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研究関連

現在教室で進行中の研究

学内では放射線科との協力体制があり、学外では国立精神・神経医療研究センターと東京都医学総合研究所との共同研究を進めています。臨床精神医学、精神病理学、社会精神医学、神経病理学、分子生物学的精神医学等の分野で広く研究活動を行なっています。具体的には精神病理学、神経病理学、精神薬理学、精神科遺伝学、老年精神医学、精神科画像学、アディクション などのグループがあります。


「作家・北杜夫の病跡学研究」について

「初老期以降のカタトニアの経過と治療反応性に関する臨床研究」について

「精神科医療の普及と教育に対するガイドラインの効果に関する研究」について

「岡谷市コホート研究」について


>>2012年以前の業績集はこちらです。

 

業績集

2018年 業績

Iizawa M, Tanabe H, Takahashi T, Ohya D, Osada R, Harada Y, Bando T, Kaneko T, Sugiyama N, Washizuka S. Age-related changes to the effects of electroconvulsive therapy in an elderly patient: a case report. Psychogeriatrics. in press.

Sasayama D, Asano S, Nogawa S, Takahashi S, Saito K, Kunugi H. A genome-wide association study on photic sneeze syndrome in a Japanese population. J Hum Genet. in press.

Yoon HS, Hattori K, Sasayama D, Kunugi H. Low cocaine- and amphetamine-regulated transcript (CART) peptide levels in human cerebrospinal fluid of major depressive disorder (MDD) patients. J Affect Disord. 2018 May;232:134-138.

Teraishi T, Kajiwara M, Hori H, Sasayama D, Hidese S, Matsuo J, Ishida I, Kajiwara Y, Ozeki Y, Ota M, Hattori K, Higuchi T, Kunugi H. (13)C-phenylalanine breath test and serum biopterin in schizophrenia, bipolar disorder and major depressive disorder. J Psychiatr Res. 2018 Apr;99:142-150.

Ishii T, Hattori K, Miyakawa T, Watanabe K, Hidese S, Sasayama D, Ota M, Teraishi T, Hori H, Yoshida S, Nunomura A, Nakagome K, Kunugi H. Increased cerebrospinal fluid complement C5 levels in major depressive disorder and schizophrenia. Biochem Biophys Res Commun. 2018 Mar 4;497(2):683-688.

Hidese S, Asano S, Saito K, Sasayama D, Kunugi H. Association of depression with body mass index classification, metabolic disease, and lifestyle: A web-based survey involving 11,876 Japanese people. J Psychiatr Res. 2018 Feb 10;102:23-28.

Ishiwata S, Hattori K, Sasayama D, Teraishi T, Miyakawa T, Yokota Y, Matsumura R, Nishikawa T, Kunugi H. Cerebrospinal fluid D-serine concentrations in major depressive disorder negatively correlate with depression severity. J Affect Disord. 2018 Jan 15;226:155-162.

Ogawa S, Koga N, Hattori K, Matsuo J, Ota M, Hori H, Sasayama D, Teraishi T, Ishida I, Yoshida F, Yoshida S, Noda T, Higuchi T, Kunugi H. Plasma amino acid profile in major depressive disorder: Analyses in two independent case-control sample sets. J Psychiatr Res. 2018 Jan;96:23-32.

Itokawa M, Miyashita M, Arai M, Dan T, Takahashi K, Tokunaga T, Ishimoto K, Toriumi K, Ichikawa T, Horiuchi Y, Kobori A, Usami S, Yoshikawa T, Amano N, Washizuka S, Okazaki Y, Miyata T. Pyridoxamine: A novel treatment for schizophrenia with enhanced carbonyl stress. Psychiatry Clin Neurosci. 2018 Jan;72(1):35-44.

2017年 業績

Nakamura T, Sugiyama N, Sasayama D, Hagiwara T, Washizuka S. Jitteriness/Anxiety Syndrome Developing Immediately following Initiation of Oral Administration of Sertraline. Case Rep Psychiatry. 2017;2017:1319505.

Takahashi Y, Ogihara T, Sasayama D, Washizuka S. Successful Readministration of Clozapine in a Patient With a History of Clozapine-Induced Elevation of Creatine Phosphokinase. Prim Care Companion CNS Disord. 2017 Aug 10;19(4).

Yoon HS, Hattori K, Ogawa S, Sasayama D, Ota M, Teraishi T, Kunugi H. Relationships of Cerebrospinal Fluid Monoamine Metabolite Levels With Clinical Variables in Major Depressive Disorder. J Clin Psychiatry. 2017 Sep/Oct;78(8):e947-e956.

Sasayama D, Sugiyama N, Yonekubo S, Pawlak A, Murasawa H, Nakamura M, Hayashi M, Ogawa T, Moro M, Washizuka S, Amano N, Hongo K, Ohnota H. Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice. Sci Rep. 2017 Jul 5;7(1):4663.

Ishiwata S, Hattori K, Sasayama D, Teraishi T, Miyakawa T, Yokota Y, Matsumura R, Yoshida F, Nishikawa T, Kunugi H. Plasma and cerebrospinal fluid G72 protein levels in schizophrenia and major depressive disorder. Psychiatry Res. 2017 Apr 27;254:244-250.

Sasayama D, Kurahashi K, Oda K, Yasaki T, Yamada Y, Sugiyama N, Inaba Y, Harada Y, Washizuka S, Honda H. Negative Correlation between Serum Cytokine Levels and Cognitive Abilities in Children with Autism Spectrum Disorder. J. Intell. 2017, 5(2), 19.

Hidese S, Hattori K, Sasayama D, Miyakawa T, Matsumura R, Yokota Y, Ishida I, Matsuo J, Noda T, Yoshida S, Teraishi T, Hori H, Ota M, Kunugi H. Cerebrospinal fluid neural cell adhesion molecule levels and their correlation with clinical variables in patients with schizophrenia, bipolar disorder, and major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Feb 24;76:12-18.

Sasayama D, Hattori K, Ogawa S, Yokota Y, Matsumura R, Teraishi T, Hori H, Ota M, Yoshida S, Kunugi H. Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome. Hum Mol Genet. 2017 Jan 1;26(1):44-51.

Ninomiya-Baba M, Matsuo J, Sasayama D, Hori H, Teraishi T, Ota M, Hattori K, Noda T, Ishida I, Shibata S, Kunugi H. Association of body mass index-related single nucleotide polymorphisms with psychiatric disease and memory performance in a Japanese population. Acta Neuropsychiatr. in press.

Tada H, Ogihara T, Nakamura T, Sasayama D, Sugiyama N, Takahashi Y, Washizuka S, Amano N. A case of severe parkinsonism in an elderly person induced by valproic acid. Psychogeriatrics. 2017 Jan;17(1):76-77.


2016年 業績

Sasayama D, Washizuka S, Honda H. Effective Treatment of Night Terrors and Sleepwalking with Ramelteon. J Child Adolesc Psychopharmacol. 2016 Dec;26(10):948.

Miyashita M, Watanabe T, Ichikawa T, Toriumi K, Horiuchi Y, Kobori A, Kushima I, Hashimoto R, Fukumoto M, Koike S, Ujike H, Arinami T, Tatebayashi Y, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Washizuka S, Yamamoto H, Miyata T, Itokawa M, Yamamoto Y, Arai M. The regulation of soluble receptor for AGEs contributes to carbonyl stress in schizophrenia. Biochem Biophys Res Commun. 2016 Oct 21;479(3):447-452.

Tsukahara T, Arai H, Kamijo T, Kobayashi Y, Washizuka S, Arito H, Nomiyama T. The Relationship between Attitudes toward Suicide and Family History of Suicide in Nagano Prefecture, Japan. Int J Environ Res Public Health. 2016 Jun 22;13(6).

Kobayashi M, Sugiyama N, Sasayama D, Sasamoto H, Miyashiro Y, Arima K, Washizuka S. Sex differences in the serum level of endogenous ligands for estrogen receptor β in the elderly population. Sci Rep. 2016 May 11;6:25878.

Hyakutake A, Kamijo T, Misawa Y, Washizuka S, Inaba Y, Tsukahara T, Nomiyama T. Cross-sectional observation of the relationship of depressive symptoms with lifestyles and parents' status among Japanese junior high school students. Environ Health Prev Med. 2016 Jul;21(4):265-73.

Tsukahara T, Arai H, Kamijo T, Kobayashi Y, Washizuka S, Arito H, Nomiyama T. Relationships between suicidal ideation and psychosocial factors among residents living in Nagano Prefecture of Japan. Environ Health Prev Med. 2016 May;21(3):164-72.

Joko T, Washizuka S, Sasayama D, Inuzuka S, Ogihara T, Yasaki T, Hagiwara T, Sugiyama N, Takahashi T, Kaneko T, Hanihara T, Amano N. Patterns of hippocampal atrophy differ among Alzheimer's disease, amnestic mild cognitive impairment, and late-life depression. Psychogeriatrics. 2016 Nov;16(6):355-361.

Nakamura T, Setsu K, Takahashi T, Miyashita M, Sugiyama N, Washizuka S, Murata S, Hanihara T, Amano N. Chronic exposure to carbon monoxide in two elderly patients using a kotatsu, a traditional Japanese charcoal-based heater. Psychogeriatrics. 2016 Sep;16(5):323-6.

Hori H, Sasayama D, Teraishi T, Yamamoto N, Nakamura S, Ota M, Hattori K, Kim Y, Higuchi T, Kunugi H. Blood-based gene expression signatures of medication-free outpatients with major depressive disorder: integrative genome-wide and candidate gene analyses. Sci Rep. 2016 Jan 5;6:18776.


2015年 業績

Hattori K,Ota M,Sasayama D,Yoshida S, Matsumura R, Miyakawa T, Yokota Y, Yamaguchi S, Noda T, Teraishi T,Hori H, Higuchi T, Kosaka S, Goto Y, Kunugi H:Increased serebrospinal fluid fibrinogen in major depressive disorder.
Scientific Reports, 17;5:11412, 2015.

Koike S, Kayama T, Arai M, Horiuchi Y, Kobori A, Miyashita M, Itokawa M, Ogasawara Y:Characterization of modified proteins in plasma from a subtype of schizophrenia based on
carbonyl stress: Protein carbonyl is a possible biomarker of psychiatric disorders.
Biochem Biophys Res Commun, 467:361-366, 2015.

Kouidrat Y, Amad A, Arai M, Miyashita M, Lalau JD, Loas G, Itokawa M: Advanced glycation end products and schizophrenia: A systematic review. J Psychiatr Res, 66-67: 112-117, 2015.

Murasugi K, Tsukahara T, Washizuka S: The development and trial of a medication discontinuation program in the department of forensic psychiatry. Ann Gen Psychiatry, 14:
11 doi 10.1186/s12991-015-0049-z, 2015.

Nakamura T,Setsu K,Takahashi T,Miyashita M,Sugiyama N,Washizuka S,Murata S,Hanihara T,Amano N: Chronic exposure to carbon monoxide in two elderly patients using a Kotatsu a toraditional Japanese charcoal-based heater. Psychogeriatrics, 9:doi: 10.1111/psyg.
12164, 2015.

Ogawa S, Hattori K, Sasayama D, Yokota Y, Matsumura R, Matsuo J, Ota M, Hori H,Teraishi T,Yoshida S,Noda T,Ohashi Y,Sato H,Higuchi T,Motohashi N,Kunugi H: Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder. Scientific Reports, 15;5:7796, 2015.

Ota M,Noda T,Sato N,Okazaki M,Ishikawa M,Hattori K,Hori H,Sasayama D,Teraishi T,Sone D,Kunugi H: Effect of electroconvulsive therapy on gray matter volume
in major depressive disorder. J Affect Disord, 186: 186-191, 2015.

Ota M,Noda T,Sato N,Hattori K,Hori H,Sasayama D,Teraishi T,Nagashima A,Obu S,Higuchi T,Kunugi H: White matter abnormalities in major depressive disorder with melancholic and atypical features:A diffusion tensor imaging study. Psychiatry clin Neurosci,
69: 360-368, 2015.

Sasaki Y, Usami M, Sasayama D, Okada T, Iwadare Y, Watanabe K, Ushijima H, Tanaka T, Harada M,Tanaka H,Kodaira M,Sugiyama N,Sawa T,Saito K: Concerns expressed by parents of children with pervasive developmental disorders for different time periods of the day:a case control study. Plos One, 21:10(4): e0124692, 2015.

Sasayama D,Hori H,Nakamura S,Yamamoto N,Hattori K,Teraishi T,Ota M,Kunugi H: Increased protein and mRNA expression of resistin after dexamethasone administration. Horm Metab Res, 47: 433-438, 2015.

Sasaki T, Kinoshita Y, Matsui S, Kakuta S, Yokota-Hashimoto H, Kinoshita K, Iwasaki Y, Kinoshita T, yada T, Amano N, Kitamura T: N-methy-D-asparate receptor coagonist Dserine
Suppresses intake of high-preference food. Am J Physiol egul Integr Comp Physiol, 309:
R561-575, 2015.

Teraishi T,Hori H,Sasayama D,Matsuo J,Ogawa S,Ota M,Hattori K,Kajiwara M,Higuchi T,Kunugi H: (13)C-tryptophan breath test detects increased catabolic turnover of tryptophan along the kynuremine pathway in patients with major depressive disorder.
Scientific Reports, 3;5:15994, 2015.

Teraishi T,Hori H,Sasayama D,Matsuo J,Ogawa S,Ishida I,Nagashima A,kinoshita Y,Ota M,Hattori K,Higuchi T,Kunuugi H: Personality in remitted major depressive disorder with single and recurrent episodes assessed with the Temperament and Character Inventory
Psychiatry Clin Neurosci, 69: 3-11, 2015.

Usami M,Iwqdare Y,Watanabe K,Ushijima H,Kodaira M,Okada T,Sasayama D,Sugiyama N,Saito K: A case-control study of the difficulties in daily functioning experienced by children with depressive disorder. J Affect Disord, 1;179:167-174, 2015.

天野直二:【精神科治療学創刊30周年記念特集A ―10年後の精神医療に望むこと、そのために今できること―】老年期・認知症のための精神医療サービスの展望.精神科治療学,30:271-276,2015.

新井誠,小堀晶子,宮下光弘,鳥海和也,堀内泰江,畠山幸子,内田美樹,井上智子,糸川昌成: カルボニルストレス代謝障害と統合失調症.日本生物学的精神医学会誌,26:27-33,2015.

高橋徹,松下正明:作家「伊藤計劃」−病と創作―.日本病跡学雑誌、89:65-80、2015.

高橋徹,多田はるか,鈴木一浩,西川景子,山本和希,高橋和史:【「ありふれた(ような)症例」から「学べた」こと】思春期・青年期2例からみる「診断保留」の意義―疾患概念の変遷と治療介入の柔軟性―.臨床精神医学,44:
1179-1185,2015.

高橋徹,多田はるか,高橋和史,鈴木一浩,山本和希,西川景子,高橋由佳,中村敏範,矢崎健彦,山田佳幸,鷲塚伸介:「気持のつらさ」と「せん妄」が併存した終末期の1例.
東京精神医学会誌,30:29-33,2015.

中村敏範,天野直二:【超高齢社会の糖尿病診療 ―ケアから血統管理まで―】糖尿病にかかわる内科医師・スタッフが・mっておくべき高齢者のこころの問題.プラクティス,
32: 40-45,2015.

福家知則,高橋徹,山田佳幸,宮下光弘,天野直二,松下正明:初老期・老年期にCotard症候群の病像を呈した統合失調症の3症例―「人生後半期精神病」の病態を考える―.
精神神経学雑誌,117:257-268,2015.

山本和希,高橋徹,鈴木一浩,西川景子,高橋由佳,中村敏範,矢崎健彦,山田佳幸,宮下光弘,鷲塚伸介,天野直二:老年期に縊頸企図を呈した3症例―人生後半期精神病との関連―.東京精神医学会誌, 30:6-11,2015.


著書(分担執筆)

荻原朋美:第11章 てんかんおよびてんかん類似症候群 Jてんかん類似症候群 一過性全健忘.兼本浩祐,丸栄一,小国弘量,池田昭夫,川合謙介編:臨床てんかん学,pp422
-424,医学書院,東京,2015.

菊地俊暁,仁王進太郎,杉山暢宏,渡邊衡一郎,鈴木映二,加藤正樹:X.抗うつ薬.
日本精神神経学会 精神科薬物療法研修特別委員会編:精神科薬物療法グッドプラクティス―ワンランク上の処方をめざして―,pp78-100,新興医学出版社,東京,2015.

萩原徹也:第4章 抑うつ障害群 11. 器質性うつ病.「精神科治療学」編集委員会編:精神科治療学 第30巻 増刊号 精神科治療における処方ガイドブック.pp124-126、
星和書店,東京,2015.

萩原徹也,天野直二:精神病理学・症候学的視点から高齢者の薬物療法を考える.
石郷岡純,加藤敏編:薬物療法を精神病理学的視点から考える.pp146-161,学樹書院,
東京,2015.

両川晃子:事例11 場面緘黙が疑われた不登校児童の登校支援に活用−小4〜中1、通常学級、自閉症スペクトラム障害・LD-.旭出学園教育研究所編: S-M社会生活能力検査の活用と事例.pp115-121,日本文化科学社,東京,2015.



2014年 業績

Arai M, Miyashita M, Kobori A, Toriumi K, Horiuchi Y, Itokawa M: Carbonyl stress and schizophrenia. Psychiatry Clin Neurosci 68: 655-665, 2014.

Fujii T, Hori H, Ota M, Hattori K, Teraishi T, Sasayama D, Yamamoto N, Higuchi T, Kunugi H: Effect of the common functional FKBP5 variant (rs1360780) on the hypothalamic-pituitary-adrenal axis and peripheral blood gene expression.
Psychoneuroendocrinology 42: 89-97, 2014.

Fujii T, Ota M, Hori H, Hattori K, Teraishi T, Sasayama D, Higuchi T, Kunugi H: Association between the common functional FKBP5 variant (rs1360780) and brain structure in a non-clinical population. J Psychiatr Res 58: 96-101, 2014.

Hori H, Teraishi T, Sasayama D, Matsuo J, Kinoshita Y, Ota M, Hattori K, Kunugi H: A latent profile analysis of schizotypy, temperament and character in a nonclinical population: Association with neurocognition. J Psychiatr Res 48: 56-64, 2014.

Hori H, Yamamoto N, Teraishi T, Ota M, Fujii T, Sasayama D, Matsuo J, Kinoshita Y, Hattori K, Nagashima A, Ishida I, Koga N, Higuchi T, Kunugi H: Cognitive effects of the ANK3 risk variants in patients with bipolar disorder and healthy individuals. J Affect Disord 158: 90-96, 2014.

Itokawa M, Miyashita M, Arai M, Miyata T: Carbonyl stress in schizophrenia. Biochem Soc Trans 42:468-472, 2014.

Kito H, Ryokawa A, Kinoshita Y, Sasayama D, Sugiyama N, Ogihara T, Yasaki T, Hagiwara T, Inuzuka S, Takahashi T, Genno H, Nose H, Hanihara T, Washizuka S, Amano N: Comparison of alterations in cerebral hemoglobin oxygenation in late life depression and Alzheimer's disease as assessed by near-infrared spectroscopy. Behav Brain Funct 10: 8, 2014.

Miyashita M, Arai M, Kobori A, Ichikawa T, Toriumi K, Niizato K, Oshima K, Okazaki Y, Yoshikawa T, Amano N, Miyata T, Itokawa M: Clinical Features of Schizphrenia with Enhanced Carbonyl Stress. Schizophr Bull 40: 1040-1046, 2014.

Miyashita M, Arai M, Yuzawa H, Niizato K, Oshima K, Kushima I, Hashimoto R, Fukumoto M, Koike S, Toyota T, Ujike H, Arinami T, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Miyata T, Itokawa M: Replication of enhanced carbonyl stress in a subpopulation of schizophrenia. Psychiatry clin Neurosci 68: 83-84, 2014.

Ota M, Wakabayashi C, Matsuo J, Kinoshita Y, Hori H, Hattori K, Sasayama D, Teraishi T, Obu S, Ozawa H, Kunugi H: Effect of L-theanine on sensorimotor gating in healthy human subjects. Psychiatry Clin Neurosci 68: 337-343, 2014.

Sasayama D, Hori H, Teraishi T, Hattori K, Ota M, Matsuo J, Kinoshita Y, Okazaki M, Arima K, Amano N, Higuchi T,Kunugi H: Benzodiazepines, benzodiazepine-like drugs, and typical antipsychotics impair manual dexterity in patients with schizophrenia. J Psychiatr Res 49: 37-42, 2014.

Sasayama D, Hori H, Yamamoto N, Nakamura S, Teraishi T, Tatsumi M, Hattori K, Ota M, Higuchi T, Kunugi H: ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering tbe expression levels of GLT8S1. J Psychiatr Res 50: 79-83, 2014.

Teraishi T, Hori H, Sasayama D, Matsuo J, Ogawa S, Ishida I, Nagashima A, Kinoshita Y, Ota M, Hattori K, Kunugi H: Relationship between Lifetime Suicide Attempts and Schizotypal Traits in patients with Schizophrenia. PLoS One 9: e107739, 2014.

Uchida M, Kaneko M, Tsukahara T, Washizuka S, Kawa S: Evaluation of the spread of pandemic influenza A/H1N1 2009 among Japanese university students. Environ Health Prev Med 19: 315-321, 2014.

岸本道太,犬塚 伸,荻原朋美,天野直二:【初診,初期治療―何を見逃してはならないか―】 急性精神病状態を診分ける ―器質性精神障害,症候性精神障害の鑑別に向けて ―. 精神科治療学 29:711-717,2014.

鬼頭 恆:近赤外線スペクトロスコピーの精神疾患の評価.精神科治療学 29:267-271,2014.

宮下光弘,新井 誠,市川智恵,鳥海和也,小堀晶子,天野直二,糸川昌成:カルボニルストレスという代謝異常と統合失調症 ―体に負担の少ないビタミンB6による治療法の研究―.総合病院精神医学 25:254-261,2014.

宮下光弘,新井 誠,市川智恵,鳥海和也,小堀晶子,天野直二,糸川昌成:【治療抵抗性統合失調症への挑戦】 カルボニルストレスからみた治療抵抗性統合失調症の理解と今後の展開.臨床精神薬理 17:1631-1636,2014.

中村敏範,天野直二:【老年精神医学とDSM-5】 血管性認知症または血管性軽度認知障害.老年精神医学雑誌 25:877-880,2014.

荻原朋美,中村敏範:【非アルツハイマー型認知症 ―第3の認知症“非AD型変性認知症”とは】 前頭側頭葉変性症 前頭側頭型認知症(FTD)を中心に.認知症の最新医療 4:154-159,2014.

白木 俊,荻原朋美,天野直二:【注意と精神疾患】 認知症と注意機能.精神科 24:67-72,2014.

高橋 徹,福家知則:【セネストパチーをめぐって】 セネストパチーからみた精神科診断学考 ―「思春期好発精神病」と「人生後半期精神病」―.精神科 24:67-72,2014.

高橋由佳,天野直二:【老年精神医学とDSM-5】 せん妄.老年精神医学雑誌 25:854-857, 2014.

高橋由佳,天野直二:【新しい知識をチェックしよう! 医療・看護のフロントライン】 新しい診断基準“DSM-5”の特徴とせん妄患者ケアのポイント. Expert Nurse 30:14-18,2014.

高橋由佳,荻原朋美,天野直二:【DSM-5をどう見るか?】 私はDSM-5のせん妄をこう見る.精神科治療学 29:960-961,2014.

鷲塚伸介:【シンプル処方の極意】 双極性障害の最適な薬物療法とは何か.臨床精神医学 43:27-32,2014.

柳川宗平,下条久志,伊藤信夫,小蜷エ光,有馬邦正,吉田邦広,天野直二,関島良樹,加藤修明,武井洋一:臨床診断:ビンスワンガー病(家族性).信州医学雑誌 62:111-139,2014.



著書(分担執筆)

杉山暢宏:第1部 抑うつとは何か 第2章 抑うつの精神医学的意味.野村総一郎編:
精神科臨床エキスパート 抑うつの鑑別を究める pp6-22.医学書院,東京,2014.

杉山暢宏:第3部 抑うつを示す疾患の鑑別と治療のポイント第11章 PMDD,更年期障害.野村総一郎編:精神科臨床エキスパート 抑うつの鑑別を究める pp181-191,医学書院、東京,2014.

杉山暢宏,高橋由佳:T双極性障害および関連障害群 物質・医薬品誘発性双極性障害および関連障害,他の特定される双極性障害および関連障害,特定不能の双極性障害および関連障害.神庭重信編: DSM-5を読み解く 伝統的精神病理,DSM-W,ICD-10をふまえた新時代の精神科診断 3双極性障害および関連障害群,抑うつ障害群,睡眠-覚醒障害群 pp85-92,中山書店,東京,2014.

高橋由佳,天野直二:T.神経認知症候群 せん妄.神庭重信,池田学編DSM-5を読み解く 伝統的精神病理、DSM-W,ICD-10をふまえた新時代の精神科診断 pp2-19,中山書店,東京,2014.

鷲塚伸介:第4部 抑うつの生物学的背景.野村総一郎編:精神科臨床エキスパート 抑うつの鑑別を究める pp211-221,医学書院,東京



2013年 業績

Hori H, Matsuo J, Teraishi T, Sasayama D, Kawamoto Y, Kinoshita Y, Ota M, Hattori K, Kunugi H: Moderating effect of schizotypy on the relationship between smoking and neurocognition. Eur Psychiatry 28: 457-462, 2013.

Hori H, Teraishi T, Sasayama D, Hattori K, Hashikura M, Higuchi T, Kunugi H: Relationship of temperament and character with cortisol reactivity to the combined dexamethasone/CRH test in depressed outpatients. J Affect Disord 147: 128-136, 2014.

Kinoshita Y, Furukawa TA, Kinoshita K, Honyashiki M, Omori IM, Marshall M, Bond GR, Huxley P, Amano N, Kingdon D: Supported employment for adults with severe mental illness.
Cochrane Database Syst Rev 9: CD008297, 2013.

Mutai H, Furukawa T, Araki K, Misawa K, Hanihara T: Long-term outcome in stroke survivors after discharge from a convalescent rehabilitation ward. Psychiatry Clin Neurosci 67: 434-440, 2013.

Ota M, Hori H, Sato N, Sasayama D, Hattori K, Teraishi T, Obu S, Nakata Y, Kunugi H:
Hypothalamic-Pituitary-Adrenal Axis Hyperactivity and Brain Differences in Healthy Women.
Neuropsychobiology 68: 205-211, 2013.

Ota M, Ishikawa M, Sato N, Hori H, Sasayama D, Hattori K, Teraishi T, Noda T, Obu S, Nakata Y, Higuchi T, Kunugi H: Discrimination between schizophrenia and major depressive disorder by magnetic resonance imaging of the female brain. J Psychiatr Res 47: 1383-1388, 2013.

Ota M, Sato N, Matsuo J, Kinoshita Y, Kawamoto Y, Hori H, Teraishi T, Sasayama D, Hattori K, Obu S, Nakata Y, Kunugi H: Multimodal image analysis of sensorimotor gating in healthy women. Brain Res 1499: 61-68, 2013.

Sasayama D, Hattori K, Wakabayashi C, Teraishi T, Hori H, Ota M, Yoshida S, Arima K, Higuchi T, Amano N, Kunugi H: Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder. J Psychiatr Res 47: 401-406, 2013.

Sasayama D, Hiraishi A, Tatsumi M, Kamijima K, Ikeda M, Umene-Nakano W, Yoshimura R, Nakamura J, Iwata N, Kunugi H: Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder. Pharmacogenomics J 13: 354-358, 2013.

Sasayama D, Hori H, Nakamura S, Miyata R, Teraishi T, Hattori K, Ota M, Yamamoto N, Higuchi T, Amano N, Kunugi H: Identification of Single Nucleotide Polymorphisms Regulating Peripheral Blood mRNA Expression with Genome-Wide Significance: An eQTL Study in the Japanese Population. Plos One 8:e54967, 2013.

Sawa T, Kodaira M, Oiji A, Sasayama D, Iwdare Y, Ushijima H, Usami M, Watanabe K, Saito K: Dysfunction of orbitofrontal and dorsolateral prefrontal cortices in children and adolescents with high-functioning pervasive developmental disorders. Ann Gen Psychiatry 12: 31, 2013.

Suzuki H, Barros RPA, Sugiyama N, Krishnan V, Yaden BC, Kim H-J, Warner M, Gustafsson J-A: Involvement of estrogen receptor β in maintenance of serotonergic neurons of the dorsal raphe. Mol Psychiatry 18: 674-680, 2013.

Takahashi T, Fuke T, Washizuka S, Hanihara T, Amano N: A review of recent case reports of cenesthopathy in Japan. Psychogeriatrics 13: 196-198, 2013.

Teraishi T, Sasayama D, Hori H, Yamamoto N, Fujii T, Matsuo J, Nagashima A, Kinoshita Y, Hattori K, Ota M, Fujii S, Kunugi H: Possible association between common variants of the phenylalanine hydroxylase (PAH) gene and memory performance in healthy adults. Behav Brain Funct 9: 30, 2013.

Uchida M, Tsukahara T, Kaneko M, Washizuka S, Kawa S: Evaluation of factors affecting variations in influenza A/H1N1 history in university students, Japan. J Infect Chemother 19: 665-672, 2013.

Usami M, Okada T, Sasayama D, Iwadare Y, Watanabe K, Ushijima H, Kodaira M, Sugiyama N, Sawa T, Saito K: What Time Periods of the Day are Concerning for Parents of Children with Attention Deficit Hyperactivity Disorder? Plos One 8: E79806, 2013.

Usami M, Sasayama D, Sugiyama N, Hosogane N, Kim S-Y, Yamashita Y, Kodaira M, Watanabe K, Iwadare Y, Sawa T, Saito K: The reliability and validity of the Questionnaire-Children with Difficulties (QCD). Child Adolesc Psychiatry Ment Health 7: 11, 2013.

Yasaki T, Takahashi Y, Takahashi T, Washizuka S, Amano N, Hanihara T: Cavum septum pellucidum and cavum vergae with late-onset catatonia. JECT 29: e45-46, 2013.

天野直二:【治療エビデンスに乏しい精神疾患に遭遇したときどうするか】全身性エリテマトーデス(SLE)の精神症状に対する治療上のポイント. 精神科治療学 28:73-77, 2013.

糸川昌成,新井 誠,宮下光弘,小堀晶子,畠山幸子,鳥海和也,市川智恵,大島健一,新里和弘,岡崎祐士,齋藤正彦:統合失調症の遺伝子研究における課題と展望 異種性と複雑系.精神医学 55:1133-1143, 2013.

犬塚 伸:【認知症に対する薬物療法の課題】 アルツハイマー型認知症の症状改善薬と向精神薬の併用による効果の増減について.精神科治療学 28:1589-1595,2013.

太田深秀,佐藤典子,石川正憲,堀 弘明,篠山大明,服部功太郎,寺石俊也,大部聡子,中田安弘,根本清貴,守口善也,橋本亮太,功刀 浩:MRIによる女性統合失調症患者と女性健常群との判別分析.精神神経学雑誌 115:1171-1177,2013.

荻原朋美,天野直二:【前頭側頭葉変性症と類縁疾患の基礎と臨床】 前頭側頭型認知症(ピック病)の臨床症状.老年精神医学雑誌 24:1233-1241,2013.

木下善弘,木下久慈:【認知行動療法】 統合失調症の認知行動療法におけるノーマライゼーション.最新精神医学 18:125-129,2013.

木下善弘,木下久慈:【精神療法の適応 話題の治療技法を中心に】 統合失調症の認知行動療法.精神療法 39:50-54,2013.

杉山暢宏:【薬物療法の適正化に向けて】 薬物療法の適正化における治療ガイドラインの役割.臨床精神医学42:217-225,2013.

高橋 徹:オピニオン 名は体を表す.精神科治療学 28:1104-1108,2013.

田中 章,柴田佳奈,天野直二:話題の論文 抗NMDA受容体脳炎の治療および長期予後因子に関する観察的コホート研究. Cognition and Dementia 12:146-147,2013.

中田佳代子,天野直二:【入院患者のうつ病・認知症 こんなときどうする?】 入院患者のうつ病:入院中の抑うつを防ぐために、できることはありますか.レジデントノート 15:2404-2409,2013.

堀 弘明,寺石俊也,篠山大明,服部功太郎,橋倉 都,樋口輝彦,功刀 浩:大うつ病性障害におけるパーソナリティはコルチゾール反応性を予測する:デキサメタゾン/CRHテストによる検討.日本神経精神薬理学雑誌 33:61-63,2013.

宮下光弘,新井 誠,市川智恵,鳥海和也,小堀晶子,天野直二,糸川昌成:【精神疾患に対する行動医学的アプローチ】 カルボニルストレスという代謝異常と統合失調症 ―体に負担の少ないビタミンB6による治療法の研究―.総合病院精神医学 25:254-261,2013.

矢崎健彦,天野直二:【せん妄の診断と治療の現在U】 精神科外来・入院患者について、どのような時にせん妄を疑い、どのように対応するか?精神科治療学 28:1187-1191,2013.

由井寿美江,荻原朋美,天野直二:【アルツハイマー病の症状,検査,診断】 アルツハイマー病にみられる行動・心理症状(BPSD).からだの科学 278:56-59,2013.

由井寿美江,荻原朋美,天野直二:【認知症に対する薬物療法の課題】 アルツハイマー型認知症の重症例に対する症状改善薬の使用法について.精神科治療学 28:1551-1555,2013.

天野直二:第2章 主要な精神疾患 §7. 認知症とせん妄 15.せん妄を疑うのはどのようなときか 16.せん妄と認知症の見分け方 17.せん妄と「レム睡眠行動障害」の見分け方 18.せん妄の原因になる主な身体疾患 19.せん妄の原因になる主な薬物 20.患者と家族への説明、家族の支援:せん妄のとき 21.せん妄の対症療法1:非薬物療法 22.せん妄の対症療法2:薬物療法.堀川直史編:ジェネラル診療シリーズ あらゆる診療科でよく出会う精神疾患を見極め、対応する ―適切な診断・治療と患者への説明、専門医との連携のために―.pp199-217,羊土社,東京,2013.

伊賀淳一,大森哲郎,小笠原一能,尾崎紀夫,神庭重信,杉山暢宏,富田真幸,野村総一郎,渡邉衡一郎:1. 大うつ病性障害 気分障害の治療ガイドライン作成委員会 大うつ病性障害・双極性障害 治療ガイドライン.pp1-80,医学書院,東京,2013.

犬塚 伸: BPSDへの対応の原則 3.BPSDへの対応(薬物療法を中心に).中島健二,天野直二,下濱 俊,冨本秀和,三村 將編:認知症ハンドブック.pp215-232,医学書院,東京,2013.

福家知則,犬塚 伸,天野直二:[章 認知症との鑑別を要する疾患 せん妄(薬剤性など).
池田 学編:脳とこころのプライマリケア2 知能の衰え.pp474-483,シナジー,東京,2013.

宮下光弘,新井 誠,市川智恵,鳥海和也,小堀晶子,天野直二,糸川昌成:第W編 医薬品開発技術 第1章 統合失調症の臨床試験.糸川昌成編:ファインケミカルシリーズ メンタル医療 ―原因解明と診断,治療の最前線―.pp133-140,シーエムシー出版,東京,2013.

天野直二:ビンスワンガー病.樋口輝彦,市川宏伸,神庭重信,浅田 隆,中込和幸編:
今日の精神疾患 治療指針.pp363-365,医学書院,東京,2013.



2012年 業績

Fujii T, Ota M, Hori H, Sasayama D, Hattori K, Teraishi T, Yamamoto N, Hashikura M, Tatsumi M, Higuchi T, Kunugi H; Association between the functional polymorphism(C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population. J Psychiatr Res, 46:555-559, 2012.

Hori H, Teraishi T, Sasayama D, Matsuo J, Kawamoto Y, Kinoshita Y, Kunugi H; Relationship between season of birth, schizotypy, temperament, character and neurocognition in a non-clinical population. Psychiatry Res, 195:69-75, 2012.

Hori H, Matsuo J, Teraishi T, Sasayama D, Kawamoto Y, Kinoshita Y, Hattori K, Hashikura M, Higuchi T, Kunugi H; Schizotypy and genetic loading for schizophrenia impact upon neuropsychological status in bipolar II and unipolar major depressive disorders. J Affect Disord, 142:225-232, 2012.

Hori H, Teraishi T, Sasayama D, Hattori K, Ota M, Matsuo J, Kawamoto Y, Kinoshita Y, Kunugi H; Schizotypal trait in healthy women is associated with a shift away from dextrality on a spatial motor control task, but not on a force control task. Psychiatry Res, 200:629-634, 2012.

Hori H, Yamamoto N, Fujii T, Teraishi T, Sasayama D, Matsuo J, Kawamoto Y, Kinoshita Y, Ota M, Hattori K, Tatsumi M, Arima K, Kunugi H; Effects of the Cacna1C risk allele on neurocognition in patients with schizophrenia and healthy individuals. Sci Rep, 2:634, 2012.

Ichikawa T, Arai M, Miyashita M, Arai M, Obata N, Nohara I, Oshima K, Niizato K, Okazaki Y, Doi N, Itokawa M; Schizophrenia: Maternal inheritance and heteroplasmy of mtDNA mutations. Mol Genet Metabo, 105:103-109, 2012.

Kaneko T, Kaneko K, Matsushita M, Kadoya M, Ihara N, Ryokawa A, Ogihara T, Inuzuka S, Ueda A: New visual rating system for medial temporal lobe atrophy: a simple diagnostic tool for routine examinations. Psychogeriatrics, 12:88-92, 2012.

Kinoshita K, Kinoshita Y, Shimodera S, Nishida A, Inoue K, Watanabe N, Oshima N, Akechi T, Sasaki T, Inoue S, Furukawa T, Okazaki Y; Not only body weight perception but also body mass index is relevant to suicidal ideation and self-harming behavior in Japanese adolescents. J Nerv Ment Dis, 200(4): 305-309, 2012.

Kodaira M, Iwadare Y, Ushijima H, Oiji A, Kato M, Sugiyama N, Sasayama D, Usami M, Watanabe K, Saito K; Poor performance on the lowa gambling task in children with obsessive-compulsive disorder. Ann Gen Psychiatry, 11(1):25, 2012.

Mutai H, Furukawa T, Araki K, Misawa K, Hanihara T: Factors associated with functional recovery and home discharge in stroke patients admitted to a convalescent rehabilitation ward. Geriatr Gerontol Int, 12:215-222, 2012.

Ota M, Ishikawa M, Sato N, Hori H, Sasayama D, Hattori K, Teraishi T, Nakata Y, Kunugi H; Glutamatergic changes in the cerebral white matter associated with schizophrenic exacerbation. Acta Psychiatr Scand, 126(1):72-78, 2012.

Sasayama D, Hattori K, Teraishi T, Hori H, Ota M, Yoshida S, Arima K, Higuchi T, Amano N, Kunugi H; Negative correlation between cerebrospinal fluid oxytocin levels and negatibe symptoms of male patients with schizophrenia. Schizophrenia Res, 139:201-206, 2012.

Sasayama D, Hori H, Teraishi T, Hattori K, Ota M, Matsuo J, Kawamoto Y, Kinoshita Y, Amano N, Kunugi H: Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults. J Neural Transm, 119:313-318, 2012.

Sasayama D, Hori H, Teraishi T, Hattori K, Ota M, Matsuo J, Kawamoto Y, Kinoshita Y, Hashikura M, Amano N, Higuchi T, Kunugi H; More severe impairment of manual dexterity in bipolar disorder compared to unipolar major depression. J Affect Disord,
136:1047-1052, 2012.

Sasayama D, Hori H, Teraishi T, Hattori K, Ota M, Tatsumi M, Higuchi T, Amano N, Kunugi H; Possible impact of ADRB3 Trp64Arg polymorphism on BMI in patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry, 38(2):341-344, 2012.

Takahashi T, Kinoshita K, Fuke T, Urushihata K, Kawamata T, Yanagisawa S, Kaneko T, Washizuka S, Hanihara T, Amano N; Acute neurogenic pulmonary edema following electroconvulsive therapy: a case report. Gen Hosp Psychiatry, 34(6):703.e9-703.e11, 2012.

Teraishi T, Ozeki Y, Hori H, Sasayama D, Chiba S, Yamamoto N, Tanaka H, Iijima Y, Matsuo J, Kawamoto Y, Kinoshita Y, Hattori K, Ota M, Kajiwara M, Terada S, Higuchi T, Kunugi H; 13C-phenylalanine breath test detects altered phenylalanine kinetics in schizophrenia patients. Transl Psychiatry, 2: e119. 2012.

天野直二;せん妄の診断と治療,そして予防.日本医事新報,4606:85-90,2012.

天野直二;【気分障害の治療ガイドライン 新訂版 身体疾患と抑うつ】全身性エリテマトーデス.精神科治療学,27巻,増刊号,235-238,2012.

天野直二:【高齢者に対する向精神薬療法の工夫】不安・焦燥.精神科,20(2):126-129,2012.

萩原徹也,荻原朋美,田中章,杉山暢宏,鷲塚伸介,天野直二;【成人の精神科臨床から見えてくる発達障害】自閉症スペクトラム障害の特性が認められた82歳の女性症例.精神科治療学,27(5):647-653,2012.

萩原徹也,鷲塚伸介;【現代思春期・青年期論2012】スキゾタイパル障害における思春・心性.精神療法,38(2):202-210,2012.

市川かおり,天野直二:【精神疾患の典型例を学ぶ】パラノイアの典型例.精神科治療学,27(7):903-906,2012.
鷲塚伸介,加藤忠史;【生活の視点から薬物療法をとらえなおす:薬にできること・できないこと】双極性障害.精神科臨床サービス,12(1):39-42,2012.

荻原朋美,鷲塚伸介;【認知症の非薬物療法の現状と課題―様々な非薬物療法をどう考えていくべきか】非薬物療法とそのエビデンス ―総論的に.認知症の最新医療,2(4):165-169,2012.

鷲塚伸介;【Lithium再考:多様なムードスタピライザーの時代にlithiumを再考する】長期lithium療法の安全性―維持療法の際に注意すべきポイント―.臨床精神薬理,15:1497-1502,2012.

矢崎健彦,市川かおり,天野直二;【精神科医の多剤併用・大量処方を考えるU】認知症進行抑制薬における2剤併用(donepezil・memantine)の意義と問題点.精神科治療学,27(2):141-147,2012.

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