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Global Medical Research Promotion

Master's Program Human Sciences, Graduate School of Medicine
Doctor's Program Medical Science Division, Department of Medical Science, Graduate School of Medicine, Science and Technology

Staff List

Professor TANAKA Naoki


E-mail : naopi(at)
※ Change (at) to @ when you send an e-mail.

Summary of Activity

Up to now, we have conducted research that spans digestive organs, metabolism, and nutrition, such as the development of foods that prevent fatty liver, liver cancer, and obesity with many doctors and international students. From 2022, we will start as the new laboratory. We will accept graduate students from overseas and promote international medical education, support international students, and strengthen joint research and collaboration with overseas universities. We will also spread Shinshu's original research results to the world, promote joint research with overseas universities, prevent pre-disease through food, and aim to achieve well-being and health.

Research Subject

  1. 1. Promotion of international medical education using ICT
  2. 2. Construction of a support system for foreign students
  3. 3. Establishment of a system for promoting international research
  4. 4. Development of preventive strategies and treatment methods for liver disease, lifestyle-related diseases, and aging-related diseases = Learn the best points of each country =
  5. 5. Study on the effects of Shinshu's original functional foods and bioactive substances = Cooperation with other universities, other faculties, and companies, including overseas =

Outlook for Research

We enthusiastically welcome students from other than Shinshu University and medical faculties, as well as students who want to play an active role globally. Together with students, we will promote international medical research/education using ICT. In basic research, experiments are mainly conducted to elucidate the mechanism of changes in disease animal models, such as steatohepatitis and liver fibrosis/cancer, using various genomic, proteomic, and metabolomic analyses. Meals make life fun and enriching, while too much eating or drinking can lead to illness. Through the analysis of pathological model animals, I would like to create a society and mechanism in which people around the world can spend healthy time from the viewpoints of nutrition and metabolism. Of course, we also conduct research that is not related to food. After entering graduate school, we will discuss with a student individually and decide the research theme, but I will be in charge of multiple themes in different fields for broadening student’s horizons.

Outlook for Students After Graduation

I hope that students who will lead the next generation will expand their opportunities overseas from Shinshu University through research. We strongly recommend studying abroad after graduation, and we provide support to students who wish to study abroad, such as mediation of study abroad destinations. International students who studied abroad in their predecessors in the Department of Metabolic Regulation have returned to their home countries and are active as instructors in medical schools and research facilities. If you are not a doctor and have a great level of expertise, you will be able to engage in research positions in a wide variety of fields.




By reducing food intake by 30%, the prevalence of liver tumors from fatty liver was reduced. The mechanism has been reported to the journal “Liver Cancer” (Ref. #3) and “EurekAlert! ”, the official site of the American Association for the Promotion of Science (AAAS), was taken up (2020). ➡

Major Publications

1. Diao. P., Jia. F., Wang. X., Hu. X., Kimura. T., Nakajima. T., Aoyama. T., Moriya. K., Koike. K., Tanaka. N. (2021) Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice. Engineering, in press (IF=7.55).

2. Jia. F., Hu. X., Kimura. T., Tanaka. N. (2021) Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies. Int J Mol Sci 22(19):10303 (IF=5.92).

3. Jia. F., Diao. P., Wang. X., Hu. X., Kimura. T., Nakamuta. M., Nakamura. I., Shirotori. S., Sato. Y., Moriya. K., Koike. K., Gonzalez. F.J., Nakayama. J., Aoyama. T., Tanaka. N. (2020) Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice. Liver Cancer 9(5):529-548 (IF=11.74). Thesis, Shinshu University Medical Award 2021

4. Diao. P., Wang. X., Jia. F., Kimura. T., Hu. X., Shirotori. S., Nakamura. I., Sato. Y., Nakayama. J., Moriya. K., Koike. K., Gonzalez. F.J., Aoyama. T., Tanaka. N. (2020) A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice. J Nutr Biochem 85:108460 (IF=6.05).

5. Hu. X., Wang. X., Jia. F., Tanaka. N., Kimura. T., Nakajima. T., Sato. Y., Moriya. K., Koike. K., Gonzalez. F. J., Nakayama. J., Aoyama. T. (2020) A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice. Carcinogenesis 41(2):159-170 (IF=4.94).

6. Wang. Y., Nakajima. T., Gonzalez. F. J., Tanaka. N. (2020) PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice. Int J Mol Sci 21(6): 2061 (IF=5.92).

7. Wang. X., Tanaka. N., Hu. X., Kimura. T., Lu. Y., Jia. F., Sato. Y., Nakayama. J., Moriya. K., Koike. K., Aoyama. T. (2019) A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice. Arch Toxicol 93(6): 1713-1725 (IF=5.15). Thesis, Shinshu University Medical Award 2020

8. Tanaka. N., Kimura. T., Fujimori. N., Nagaya. T., Komatsu. M., Tanaka. E. (2019) Current status, problems, and perspectives of non-alcoholic fatty liver disease research. World J Gastroenterol 25 (2): 163-177 (IF=5.74).

9. Hu. X., Tanaka. N., Guo. R., Lu. Y., Nakajima. T., Gonzalez. F. J., Aoyama. T. (2017) PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis. J Nutr Biochem 39: 77-85 (IF=6.05). Thesis, Shinshu University Medical Award 2019

10. Tanaka. N., Aoyama. T., Kimura. S., Gonzalez. F. J. (2017) Targeting nuclear receptors for treating fatty liver disease. Pharmacol Ther 179: 142-157 (IF=12.31).

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