Joint research groups, including Associate Professor Ryoichi Arai of the Institute for Biomedical Sciences and the Department of Applied Biology, Faculty of Textile Science and Technology at Shinshu University, Senior Assistant Professor Norifumi Kawakami and Professor Kenji Miyamoto of the Faculty of Science and Technology at Keio University, and Professor Masahide Kikkawa of the Graduate School of Medicine at University of Tokyo, have succeeded in elucidating the detailed conformation of the artificially designed protein nanoparticle “truncated icosahedral protein composed of 60-mer fusion protein” (TIP60) through single-particle cryo-electron microscopy analysis. TIP60 was found to be a characteristic icosahedral 60-meric porous hollow nanoparticle structure with 20 pores in an orthotriangular shape.

The findings have been published online in the Royal Society of Chemistry’s journal “Chemical Communications”.

Please refer to the details below for more information.
Title: Icosahedral 60-meric porous structure of designed supramolecular protein nanoparticle TIP60
Authors: Junya Obata, Norifumi Kawakami, Akihisa Tsutsumi, Erika Nasu, Kenji Miyamoto, Masahide Kikkawa, Ryoichi Arai
Journal: Chemical Communications
Published on October 5, 2021
DOI: 10.1039/D1CC03114G