-related disease
Texas Heart Institute, USA
Chu-Huang Chen
Research Field
Lipoprotein subfractions, atherosclerosis
Research Theme
Dr. Chen defined the terms L5, V5, and H5 as the most electronegative subfractions of LDL, VLDL, and HDL. His current focus is on the roles of the subfractions in vascular pathology and determining their clinical relevance.