Web of Science

　Researcher ID:E-7103-2010

受賞

　成人血管病研究振興財団　岡本研究奨励賞（2000）
　日本生化学会奨励賞（2000）
　日本薬理学会学術奨励賞（2001）
　バイオビジネスコンペJAPAN優秀賞（2008）
　第12回高峰譲吉研究奨励賞（2008）
　日本学術振興会賞（2009）
　文部科学大臣表彰 科学技術賞（開発部門）(2016)

主要論文

● Sawamura, T., Kume, N., Aoyama, T., Moriwaki, H., Hoshikawa, H., Aiba, Y., Tanaka, T., Miwa, S., Katsura, Y., Kita, T. and Masaki, T.: An endothelial receptor for oxidized low-density lipoprotein. Nature, 386:73-77, 1997.
● Hosokawa, H., Sawamura, T., Kobayashi, S., Ninomiya, H., Miwa, S. and Masaki, T.: Cloning and characterization of a brain-specific cationic amino acid transporter. J Biol Chem, 272:8717-8722, 1997.
● Oka, K., Sawamura, T., Kikuta, K., Itokawa, S., Kume, N., Kita, T. and Masaki, T.: Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc Natl Acad Sci U S A, 95:9535-9540, 1998.
● Kikuta, K., Sawamura, T., Miwa, S., Hashimoto, N. and Masaki, T.: High-affinity arginine transport of bovine aortic endothelial cells is impaired by lysophosphatidylcholine. Circ Res, 83:1088-1096, 1998.
● Kakutani, M., Masaki, T. and Sawamura, T.: A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1. Proc Natl Acad Sci U S A, 97:360-364, 2000.
● Delneste, Y., Magistrelli, G., Gauchat, J., Haeuw, J., Aubry, J., Nakamura, K., Kawakami-Honda, N., Goetsch, L., Sawamura, T., Bonnefoy, J. and Jeannin, P.: Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity, 17:353, 2002.
● Honjo, M., Nakamura, K., Yamashiro, K., Kiryu, J., Tanihara, H., McEvoy, L.M., Honda, Y., Butcher, E.C., Masaki, T. and Sawamura, T.: Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Proc Natl Acad Sci U S A, 100:1274-1279, 2003.
● Li, L., Roumeliotis, N., Sawamura, T. and Renier, G.: C-reactive protein enhances LOX-1 expression in human aortic endothelial cells. Relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction. Circ Res, 95:877-883, 2004.
● Inoue, K., Arai, Y., Kurihara, H., Kita, T. and Sawamura, T.: Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice. Circ Res, 97:176-184, 2005.
● Hinagata, J., Kakutani, M., Fujii, T., Naruko, T., Inoue, N., Fujita, Y., Mehta, J.L., Ueda, M. and Sawamura, T.: Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model. Cardiovasc Res, 69:263-271, 2006.
● Mehta, J.L., Sanada, N., Hu, C.P., Chen, J., Dandapat, A., Sugawara, F., Satoh, H., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Takeya, M., Schnackenberg, L., Beger, R., Hermonat, P.L., Thomas, M. and Sawamura, T.: Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet.Circ Res, 100:1634-1642, 2007. 
● Yao, E.H., Fukuda, N., Ueno, T., Matsuda, H., Matsumoto, K., Nagase, H., Matsumoto, Y., Takasaka, A., Serie, K., Sugiyama, H. and Sawamura, T.: Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury. Hypertension, 52:86-92, 2008.
● Ishigaki, Y., Katagiri, H., Gao, J., Yamada, T., Imai, J., Uno, K., Hasegawa, Y., Kaneko, K., Ogihara, T., Ishihara, H., Sato, Y., Takikawa, K., Nishimichi, N., Matsuda, H., Sawamura, T. and Oka, Y.: Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis. Circulation, 118:75-83, 2008.
● Lu, J., Yang, J.H., Burns, A.R., Chen, H.H., Tang, D., Walterscheid, J.P., Suzuki, S., Yang, C.Y., Sawamura, T. and Chen, C.H.: Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. Circ Res, 104:619-627, 2009.
● Ueno, T., Fukuda, N., Tsunemi, A., Yao, E.H., Matsuda, H., Tahira, K., Matsumoto, T., Matsumoto, K., Matsumoto, Y., Nagase, H., Sugiyama, H. and Sawamura, T.: A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function. J Hypertens, 27:508-516, 2009.
● Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and
Sawamura, T.: Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects. Clin Chem, 55:285-294, 2009.
● Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.: LOX-1 mediates vascular lipid retention under hypertensive state. J Hypertens, 28:1273-1280, 2010.
● Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.: LOX index, a novel predictive biochemical marker for coronary heart disease and stroke. Clin Chem, 56:550-558, 2010.
● Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.: Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation. Clin Chem, 57:1398-1405. 2011.
● Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.: Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis. Arthritis Rheum, 64:1024-1034. 2012.
● Morton, J.S., Abdalvand, A., Jiang, Y., Sawamura, T., Uwiera, R.R. and Davidge, S.T.: Lectin-like oxidized low-density lipoprotein 1 receptor in a reduced uteroplacental perfusion pressure rat model of preeclampsia. Hypertension, 59:1014-1020. 2012.
● Chan, H.C., Ke, L.Y., Chu, C.S., Lee, A.S., Shen, M.Y., Cruz, M.A., Hsu, J.F., Cheng, K.H., Chan, H.C., Lu, J., Lai, W.T., Sawamura, T., Sheu, S.H., Yen, J.H. and Chen, C.H.: Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood, 2013.
● Yamamoto, K., Kakino, A., Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.: Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor. FASEB J, 29:3342-3356, 2015.
● Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.: Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state. Bone, 75:170-182, 2015.
● Stancel, N., Chen, C.C., Ke, L.Y., Chu, C.S., Lu, J., Sawamura, T. and Chen, C.H.: Interplay between CRP, atherogenic LDL, and LOX-1 and its potential role in the pathogenesis of atherosclerosis. Clin Chem, 62:320-327, 2016.
● Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.: Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice. Circ J, 80:2541-2549, 2016.
● Shen, M.Y., Chen, F.Y., Hsu, J.F., Fu, R.H., Chang, C.M., Chang, C.T., Liu, C.H., Wu, J.R., Lee, A.S., Chan, H.C., Sheu, J.R., Lin, S.Z., Shyu, W.C., Sawamura, T., Chang, K.C., Hsu, C.Y. and Chen, C.H.: Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation. Blood, 127:1336-1345, 2016.
● Okamura, T., Miura, K., Sawamura, T., Kadota, A., Hisamatsu, T., Fujiyoshi, A., Miyamatsu, N., Takashima, N., Miyagawa, N., Kadowaki, T., Ohkubo, T., Murakami, Y., Nakamura, Y., Ueshima, H. and Group, S.R.: Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese. J Clin Lipidol, 10:172-180. e1, 2016.
● Wang, Y.C., Lee, A.S., Lu, L.S., Ke, L.Y., Chen, W.Y., Dong, J.W., Lu, J., Chen, Z., Chu, C.S., Chan, H.C., Kuzan, T.Y., Tsai, M.H., Hsu, W.L., Dixon, R.A.F., Sawamura, T., Chang, K.C. and Chen, C.H.: Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo. Aging Cell, e12792, 2018.

所属学会

日本生化学会
日本薬理学会
日本循環器学会
日本動脈硬化学会
日本生理学会
日本免疫学会
国際心臓研究学会
日本循環薬理学会
日本心血管内分泌代謝学会
高血圧関連疾患モデル学会