- Genetic Factors Involved in Habituation of Exercise
Department of Advanced Medicine for Health Promotion
Genetic Factors Involved in Habituation of Exercise
The team had earlier developed “Interval Walking training”, a method of exercise in which brisk walking and slow walking are repeated alternately for 3 minutes each. Next, they sought to identify the factors needed to continue Interval Walking training over the long term. They conducted the study with 696 participants (196 men and 500 women). The subjects were instructed to perform the brisk walking for 15 minutes at a time, for more than 4 days a week, for 22 months.
The results showed that 15% of the male participants who had 2 specific types of the DNA controlling blood pressure via gene expression of the vasopressin V1a receptor were significantly less likely to continue exercise. When people move their body, the brain signals for an increase in blood pressure to raise blood flow to the muscles. However, those possessing the particular genotypes exhibit a dysfunction in this mechanism, and presumptively halt exercise.
The team aims to advance its research on DNA genotypes among women in the near future.
J Appl Physiol 118, 595-603, 2015