Department of Molecular & Cellular Physiology is focusing on the relevance between synaptic defect and the pathophysiology of neurodevelopmental disorders, such as autism.


Pang B#, Mori T#, Badawi M, Zhou M, Guo Q, Kouyama-Suzuki E, Yanagawa T, Yoshinori Shirai Y, Tabuchi K.
An epilepsy-associated mutation of salt-inducible kinase 1 increases the susceptibility to epileptic seizures and interferes with adrenocorticotropic hormone therapy for infantile spasms in mice.
Int J Mol Sci. 23(14):7927. 2022
#These authors contributed equally to this work.

Uemura T, Suzuki E, Kawase S, Kurihara T, Yasumura M, Yoshida T, Fukai S, Yamazaki M, Fei P, Abe M, Watanabe M, Sakimura K, Mishina M, Tabuchi K.
Neurexins Play a Crucial Role in Cerebellar Granule Cell Survival by Organizing Autocrine Machinery for Neurotrophins.
Cell Rep. 39(1):110624. 2022

Kim, D.#, Jung, H.#, Shirai, Y.#, Kim, H., Kim, J., Lim, D., Mori, T., Lee, H., Park, D., Kim, H. Y., Guo, Q., Pang, B., Qiu, W., Cao, X., Kouyama-Suzuki, E., Uemura, T., Kasem, E., Fu, Y., Kim, S., Tokunaga, A., Yoshizawa, T., Suzuki, T., Sakagami, H., Lee, K. J., Ko, J., Tabuchi, K.*, and Um, J. W.*
IQSEC3 deletion impairs fear memory through upregulation of ribosomal S6 kinase 1 signaling in the hippocampus.
Biol Psychiatry 91(9):821-831.2022
#These authors contributed equally to this work. *Last two are corresponding authors.

Mehta, A.#, Shirai, Y.#, Kouyama-Suzuki, E., Zhou, M., Yoshizawa, T., Yanagawa, T., Mori, T. and Tabuchi, K.
IQSEC2 Deficiency Results in Abnormal Social Behaviors Relevant to Autism by Affecting Functions of Neural Circuits in the Medial Prefrontal Cortex
Cells 10 (10): 2021
#These authors contributed equally to this work.

Iizumi S, Uchida F, Nagai H, Takaoka S, Fukuzawa S, Kanno NI, Yamagata K, Tabuchi K, Yanagawa T, Bukawa H.
MicroRNA 142-5p promotes tumor growth in oral squamous cell carcinoma via the PI3K/AKT pathway by regulating PTEN.
Heliyon. 7(10):2021

Aihara Y, Yanagawa T, Sasaki M, Sasaki K, Shibuya Y, Adachi K, Togashi S, Takaoka S, Tabuchi K, Bukawa H, Sekido M.
Nasal molding prevents relapse of nasal deformity after primary rhinoplasty in patients with unilateral complete cleft lip: An outcomes-based comparative study of palatal plate alone versus nasoalveolar molding.
Clin Exp Dent Res. :Oct 24.2021

Yoshida, T., Yamagata, A., Imai, A., Kim, J., Izumi, H., Nakashima, S., Shiroshima, T., Maeda, A., Iwasawa-Okamoto, S., Azechi, K., Osaka, F., Saitoh, T., Maenaka, K., Shimada, T., Fukata, Y., Fukata, M., Matsumoto, J., Nishijo, H., Takao, K., Tanaka, S., Okabe, S., Tabuchi, K., Uemura, T., Mishina, M., Mori, H. and Fukai, S.
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
Nat Commun 12 (1): 1848. 2021

Kim, S., Park, D., Kim, J., Kim, D., Kim, H., Mori, T., Jung, H., Lee, D., Hong, S., Jeon, J., Tabuchi, K., Cheong, E., Kim, J., Um, J. W. and Ko, J.
Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior
Cell Rep 36 (3): 109417. 2021

Suzuki, T., Terada, N., Higashiyama, S., Kametani, K., Shirai, Y., Honda, M., Kai, T., Li, W. and Tabuchi, K.
Non-microtubule tubulin-based backbone and subordinate components of postsynaptic density lattices
Life Sci Alliance 4 (7): 2021

Cao, X., Qiu, W., Pang, B., Zhou, M., Mehta, A., Guo, Q., Shirai, Y., Mori, T. and Tabuchi, K.
Inhibition of CASK Expression by Virus-mediated RNA Interference in Medial Prefrontal Cortex Affects Social Behavior in the Adult Mouse
Shinshu Med J, 69 (1): 45-52. 2021

Badawi, M.#, Mori, T.#, Kurihara, T., Yoshizawa, T., Nohara, K., Kouyama-Suzuki, E., Yanagawa, T., Shirai, Y. and Tabuchi, K.
Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1
Front Mol Neurosci. 14:706494.2021
#These authors contributed equally to this work.

Lai, E. S. K., Nakayama, H., Miyazaki, T., Nakazawa, T., Tabuchi, K., Hashimoto, K., Watanabe, M. and Kano, M.
An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum
Front Neural Circuits 15: 676891. 2021

Cao, X., Kouyama-Suzuki, E., Pang, B., Kurihara, T., Mori, T., Yanagawa, T., Shirai, Y. and Tabuchi, K.
Inhibition of DNA ligase IV enhances the CRISPR/Cas9-mediated knock-in efficiency in mouse brain neurons
Biochem Biophys Res Commun 533 (3): 449-457. 2020

Kurihara, T., Kouyama-Suzuki, E., Satoga, M., Li, X., Badawi, M., Thiha, Baig, D. N., Yanagawa, T., Uemura, T., Mori, T. and Tabuchi, K.
DNA repair protein RAD51 enhances the CRISPR/Cas9-mediated knock-in efficiency in brain neurons
Biochem Biophys Res Commun 524 (3): 621-628. 2020

Hirohata, H., Yanagawa, T., Takaoka, S., Yamagata, K., Sasaki, K., Shibuya, Y., Uchida, F., Fukuzawa, S., Tabuchi, K., Hasegawa, S., Ishibashi-Kanno, N., Sekido, M. and Bukawa, H.
A small number of residual teeth after the mandibular resection of oral cancer is associated with titanium reconstruction plate exposure
Clin Exp Dent Res 5 (5): 469-475. 2019

Mori, T., Kasem, E. A., Suzuki-Kouyama, E., Cao, X., Li, X., Kurihara, T., Uemura, T., Yanagawa, T. and Tabuchi, K.
Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by down-regulating GluN2B
Mol Psychiatry 24 (7): 1079-1092. 2019

Han, K. A., Ko, J. S., Pramanik, G., Kim, J. Y., Tabuchi, K., Um, J. W. and Ko, J.
PTPsigma Drives Excitatory Presynaptic Assembly via Various Extracellular and Intracellular Mechanisms
J Neurosci 38 (30): 6700-6721. 2018

Kasem, E., Kurihara, T. and Tabuchi, K.
Neurexins and neuropsychiatric disorders
Neurosci Res 127: 53-60. 2018

Cao, X. and Tabuchi, K.
Functions of synapse adhesion molecules neurexin/neuroligins and neurodevelopmental disorders
Neurosci Res 116: 3-9. 2017

Takahashi, H., Matsuda, K., Tabuchi, K. and Ko, J.
Central synapse, neural circuit, and brain function
Neurosci Res 116: 1-2. 2017

Baig, D. N., Yanagawa, T. and Tabuchi, K.
Distortion of the normal function of synaptic cell adhesion molecules by genetic variants as a risk for autism spectrum disorders
Brain Res Bull 129: 82-90. 2017

Miki, T., Kaufmann, W. A., Malagon, G., Gomez, L., Tabuchi, K., Watanabe, M., Shigemoto, R. and Marty, A.
Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses
Proc Natl Acad Sci U S A 114 (26): E5246-e5255. 2017

Ito, S., Kimura, S., Warabi, E., Kawachi, Y., Yamatoji, M., Uchida, F., Ishibashi-Kanno, N., Yamagata, K., Hasegawa, S., Shoda, J., Tabuchi, K., Sakai, S., Bukawa, H., Sekido, M. and Yanagawa, T.
p62 modulates the intrinsic signaling of UVB-induced apoptosis
J Dermatol Sci 83 (3): 226-33. 2016

Um, J. W., Choii, G., Park, D., Kim, D., Jeon, S., Kang, H., Mori, T., Papadopoulos, T., Yoo, T., Lee, Y., Kim, E., Tabuchi, K. and Ko, J.
IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation
J Biol Chem 291 (19): 10119-30. 2016

Uemura, T., Mori, T., Kurihara, T., Kawase, S., Koike, R., Satoga, M., Cao, X., Li, X., Yanagawa, T., Sakurai, T., Shindo, T. and Tabuchi, K.
Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
Sci Rep 6: 35861. 2016

Anderson, G. R., Aoto, J., Tabuchi, K., Foldy, C., Covy, J., Yee, A. X., Wu, D., Lee, S. J., Chen, L., Malenka, R. C. and Sudhof, T. C.
beta-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling
Cell 162 (3): 593-606. 2015

Aoto, J., Foldy, C., Ilcus, S. M., Tabuchi, K. and Sudhof, T. C.
Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses
Nat Neurosci 18 (7): 997-1007. 2015

Ko, J. S., Pramanik, G., Um, J. W., Shim, J. S., Lee, D., Kim, K. H., Chung, G. Y., Condomitti, G., Kim, H. M., Kim, H., de Wit, J., Park, K. S., Tabuchi, K. and Ko, J.
PTPsigma functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission
Proc Natl Acad Sci U S A 112 (6): 1874-9. 2015

Nagaoka, T., Tabuchi, K. and Kishi, M.
PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2
Sci Rep 5: 12916. 2015

Azuma, M., Yanagawa, T., Ishibashi-Kanno, N., Uchida, F., Ito, T., Yamagata, K., Hasegawa, S., Sasaki, K., Adachi, K., Tabuchi, K., Sekido, M. and Bukawa, H.
Mandibular reconstruction using plates prebent to fit rapid prototyping 3-dimensional printing models ameliorates contour deformity
Head Face Med 10: 45. 2014

Um, J. W., Pramanik, G., Ko, J. S., Song, M. Y., Lee, D., Kim, H., Park, K. S., Sudhof, T. C., Tabuchi, K. and Ko, J.
Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins
Cell Rep 6 (6): 1096-109. 2014

Li, H., Guo, Q., Inoue, T., Polito, V. A., Tabuchi, K., Hammer, R. E., Pautler, R. G., Taffet, G. E. and Zheng, H.
Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
Mol Neurodegener 9: 28. 2014

Ito, T., Kimura, S., Seto, K., Warabi, E., Kawachi, Y., Shoda, J., Tabuchi, K., Yamagata, K., Hasegawa, S., Bukawa, H., Ishii, T. and Yanagawa, T.
Peroxiredoxin I plays a protective role against UVA irradiation through reduction of oxidative stress
J Dermatol Sci 74 (1): 9-17. 2014

Isshiki, M., Tanaka, S., Kuriu, T., Tabuchi, K., Takumi, T. and Okabe, S.
Enhanced synapse remodelling as a common phenotype in mouse models of autism
Nat Commun 5: 4742. 2014

Aoto, J., Martinelli, D. C., Malenka, R. C., Tabuchi, K. and Sudhof, T. C.
Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking
Cell 154 (1): 75-88. 2013

Budreck, E. C., Kwon, O. B., Jung, J. H., Baudouin, S., Thommen, A., Kim, H. S., Fukazawa, Y., Harada, H., Tabuchi, K., Shigemoto, R., Scheiffele, P. and Kim, J. H.
Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling
Proc Natl Acad Sci U S A 110 (2): 725-30. 2013

Sasaki, H., Togashi, S., Karube, R., Yanagawa, T., Nakane, S., Tabuchi, K., Ishibashi, N., Shinya, Y., Ito, H., Yamagata, K., Onizawa, K., Adachi, K., Sekido, M. and Bukawa, H.
Presurgical nasoalveolar molding orthopedic treatment improves the outcome of primary cheiloplasty of unilateral complete cleft lip and palate, as assessed by naris morphology and cleft gap
J Craniofac Surg 23 (6): 1596-601. 2012

Karube, R., Sasaki, H., Togashi, S., Yanagawa, T., Nakane, S., Ishibashi, N., Yamagata, K., Onizawa, K., Adachi, K., Tabuchi, K., Sekido, M. and Bukawa, H.
A novel method for evaluating postsurgical results of unilateral cleft lip and palate with the use of Hausdorff distance: presurgical orthopedic treatment improves nasal symmetry after primary cheiloplasty
Oral Surg Oral Med Oral Pathol Oral Radiol 114 (6): 704-11. 2012

Etherton, M. R., Tabuchi, K., Sharma, M., Ko, J. and Sudhof, T. C.
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus
EMBO J 30 (14): 2908-19. 2011

Etherton, M., Foldy, C., Sharma, M., Tabuchi, K., Liu, X., Shamloo, M., Malenka, R. C. and Sudhof, T. C.
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function
Proc Natl Acad Sci U S A 108 (33): 13764-9. 2011

Li, H., Wang, B., Wang, Z., Guo, Q., Tabuchi, K., Hammer, R. E., Sudhof, T. C. and Zheng, H.
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
Proc Natl Acad Sci U S A 107 (40): 17362-7. 2010

Li, H., Wang, Z., Wang, B., Guo, Q., Dolios, G., Tabuchi, K., Hammer, R. E., Sudhof, T. C., Wang, R. and Zheng, H.
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis
J Biol Chem 285 (40): 30598-605. 2010

Fukata, Y., Lovero, K. L., Iwanaga, T., Watanabe, A., Yokoi, N., Tabuchi, K., Shigemoto, R., Nicoll, R. A. and Fukata, M.
Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy
Proc Natl Acad Sci U S A 107 (8): 3799-804. 2010

Blundell, J., Blaiss, C. A., Etherton, M. R., Espinosa, F., Tabuchi, K., Walz, C., Bolliger, M. F., Sudhof, T. C. and Powell, C. M.
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior
J Neurosci 30 (6): 2115-29. 2010

Tabuchi, K., Chen, G., Sudhof, T. C. and Shen, J.
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration
J Neurosci 29 (22): 7290-301. 2009

Blundell, J., Tabuchi, K., Bolliger, M. F., Blaiss, C. A., Brose, N., Liu, X., Sudhof, T. C. and Powell, C. M.
Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2
Genes Brain Behav 8 (1): 114-26. 2009

Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M. and Sudhof, T. C.
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
Science 318 (5847): 71-6. 2007

Dudanova, I., Tabuchi, K., Rohlmann, A., Sudhof, T. C. and Missler, M.
Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation
J Comp Neurol 502 (2): 261-74. 2007

Yanagawa, T., Yoshida, H., Yamagata, K., Onizawa, K., Tabuchi, K., Koyama, Y., Iwasa, S., Shimoyamada, H., Harada, H. and Omura, K.
Loss of cytokeratin 13 expression in squamous cell carcinoma of the tongue is a possible sign for local recurrence
J Exp Clin Cancer Res 26 (2): 215-20. 2007

Ho, A., Morishita, W., Atasoy, D., Liu, X., Tabuchi, K., Hammer, R. E., Malenka, R. C. and Sudhof, T. C.
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family
J Neurosci 26 (50): 13089-101. 2006

Shah, S., Lee, S. F., Tabuchi, K., Hao, Y. H., Yu, C., LaPlant, Q., Ball, H., Dann, C. E., 3rd, Sudhof, T. and Yu, G.
Nicastrin functions as a gamma-secretase-substrate receptor
Cell 122 (3): 435-47. 2005

Yuasa, Y., Okabe, M., Yoshikawa, S., Tabuchi, K., Xiong, W. C., Hiromi, Y. and Okano, H.
Drosophila homeodomain protein REPO controls glial differentiation by cooperating with ETS and BTB transcription factors
Development 130 (11): 2419-28. 2003

Tabuchi, K., Biederer, T., Butz, S. and Sudhof, T. C.
CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein
J Neurosci 22 (11): 4264-73. 2002

Tabuchi, K. and Sudhof, T. C.
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing
Genomics 79 (6): 849-59. 2002

Honarpour, N., Tabuchi, K., Stark, J. M., Hammer, R. E., Sudhof, T. C., Parada, L. F., Wang, X., Richardson, J. A. and Herz, J.
Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1
Neuroscience 106 (2): 263-74. 2001

Tabuchi, K., Sawamoto, K., Suzuki, E., Ozaki, K., Sone, M., Hama, C., Tanifuji-Morimoto, T., Yuasa, Y., Yoshihara, Y., Nose, A. and Okano, H.
GAL4/UAS-WGA system as a powerful tool for tracing Drosophila transsynaptic neural pathways
J Neurosci Res 59 (1): 94-9. 2000

Yanagawa, T., Harada, H., Iwasa, S., Tabuchi, K., Omura, K., Suzuki, H., Yusa, H., Yamagata, K., Onizawa, K., Ishii, T. and Yoshida, H.
c-Abl expression in oral squamous cell carcinomas
Oral Oncol 36 (1): 89-94. 2000

Yanagawa, T., Iwasa, S., Ishii, T., Tabuchi, K., Yusa, H., Onizawa, K., Omura, K., Harada, H., Suzuki, H. and Yoshida, H.
Peroxiredoxin I expression in oral cancer: a potential new tumor marker
Cancer Lett 156 (1): 27-35. 2000

Yanagawa, T., Ishikawa, T., Ishii, T., Tabuchi, K., Iwasa, S., Bannai, S., Omura, K., Suzuki, H. and Yoshida, H.
Peroxiredoxin I expression in human thyroid tumors
Cancer Lett 145 (1-2): 127-32. 1999

Yoshihara, Y., Mizuno, T., Nakahira, M., Kawasaki, M., Watanabe, Y., Kagamiyama, H., Jishage, K., Ueda, O., Suzuki, H., Tabuchi, K., Sawamoto, K., Okano, H., Noda, T. and Mori, K.
A genetic approach to visualization of multisynaptic neural pathways using plant lectin transgene
Neuron 22 (1): 33-41. 1999

Tsuji, M. H., Yanagawa, T., Iwasa, S., Tabuchi, K., Onizawa, K., Bannai, S., Toyooka, H. and Yoshida, H.
Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis
Cancer Lett 138 (1-2): 53-9. 1999

Tabuchi, K., Yoshikawa, S., Yuasa, Y., Sawamoto, K. and Okano, H.
A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells
Neurosci Lett 257 (1): 49-52. 1998

Hamada, S., Senzaki, K., Hamaguchi-Hamada, K., Tabuchi, K., Yamamoto, H., Yamamoto, T., Yoshikawa, S., Okano, H. and Okado, N.
Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken
Brain Res Mol Brain Res 54 (2): 199-211. 1998


Department of Molecular &
Cellular Physiology,
Shinshu University School of Medicine

3-1-1 Asahi, Matsumoto,
Nagano 390-8621

PHONE: +81-263-37-3775
FAX: +81-263-37-3776
E-mail: ktabuchi@shinshu-u.ac.jp