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SHISHU UNIVERSITY

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Profile of Departments

Division of Biotechnology

We collaborate over a wide range of research areas, including regenerative medicine, biomedical engineering, and molecular medicine engineering, to discover innovative technologies using biotechnological methods.

  • 1. Artificial synapse formation assay: Synaptic organizer-expressing non-neuronal cells (red) induce the accumulation of the presynaptic marker VAMP2 (green) on their surface, indicating the formation of presynapse-like structures.
  • 2. Monkey undifferentiated iPS cells
  • 3. Anti-metastatic cells (yellow and red) that target cancer precursor (green) in the lung
  • 4. Development of antibiotic-producing bacteria

Researchers List

Researcher Directory
Head of the Division of Biotechnology
Academic Assembly Professor (Institute of Humanities)
Ph. D. in Medicine
Research Professor
Takeshi Uemura
Career
2003　Graduate School of Medicine, The University of Tokyo
2003　Researcher, The University of Tokyo
2006　Assistant Professor, The University of Tokyo
2013　Senior Assistant Professor, Shinshu University
2014　Associate Professor, Shinshu University
2023　Professor, Shinshu University
Research Field
Molecular Brain Science
Research Theme
We study the mechanisms of neural circuit formation and regulation underlying higher brain functions, and how their disruption leads to neuropsychiatric disorders. We also develop functional biomaterials that support cellular function.
Home Page
https://www.shinshu-u.ac.jp/faculty/medicine/eng/graduate/course/117587.html
https://www.shinshu-u.ac.jp/institution/kiban/generesmt/english.html
Message
Starting from fundamental research at the molecular, cellular, and tissue levels, we take on the challenge of understanding and controlling biological systems from an interdisciplinary perspective. We promote research that spans from basic science to application and societal implementation, aiming to contribute to solving medical and health issues faced by a super-aged society.
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Research Professor
Sachie Hiratsuka
Researcher Directory
Research Field
Tumorigenesis, Tumor metastasis
Research Theme
A primary tumor prepares the preferable microenvironment in the secondary organ before metastasis. We are trying to establish of diagnosis and therapy for early metastasis, especially focusing on the pre-metastatic phase.
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Research Professor
Yuji Shiba
Researcher Directory
Research Field
Cardiac regeneration, Stem cell biology
Research Theme
Stem cell therapy for cardiac repair
Academic Assembly Associate Professor (Institute of Agriculture)
Ph. D. in Engineering
Research Professor
Takeshi Hosaka
Researcher Directory
Research Field
Applied Microbiology, Antibiotics
Research Theme
The truth about antibiotics and antibiotic producers: their understanding and applications
Academic Assembly Professor (Institute of Health Science)
Ph. D. in Medicine
Uemura Unit
Kaoru Aoki
Researcher Directory
Research Field
Drug Delivery System for Anticancer Drugs for Bone and Soft Tissue Sarcomas
Research Theme
Bone and soft tissue sarcomas are rare cancer, and research and development of therapeutic agents have not progressed as much as in the case of carcinomas. I am developing drug delivery systems to improve the efficacy and reduce the side effects of conventional anticancer drugs for bone and soft tissue sarcomas.
Academic Assembly Associate Professor (Institute of Medicine)
Ph. D. in Medicine
Uemura Unit
Hisao Haniu
Researcher Directory
Research Field
Biotechnology and Biomaterials, Nanobioscience, Risk sciences of radiation and chemicals, Environmental impact assessment
Research Theme
Safety evaluation and basic science of carbon nanotube and other nanomaterials for medical application.
Development of evaluation methods using proteomic technique for personalized safety.
Academic Assembly Associate Professor (Institute of Medicine)
Ph. D. in Science
Hiratsuka Unit
Takeshi Tomita
Researcher Directory
Research Field
Biochemistry, Protein structure and function
Research Theme
Molecular mechanisms of inflammatory responses controlled by zinc finger proteins
Functional analysis of Non-histone chromatin proteins
Structure and function of serum amyloid proteins
Academic Assembly Associate Professor (Institute of Agriculture)
Ph. D. in Engineering
Hosaka Unit
Masaki Ihara
Researcher Directory
Research Field
Protein Engineering, Metabolic Engineering
Research Theme
We are trying to establish the green bio-refinery industry using microalgae re-enegineered by protein engineering and metabolic engineering techniques.
Academic Assembly Senior Assistant Professor (Institute of Medicine)
Ph. D. in Medicine
Shiba Unit
Shin Kadota
Researcher Directory
Research Field
Stem cell biology, Cardiology
Research Theme
Development of the cardiac regenerative therapy using pluripotent stem cell-derived cardiomyocytes (PSC-CMs), Search for novel factors to enhance maturation of PSC-CMs, Development of the biopacemaker using PSC-CMs
Academic Assembly Assistant Professor (Institute of Medicine)
Ph. D. in Science
Shiba Unit
Daihachiro Tomotsune
Researcher Directory
Research Field
Anatomy, Embryology, Molecular Biology, Epigenetics
Research Theme
Stability and variability of differentiation state in human pluripotent stem cells
Academic Assembly Assistant Professor (Institute of Medicine)
Ph. D. in Science
Hiratsuka Unit
Masayoshi Kato
Researcher Directory
Research Field
Cell biology and Molecular biology
Research Theme
Questing of the signal transduction controlling actin cytoskeletal reorganization.
The study is performed focusing on the signal transduction regulating cell movements such as migration, fusion, adhesion, vesicle transport, chemotaxis, and invasion of cancer cell.
Academic Assembly Assistant Professor (Institute of Medicine)
Ph. D. in Science
Hiratsuka Unit
Chifumi Fujii
Researcher Directory
Research Field
Biochemistry, Molecular Oncology
Research Theme
The roles of inflammation and microenvironment in cancer progression
Study on the novel therapeutic approach to cancer with inflammasome inhibitors