研究テーマ一覧>テーマ4 前へ 次へ

テーマ4:膠原病の難治性病態解明と新規治療法の開発

臨床研究として、難治性膠原病および類縁疾患の治療戦略の確立を目指して以下の研究テーマを中心に取り組んでいる。

  • 急速進行性間質性肺炎を合併した難治性皮膚筋炎・多発性筋炎に対するマルチターゲット免疫抑制療法の開発
  • 免疫介在性肥厚性硬膜炎に関する早期診断・治療指針の開発

基礎研究では、難治性膠原病の免疫学的病態機序の解明と分子標的治療の開発を目指して、以下の研究を中心に取り組んでいる。

  • 炎症性筋炎・全身性血管炎の病態関連リンパ球サブセットおよび伝達シグナルの研究
  • 膠原病における制御性T細胞の機能評価と自己免疫制御システムの回復・再生を目指した研究

関連した主な業績・発表

  • Shimojima Y, Ishii W, et al. Coadministration of tacrolimus with corticosteroid accelerates recovery in refractory patients with polymyositis/ dermatomyositis: a retrospective study. BMC Musculoskelet Disord 13:228, 2012
  • Shimojima Y, Ishii W, et al. Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis. Clin Med Insights Arthritis Musculoskelet Disord 5:43-52, 2012
  • Shimojima Y, Ishii W, et al. Phenotypes of Peripheral Blood Lymphocytes and Cytokine Expression in Polymyositis and Dermatomyositis before Treatment and after Clinical Remission. Clin Med Insights Arthritis Musculoskelet Disord 5:77-87, 2012
  • Shimojima Y, Matsuda M, et al. Adalimumab monotherapy in a patient with psoriatic arthritis associated with chronic renal failure on hemodialysis: a case report and literature review. Clin Med Insights Case Rep 5:13-7, 2012
  • Ozawa K, Tazawa K, et al. Transient pulmonary edema following adrenal infarction in a patient with primary anti-phospholipid syndrome. Clin Med Insights Case Rep 5:163-8, 2012
  • Ogawa Y, Nakagawa M, et al. Lip biopsy in Mikulicz's disease phenotype IgG4-related disease. Intern Med 52:1007-8, 2013
  • Ueno K, Matsushima A, et al. Polyarteritis nodosa with central nervous system involvement mimicking relapsing-remitting multiple sclerosis. Mod Rheumatol 24: 525-8, 2014
  • Sato M, Kodaira M, et al. Multifocal Fibrosclerosis with Hypertrophic Pachymeningitis and a Soft Tissue Mass around the Thoracic Vertebral Bodies: A Case Report with Review of the Literature. Intern Med 54:2267-72, 2015
  • Shimojima Y, Ishii W, et al. Imbalanced expression of dysfunctional regulatory T cells and T-helper cells relates to immunopathogenesis in polyarteritis nodosa. Mod Rheumatol 2016 (published online)
  • Shimojima Y, Ishii W, et al. Effective use of calcineurin inhibitor in combination therapy for interstitial lung disease complicated with dermatomyositis and polymyositis. J Clin Rheumatol 2016 (in press)
  • Ueno K, Shimojima Y, et al. Advantage of administering tacrolimus for improving prognosis of patients with polymyositis and dermatomyositis. Int J Rheum Dis 2016 (in press)