JAPANESE ENGLISH

神経可塑性学

概要

1995年10月開設。シナプス後部のタンパク質ワールドを明らかにする。新規のシナプス後肥厚部 (PSD)タンパク質をコードする遺伝子を発見し、その解析から、未知の脳の原理の発見を目指す。PSDの分子構築、PSDを中心としたシナプス可塑性の ダイナミクスを明らかにする。

また、新規PSDタンパク質から創薬への展開、疾患との関連の解明、神経系疾患の予防と治療への展開を目指す。

研究テーマ

  1. Dem Project：新規及び機能未知のシナプス後部タンパク質の性質と機能の解明
    (Dem, dendritic mRNAを有する分子）
  2. 中枢神経系シナプス後肥厚部（postsynaptic density, PSD）の分子構築の解明
  3. シナプス可塑性発現の分子メカニズム．特にPSD形成と再編のメカニズムの解明
  4. シナプス後部 Membrane Rafts (Postsynaptic  membrane rafts) の研究
  5. シナプス分子の異常による神経疾患の基礎的研究

スタッフ

助教

白井　良憲

学生数

博士課程学生数

0名

研究室の所在及び連絡先

信州大学松本キャンパス　医学系研究科　疾患予防医科学系専攻研究棟　東棟1階
連絡先：Tel: 0263-37-2683　

主要な成果/Major Publications

  1. Yoshinori Shirai, Masahiko Watanabe, Hiroyuki Sakagami and Tatsuo Suzuki (2015) Novel splice variants in the 5’UTR of Gtf2i expressed in the rat brain: alternative 5’UTRs and differential expression in the neuronal dendrites. J. Neurochemistry (in press)
  2. LiYing Zhao, Hiroyuki Sakagami and Tatsuo Suzuki (2014) Detergent-dependent separation of postsynaptic density (PSD), membrane rafts and other subsynaptic structures from the synaptic plasma membrane of rat forebrain. J. Neurochemistry 131: 147-162
  3. Suzuki T and Yao WD (2013) Molecular and Structural Bases for Postsynaptic Signal Processing and Synaptic Plasticity: Postsynaptic density (PSD) and Postsynaptic Membrane Rafts (PSR). Invited Review, J. Neurogenetics　2 :1 - 14
  4. Liu Q, Yao WD and Suzuki T (2013) Specific interaction of postsynaptic densities with membrane rafts isolated from synaptic plasma membranes. J Neurogenetics. 27:43-58.
  5. Suzuki T, Zhang J, Miyazawa S, Liu Q, Farzan MR, Yao WD (2011) Association of Membrane Rafts and Postsynaptic Density: Proteomics, Biochemical, and Ultrastructural Analyses. J. Neurochem. 119: 64-77.
  6. Zhang B, Luo S, Wang Q, Suzuki T, XiongW-C, Mei L (2008) LRP4 serves as a co-receptor of agrin. Neuron 60: 285-297.
  7. Suzuki T, Du F, Tian QB, Zhang JP and Endo S (2007) CaM kinase IIα clusters are associated with stable lipid rafts and their formation traps PSD-95. J. Neurochem. 104: 596-610.
  8. Suzuki T, Tian Q-B, Kuromitsu J, Kawai T, and Endo S (2007) Characterization of mRNA species that are associated with postsynaptic density fraction by gene chip microarray analysis. Neurosci Res. 57: 61-85.
  9. Tian Q-B, Suzuki T, Yamauchi T, Sakagami H, Yoshimura Y, Miyazawa S, Nakayama K, Saitoh F, Zhang J-P, Kondo H and Endo S (2006) Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca2+/calmodulin-dependent protein kinase II. Eur. J. Neurosci. 23: 2864-2876.
  10. Suzuki T., Li W., Zhang J-P., Qin Tian Q-B., Sakagami H., Usuda N., Kondo H., Fujii T. and Endo S. (2005) A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), form a multi-protein complex with various postsynaptic density proteins. Eur. J. Neurosci. 21: 339-350.
  11. Saitoh F., Tian Q-B, Okano A., Sakagami H, Kondo H. and Suzuki T. (2004) NIDD, a novel DHHC-containing protein, targets neuronal nitric oxide synthase (nNOS) to the membrane through a PDZ-dependent interaction and regulates nNOS activity. J. Biol. Chem. 279: 29461-29468.
  12. Li W, Okano A, Tian QB, Nakayama K, Furihata T, Nawa H, and Suzuki T (2001) Characterization of a novell synGAP isoform, synGAP-β. J Biol. Chem. 276: 21417-21424.

（その他の業績については、教室の独自サイト http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/grdkarei/i-kaso/ をご覧下さい）

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