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膵β細胞からのインスリン分泌機構

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1.             Komatsu M, Aizawa T. Enhancement of the incretin pathway in response to bariatric surgery is important for restoration of beta cell function. Diabetologia 52: 374-375, 2009.

 

2.             Aizawa T, Komatsu M. Rab27a: a new face in beta cell metabolism-secretion coupling. J Clin Invest 115: 227-230, 2005.

 

3.             Yamada S, Komatsu M, Sato Y, Yamauchi K, Aizawa T, Kojima I. Nutrient modulation of palmitoylated 24-kilodalton protein in rat pancreatic islets. Endocrinology 144: 5232-5241, 2003.

 

4.          Straub SG, Mulvaney-Musa J, Yajima H, Weiland GA, Sharp GW. Stimulation of insulin secretion by denatonium, one of the most bitter-tasting substances known. Diabetes 52: 356-364, 2003.

 

5.          Yamada S, Komatsu M, Sato Y, Yamauchi K, Kojima I, Aizawa T, et al. Time-dependent stimulation of insulin exocytosis by 3',5'-cyclic adenosine monophosphate in the rat islet beta-cell. Endocrinology 143: 4203-4209, 2002.

 

6.          Yamada S, Komatsu M, Aizawa T, Sato Y, Yajima H, Yada T, et al. Time-dependent potentiation of the beta-cell is a Ca2+-independent phenomenon. J Endocrinol 172: 345-354, 2002.

 

7.          Straub SG, Yajima H, Komatsu M, Aizawa T, Sharp GW. The effects of cerulenin, an inhibitor of protein acylation, on the two phases of glucose-stimulated insulin secretion. Diabetes 51 Suppl 1: S91-95, 2002.

 

8.          Komatsu M, Sato Y, Yamada S, Yamauchi K, Hashizume K, Aizawa T. Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon. Diabetes 51 Suppl 1: S29-32, 2002.

 

9.          Bratanova-Tochkova TK, Cheng H, Daniel S, Gunawardana S, Liu YJ, Mulvaney-Musa J, et al. Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion. Diabetes 51 Suppl 1: S83-90, 2002.

 

10.        Aizawa T, Sato Y, Komatsu M. Importance of nonionic signals for glucose-induced biphasic insulin secretion. Diabetes 51 Suppl 1: S96-98, 2002.

 

11.        Yamada S, Komatsu M, Sato Y, Yamauchi K, Aizawa T, Hashizume K. Glutamate is not a major conveyer of ATP-sensitive K+ channel-independent glucose action in pancreatic islet beta cell. Endocr J 48(3): 391-395, 2001.

 

12.       Yajima H, Komatsu M, Sato Y, Yamada S, Yamauchi K, Sharp GW, et al. Norepinephrine inhibits glucose-stimulated, Ca2+-independent insulin release independently from its action on adenylyl cyclase. Endocr J 48: 647-654, 2001.

 

13.        Komatsu M, Sato Y, Aizawa T, Hashizume K. KATP channel-independent glucose action: an elusive pathway in stimulus-secretion coupling of pancreatic beta-cell. Endocr J 48: 275-288, 2001.

 

14.        Aizawa T, Kaneko T, Yamauchi K, Yajima H, Nishizawa T, Yada T, et al. Size-related and size-unrelated functional heterogeneity among pancreatic islets. Life Sci 69: 2627-2639, 2001.

 

15.        Yajima H, Komatsu M, Yamada S, Straub SG, Kaneko T, Sato Y, et al. Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets. Diabetes 49: 712-717, 2000.

 

16.        Aizawa T, Kaneko T, Yajima H, Yamada S, Sato Y, Kanda Y, et al. Rapid oscillation of insulin release by the rat pancreatic islets under stringent Ca2+-free conditions. J Endocrinol 166: 545-551, 2000.

 

17.        Yajima H, Komatsu M, Schermerhorn T, Aizawa T, Kaneko T, Nagai M, et al. cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets. Diabetes 48: 1006-1012, 1999.

 

18.        Sato Y, Anello M, Henquin JC. Glucose regulation of insulin secretion independent of the opening or closure of adenosine triphosphate-sensitive K+ channels in beta cells. Endocrinology 140: 2252-2257, 1999.

 

19.        Komatsu M, Yajima H, Yamada S, Kaneko T, Sato Y, Yamauchi K, et al. Augmentation of Ca2+-stimulated insulin release by glucose and long-chain fatty acids in rat pancreatic islets: free fatty acids mimic ATP-sensitive K+ channel-independent insulinotropic action of glucose. Diabetes 48: 1543-1549, 1999.

 

20.        Eto K, Tsubamoto Y, Terauchi Y, et al. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283: 981-985, 1999.

 

21.        Sato Y, Nenquin M, Henquin JC. Relative contribution of Ca2+-dependent and Ca2+-independent mechanisms to the regulation of insulin secretion by glucose. FEBS Lett 421:115-119, 1998.

 

22.        Sato Y, Mariot P, Detimary P, Gilon P, Henquin JC. Okadaic acid-induced decrease in the magnitude and efficacy of the Ca2+ signal in pancreatic beta cells and inhibition of insulin secretion. Br J Pharmacol 123: 97-105, 1998.

 

23.        Sato Y, Henquin JC. The K+-ATP channel-independent pathway of regulation of insulin secretion by glucose: in search of the underlying mechanism. Diabetes 47:1713-1721, 1998.

 

24.        Komatsu M, Sharp GW. Palmitate and myristate selectively mimic the effect of glucose in augmenting insulin release in the absence of extracellular Ca2+. Diabetes 47: 352-357, 1998.

 

25.        Komatsu M, Noda M, Sharp GW. Nutrient augmentation of Ca2+-dependent and Ca2+-independent pathways in stimulus-coupling to insulin secretion can be distinguished by their guanosine triphosphate requirements: studies on rat pancreatic islets. Endocrinology 139:1172-1183, 1998.

 

26.        Aizawa T, Komatsu M, Asanuma N, Sato Y, Sharp GW. Glucose action 'beyond ionic events' in the pancreatic beta cell. Trends Pharmacol Sci 19: 496-499, 1998.

 

27.        Terauchi Y, Iwamoto K, Tamemoto H, et al. Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. J Clin Invest 99: 861-866, 1997.

 

28.        Suzuki N, Aizawa T, Asanuma N, Sato Y, Komatsu M, Hidaka H, et al. An early insulin intervention accelerates pancreatic beta-cell dysfunction in young Goto-Kakizaki rats, a model of naturally occurring noninsulin-dependent diabetes. Endocrinology 138:1106-1110, 1997.

 

29.        Komatsu M, Schermerhorn T, Noda M, Straub SG, Aizawa T, Sharp GW. Augmentation of insulin release by glucose in the absence of extracellular Ca2+: new insights into stimulus-secretion coupling. Diabetes 46:1928-1938, 1997.

 

30.        Asanuma N, Aizawa T, Sato Y, et al. Two signaling pathways, from the upper glycolytic flux and from the mitochondria, converge to potentiate insulin release. Endocrinology 138: 751-755, 1997.

31.        Noda M, Komatsu M, Sharp GW. The betaHC-9 pancreatic beta-cell line preserves the characteristics of progenitor mouse islets. Diabetes 45:1766-1773, 1996.

 

32.        Komatsu M, Schermerhorn T, Straub SG, Sharp GW. Pituitary adenylate cyclase-activating peptide, carbachol, and glucose stimulate insulin release in the absence of an increase in intracellular Ca2+. Mol Pharmacol 50: 1047-1054, 1996.

 

33.        Garcia-Barrado MJ, Gilon P, Sato Y, Nenquin M, Henquin JC. No evidence for a role of reverse Na+-Ca2+ exchange in insulin release from mouse pancreatic islets Am J Physiol 271: E426-433, 1996.

 

34.        Aizawa T, Asanuma N, Terauchi Y, et al. Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene. Biochem Biophys Res Commun 229: 460-465, 1996.

 

35.        Komatsu M, Schermerhorn T, Aizawa T, Sharp GW. Glucose stimulation of insulin release in the absence of extracellular Ca2+ and in the absence of any increase in intracellular Ca2+ in rat pancreatic islets. Proc Natl Acad Sci U S A 92: 10728-10732, 1995.

 

36.        Komatsu M, McDermott AM, Sharp GW. Sodium fluoride stimulates exocytosis at a late site of calcium interaction in stimulus-secretion coupling: studies with the RINm5F beta cell line. Mol Pharmacol 47: 496-508, 1995.

 

37.        Komatsu M, McDermott AM, Gillison SL, Sharp GW. Time course of action of pertussis toxin to block the inhibition of stimulated insulin release by norepinephrine. Endocrinology 136:1857-1863, 1995.

 

38.        Eddlestone GT, Komatsu M, Shen L, Sharp GW. Mastoparan increases the intracellular free calcium concentration in two insulin-secreting cell lines by inhibition of ATP-sensitive potassium channels. Mol Pharmacol 47: 787-797, 1995.

39.       Aizawa T, Sato Y, Ishihara F, Taguchi N, Komatsu M, Suzuki N, et al. ATP-sensitive K+ channel-independent glucose action in rat pancreatic beta-cell. Am J Physiol 266: C622-627, 1994.

 

40.        Aizawa T, Komatsu M, Sato Y, Ishihara F, Suzuki N, Nishii N, et al. Insulin secretion by the pancreatic beta cell of aged rats. Pancreas 9: 454-459, 1994.

 

41.        Komatsu M, McDermott AM, Gillison SL, Sharp GW. Mastoparan stimulates exocytosis at a Ca2+-independent late site in stimulus-secretion coupling. Studies with the RINm5F beta-cell line J Biol Chem 268: 23297-23306, 1993.

 

42.        Sato Y, Aizawa T, Komatsu M, Okada N, Yamada T. Dual functional role of membrane depolarization/Ca2+ influx in rat pancreatic B-cell. Diabetes 41: 438-443, 1992.

 

43.        Komatsu M, Aizawa T, Yokokawa N, Sato Y, Okada N, Takasu N, et al. Mastoparan-induced hormone release from rat pancreatic islets. Endocrinology 130: 221-228, 1992.

 

44.        Komatsu M, Yokokawa N, Nagasawa Y, et al. Gradual delay in glucose-induced first phase insulin secretion by the pancreatic islets of 7 week-, 6 month-, and 1 year-old rats. J Gerontol 46: B59-64, 1991.

 

45.        Yokokawa N, Komatsu M, Takeda T, Aizawa T, Yamada T. Mastoparan, a wasp venom, stimulates insulin release by pancreatic islets through pertussis toxin sensitive GTP-binding protein. Biochem Biophys Res Commun 158: 712-716, 1989.

 

46.        Komatsu M, Yokokawa N, Takeda T, Nagasawa Y, Aizawa T, Yamada T. Pharmacological characterization of the voltage-dependent calcium channel of pancreatic B-cell. Endocrinology 125: 2008-2014, 1989.

 

47.        Komatsu M, Aizawa T, Takasu N, Yamada T. Glucose raises cytosolic free calcium in the rat pancreatic islets. Horm Metab Res 21: 405-409, 1989.

 

48.        Takasu N, Komatsu M, Aizawa T, Yamada T. Hydrogen peroxide generation in whole rat pancreatic islets; synergistic regulation by cytoplasmic free calcium and protein kinase-C. Biochem Biophys Res Commun 155: 569-575, 1988.

 

 

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