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修士課程 医科学専攻

組織発生学

分野の概要

組織発生学講座(臓器工学)はES細胞を用いた臓器創生と臨床応用に自らの人生をかけようとする集団の形成と育成を目指す。

研究テーマ

  1. マウス、サル、ヒトES細胞の分化誘導
  2. ES細胞由来分化細胞の細胞生物学的解析
  3. ES細胞由来分化細胞の移植
  4. ES細胞の臨床応用のための基盤的研究(凍結法、培地開発、大量培養法、奇形腫形成抑制、拒絶抑制、培養のオート化)
  5. ES細胞由来分化細胞を用いた生体物質創製技術開発
  6. iPS細胞の細胞生物学的研究
  7. 肝-膵臓間の分化転換に関する研究
  8. PcG/trxGに焦点を当てた細胞形質の維持機構の研究

スタッフ

教授

佐々木 克典

准教授

城倉 浩平

助教

岳 鳳鳴

その他

2名

学生数

修士課程学生数

2名

研究室の所在及び連絡先

研究室の場所:基礎棟4階
連絡先:katsmd@shinshu-u.ac.jp

主要な成果/Major Publications

  1. Hirashima K, Yue F, Tomotsune D, Sasaki K
    Cardiac portion of the stomach: a deep region within the abdomen
    Abdomen. July 31, 2017. (First online)
  2. Nakamura S, Takizawa S, Yokoyama T, Tomotsune D, Yue F, Sasaki K
    Simple Isolation of Pancreatic Progenitor Cells from Human Induced Pluripotent Stem Cells Using the ALDEFLUOR
    Stem Cell: Advanced Research and Therapy. 2017. Jan 11. (First online)
  3. Hirashima K, Yue F, Tomotsune D, Sasaki K
    Earlobe-like peritoneal appendage near the angle of His: a useful landmark for demarcating the lateral margin of the gastric cardia
    Anatomical Science International. September 22, 2016. (First online)
  4. Yue F, Hirashima K, Tomotsune D, Takizawa-Shirasawa S, Yokoyama T, Sasaki K
    Reprogramming of retinoblastoma cancer cells into cancer stem cells
    Biochem Biophys Res Commun. . 2017 Jan 22;482(4):549-555.
  5. Tomotsune D, Hirashima K, Fujii M, Yue F, Matsumoto K, Takizawa-Shirasawa S, Yokoyama T, Sasaki K
    Enrichment of Pluripotent Stem Cell-Derived Hepatocyte-Like Cells by Ammonia Treatment
    PLOS ONE. 2016 Sep 15;11(9):e0162693. doi: 10.1371/journal.pone.0162693.
  6. Seguchi S, Yue F, Asanuma K, Sasaki K
    Experimental splenosis in the liver and lung spread through the vasculature
    Cell Tissue Res. 360:287-296, 2015.
  7. Takahashi Y, Tomotsune D, Takizawa S, Yue F, Nagai M, Yokoyama T, Hirashima K, Sasaki K
    New model for cardiomyocyte sheet transplantation using a virus-cell fusion technique.
    World J Stem Cells. 7(5):883-893, 2015
  8. Sasaki K
    Large-scale generation of differentiated cells to achieve regenerative medicine
    stem cell research&therapy. 5:10- , 2014
  9. Mogi A, Takei S, Shimizu H, Miura H, Tomotsune D, Sasaki K
    Effects of Fluid Dynamic Forces Created by Rotary Orbital Suspension Culture on Cardiomyogenic Differetiation of Human Embryonic Stem Cells
    J.Med.Eng. 34(2) 101-108, 2014
  10. Ichikawa H., Kanoh Y., Shirasawa S., Yokoyama T., Yue F., Tomotsune D., Sasaki K.
    Unique kinetics of Oct3/4microlocalization following dissociation of human embryonic stem cell colonies
    Ann. Anat. 195:50-56, 2013