学術論文・書籍

学術論文・書籍（2014年まで）

2014（H26）年

  • Luo H, Sawashita J, Tian G, Liu Y, Li L, Ding Z, Xu Z, Yang M, Miyahara H, Mori M, Qian J, Wang Y, Higuchi K. Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney and heart. Lab Invest 95(3):320-33 (2015 Mar), Epub 2014 Dec 29.
  • Masuki S, Mori M, Tabara Y, Sakurai A, Hashimoto S, Morikawa M, Miyagawa K, Sumiyoshi E, Miki T, Higuchi K, Nose H, and Shinshu University Genetic Research Consortium. "The factors affecting adherence to a long-term interval walking training program in middle-aged and older people" Journal of Applied Physiology 118(5):595-603 (2015 Mar 1), Epub 2014 Dec 24.
  • Unno K, Yamamoto H, Toda M, Gagiwara S, Iguchi K, Hoshino M, Takabayashi F, Hasegawa-Ishii S, Shimada A, Hosokawa M, Higuchi K, Mori M. Novel Frame-shift mutation in Slc5a2 encoding SGLT2 in a strain od Senescence-Accelerated Mouse SAMP10. BBRC 454(1):89-94 (Nov 7), Epub 2014 Oct 17.
  • Zhang B, Bian X, He P, Fu X, Higuchi K, Yang X, Li D. The toxicity mechanisms of action of aβ25-35 in isolated rat cardiac myocytes. Molecules 19(8):12242-57.
  • Higuchi K, Urano M, Takahashi RH, Oshiro H, Matsubayashi J, Nagai T, Obikane H, Shimojo H, Nagao T. Cytological features of mammary analogue secretory carcinoma of salivary gland: Fine-needle aspiration of seven cases. Diagn Cytopathol Epub 2014 Mar 3.
  • Mori M, Tian G, Ishikawa A, Higuchi K. Diversity and complexity of the mouse Saa1 and Saa2 genes. Exp Anim 63(1):99-106.
  • “Brain and Nerve” 66(7)
    1. 矢崎正英、池田修一。アミロイドとは。pp.723-30.
    2. 矢崎正英、樋口京一。老人性全身性アミロイドーシス。pp.817-26.
  • 『別冊日本臨床　新領域別症候群シリーズ』28 矢崎正英、池田修一。シトルリン欠損症ー成人型シトルリン血漿。pp.610-4.
  • "XIIIth International Symposium on Amyloidosis From Molecular Mechanisms Towards the Cure of Systemic Amyloidosis", Bouke P.C. Hazenberg & Johan Bijzet eds, 496 pages, Zalsman Groningen B. V., (Netherlands). Published on January.
    1. Qian J, Hirose M, Zhang B, Wang Y, Tian G, Luo H, Liu Y, Fu X, Ge F, Sawashita J, Mori M, Fujimoto M, Nakai A, Higuchi K. Heat shock factor 1 (Hsf1) plays a key role in AApoAII cardiac amyloidosis in mice. pp. 122-5.
    2. Sawashita J, Zhang B, Hasegawa K, Mori M, Naiki H, Kametani F, Higuchi K. The C-terminal sequence of type F apolipoprotein A-II inhibits the polymerization of apolipoprotein A-II into amyloid fibrils in mice. pp. 126-9.
  • 樋口京一、森政之。老化のモデル生物が果たす役割。『老化の生物学』、石井直明、丸山直記編、化学同人、pp. 306-21.
  • 樋口京一、池田修一。アミロイド（伝播する蛋白質：プリオノイド仮説）。『神経内科』、第81巻6号、pp. 602-9.
  • 小野賢二郎、山田正仁、樋口京一。脳アミロイドーシスの病態と伝播。『Dementia Japan』、第28巻3号、pp. 267-74.

2013（H25）年

  • Murakami T, Ishiguro N, Higuchi K. Transmission of systemic AA amyloidosis in animals. Vet Path 51:363-71 (2014), Epub 2013 Nov 26.
  • Mori M, Tian G, Higuchi K. AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform. Amyloid 21:1-8 (2014), Epub 2013 Nov 14.
  • Tian G, Sawashita J, Kubo H, Nishio S, Hashimoto S, Suzuki N, Yoshimura G, Tsuruoka M, Wang Y, Liu Y, Luo H, Xu Z, Mori M, Kitano M, Hosoe K, Takeda T, Usami S, Higuchi K. Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence Accelerated Mice. Antioxidants & Redox Signaling 20(16):2606-20 (2014), Epub 2013 Oct 14 (First ver), 2013 Dec 14 (Second ver).
  • Masuki S, Sumiyoshi E, Koshimizu TA, Qian J, Higuchi K, Tsujimoto G, Nose H. Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice. J Physiol 591(Pt 14): 3651-65.
  • Higuchi K. Transmission of AA amyloidosis may cause outbreaks of amyloid A amyloidosis in chickens. Amyloid 20(2): 59-60.
  • Mori M, Gotoh S, Taketani S, Hiai H, Higuchi K. Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene. Exp Eye Res 112C: 45-50.
  • Tanisawa K, Mikami E, Fuku N, Honda Y, Honda S, Ohsawa I, Ito M, Endo S, Ihara K, Ohno K, Kishimoto Y, Ishigami A, Maruyama N, Sawabe M, Iseki H, Okazaki Y, Hasegawa-Ishii S, Takei S, Shimada A, Hosokawa M, Mori M, Higuchi K, Takeda T, Higuchi M, Tanaka M. Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. BMC Genomics 14(1):248.
  • Luo H, Higuchi K, Matsumoto K, Mori M. An interleukin-33 gene polymorphism is a modifier for eosinophilia in rats. Genes Immun 14(3): 192-7.
  • The Senescence-Accelerated Mouse (SAM): Achievements and Future Directions. Takeda T, Akiguchi I, Higuchi K, Hosokawa M, Hosokawa T, Nomura Y eds, Elsevier B.V. Amsterdam, The Netherlands
    1. Takeda T, Hosokawa M, Higuchi K, Senescence-accelerated mouse (SAM). pp. 3-8
    2. Mori M, Higuchi K. Genetic characteristics of SAM strains. pp. 37-43
    3. Higuchi K, Mori M, Sawashita J. Mouse senile systemic AApoAII amyloidosis: pathology, genetics and transmission. pp. 301-10
    4. Umezawa M, Kohno A, Higuchi K, Hosokawa M. Diet and longevity in senescence-accelerated mice. pp. 451-61
    5. Sawashita J, Higuchi K. Diets supplemented with reduced coenzyme Q10 decreased age-related senescence in Senescence-Accelerated Mouse Prone 1 (SAMP1) mice. pp. 499-508
    6. Mori M, Higuchi K. Genetic profile of SAM strains. a. Biochemical and immunogenetic markers. pp. 571-3
    7. Mori M, Higuchi K. Genetic profile of SAM strains. b. Microsatellite markers. pp. 575-8
  • 樋口京一。全身性アミロイドーシスは伝播するか？（チーター及びマウス）。『Dementia Japan』、27(1): 54-61.

2012（H24）年

  • Yoshida K, Higuchi K, Ikeda S. Can prion-like propagation occur in neurodegenerative diseases?: in view of transmissible systemic amyloidosis. Brain Nerve 64(6): 665-74.

2011（H23）年

  • Chen L, Une Y, Higuchi K, Mori M. Cheetahs have 4 serum amyloid A genes evolved through repeated duplication events. J Hered 103(1): 115-29 (2012). Epub 2011 Oct 10.
  • Wall JS, Richey T, Stuckey A, Donnell R, Macy S, Martin EB, Williams A, Higuchi K, Kennel SJ. In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides. Proc Natl Acad Sci U S A 108(34): E586-94. Epub 2011 Aug 1.
  • Wang Y, Sawashita J, Qian J, Zhang B, Fu X, Tian G, Chen L, Mori M, Higuchi K. ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis. J Lipid Res 52(8): 1461-70. Epub 2011 May 26.
  • Imanishi H, Yokota M, Mori M, Shimizu A, Nakada K, Hayashi J. Nuclear but not mitochondrial DNA involvement in respiratory complex I defects found in Senescence-Accelerated Mouse Strain, SAMP8. Exp Anim 60(4): 397-404.
  • Tomozawa H, Nishio A, Higuchi K, Matsumoto K, Mori M. Genes for difference in eosinophilic phenotype between MES and BN.MES-Cyba(mes) rats are on chromosomes 9, 5, and 1. Exp Anim 60(2): 151-60.
  • 樋口京一。プリオン病以外のアミロイドーシスは伝播するか？（１）全身性アミロイドーシス。『アミロイドーシス診療のすべて ーガイドライン完全詳解ー』、山田正仁編、医歯薬出版、pp. 197-204.
  • "XIIth International Symposium on Amyloidosis From Molecular Mechanisms Towards the Cure of Systemic Amyloidosis" Amyloid 18(suppl 1), Westermark P ed, 238 pages, Informa Healthcare (UK). Published on June.
    1. Sawashita J, Kametani F, Hasegawa K, Mori M, Naiki H, Higuchi K. Amyloid fibrils formed by selective N- and C-terminal sequences of mouse apolipoprotein A-II. pp.19-21.
    2. Higuchi K, Qian J, Yan J, Ge F, Zhang B, Fu X, Tomozawa H, Sawashita J, Mori M. Mouse apoA-II amyloid fibrils deposit in skeletal muscle and exhibit amyloidosis-enhancing activity. pp. 42-4.

2010（H22）年

  • Schmelzer C, Okun J, Haas D, Higuchi K, Sawashita J, Mori M, Döring F. The reduced form of Coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice. IUBMB Life 62(11): 812-8.
  • Qian J, Yan J, Ge F, Zhang B, Fu X, Tomozawa H, Sawashita J, Mori M, Higuchi K. Mouse senile amyloid fibrils deposited in skeletal muscle exhibit amyloidosis-enhancing activity. PLoS Pathogens 6(5): e1000914. (Epub 2010 May 20)
  • Zhang P, Fu X, Sawashita J, Yao J, Zhang B, Qian J, Tomozawa H, Mori M, Ando Y, Naiki H, Higuchi K. Mouse model to study human Aβ2M amyloidosis: Generation of a transgenic mouse with excessive expression of human β2-microglobulin. Amyloid 17(2): 50-62.
  • Tomozawa H, Nishio A, Okuhara U, Higuchi K, Matsumoto K, Mori M. BN.MES-Cybames congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia. Exp Animal 59(4): 469-78.
  • Okudaira S, Shimizu M, Otsuki B, Nakanishi R, Ohta A, Higuchi K, Hosokawa M, Tsuboyama T, Nakamura T. Quantitative trait locus on chromosome X affects bone loss after maturation in mice. J Bone Miner Metab Epub 2010 Mar 31.
  • Nakajima K, Takeoka M, Mori M, Hashimoto S, Sakurai A, Nose H, Higuchi K, Itano N, Shiohara M, Oh T, Taniguchi S. Exercise effects on methylation of ASC gene. Int J Sports Med 31(9): 671-5. Epub 2010 Mar 3.
  • Masuki S, Mori M, Tabara Y, Miki T, Sakurai A, Morikawa M, Miyagawa K, Higuchi K, Nose H, Shinshu University Genetic Research Consortium. Vasopressin V1a receptor polymorphism and interval walking training effects in middle-aged and older people. Hypertension 55(3): 747-54.
  • Chambers JK, Kanda T, Shirai A, Higuchi K, Ikeda SI, Une Y. Senile systemic amyloidosis in an aged savannah monkey (Cercopithecus aethiops) with tenosynovial degeneration. J Vet Med Sci 72(5): 657-9. Epub 2010 Jan 15.
  • 銭 金澤、弘瀬雅教、王 耀勇、張 蓓茹、付 笑影、澤下仁子、張 鵬尭、友澤 寛、森 政之、中井 彰、樋口京一。マウス老化アミロイドーシスにおける熱ストレス応答の役割：HSF1ノックアウトマウスを用いた解析。『基礎老化研究』 34(3): 23-6。
  • 樋口京一､池田修一。全身性アミロイドーシスの伝播。『プリオン病と遅発性ウイルス感染症』（水沢英洋 編）pp.40-50、金原出版。

2009（H21）年

  • Schmelzer C, Kubo H, Mori M, Sawashita J, Kitano M, Hosoe K, Boomgaaden I, Döring F, Higuchi K. Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a PPAR-α gene expression signature in SAMP1 mice. Mol Nutr Food Res 54(6): 805-15 (2010). Epub 2009 Dec 3.
  • Mori M, Higuchi K, Sakurai A, Tabara Y, Miki T, Nose H. Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases. J Physiol 587: 5577-84. Epub 2009 Sep 7.
  • Sawashita J, Onitsuka S, Gen-no H, Ishikawa S, Iino F, Tateishi N, Murakami T, Seki Y, Nagaiwa T, Hanaoka M, Hama S, Nose H, Higuchi K. Effects of mild calorie restriction and high-intensity interval walking in middle-aged and older overweight Japanese. Exp Gerontol 44(10): 666-75. Epub 2009 Jul 26.
  • Sawashita J, Kametani F, Hasegawa K, Tsutsumi-Y S, Zhang B, Yan J, Mori M, Naiki H, Higuchi K. Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II. Biochim Biophys Acta - Proteins & Proteomics 1794(10): 1517-29. Epub 2009 Jul 10.
  • Mori M, Li G, Hashimoto M, Nishio A, Tomozawa H, Suzuki N, Usami S, Higuchi K, Matsumoto K. Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba). J Luek Biol 86(3): 473-8. Epub 2009 Apr 30.
  • Zhang G, Fu X, Takeda T, Higuchi K, Mori M. Dysfunction in ABCB1A has only a weak effect on susceptibility to dextran sulfate sodium-induced colitis in SAM strains. Exp Anim 58(4): 421-5.
  • Mori M, Fu X, Chen L, Zhang G, Higuchi K. Hereditary pancreatitis model WBN/Kob rat strain has a unique haplotype in the Pdwk1 region on chromosome 7. Exp Anim 58(4): 409-13.
  • Umezawa M, Higuchi K, Mori M, Matsushita T, Hosokawa M. Effect of dietary unsaturated fatty acids on senile amyloidosis in senescence-accelerated mice. J Gerontol A Biol Sci Med Sci 64(6): 646-52. Epub 2009 Apr 17.
  • Yoshida T, Zhang P, Fu X, Higuchi K, Ikeda S. Slaughtered aged cattle might become one dietary source exhibiting amyloid enhancing factor activity. Amyloid 16(1): 25-31.
  • 樋口京一。アミロイド－シスの伝播 ～チータのアミロイドーシスを例に～。『血液フロンティア』 19(9): 1397-402、医薬ジャーナル社。
  • 樋口京一。アミロイド。『新老年学 (第3版) 』 pp. 55-62、東京大学出版会。
  • 医学のあゆみ『アミロイドーシス UPDATE』225(5)、医歯薬出版。
    1. 樋口京一､前田秀一郎。アミロイドーシスのモデル動物。pp. 423-8。
    2. 樋口京一。アミロイドーシスの伝播 -プリオン病以外のアミロイドーシスは伝播するのか？ pp. 436-40。