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発表論文COMPANY

発表した論文は年々注目を集め、これまで延べ約1万2千回以上、平均60回以上引用されています(h-index 62)。

  1. Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.: Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice. Circ J, 80:2541-2549, 2016.
  2. Chen, M.,  Qiu, H., Lin, X., Nam, D., Ogbu-Nwobodo, L., Archibald, H., Joslin, A., Wun, T., Sawamura, T. and Green, R.:Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy. Blood Cells Mol Dis, 60:44-48, 2016.
  3. Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura, T. and Minatoguchi, S.: Deletion of LOX-1 protects against heart failure induced by doxorubicin. PLoS One, 11:e0154994, 2016.
  4. Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.: High levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in acute stroke: an age- and sex-matched cross-sectional study. J Atheroscler Thromb, 2016.
  5. Chang, C.T., Wang, G.J., Kuo, C.C., Hsieh, J.Y., Lee, A.S., Chang, C.M., Wang, C.C., Shen, M.Y., Huang, C.C., Sawamura, T., Yang, C.Y., Stancel, N. and Chen, C.H.: Electronegative low-density lipoprotein increases coronary artery disease risk in uremia patients on maintenance hemodialysis. Medicine (Baltimore), 95:e2265, 2016.
  6. Hashimoto, K., Mori, S., Oda, Y., Nakano, A., Sawamura, T. and Akagi, M.: Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis. Scand J Rheumatol, 1-11, 2016
  7. Okamura, T., Miura, K., Sawamura, T., Kadota, A., Hisamatsu, T., Fujiyoshi, A., Miyamatsu, N., Takashima, N., Miyagawa, N., Kadowaki, T., Ohkubo, T., Murakami, Y., Nakamura, Y., Ueshima, H. and Group, S.R.: Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese. J Clin Lipidol, 10:172-180. e1, 2016.
  8. Shen, M.Y., Chen, F.Y., Hsu, J.F., Fu, R.H., Chang, C.M., Chang, C.T., Liu, C.H., Wu, J.R., Lee, A.S., Chan, H.C., Sheu, J.R., Lin, S.Z., Shyu, W.C., Sawamura, T., Chang, K.C., Hsu, C.Y. and Chen, C.H.: Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation. Blood, 127:1336-1345, 2016
  9. Chang, K.C., Lee, A.S., Chen, W.Y., Lin, Y.N., Hsu, J.F., Chan, H.C., Chang, C.M., Chang, S.S., Pan, C.C., Sawamura, T., Chang, C.T., Su, M.J. and Chen, C.H.: Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction. J Mol Cell Cardiol, 84:36-44, 2015.
  10. Ding, Z., Liu, S., Wang, X., Deng, X., Fan, Y., Shahanawaz, J., Shmookler Reis, R.J., Varughese, K.I., Sawamura, T. and Mehta, J.L.: Cross-talk between LOX-1 and PCSK9 in vascular tissues. Cardiovasc Res, 107:556-567, 2015.
  11. Lin, F.Y., Tsao, N.W., Shih, C.M., Lin, Y.W., Yeh, J.S., Chen, J.W., Nakagami, H., Morishita, R., Sawamura, T. and Huang, C.Y.: The biphasic effects of oxidized-low density lipoprotein on the vasculogenic function of endothelial progenitor cells. PLoS One, 10:e0123971, 2015.
  12. Sugiyama, D., Higashiyama, A., Wakabayashi, I., Kubota, Y., Adachi, Y., Hayashibe, A., Kawamura, K., Kuwabara, K., Nishimura, K., Kadota, A., Nishida, Y., Hirata, T., Imano, H., Miyamatsu, N., Miyamoto, Y., Sawamura, T. and Okamura, T.: The Relationship between Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B and the Cardio-Ankle Vascular Index in Healthy Community Inhabitants: The KOBE Study. J Atheroscler Thromb, 22:499-508, 2015.
  13. Yamamoto, K., Kakino, A., Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.: Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor. FASEB J, 29:3342-3356, 2015.
  14. Uetake, Y., Ikeda, H., Irie, R., Tejima, K., Matsui, H., Ogura, S., Wang, H., Mu, S., Hirohama, D., Ando, K., Sawamura, T., Yatomi, Y., Fujita, T. and Shimosawa, T.: High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice. Lipids Health Dis, 14:6, 2015.
  15. Tomita, T., Ieguchi, K., Sawamura, T. and Maru, Y.: Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor. PLoS One, 10:e0118835, 2015.
  16. Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.: Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state. Bone, 75:170-182, 2015.
  17. Morton, J.S., Quon, A., Cheung, P.Y., Sawamura, T. and Davidge, S.T.: Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia. Am J Physiol Regul Integr Comp Physiol, 308:R163-172, 2015.
  18. Shiraki, T., Aoyama, T., Yokoyama, C., Hayakawa, Y., Tanaka, T., Nishigaki, K., Sawamura, T. and Minatoguchi, S.: LOX-1 plays an important role in ischemia-induced angiogenesis of limbs. PLoS One, 9:e114542, 2014.
  19. Khaidakov, M., Mercanti, F., Wang, X., Ding, Z., Dai, Y., Romeo, F., Sawamura, T. and Mehta, J.L.: Prevention of export of anoxia/reoxygenation injury from ischemic to nonischemic cardiomyocytes via inhibition of endocytosis. Am J Physiol Heart Circ Physiol, 306:H1700-1707, 2014.
  20. Misaka, T., Suzuki, S., Sakamoto, N., Yamaki, T., Sugimoto, K., Kunii, H., Nakazato, K., Saitoh, S., Sawamura, T., Ishibashi, T. and Takeishi, Y.: Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome. Biomed Res Int, 2014:649185, 2014.
  21. Uzui, H., Hayashi, H., Nakae, I., Matsumoto, T., Uenishi, H., Hayasaki, H., Asaji, T., Matsui, S., Miwa, K., Lee, J.D., Tada, H., Sawamura, T. and Fujita, M.: Pitavastatin decreases serum LOX-1 ligand levels and MT1-MMP expression in CD14-positive mononuclear cells in hypercholesterolemic patients. Int J Cardiol, 176:1230-1232, 2014.
  22. Arai, H., Kokubo, Y., Watanabe, M., Sawamura, T., Ito, Y., Minagawa, A., Okamura, T. and Miyamato, Y.: Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study. J Atheroscler Thromb, 20:195-203. 2013.
  23. Chan, H.C., Ke, L.Y., Chu, C.S., Lee, A.S., Shen, M.Y., Cruz, M.A., Hsu, J.F., Cheng, K.H., Chan, H.C., Lu, J., Lai, W.T., Sawamura, T., Sheu, S.H., Yen, J.H. and Chen, C.H.: Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood, 2013.
  24. Chu, C.S., Wang, Y.C., Lu, L.S., Walton, B., Yilmaz, H.R., Huang, R.Y., Sawamura, T., Dixon, R.A., Lai, W.T., Chen, C.H. and Lu, J.: Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor. PLoS One, 8:e70533. 2013.
  25. English, F.A., McCarthy, F.P., McSweeney, C.L., Quon, A.L., Morton, J.S., Sawamura, T., Davidge, S.T. and Kenny, L.C.: Inhibition of lectin-like oxidized low-density lipoprotein-1 receptor protects against plasma-mediated vascular dysfunction associated with pre-eclampsia. Am J Hypertens, 26:279-286. 2013.
  26. Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell, E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama, A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami, Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller, L.H., Ueshima, H. and Group, E.J.S.: LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men. Atherosclerosis, 229:240-245. 2013.
  27. Takanabe-Mori, R., Ono, K., Wada, H., Takaya, T., Ura, S., Yamakage, H., Satoh-Asahara, N., Shimatsu, A., Takahashi, Y., Fujita, M., Fujita, Y., Sawamura, T. and Hasegawa, K.: Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokers. J Atheroscler Thromb, 20:585-590. 2013.
  28. Viola, M., Bartolini, B., Vigetti, D., Karousou, E., Moretto, P., Deleonibus, S., Sawamura, T., Wight, T.N., Hascall, V.C., De Luca, G. and Passi, A.: Oxidized Low Density Lipoprotein (LDL) Affects Hyaluronan Synthesis in Human Aortic Smooth Muscle Cells. J Biol Chem, 288:29595-29603. 2013.
  29. Wu, Z., Sawamura, T., Kurdowska, A.K., Ji, H.L., Idell, S. and Fu, J.: LOX-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model. Infect Immun, 79:2865-2870. 2011.
  30. Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.: Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis. Arthritis Rheum, 64:1024-1034. 2012.
  31. Morton, J.S., Abdalvand, A., Jiang, Y., Sawamura, T., Uwiera, R.R. and Davidge, S.T.: Lectin-like oxidized low-density lipoprotein 1 receptor in a reduced uteroplacental perfusion pressure rat model of preeclampsia. Hypertension, 59:1014-1020. 2012.
  32. Sato, K., Nakano, K., Katsuki, S., Matoba, T., Osada, K., Sawamura, T., Sunagawa, K. and Egashira, K.: Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe. J Atheroscler Thromb, 19:986-998. 2012.
  33. Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.: Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation. Clin Chem, 57:1398-1405. 2011.
  34. Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.: An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment. J Atheroscler Thromb, 18:818-828. 2011.
  35. Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.: Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox. Proc Jpn Acad Ser B Phys Biol Sci, 87:104-113. 2011.
  36. Uchida, K., Suehiro, A., Nakanishi, M., Sawamura, T. and Wakabayashi, I.: Associations of atherosclerotic risk factors with oxidized low-density lipoprotein evaluated by LOX-1 ligand activity in healthy men. Clin Chim Acta, 412:1643-1647. 2011.
  37. Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R. and Sawamura, T.: C-reactive protein uptake by macrophage cell line via class-A scavenger receptor. Clin Chem, 56:478-481, 2010.
  38. Takaya, T., Wada, H., Morimoto, T., Sunagawa, Y., Kawamura, T., Takanabe-Mori, R., Shimatsu, A., Fujita, Y., Sato, Y., Fujita, M., Kimura, T., Sawamura, T. and Hasegawa, K.: Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts. Circ J, 74:723-729, 2010.
  39. Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.: LOX index, a novel predictive biochemical marker for coronary heart disease and stroke. Clin Chem, 56:550-558, 2010.
  40. Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K. and Horie, M.: Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans. Lipids, 45:329-335, 2010.
  41. Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.: LOX-1 mediates vascular lipid retention under hypertensive state. J Hypertens, 28:1273-1280, 2010.
  42. Kishimoto, H., Akagi, M., Zushi, S., Teramura, T., Onodera, Y., Sawamura, T. and Hamanishi, C.: Induction of hypertrophic chondrocyte-like phenotypes by oxidized LDL in cultured bovine articular chondrocytes through increase in oxidative stress. Osteoarthritis Cartilage, 18:1284-1290, 2010.
  43. Matsutake, T., Sawamura, T. and Srivastava, P.K.: High efficiency CD91- and LOX-1-mediated re-presentation of gp96-chaperoned peptides by MHC II molecules. Cancer Immun, 10:7, 2010.
  44. Qiu, Y., Yanase, T., Hu, H., Tanaka, T., Nishi, Y., Liu, M., Sueishi, K., Sawamura, T. and Nawata, H.: Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development. Endocrinology, 151:3307-3316, 2010.
  45. Takanabe-Mori, R., Ono, K., Sowa, N., Wada, H., Takaya, T., Horie, T., Satoh-Asahara, N., Shimatsu, A., Fujita, M., Sawamura, T. and Hasegawa, K.: Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice. Biochem Biophys Res Commun, 398:576-580, 2010.
  46. Taye, A., Sawamura, T. and Morawietz, H.: Aldosterone augments LOX-1-mediated low-density lipoprotein uptake in human umbilical artery endothelial cells. Pharmacol Rep, 62:311-318, 2010.
  47. Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T.: Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects. Clin Chem, 55:285-294, 2009.
  48. Kang, B.Y., Hu, C., Prayaga, S., Khaidakov, M., Sawamura, T., Seung, K.B. and Mehta, J.L.: LOX-1 dependent overexpression of immunoglobulins in cardiomyocytes in response to angiotensin II. Biochem Biophys Res Commun, 379:395-399, 2009.
  49. Sankaralingam, S., Xu, Y., Sawamura, T. and Davidge, S.T.: Increased lectin-like oxidized low-density lipoprotein receptor-1 expression in the maternal vasculature of women with preeclampsia: role for peroxynitrite. Hypertension, 53:270-277, 2009.
  50. Lu, J., Yang, J.H., Burns, A.R., Chen, H.H., Tang, D., Walterscheid, J.P., Suzuki, S., Yang, C.Y., Sawamura, T. and Chen, C.H.: Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. Circ Res, 104:619-627, 2009.
  51. Akagi, M., Ueda, A., Teramura, T., Kanata, S., Sawamura, T. and Hamanishi, C.: Oxidized LDL binding to LOX-1 enhances MCP-1 expression in cultured human articular chondrocytes. Osteoarthritis Cartilage, 17:271-275, 2009.
  52. Ueno, T., Fukuda, N., Tsunemi, A., Yao, E.H., Matsuda, H., Tahira, K., Matsumoto, T., Matsumoto, K., Matsumoto, Y., Nagase, H., Sugiyama, H. and Sawamura, T.: A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function. J Hypertens, 27:508-516, 2009.
  53. Inomata, Y., Fukushima, M., Hara, R., Takahashi, E., Honjo, M., Koga, T., Kawaji, T., Satoh, H., Takeya, M., Sawamura, T. and Tanihara, H.: Suppression of choroidal neovascularization in lectin-like oxidized low-density lipoprotein receptor type 1-deficient mice. Invest Ophthalmol Vis Sci, 50:3970-3976, 2009.
  54. Schaeffer, D.F., Riazy, M., Parhar, K.S., Chen, J.H., Duronio, V., Sawamura, T. and Steinbrecher, U.P.: LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma. J Lipid Res, 50:1676-1684, 2009.
  55. Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y. and Takeishi, Y.: LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells. Cardiovasc Res, 84:127-136, 2009.
  56. Sakamoto, N., Ishibashi, T., Sugimoto, K., Sawamura, T., Sakamoto, T., Inoue, N., Saitoh, S., Kamioka, M., Uekita, H., Ohkawara, H., Suzuki, K., Teramoto, T., Maruyama, Y. and Takeishi, Y.: Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+ signaling pathways in endothelial cells. J Cell Physiol, 220:706-715, 2009.
  57. Eichhorn, B., Muller, G., Leuner, A., Sawamura, T., Ravens, U. and Morawietz, H.: Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet. Cardiovasc Res, 82:493-502, 2009.
  58. Sankaralingam, S., Xu, H., Jiang, Y., Sawamura, T. and Davidge, S.T.: Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase. Hypertension, 54:897-904, 2009.
  59. Zushi, S., Akagi, M., Kishimoto, H., Teramura, T., Sawamura, T. and Hamanishi, C.: Induction of bovine articular chondrocyte senescence with oxidized low-density lipoprotein through lectin-like oxidized low-density lipoprotein receptor 1. Arthritis Rheum, 60:3007-3016, 2009.
  60. Iwamoto, S., Nishimichi, N., Tateishi, Y., Sato, Y., Horiuchi, H., Furusawa, S., Sawamura, T. and Matsuda, H.: Generation and characterization of chicken monoclonal antibodies against human LOX-1. MAbs, 1:357-363, 2009.
  61. Hu, C., Chen, J., Dandapat, A., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Li, D., Hermonat, P.L., Sawamura, T. and Mehta, J.L.: LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice. J Mol Cell Cardiol, 44:76-83, 2008.
  62. Tang, D., Lu, J., Walterscheid, J.P., Chen, H.H., Engler, D.A., Sawamura, T., Chang, P.Y., Safi, H.J., Yang, C.Y. and Chen, C.H.: Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1. J Lipid Res, 49:33-47, 2008.
  63. Sato, Y., Nishimichi, N., Nakano, A., Takikawa, K., Inoue, N., Matsuda, H. and Sawamura, T.: Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB. Atherosclerosis, 200:303-309, 2008.
  64. Honjo, T., Otsui, K., Shiraki, R., Kawashima, S., Sawamura, T., Yokoyama, M. and Inoue, N.: Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells. Endothelium, 15:137-141, 2008.
  65. Yao, E.H., Fukuda, N., Ueno, T., Matsuda, H., Matsumoto, K., Nagase, H., Matsumoto, Y., Takasaka, A., Serie, K., Sugiyama, H. and Sawamura, T.: Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury. Hypertension, 52:86-92, 2008.
  66. Ishigaki, Y., Katagiri, H., Gao, J., Yamada, T., Imai, J., Uno, K., Hasegawa, Y., Kaneko, K., Ogihara, T., Ishihara, H., Sato, Y., Takikawa, K., Nishimichi, N., Matsuda, H., Sawamura, T. and Oka, Y.: Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis. Circulation, 118:75-83, 2008.
  67. Hu, C., Dandapat, A., Sun, L., Chen, J., Marwali, M.R., Romeo, F., Sawamura, T. and Mehta, J.L.: LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet. Cardiovasc Res, 79:287-293, 2008.
  68. Hu, C., Dandapat, A., Sun, L., Marwali, M.R., Inoue, N., Sugawara, F., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Hermonat, P.L., Sawamura, T. and Mehta, J.L.: Modulation of angiotensin II-mediated hypertension and cardiac remodeling by lectin-like oxidized low-density lipoprotein receptor-1 deletion. Hypertension, 52:556-562, 2008.
  69. Sato, Y., Baba, T., Zubair, M., Miyabayashi, K., Toyama, Y., Maekawa, M., Owaki, A., Mizusaki, H., Sawamura, T., Toshimori, K., Morohashi, K. and Katoh-Fukui, Y.: Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature. Mol Reprod Dev, 75:1361-1371, 2008.
  70. Satoh, H., Kiyota, E., Terasaki, Y., Sawamura, T., Takagi, K., Mizuta, H. and Takeya, M.: Expression and localization of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in murine and human placentas. J Histochem Cytochem, 56:773-784, 2008.
  71. Hamilton, R.T., Asatryan, L., Nilsen, J.T., Isas, J.M., Gallaher, T.K., Sawamura, T. and Hsiai, T.K.: LDL protein nitration: implication for LDL protein unfolding. Arch Biochem Biophys, 479:1-14, 2008.
  72. Akagi, M., Kanata, S., Mori, S., Itabe, H., Sawamura, T. and Hamanishi, C.: Possible involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system in pathogenesis and progression of human osteoarthritis. Osteoarthritis Cartilage, 15:281-290, 2007.
  73. Mehta, J.L., Sanada, N., Hu, C.P., Chen, J., Dandapat, A., Sugawara, F., Satoh, H., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Takeya, M., Schnackenberg, L., Beger, R., Hermonat, P.L., Thomas, M. and Sawamura, T.: Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res, 100:1634-1642, 2007.
  74. Marwali, M.R., Hu, C.P., Mohandas, B., Dandapat, A., Deonikar, P., Chen, J., Cawich, I., Sawamura, T., Kavdia, M. and Mehta, J.L.: Modulation of ADP-induced platelet activation by aspirin and pravastatin: role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling. J Pharmacol Exp Ther, 322:1324-1332, 2007.
  75. Hu, C., Dandapat, A., Chen, J., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Sawamura, T. and Mehta, J.L.: LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion. Cardiovasc Res, 76:292-302, 2007.
  76. Hinagata, J., Kakutani, M., Fujii, T., Naruko, T., Inoue, N., Fujita, Y., Mehta, J.L., Ueda, M. and Sawamura, T.: Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model. Cardiovasc Res, 69:263-271, 2006.
  77. Murphy, J.E., Tacon, D., Tedbury, P.R., Hadden, J.M., Knowling, S., Sawamura, T., Peckham, M., Phillips, S.E., Walker, J.H. and Ponnambalam, S.: LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells. Biochem J, 393:107-115, 2006.
  78. Ma, F.X., Zhou, B., Chen, Z., Ren, Q., Lu, S.H., Sawamura, T. and Han, Z.C.: Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase. J Lipid Res, 47:1227-1237, 2006.
  79. Tanigawa, H., Miura, S., Matsuo, Y., Fujino, M., Sawamura, T. and Saku, K.: Dominant-negative LOX-1 blocks homodimerization of wild-type LOX-1-induced cell proliferation through extracellular signal regulated kinase 1/2 activation. Hypertension, 48:294-300, 2006.
  80. Akagi, M., Nishimura, S., Yoshida, K., Kakinuma, T., Sawamura, T., Munakata, H. and Hamanishi, C.: Cyclic tensile stretch load and oxidized low density lipoprotein synergistically induce lectin-like oxidized ldl receptor-1 in cultured bovine chondrocytes, resulting in decreased cell viability and proteoglycan synthesis. J Orthop Res, 24:1782-1790, 2006.
  81. Kanata, S., Akagi, M., Nishimura, S., Hayakawa, S., Yoshida, K., Sawamura, T., Munakata, H. and Hamanishi, C.: Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma. Biochem Biophys Res Commun, 348:1003-1010, 2006.
  82. Tanigawa, H., Miura, S., Zhang, B., Uehara, Y., Matsuo, Y., Fujino, M., Sawamura, T. and Saku, K.: Low-density lipoprotein oxidized to various degrees activates ERK1/2 through LOX-1. Atherosclerosis, 188:245-250, 2006.
  83. Oka, K., Yasuhara, M., Suzumura, K., Tanaka, K. and Sawamura, T.: Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits. J Cardiovasc Pharmacol, 48:177-183, 2006.
  84. Puccetti, L., Sawamura, T., Pasqui, A.L., Pastorelli, M., Auteri, A. and Bruni, F.: Atorvastatin reduces platelet-oxidized-LDL receptor expression in hypercholesterolaemic patients. Eur J Clin Invest, 35:47-51, 2005.
  85. Pasini, A.F., Garbin, U., Nava, M.C., Stranieri, C., Davoli, A., Sawamura, T., Lo Cascio, V. and Cominacini, L.: Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation. J Hypertens, 23:589-596, 2005.
  86. Theriault, J.R., Mambula, S.S., Sawamura, T., Stevenson, M.A. and Calderwood, S.K.: Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells. FEBS Lett, 579:1951-1960, 2005.
  87. Limor, R., Kaplan, M., Sawamura, T., Sharon, O., Keidar, S., Weisinger, G., Knoll, E., Naidich, M. and Stern, N.: Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway. Am J Hypertens, 18:299-307, 2005.
  88. Inoue, K., Arai, Y., Kurihara, H., Kita, T. and Sawamura, T.: Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice. Circ Res, 97:176-184, 2005.
  89. Chen, M. and Sawamura, T.: Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1). J Mol Cell Cardiol, 39:553-561, 2005.
  90. Chen, K., Chen, J., Liu, Y., Xie, J., Li, D., Sawamura, T., Hermonat, P.L. and Mehta, J.L.: Adhesion molecule expression in fibroblasts: alteration in fibroblast biology after transfection with LOX-1 plasmids. Hypertension, 46:622-627, 2005.
  91. Cominacini, L., Anselmi, M., Garbin, U., Fratta Pasini, A., Stranieri, C., Fusaro, M., Nava, C., Agostoni, P., Keta, D., Zardini, P., Sawamura, T. and Lo Cascio, V.: Enhanced plasma levels of oxidized low-density lipoprotein increase circulating nuclear factor-kappa B activation in patients with unstable angina. J Am Coll Cardiol, 46:799-806, 2005.
  92. Bruni, F., Pasqui, A.L., Pastorelli, M., Bova, G., Cercignani, M., Palazzuoli, A., Sawamura, T., Gioffre, W.R., Auteri, A. and Puccetti, L.: Different effect of statins on platelet oxidized-LDL receptor (CD36 and LOX-1) expression in hypercholesterolemic subjects. Clin Appl Thromb Hemost, 11:417-428, 2005.
  93. Li, L., Sawamura, T. and Renier, G.: Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation. Circ Res, 94:892-901, 2004.
  94. Smirnova, I.V., Kajstura, M., Sawamura, T. and Goligorsky, M.S.: Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation. Am J Physiol Heart Circ Physiol, 287:H782-790, 2004.
  95. Imanishi, T., Hano, T., Sawamura, T. and Nishio, I.: Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction. Clin Exp Pharmacol Physiol, 31:407-413, 2004.
  96. Nishimura, S., Akagi, M., Yoshida, K., Hayakawa, S., Sawamura, T., Munakata, H. and Hamanishi, C.: Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB. Osteoarthritis Cartilage, 12:568-576, 2004.
  97. Smirnova, I.V., Sawamura, T. and Goligorsky, M.S.: Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in endothelial cells by nitric oxide deficiency. Am J Physiol Renal Physiol, 287:F25-32, 2004.
  98. Pavan, L., Hermouet, A., Tsatsaris, V., Therond, P., Sawamura, T., Evain-Brion, D. and Fournier, T.: Lipids from oxidized low-density lipoprotein modulate human trophoblast invasion: involvement of nuclear liver X receptors. Endocrinology, 145:4583-4591, 2004.
  99. Li, L., Roumeliotis, N., Sawamura, T. and Renier, G.: C-reactive protein enhances LOX-1 expression in human aortic endothelial cells: relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction. Circ Res, 95:877-883, 2004.
  100. Suga, M., Sawamura, T., Nakatani, T. and Kitamura, S.: Expression of lectin-like oxidized low-density lipoprotein receptor-1 in allografted hearts. Transplant Proc, 36:2440-2442, 2004.
  101. Kakinuma, T., Yasuda, T., Nakagawa, T., Hiramitsu, T., Akiyoshi, M., Akagi, M., Sawamura, T. and Nakamura, T.: Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage. Arthritis Rheum, 50:3495-3503, 2004.
  102. Sakurai, K., Cominacini, L., Garbin, U., Fratta Pasini, A., Sasaki, N., Takuwa, Y., Masaki, T. and Sawamura, T.: Induction of endothelin-1 production in endothelial cells via co-operative action between CD40 and lectin-like oxidized LDL receptor (LOX-1). J Cardiovasc Pharmacol, 44 Suppl 1:S173-180, 2004.
  103. Honjo, M., Sawamura, T., Hinagata, J., Nakamura, K., Sanada, N., Tanihara, H., Honda, Y. and Kiryu, J.: Expression of LOX-1, an oxidized low-density lipoprotein receptor, in choroidal neovascularization. Arch Ophthalmol, 122:1873-1876, 2004.
  104. Kashiwakura, Y., Watanabe, M., Kusumi, N., Sumiyoshi, K., Nasu, Y., Yamada, H., Sawamura, T., Kumon, H., Takei, K. and Daida, H.: Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell. Circulation, 110:3329-3334, 2004.
  105. Kataoka, K., Hasegawa, K., Sawamura, T., Fujita, M., Yanazume, T., Iwai-Kanai, E., Kawamura, T., Hirai, T., Kita, T. and Nohara, R.: LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun, 300:656-660, 2003.
  106. Honjo, M., Nakamura, K., Yamashiro, K., Kiryu, J., Tanihara, H., McEvoy, L.M., Honda, Y., Butcher, E.C., Masaki, T. and Sawamura, T.: Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Proc Natl Acad Sci U S A, 100:1274-1279, 2003.
  107. Li, D., Liu, L., Chen, H., Sawamura, T., Ranganathan, S. and Mehta, J.L.: LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells. Circulation, 107:612-617, 2003.
  108. Cominacini, L., Fratta Pasini, A., Garbin, U., Nava, C., Davoli, A., Criscuoli, M., Crea, A., Sawamura, T. and Lo Cascio, V.: Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation. J Am Coll Cardiol, 42:1838-1844, 2003.
  109. Tatsuguchi, M., Furutani, M., Hinagata, J., Tanaka, T., Furutani, Y., Imamura, S., Kawana, M., Masaki, T., Kasanuki, H., Sawamura, T. and Matsuoka, R.: Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction. Biochem Biophys Res Commun, 303:247-250, 2003.
  110. Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Romeo, F. and Mehta, J.L.: Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction. J Am Coll Cardiol, 41:1048-1055, 2003.
  111. Li, D., Liu, L., Chen, H., Sawamura, T. and Mehta, J.L.: LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol, 23:816-821, 2003.
  112. Wilson, S.H., Chade, A.R., Feldstein, A., Sawamura, T., Napoli, C., Lerman, A. and Lerman, L.O.: Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia. Nephrol Dial Transplant, 18:703-709, 2003
  113. Rodriguez-Porcel, M., Lerman, L.O., Herrmann, J., Sawamura, T., Napoli, C. and Lerman, A.: Hypercholesterolemia and hypertension have synergistic deleterious effects on coronary endothelial function. Arterioscler Thromb Vasc Biol, 23:885-891, 2003.
  114. Rodriguez-Porcel, M., Lerman, A., Herrmann, J., Schwartz, R.S., Sawamura, T., Condorelli, M., Napoli, C. and Lerman, L.O.: Hypertension exacerbates the effect of hypercholesterolemia on the myocardial microvasculature. Cardiovasc Res, 58:213-221, 2003.
  115. Chade, A.R., Rodriguez-Porcel, M., Grande, J.P., Zhu, X., Sica, V., Napoli, C., Sawamura, T., Textor, S.C., Lerman, A. and Lerman, L.O.: Mechanisms of renal structural alterations in combined hypercholesterolemia and renal artery stenosis. Arterioscler Thromb Vasc Biol, 23:1295-1301, 2003.
  116. Li, L., Sawamura, T. and Renier, G.: Glucose enhances endothelial LOX-1 expression: role for LOX-1 in glucose-induced human monocyte adhesion to endothelium. Diabetes, 52:1843-1850, 2003.
  117. Hu, B., Li, D., Sawamura, T. and Mehta, J.L.: Oxidized LDL through LOX-1 modulates LDL-receptor expression in human coronary artery endothelial cells. Biochem Biophys Res Commun, 307:1008-1012, 2003.
  118. Chade, A.R., Best, P.J., Rodriguez-Porcel, M., Herrmann, J., Zhu, X., Sawamura, T., Napoli, C., Lerman, A. and Lerman, L.O.: Endothelin-1 receptor blockade prevents renal injury in experimental hypercholesterolemia. Kidney Int, 64:962-969, 2003.
  119. Cominacini, L., Fratta Pasini, A., Garbin, U., Pastorino, A., Rigoni, A., Nava, C., Davoli, A., Lo Cascio, V. and Sawamura, T.: The platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells. J Am Coll Cardiol, 41:499-507, 2003.
  120. Kuhlmann, C.R., Schafer, M., Li, F., Sawamura, T., Tillmanns, H., Waldecker, B. and Wiecha, J.: Modulation of endothelial Ca(2+)-activated K(+) channels by oxidized LDL and its contribution to endothelial proliferation. Cardiovasc Res, 60:626-634, 2003.
  121. Honjo, M., Tanihara, H., Nishijima, K., Kiryu, J., Honda, Y., Yue, B.Y. and Sawamura, T.: Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina. Arch Ophthalmol, 120:1707-1713, 2002.
  122. Jono, T., Miyazaki, A., Nagai, R., Sawamura, T., Kitamura, T. and Horiuchi, S.: Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE). FEBS Lett, 511:170-174, 2002.
  123. Li, D., Chen, H., Romeo, F., Sawamura, T., Saldeen, T. and Mehta, J.L.: Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1. J Pharmacol Exp Ther, 302:601-605, 2002.
  124. Honjo, M., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Honda, Y. and Tanihara, H.: A myosin light chain kinase inhibitor, ML-9, lowers the intraocular pressure in rabbit eyes. Exp Eye Res, 75:135-142, 2002.
  125. Morawietz, H., Duerrschmidt, N., Niemann, B., Galle, J., Sawamura, T. and Holtz, J.: Augmented endothelial uptake of oxidized low-density lipoprotein in response to endothelin-1. Clin Sci (Lond), 103 Suppl 48:9S-12S, 2002.
  126. Delneste, Y., Magistrelli, G., Gauchat, J., Haeuw, J., Aubry, J., Nakamura, K., Kawakami-Honda, N., Goetsch, L., Sawamura, T., Bonnefoy, J. and Jeannin, P.: Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity, 17:353-362, 2002.
  127. Nakagawa, T., Akagi, M., Hoshikawa, H., Chen, M., Yasuda, T., Mukai, S., Ohsawa, K., Masaki, T., Nakamura, T. and Sawamura, T.: Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis. Arthritis Rheum, 46:2486-2494, 2002.
  128. Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Antakli, T. and Mehta, J.L.: LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation. Am J Physiol Heart Circ Physiol, 283:H1795-1801, 2002.
  129. Imanishi, T., Hano, T., Sawamura, T., Takarada, S. and Nishio, I.: Oxidized low density lipoprotein potentiation of Fas-induced apoptosis through lectin-like oxidized-low density lipoprotein receptor-1 in human umbilical vascular endothelial cells. Circ J, 66:1060-1064, 2002.
  130. Nakagawa, T., Yasuda, T., Hoshikawa, H., Shimizu, M., Kakinuma, T., Chen, M., Masaki, T., Nakamura, T. and Sawamura, T.: LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt. Biochem Biophys Res Commun, 299:91-97, 2002.
  131. Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Sawamura, T., Kita, T. and Yonehara, S.: Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) supports cell adhesion to fibronectin. FEBS Lett, 504:65-68, 2001.
  132. Honjo, M., Tanihara, H., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Narumiya, S. and Honda, Y.: Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest Ophthalmol Vis Sci, 42:137-144, 2001.
  133. Iwakura, A., Fujita, M., Hasegawa, K., Toyokuni, S., Sawamura, T., Nohara, R., Sasayama, S. and Komeda, M.: Pericardial fluid from patients with ischemic heart disease induces myocardial cell apoptotis via an oxidant stress-sensitive p38 mitogen-activated protein kinase pathway. J Mol Cell Cardiol, 33:419-430, 2001.
  134. White, S.J., Nicklin, S.A., Sawamura, T. and Baker, A.H.: Identification of peptides that target the endothelial cell-specific LOX-1 receptor. Hypertension, 37:449-455, 2001.
  135. Nagase, M., Ando, K., Nagase, T., Kaname, S., Sawamura, T. and Fujita, T.: Redox-sensitive regulation of lox-1 gene expression in vascular endothelium. Biochem Biophys Res Commun, 281:720-725, 2001.
  136. Chen, M., Kakutani, M., Naruko, T., Ueda, M., Narumiya, S., Masaki, T. and Sawamura, T.: Activation-dependent surface expression of LOX-1 in human platelets. Biochem Biophys Res Commun, 282:153-158, 2001.
  137. Kakutani, M., Ueda, M., Naruko, T., Masaki, T. and Sawamura, T.: Accumulation of LOX-1 ligand in plasma and atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits: identification by a novel enzyme immunoassay. Biochem Biophys Res Commun, 282:180-185, 2001.
  138. Cominacini, L., Rigoni, A., Pasini, A.F., Garbin, U., Davoli, A., Campagnola, M., Pastorino, A.M., Lo Cascio, V. and Sawamura, T.: The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide. J Biol Chem, 276:13750-13755, 2001.
  139. Chen, M., Narumiya, S., Masaki, T. and Sawamura, T.: Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding. Biochem J, 355:289-296, 2001.
  140. Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Sawamura, T., Kita, T. and Yonehara, S.: LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria. J Immunol, 166:5108-5114, 2001.
  141. Halvorsen, B., Staff, A.C., Henriksen, T., Sawamura, T. and Ranheim, T.: 8-iso-prostaglandin F(2alpha) increases expression of LOX-1 in JAR cells. Hypertension, 37:1184-1190, 2001.
  142. Morawietz, H., Duerrschmidt, N., Niemann, B., Galle, J., Sawamura, T. and Holtz, J.: Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells. Biochem Biophys Res Commun, 284:961-965, 2001.
  143. Chen, M., Inoue, K., Narumiya, S., Masaki, T. and Sawamura, T.: Requirements of basic amino acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoprotein. FEBS Lett, 499:215-219, 2001.
  144. Honjo, M., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Honda, Y. and Tanihara, H.: Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes. Arch Ophthalmol, 119:1171-1178, 2001.
  145. Chen, M., Nagase, M., Fujita, T., Narumiya, S., Masaki, T. and Sawamura, T.: Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE. Biochem Biophys Res Commun, 287:962-968, 2001.
  146. Iwai-Kanai, E., Hasegawa, K., Sawamura, T., Fujita, M., Yanazume, T., Toyokuni, S., Adachi, S., Kihara, Y. and Sasayama, S.: Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes. Circulation, 104:2948-2954, 2001.
  147. Kakutani, M., Masaki, T. and Sawamura, T.: A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1. Proc Natl Acad Sci U S A, 97:360-364, 2000.
  148. Aoyama, T., Chen, M., Fujiwara, H., Masaki, T. and Sawamura, T.: LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells. FEBS Lett, 467:217-220, 2000.
  149. Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Murase, T., Sawamura, T., Masaki, T., Hashimoto, N. and Kita, T.: Biosynthesis and post-translational processing of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1). N-linked glycosylation affects cell-surface expression and ligand binding. J Biol Chem, 275:6573-6579, 2000.
  150. Murase, T., Kume, N., Kataoka, H., Minami, M., Sawamura, T., Masaki, T. and Kita, T.: Identification of soluble forms of lectin-like oxidized LDL receptor-1. Arterioscler Thromb Vasc Biol, 20:715-720, 2000.
  151. Chen, M., Kakutani, M., Minami, M., Kataoka, H., Kume, N., Narumiya, S., Kita, T., Masaki, T. and Sawamura, T.: Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol, 20:1107-1115, 2000.
  152. Cominacini, L., Pasini, A.F., Garbin, U., Davoli, A., Tosetti, M.L., Campagnola, M., Rigoni, A., Pastorino, A.M., Lo Cascio, V. and Sawamura, T.: Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J Biol Chem, 275:12633-12638, 2000.
  153. Minami, M., Kume, N., Kataoka, H., Morimoto, M., Hayashida, K., Sawamura, T., Masaki, T. and Kita, T.: Transforming growth factor-beta(1) increases the expression of lectin-like oxidized low-density lipoprotein receptor-1. Biochem Biophys Res Commun, 272:357-361, 2000.
  154. Iwakura, A., Fujita, M., Hasegawa, K., Sawamura, T., Nohara, R., Sasayama, S. and Komeda, M.: Pericardial fluid from patients with unstable angina induces vascular endothelial cell apoptosis. J Am Coll Cardiol, 35:1785-1790, 2000.
  155. Kume, N., Moriwaki, H., Kataoka, H., Minami, M., Murase, T., Sawamura, T., Masaki, T. and Kita, T.: Inducible expression of LOX-1, a novel receptor for oxidized LDL, in macrophages and vascular smooth muscle cells. Ann N Y Acad Sci, 902:323-327, 2000.
  156. Kataoka, H., Kume, N., Minami, M., Moriwaki, H., Sawamura, T., Masaki, T. and Kita, T.: Expression of lectin-like oxidized LDL receptor-1 in human atherosclerotic lesions. Ann N Y Acad Sci, 902:328-335, 2000.
  157. Yoneda, T., Fujita, M., Kihara, Y., Hasegawa, K., Sawamura, T., Tanaka, T., Inanami, M., Nohara, R. and Sasayama, S.: Pericardial fluid from patients with ischemic heart disease accelerates the growth of human vascular smooth muscle cells. Jpn Circ J, 64:495-498, 2000.
  158. Nagase, M., Kaname, S., Nagase, T., Wang, G., Ando, K., Sawamura, T. and Fujita, T.: Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis. J Am Soc Nephrol, 11:1826-1836, 2000.
  159. Chen, H., Li, D., Sawamura, T., Inoue, K. and Mehta, J.L.: Upregulation of LOX-1 expression in aorta of hypercholesterolemic rabbits: modulation by losartan. Biochem Biophys Res Commun, 276:1100-1104, 2000.
  160. Araki, M., Hasegawa, K., Iwai-Kanai, E., Fujita, M., Sawamura, T., Kakita, T., Wada, H., Morimoto, T. and Sasayama, S.: Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes. J Am Coll Cardiol, 36:1411-1418, 2000.
  161. Jiang, H., Hidaka, K., Sawamura, T., Arai, Y., Takihara, Y., Ota, A. and Morisaki, T.: Regeneration of cardiac muscle in normal adult C57BL/6 mice. Cardiac and Vascular Regeneration, 1(4):268-273, 2000.
  162. Kaburagi, S., Hasegawa, K., Morimoto, T., Araki, M., Sawamura, T., Masaki, T. and Sasayama, S.: The role of endothelin-converting enzyme-1 in the development of alpha1-adrenergic-stimulated hypertrophy in cultured neonatal rat cardiac myocytes. Circulation, 99:292-298, 1999.
  163. Aoyama, T., Sawamura, T., Furutani, Y., Matsuoka, R., Yoshida, M.C., Fujiwara, H. and Masaki, T.: Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene. Biochem J, 339 (Pt 1):177-184, 1999.
  164. Li, D.Y., Zhang, Y.C., Philips, M.I., Sawamura, T. and Mehta, J.L.: Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation . Circ Res, 84:1043-1049, 1999.
  165. Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Moriwaki, H., Murase, T., Sawamura, T., Masaki, T., Hashimoto, N. and Kita, T.: Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions. Circulation, 99:3110-3117, 1999.
  166. Hosokawa, H., Ninomiya, H., Sawamura, T., Sugimoto, Y., Ichikawa, A., Fujiwara, K. and Masaki, T.: Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain. Brain Res, 838:158-165, 1999.
  167. Morawietz, H., Rueckschloss, U., Niemann, B., Duerrschmidt, N., Galle, J., Hakim, K., Zerkowski, H.R., Sawamura, T. and Holtz, J.: Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein. Circulation, 100:899-902, 1999.
  168. Aoyama, T., Fujiwara, H., Masaki, T. and Sawamura, T.: Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells. J Mol Cell Cardiol, 31:2101-2114, 1999.
  169. Fujita, M., Ikemoto, M., Tanaka, T., Tamaki, S., Yamazato, A., Sawamura, T., Hasegawa, K., Kihara, Y., Nohara, R. and Sasayama, S.: Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris. Angiogenesis, 2:105-108, 1998.
  170. Hoshikawa, H., Sawamura, T., Kakutani, M., Aoyama, T., Nakamura, T. and Masaki, T.: High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1). Biochem Biophys Res Commun, 245:841-846, 1998.
  171. Kido, T., Sawamura, T. and Masaki, T.: The processing pathway of endothelin-1 production. J Cardiovasc Pharmacol, 31 Suppl 1:S13-15, 1998.
  172. Nicholson, B., Sawamura, T., Masaki, T. and MacLeod, C.L.: Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines. J Biol Chem, 273:14663-14666, 1998.
  173. Hasegawa, H., Hiki, K., Sawamura, T., Aoyama, T., Okamoto, Y., Miwa, S., Shimohama, S., Kimura, J. and Masaki, T.: Purification of a novel endothelin-converting enzyme specific for big endothelin-3. FEBS Lett, 428:304-308, 1998.
  174. Oka, K., Sawamura, T., Kikuta, K., Itokawa, S., Kume, N., Kita, T. and Masaki, T.: Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc Natl Acad Sci U S A, 95:9535-9540, 1998.
  175. Kume, N., Murase, T., Moriwaki, H., Aoyama, T., Sawamura, T., Masaki, T. and Kita, T.: Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res, 83:322-327, 1998.
  176. Murase, T., Kume, N., Korenaga, R., Ando, J., Sawamura, T., Masaki, T. and Kita, T.: Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res, 83:328-333, 1998.
  177. Zhang, X.F., Komuro, T., Miwa, S., Minowa, T., Iwamuro, Y., Okamoto, Y., Ninomiya, H., Sawamura, T. and Masaki, T.: Role of nonselective cation channels as Ca2+ entry pathway in endothelin-1-induced contraction and their suppression by nitric oxide. Eur J Pharmacol, 352:237-245, 1998.
  178. Moriwaki, H., Kume, N., Sawamura, T., Aoyama, T., Hoshikawa, H., Ochi, H., Nishi, E., Masaki, T. and Kita, T.: Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein. Arterioscler Thromb Vasc Biol, 18:1541-1547, 1998.
  179. Kikuta, K., Sawamura, T., Miwa, S., Hashimoto, N. and Masaki, T.: High-affinity arginine transport of bovine aortic endothelial cells is impaired by lysophosphatidylcholine. Circ Res, 83:1088-1096, 1998.
  180. Moriwaki, H., Kume, N., Kataoka, H., Murase, T., Nishi, E., Sawamura, T., Masaki, T. and Kita, T.: Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-alpha. FEBS Lett, 440:29-32, 1998.
  181. Hosokawa, H., Sawamura, T., Kobayashi, S., Ninomiya, H., Miwa, S. and Masaki, T.: Cloning and characterization of a brain-specific cationic amino acid transporter. J Biol Chem, 272:8717-8722, 1997.
  182. Sawamura, T., Kume, N., Aoyama, T., Moriwaki, H., Hoshikawa, H., Aiba, Y., Tanaka, T., Miwa, S., Katsura, Y., Kita, T. and Masaki, T.: An endothelial receptor for oxidized low-density lipoprotein. Nature, 386:73-77, 1997.
  183. Kido, T., Sawamura, T., Hoshikawa, H., D'Orleans-Juste, P., Denault, J.B., Leduc, R., Kimura, J. and Masaki, T.: Processing of proendothelin-1 at the C-terminus of big endothelin-1 is essential for proteolysis by endothelin-converting enzyme-1 in vivo. Eur J Biochem, 244:520-526, 1997.
  184. Nagase, M., Hirose, S., Sawamura, T., Masaki, T. and Fujita, T.: Enhanced expression of endothelial oxidized low-density lipoprotein receptor (LOX-1) in hypertensive rats. Biochem Biophys Res Commun, 237:496-498, 1997.
  185. Komuro, T., Miwa, S., Zhang, X.F., Minowa, T., Enoki, T., Kobayashi, S., Okamoto, Y., Ninomiya, H., Sawamura, T., Kikuta, K., Iwamuro, Y., Furutani, H., Hasegawa, H., Uemura, Y., Kikuchi, H. and Masaki, T.: Physiological role of Ca2+-permeable nonselective cation channel in endothelin-1-induced contraction of rabbit aorta. J Cardiovasc Pharmacol, 30:504-509, 1997.
  186. Matsuoka, R., Sawamura, T., Yamada, K., Yoshida, M., Furutani, Y., Ikura, T., Shiraki, T., Hoshikawa, H., Shimada, K., Tanzawa, K. and Masaki, T.: Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1. Cytogenet Cell Genet, 72:322-324, 1996.
  187. Denault, J.B., Claing, A., D'Orleans-Juste, P., Sawamura, T., Kido, T., Masaki, T. and Leduc, R.: Processing of proendothelin-1 by human furin convertase. FEBS Lett, 362:276-280, 1995.
  188. Shiraki, T., Sawamura, T., Ikura, T., Kobayashi, S., Miwa, S. and Masaki, T.: Genetic transfer of endothelin converting enzyme activity to CHO-K1 cells: detection of positive cells by reverse hemolytic plaque assay. FEBS Lett, 351:197-200, 1994.
  189. Ikura, T., Sawamura, T., Shiraki, T., Hosokawa, H., Kido, T., Hoshikawa, H., Shimada, K., Tanzawa, K., Kobayashi, S., Miwa, S. and et al.: cDNA cloning and expression of bovine endothelin converting enzyme. Biochem Biophys Res Commun, 203:1417-1422, 1994.
  190. Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kimura, S.: Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane. Biochim Biophys Acta, 1161:295-302, 1993.
  191. Sakamoto, A., Yanagisawa, M., Sawamura, T., Enoki, T., Ohtani, T., Sakurai, T., Nakao, K., Toyo-oka, T. and Masaki, T.: Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J Biol Chem, 268:8547-8553, 1993.
  192. Giaid, A., Polak, J.M., Gaitonde, V., Hamid, Q.A., Moscoso, G., Legon, S., Uwanogho, D., Roncalli, M., Shinmi, O., Sawamura, T. and et al.: Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung. Am J Respir Cell Mol Biol, 4:50-58, 1991.
  193. Sawamura, T., Kasuya, Y., Matsushita, Y., Suzuki, N., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and et al.: Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells. Biochem Biophys Res Commun, 174:779-784, 1991.
  194. Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.: Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: evidence for a cathepsin D-like enzyme. Biochem Biophys Res Commun, 168:1230-1236, 1990.
  195. Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Kobayashi, M., Mitsui, Y., Yanagisawa, M., Goto, K. and Masaki, T.: Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells. Biochem Biophys Res Commun, 169:1138-1144, 1990.
  196. Usuki, S., Saitoh, T., Sawamura, T., Suzuki, N., Shigemitsu, S., Yanagisawa, M., Goto, K., Onda, H., Fujino, M. and Masaki, T.: Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid. Gynecol Endocrinol, 4:85-97, 1990.
  197. Giaid, A., Hamid, Q.A., Springall, D.R., Yanagisawa, M., Shinmi, O., Sawamura, T., Masaki, T., Kimura, S., Corrin, B. and Polak, J.M.: Detection of endothelin immunoreactivity and mRNA in pulmonary tumours. J Pathol, 162:15-22, 1990.
  198. Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kimura, S.: Analysis of big endothelin-1 digestion by cathepsin D. Biochem Biophys Res Commun, 172:883-889, 1990.
  199. Kimura, S., Kasuya, Y., Sawamura, T., Shinimi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.: Conversion of big endothelin-1 to 21-residue endothelin-1 is essential for expression of full vasoconstrictor activity: structure-activity relationships of big endothelin-1. J Cardiovasc Pharmacol, 13 Suppl 5:S5-7; discussion S18, 1989.
  200. Shinmi, O., Kimura, S., Yoshizawa, T., Sawamura, T., Uchiyama, Y., Sugita, Y., Kanazawa, I., Yanagisawa, M., Goto, K. and Masaki, T.: Presence of endothelin-1 in porcine spinal cord: isolation and sequence determination. Biochem Biophys Res Commun, 162:340-346, 1989.
  201. Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M. and Masaki, T.: Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: evidence for biosynthetic pathway of endothelin-1. Biochem Biophys Res Commun, 162:1287-1294, 1989.
  202. Shinmi, O., Kimura, S., Sawamura, T., Sugita, Y., Yoshizawa, T., Uchiyama, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kanazawa, I.: Endothelin-3 is a novel neuropeptide: isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain. Biochem Biophys Res Commun, 164:587-593, 1989.
  203. Kimura, S., Kasuya, Y., Sawamura, T., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.: Structure-activity relationships of endothelin: importance of the C-terminal moiety. Biochem Biophys Res Commun, 156:1182-1186, 1988.     

総説COMPANY

    
  1. Stancel, N., Chen, C.C., Ke, L.Y., Chu, C.S., Lu, J., Sawamura, T. and Chen, C.H.: Interplay between CRP, Atherogenic LDL, and LOX-1 and Its Potential Role in the Pathogenesis of Atherosclerosis. Clin Chem, 62:320-327, 2016.
  2. Sawamura, T., Wakabayashi, I. and Okamura, T.: LOX-1 in atherosclerotic disease. Clin Chim Acta, 440:157-163, 2015.
  3. Prabhudas, M. Bowdish, D. Drickamer, K. Febbraio, M. Herz, J. Kobzik, L. Krieger, M. Loike, J. Means, T. K. Moestrup, S. K. Post, S. Sawamura, T. Silverstein, S. Wang, X. Y. El Khoury, J.: Standardizing scavenger receptor nomenclature. Journal of immunology,192: 1997-2006, 2014.
  4. Sawamura, T., Kakino, A. and Fujita, Y.: LOX-1: a multiligand receptor at the crossroads of response to danger signals. Curr Opin Lipidol, 23:439-445, 2012.
  5. Yoshimoto, R., Fujita, Y., Kakino, A., Iwamoto, S., Takaya, T., Sawamura, T.: The discovery of LOX-1, its ligands and clinical significance. Cardiovasc Drugs Ther, 25:379-391, 2011.
  6. Mehta, J. L., Khaidakov, M., Hermonat, P. L., Mitra, S., Wang, X., Novelli, G., Sawamura, T.: LOX-1: a new target for therapy for cardiovascular diseases. Cardiovasc Drugs Ther, 25:495-500, 2011.
  7. Ogura, S., Kakino, A., Sato, Y., Fujita, Y., Iwamoto, S., Otsui, K., Yoshimoto, R. and Sawamura, T.: LOX-1: the multifunctional receptor underlying cardiovascular dysfunction. Circ J, 73:1993-1999, 2009.
  8. Sawamura,T.: New Idol of Cholesterol Reduction? Clinical Chemistry, 55:2082-2084, 2009.
  9. Inoue, N. and Sawamura, T.: Lectin-like oxidized LDL receptor-1 as extracellular chaperone receptor: Its versatile functions and human diseases. Methods, 43:218-222, 2007.
  10. Masaki,T., Sawamura,T.: Endothelin and endothelial dysfunction. Proceedings of the Japan Academy Series B-Physical and Biological Sciences, 82:17-24, 2006.
  11. Sawamura, T.: LOX-1 Unlocked. Structure (Camb), 13:834-835, 2005.
  12. Sawamura, T.: LOX-1, a lectin-like oxidized LDL receptor identified form endothelial cells, in endothelial dysfunction. International Congress Series 1262, 531-534, 2004.
  13. Sakurai, K., Sawamura, T.: Stress and vascular responses: endothelial dysfunction via lectin-like oxidized low-density lipoprotein receptor-1: close relationships with oxidative stress. J Pharmacol Sci, 91, 182-186, 2003.
  14. Chen, M., Masaki, T. and Sawamura, T.: LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther, 95:89, 2002.
  15. Chen M, Sawamura T. LOX-1, a potential inflammatory mediator in atherosclerosis. In J.L.Mehta. inflammatory and infectious Basis of Atherosclerosis, Birkhauser, 103-111, 2001.
  16. Sawamura, T., Chen M., Kakutani M., Masaki T. LOX-1, an endothelial receptor for oxidized LDL: Implications for Induction of Endothelium Dysfunction in the Pathogenesis of Vascular Diseases. In: Suzuki K., Ikeda Y., Maruyama, I. eds. New Frontier in Vascular Biology; Thrombosis and Hemostasis, Eibun Press, 43-48, 2000.
  17. Sawamura, T., Kakutani M., Chen M., Masaki T. LOX-1, an endothelial receptor for oxidized LDL. In: Kita T., Yokode Y. eds. Lipoprotein metabolism and atherogenesis, Springer, 193-198, 2000.
  18. Masaki, T., Miwa, S., Sawamura, T., Ninomiya, H. and Okamoto, Y.: Subcellular mechanisms of endothelin action in vascular system. Eur J Pharmacol, 375:133-138, 1999.
  19. Chen M., Sawamura, T. Northern blot analysis to quantify gene expression in vascular diseases. In: Baker A.H. ed. Methods in Molecular Biology 30, 181-188, 1999.