Mori M, Tian G, Ishikawa A, Higuchi K. Diversity and complexity of the mouse Saa1 and Saa2 genes. Exp Anim (in press)

Mori M, Tian G, Higuchi K. AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform. Amyloid (in press)

Murakami T, Ishiguro N, Higuchi K. Transmission of systemic AA amyloidosis in animals. Vet Path (in press)

Tian G, Sawashita J, Kubo H, Nishio S, Hashimoto S, Suzuki N, Yoshimura G, Tsuruoka M, Wang Y, Liu Y, Luo H, Xu Z, Mori M, Kitano M, Hosoe K, Takeda T, Usami S, Higuchi K. Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence Accelerated Mice. Antioxidants & Redox Signaling. Epub 2013 Oct 14

Masuki S, Sumiyoshi E, Koshimizu TA, Qian J, Higuchi K, Tsujimoto G, Nose H. Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice. J Physiol 591(Pt 14): 3651-65.

Higuchi K. Transmission of AA amyloidosis may cause outbreaks of amyloid A amyloidosis in chickens. Amyloid 20(2): 59-60.

Mori M, Gotoh S, Taketani S, Hiai H, Higuchi K. Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene. Exp Eye Res 112C: 45-50.

Tanisawa K, Mikami E, Fuku N, Honda Y, Honda S, Ohsawa I, Ito M, Endo S, Ihara K, Ohno K, Kishimoto Y, Ishigami A, Maruyama N, Sawabe M, Iseki H, Okazaki Y, Hasegawa-Ishii S, Takei S, Shimada A, Hosokawa M, Mori M, Higuchi K, Takeda T, Higuchi M, Tanaka M. Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. BMC Genomics 14(1):248.

Luo H, Higuchi K, Matsumoto K, Mori M. An interleukin-33 gene polymorphism is a modifier for eosinophilia in rats. Genes Immun 14(3): 192-197.

$BHu8}5~0l!#A4?H@-%"%_%m%$%I!<%7%9$OEAGE$9$k$+!)!J%A!<%?!<5Z$S%^%&%9!K!X(BDementia Japan$B!Y(B 27(1): 54-61.

Yoshida K, Higuchi K, Ikeda S. Can prion-like propagation occur in neurodegenerative diseases?: in view of transmissible systemic amyloidosis. Brain Nerve 64(6): 665-74.

Chen L, Une Y, Higuchi K, Mori M. Cheetahs have 4 serum amyloid A genes evolved through repeated duplication events. J Hered 103(1): 115-29 (2012). Epub 2011 Oct 10.

Wall JS, Richey T, Stuckey A, Donnell R, Macy S, Martin EB, Williams A, Higuchi K, Kennel SJ. In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides. Proc Natl Acad Sci U S A 108(34): E586-94. Epub 2011 Aug 1.

Wang Y, Sawashita J, Qian J, Zhang B, Fu X, Tian G, Chen L, Mori M, Higuchi K. ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis. J Lipid Res 52(8): 1461-70. Epub 2011 May 26.

Imanishi H, Yokota M, Mori M, Shimizu A, Nakada K, Hayashi J. Nuclear but not mitochondrial DNA involvement in respiratory complex I defects found in Senescence-Accelerated Mouse Strain, SAMP8. Exp Anim 60(4): 397-404.

Tomozawa H, Nishio A, Higuchi K, Matsumoto K, Mori M. Genes for difference in eosinophilic phenotype between MES and BN.MES-Cyba(mes) rats are on chromosomes 9, 5, and 1. Exp Anim 60(2): 151-60.

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"XIIth International Symposium on Amyloidosis From Molecular Mechanisms Towards the Cure of Systemic Amyloidosis" Amyloid 18(suppl 1), Westermark P eds, 238 pages, Informa Healthcare (UK). Published on June.

1. Sawashita J, Kametani F, Hasegawa K, Mori M, Naiki H, Higuchi K. Amyloid fibrils formed by selective N- and C-terminal sequences of mouse apolipoprotein A-II. pp.19-21.

2. Higuchi K, Qian J, Yan J, Ge F, Zhang B, Fu X, Tomozawa H, Sawashita J, Mori M. Mouse apoA-II amyloid fibrils deposit in skeletal muscle and exhibit amyloidosis-enhancing activity. pp. 42-4.

Schmelzer C, Okun J, Haas D, Higuchi K, Sawashita J, Mori M, D$(D+S(Bring F. The reduced form of Coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice. IUBMB Life 62(11): 812-8.

Qian J, Yan J, Ge F, Zhang B, Fu X, Tomozawa H, Sawashita J, Mori M, Higuchi K. Mouse senile amyloid fibrils deposited in skeletal muscle exhibit amyloidosis-enhancing activity. PLoS Pathogens 6(5): e1000914. (Epub 2010 May 20)

Zhang P, Fu X, Sawashita J, Yao J, Zhang B, Qian J, Tomozawa H, Mori M, Ando Y, Naiki H, Higuchi K. Mouse model to study human A$B&B(B2M amyloidosis: Generation of a transgenic mouse with excessive expression of human $B&B(B2-microglobulin. Amyloid 17(2): 50-62.

Tomozawa H, Nishio A, Okuhara U, Higuchi K, Matsumoto K, Mori M. BN.MES-Cybames congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia. Exp Animal 59(4): 469-78.

Okudaira S, Shimizu M, Otsuki B, Nakanishi R, Ohta A, Higuchi K, Hosokawa M, Tsuboyama T, Nakamura T. Quantitative trait locus on chromosome X affects bone loss after maturation in mice. J Bone Miner Metab Epub 2010 Mar 31.

Nakajima K, Takeoka M, Mori M, Hashimoto S, Sakurai A, Nose H, Higuchi K, Itano N, Shiohara M, Oh T, Taniguchi S. Exercise effects on methylation of ASC gene. Int J Sports Med 31(9): 671-5. Epub 2010 Mar 3.

Masuki S, Mori M, Tabara Y, Miki T, Sakurai A, Morikawa M, Miyagawa K, Higuchi K, Nose H, Shinshu University Genetic Research Consortium. Vasopressin V1a receptor polymorphism and interval walking training effects in middle-aged and older people. Hypertension 55(3): 747-54.

Chambers JK, Kanda T, Shirai A, Higuchi K, Ikeda SI, Une Y. Senile systemic amyloidosis in an aged savannah monkey (Cercopithecus aethiops) with tenosynovial degeneration. J Vet Med Sci 72(5): 657-9. Epub 2010 Jan 15.

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Schmelzer C, Kubo H, Mori M, Sawashita J, Kitano M, Hosoe K, Boomgaaden I, D$(D+S(Bring F, Higuchi K. Supplementation with the reduced form of Coenzyme Q₁₀ decelerates phenotypic characteristics of senescence and induces a PPAR-$B&A(B gene expression signature in SAMP1 mice. Mol Nutr Food Res 54(6): 805-15 (2010). Epub 2009 Dec 3.

Mori M, Higuchi K, Sakurai A, Tabara Y, Miki T, Nose H. Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases. J Physiol 587: 5577-84. Epub 2009 Sep 7.

Sawashita J, Onitsuka S, Gen-no H, Ishikawa S, Iino F, Tateishi N, Murakami T, Seki Y, Nagaiwa T, Hanaoka M, Hama S, Nose H, Higuchi K. Effects of mild calorie restriction and high-intensity interval walking in middle-aged and older overweight Japanese. Exp Gerontol 44(10): 666-75. Epub 2009 Jul 26.

Sawashita J, Kametani F, Hasegawa K, Tsutsumi-Y S, Zhang B, Yan J, Mori M, Naiki H, Higuchi K. Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II. Biochim Biophys Acta - Proteins & Proteomics 1794(10): 1517-29. Epub 2009 Jul 10.

Mori M, Li G, Hashimoto M, Nishio A, Tomozawa H, Suzuki N, Usami S, Higuchi K, Matsumoto K. Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba). J Luek Biol 86(3): 473-8. Epub 2009 Apr 30.

Zhang G, Fu X, Takeda T, Higuchi K, Mori M. Dysfunction in ABCB1A has only a weak effect on susceptibility to dextran sulfate sodium-induced colitis in SAM strains. Exp Anim 58(4): 421-5.

Mori M, Fu X, Chen L, Zhang G, Higuchi K. Hereditary pancreatitis model WBN/Kob rat strain has a unique haplotype in the Pdwk1 region on chromosome 7. Exp Anim 58(4): 409-13.

Umezawa M, Higuchi K, Mori M, Matsushita T, Hosokawa M. Effect of dietary unsaturated fatty acids on senile amyloidosis in senescence-accelerated mice. J Gerontol A Biol Sci Med Sci 64(6): 646-52. Epub 2009 Apr 17.

Yoshida T, Zhang P, Fu X, Higuchi K, Ikeda S. Slaughtered aged cattle might become one dietary source exhibiting amyloid enhancing factor activity. Amyloid 16(1): 25-31.

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Zhang B, Une Y, Fu X, Yan J, Ge F, Yao J, Sawashita J, M Mori, Tomozawa H, Kametani F, Higuchi K. Fecal translation of AA amyloidosis in the cheetah contributions to high incidence of disease. Proc Nat Acad Sci USA 105: 7263-8. Epub 2008 May 12.

Zhang B, Une Y, Ge F, Fu X, Qian J, Zhang P, Sawashita J, Higuchi K, Mori M. Characterization of the cheetah serum amyloid A1 (SAA1) gene: critical role and functional polymorphism of a cis-acting element. J Heredity 99: 355-63. Epub 2008 Mar 28.

Zhang G, Zhang B, Fu X, Tomozawa H, Matsumoto K, Higuchi K, Mori M. Senescence-Accelerated Mouse (SAM) strains have a spontaneous mutation in the Abcb1a gene. Exp Anim 57(4): 413-7.

"Biophysical Inquiry into Protein Aggregation and Amyloid Diseases " P.L. San Biagio and D. Bulone Eds. Research SignPost, India.

Higuchi K, Fu X, B Zhang, Sawashita J, Mori M. Genetics and transmission of mouse systemic amyloidosis. 253-67.

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Yan J, Fu X, Ge F, Zhang B, Yao J, Zhang H, Qian J, Tomozawa H, Naiki H, Sawashita J, Mori M, Higuchi K. Cross-seeding and cross-competition in mouse apolipoprotein A-II amyloid fibrils (AApoAII) and protein A amyloid fibrils (AA). Am J Pathol 171(1): 172-80. Epub 2007 May 18.

Ge F, Yao J, Fu X, Guo Z, Yan J, Zhang B, Zhang H, Tomozawa H, Miyazaki J, Sawashita J, Mori M, Higuchi K. Amyloidosis in transgenic mice expressing murine amyloidogenic apolipoprotein A-II (Apoa2^C). Lab Invest 87(7): 633-43. Epub 2007 Apr 30.

Mori M, Sawashita J, Higuchi K. Functional Polymorphisms of the LSS and Fdft1 genes in laboratory rats. Exp Anim 56(2): 93-101.

Otsuki B, Matsumura T, Shimizu M, Mori M, Okudaira S, Nakanishi R, Higuchi K, Hosokawa M, Tsuboyama T, Nakamura T. Quantitative Trait Locus that Determines the Cross-sectional Shape of the Femur in SAMP6 and SAMP2 mice. J Bone Miner Res 22(5): 675-85.

Chiba T, Yao J, Higami Y, Shimokawa I, Hosokawa M, Higuchi K. Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysis. Mamm Genome 18(2): 105-12. Epub 2007 Feb 28.

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"XIth International Symposium on Amyloidosis" Skinner M, Berk JL, Connors LH, Seldin DC eds. CRC Press, USA.

1. Fu X, Korenaga T, Yan J, Ge F, Zhang B, Qian J, Naiki H, Sawashita J, Mori M, Higuchi K. Mouse senile amyloidosis: possible horizontal transmission in the mouse room. pp. 10-2.


2. Higuchi K, Ge F, Fu X, Yao J, Zhang B, Zhang H, Qian J, Sawashita J, Mori M. Amyloidosis in the transgenic mice of mouse amyloidogenic apolipoprotein A-II (Apoa2^C). pp. 143-5.

Mori M, Higuchi K, Matsumoto K. A Third locus for eosinophilia on chromosome 1 of the MES rats. Exp Anim 55(5): 497-500.

Nakanishi R, Shimizu M, Mori M, Akiyama H, Othuki B, Okudaira S, Hashimoto M, Higuchi K, Tsuboyama T, Nakamura T. Secreted Frizzled-Related Protein 4 as a negative regulator of bone formation and a candidate gene affecting peak bone mineral density in mice. J Bone Mineral Res 21(11): 1713-21.

Zhang H, Sawashita J, Fu X, Korenaga T, Yan J, Mori M, Higuchi K. Transmissibility of mouse AApoAII amyloid fibrils: inactivation by physical and chemical methods. FASEB J 20(7): 1012-4. Epub 2006 Mar 20.

Korenaga T, Yan J, Sawashita J, Matsusita T, Naiki H, Hosokawa M, Mori M, Higuchi K, Fu X. Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis. Am J Pathol 168(3): 898-906.

Mori M, Li G, Abe I, Nakayama J, Guo Z, Sawashita J, Ugawa T, Nishizono, Serikawa T, Higuchi K, Shumiya S. Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. J Clin Invest 116(2): 395-404. Epub 2006 Jan 26.

Yan J, Fujii K, Yao J, Kishida H, Hosoe K, Sawashita J, Takeda T, Mori M, Higuchi K. Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. Exp Gerontol 41(2): 130-40. Epub 2006 Jan 4.

Tojo K, Tokuda T, Hoshii Y, Fu X, Higuchi K, Matsui T, Kametani F, Ikeda S. Unexpectedly high incidence of visceral AA-amyloidosis in slaughtered cattle in Japan. Amyloid 12(2): 103-8.

Li G, Guo Z, Higuchi K, Kawakubo M, Matsumoto K, Mori M. A locus for eosinophilia in the MES rat is on Chromosome 19. Mamm Genome 16(7): 516-23.

"Amyloid and Amyloidosis" Grateau G, Kyle RA, Skinner M Eds. CRC Press, USA 551 pages.

1. Sawashita J, Zhang H, Fu X, Korenaga T, Mori M, Higuchi K. Transmission of Mouse AApoAII Amyloidosis by the Amyloid Fibrils; Inhibitory Effects on Transmission by the Denaturation / Degradation of Amyloid Fibrils. pp. 457-9.


2. Korenaga T, Fu X, Mori M, Sawashita J, Naiki H, Matsushita T, Higuchi K. Transmission of Mouse AApoAII Amyloidosis from Mother to Pups. pp. 460-2.

Fu X, Korenaga T, Xing Y, Fu L, Guo Z, Matsushita T, Hosokawa M, Naiki H, Baba S, Kawata Y, Ikeda S, Ishihara T, Mori M, Higuchi K. Induction of AApoAII amyloidosis by various heterogeneous amyloid fibrils. FEBS Lett 563: 179-84.

Korenaga T, Fu X, Xing Y, Matsusita T, Kuramoto K, Syumiya S, Hasegawa K, Naiki H, Ueno M, Ishihara T, Hosokawa M, Mori M, Higuchi K. Tissue Distribution, Biochemical Properties and Transmission of Mouse Type A AApoAII Amyloid Fibrils. Am J Pathol 164: 1597-606.

Yao J, Chiba T, Sakai J, Hirose K, Yamamoto M, Hada A, Kuramoto K, Higuchi K, Mori M. Mouse testis transcriptome revealed using serila analysis of gene expression. Mamm Genome 15: 433-51.

Yazaki M, Fushimi T, Tokuda T, Kametani F, Yamamoto K, Matsuda M, Shimojo H, Hoshii Y, Higuchi K, Ikeda S. A patient with severe renal amyloidosis associated with an immunoglobulin gamma-heavy chain fragment. Am J Kidney Dis 43: e23-8.

Wei L, Kawano H, Fu X, Cui D, Ito S, Yamamura K, Ishihara T, Tokuda T, Higuchi K, Maeda S. Deposition of transthyretin amyloid is not accelerated by the same amyloid in vivo. Amyloid 11(2): 113-20.

Tojo K, Tokuda T, Yazaki M, Oide T, Nakamura A, Mitsuhashi S, Kaneko K, Maruyama K, Kametani F, Higuchi K, Ikeda SI. Paraneoplastic Sensorimotor Neuropathy and Encephalopathy Associated with Anti-alpha-Enolase Antibody in a Case of Gastric Adenocarcinoma. Eur Neurol 51: 231-3.

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"The Senescence-Accelerated Mouse (SAM): an animal model of senescence" Nomura Y, Takeda T, Okuma Y Eds. Elsevier BV Amsterdam, The Netherlands, 448 pages.

1. Higuchi K, Xing Y, Fu X, Korenaga T, Guo Z, Nakamura A, Mori M. Mouse senile amyloidosis in the SAM model. pp. 35-40.


2. Sawashita J, Higuchi K, Nakai K, Murase S, Hosokawa M, Miyamoto M, Akiguchi I, Yakeda T. Homepage of the Council for SAM Research (http://samrc.md/shinshu-u.ac.jp). pp. 175-8.


3. Mori M, Higuchi K. Genetic monitoring system for SAM strains utilizing DNA markers. 187-190


4. Yanagidaira Y, Higuchi K. Physiological characteristics in SAMP1 and SAMP2 mice. pp. 191-6.

5. Toichi E, Matsushita T, Higuchi K, Hosokawa T, Hosokawa M, Hosono M. Relationship between immune activity, senile amyloidosis and life span of hybrids of SAMP1 and B1-.BR mice. pp. 357-61.

6. Fu X, Korenaga T, Xing Y, Fu L, Guo Z, Matsushita T, Hosokawa M, Naiki H, Mori M, Higuchi K. Induction of AApoAII and AA amyloidosis by the injections of various amyloid fibrils. pp. 383-6.


7. Umezawa M, Okumura H, Hosokawa M, Takeda T, Higuchi K. Effects of dietary fats on senile amyloidosis in SAMP1 mice. pp. 427-31.

Mori M, Yamasaki K, Nakanishi S, Kitada K, Higuchi K, Namiki C, Hamada S, Serikawa T. A New Beige Mutant Rat ACI/N-Lystbg-Kyo. Exp Anim 52: 31-6.

Umezawa M, Tatematsu K, Korenaga T, Fu X, Matushita T, Okuyama H, Hosokawa M, Takeda T, Higuchi K. Dietary fat modulation of apoA-II metabolism and prevention of senile amyloidosis in the senescence- accelerated mouse. J Lipid Res 44: 762-9.

Yanagidaira Y, Higuchi K, Nose H. Diurnal rhythm disorder of behavioral activity in SAMP1 mice is partially normalized by spontaneous wheel running. Physiol Behav 80, 195-201.

Kitagawa K, Wang J, Mastushita T. Kogishi K, Hosokawa M, Fu X, Guo Z, Mori M, Higuchi K. Polymorphisms of mouse apolipoprotein A-II: seven alleles found among 41 inbred strains of mice. Amyloid 10: 207-14.

Guo Z, Mori M, Fu X, Yao J, Xing Y, Korenaga T, Li G, Matsushita T, Hosokawa M, Higuchi K. Amyloidosis modifier genes in less amyloidogenic A/J mouse strain. Lab Invest 83:1605-13.

Guo Z, Higuchi K, Mori M. Spontaneous hypomorphic mutations in antioxidant enzymes of mice. Free Radic Biol Med 35: 1645-52.

Masui N, Nishikawa T, Takagi Y, Mori M, Suzuki T, Sato K. The Rat Lysosomal Trafficking Regulator (Lyst) Gene is Mapped on the Telomeric Region of Chromosome 17. Exp Anim 52: 89-91.

Anunciado RV, Nishimura M, Mori M, Ishikawa A, Tanaka S, Horio F, Ohno T, Namikawa T. Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J) F2 mice. Exp Anim 52: 37-42.

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Xing Y, Nakamura A, Korenaga T, Guo Z, Yao J, Fu X, Matsushita T, Kogishi K, Hosokawa M, Kametani F, Mori M, Higuchi K. Induction of protein conformational change in mouse senile amyloidosis. J Biol Chem 277: 33164-9.

Xing Y, Higuchi K. Amyloid Fibril Proteins. Mech Ageing Dev 123: 1625-36.

Shimizu M, Higuchi K, Kasai S, Tsuboyama T, Matsushita M, Matsumura T, Okudaira S, Mori M, Koizumi A, Nakamura T, Hosokawa M. A congenic mouse and candidate gene at the Chr 13 locus regulating bone density. Mamm Genome 13: 335-40.

Kaneko K, Nakamura A, Yoshida K, Kametani F, Higuchi K, Ikeda S. Glial fibrillary acidic protein is greatly modified by oxidative stress in aceruloplasminemia brain. Free Radic Res 36: 303-6.

Ohta A, Akiguchi I, Seriu N, Ohnishi K, Yagi H, Higuchi K, Hosokawa M. Deterioration in learning and memory of inferential tasks for evaluation of transitivity and symmetry in aged SAMP8 mice. Hippocampus 12: 803-10.

Suzuki T, Tozuka M, Kazuyoshi Y, Sugano M, Nakabayashi T, Okumura N, Hidaka H, Katsuyama T, Higuchi K. Predominant apolipoprotein J exists as lipid-poor mixtures in cerebrospinal fluid. Ann Clin Lab Sci 32: 369-76.

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Xing Y, Nakamura A, Chiba T, Kogishi K, Matsushita T, Li F, Guo Z, Hosokawa M, Mori M, Higuchi K. Transmission of mouse senile amyloidosis. Lab Invest 81: 493-9.

Mori M, Toyokuni S, Kondo S, Kasai H, Naiki H, Toichi H, Hosokawa M, Higuchi K. Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence. Free Radic Biol Med 30: 1130-6.

Fu L, Matsuyama I, Chiba T, Xing Y, Korenaga T, Guo Z, Nakayama J, Mori M, Higuchi K. Extra-hepatic expression of apolipoprotein A-II in mouse tissues: Possible contribution to mouse senile amyloidosis. J Histochem Cytochem 49: 739-48.

Mizutani J, Chiba T, Tanaka M, Higuchi K, Mori M. Unique mutations in mitochondrial DNA of Senescence-Accelerated Mouse (SAM) strains. J Hered 92: 352-5.

Shimizu M, Higuchi K, Kasai S, Tsuboyama T, Matsushita M, Mori M, Shimizu Y, Nakamura T, Hosokawa M. Chromosome 13 locus, pbd2, regulates bone density in mice. J Bone Mineral Res 16: 1972-82.

Ohta A, Higuchi K, Seriu N, Ohnishi K, Yagi H, Higuchi K, Hosokawa M. Deterioration in learning and memory of fear conditioning in response to context in aged SAMP8 mice. Neurobiol Aging 22: 479-84.

Tsuji A, Nishikawa T, Mori M, Suda K, Nishimori I, Nishimura M. Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat. Genomics 74: 365-9.

Anunciado RVP, Nishimura M, Mori M., Ishikawa A, Tanaka S, Horio F, Ohno T, Namikawa T. Quantitative trait loci for body weight in the intercross between SM/J and A/J mice. Exp Anim 50: 319-24.

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$BHu8}5~0l!"G__7bCSAMP$B$H%j%]CAGrGeriatric Medicine$B!Y(B39: 1399-404.

Wang J, Matsushita T, Kogishi K, Xia C, Ohta A, Chiba T, Nakamura A, Kondo H, Mori M, Hosokawa M, Higuchi K. Wild type ApoA-II gene does not rescue Senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality. J Gerontol B Biol Sci 55A: B432-9.

Guo Z, Toichi E, Hosono M, Hosokawa T, Hosokawa M, Higuchi K, Mori M. Genetic analysis of lifespan in hybrid progeny derived from the SAMP1 mouse strain with accelerated senescence. Mech Ageing Dev 118: 35-44.

Nishikawa T, Takahashi JA, Matsushita T, Ohnishi K, Higuchi K, Hashimoto N, Hosokawa M. Tubular aggregates in the skeletal muscle of the senescence-accelerated mouse; SAM. Mech Ageing Dev 114: 89-99.

Umezawa M, Takeda T, Kogishi K, Higuchi K, Matushita T, Wang J, Chiba T, Hosokawa M. Serum lipid concentrations and mean life span are modulated by dietary polyunsaturated fatty acids in the Senescence-accelerated mouse. J Nutr 130: 221-7.

Anunciado RVP, Ohno T, Mori M, Ishikawa A, Tanaka S, Horio F, Nishimura M, Namikawa T. Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis. Exp Anim 49: 217-24.

Yazaki M, Tokuda T, Nakamura A, Higashikata T, Koyama J, Higuchi K, Harihara Y, Baba S, Kametani F, Ikeda S. Cardiac amyloid in patients with familial amyloid polyneuropathy consists of abundant wild-type transthyretin. Biochem Biophys Res Commun 274: 702-6.

Sakata C, Tanaka H, Takemura S, Hirohashi K, Minamiyama Y, Nakamura A, Inoue M, Kinoshita H. Post-ischemic intraportal adenosine administration protects against reperfusion injury of canine liver. J Hepatobiliary Pancreas Surg 7: 78-85.

Nakamura A, Park A, Nagata K, Sato EF, Kashiba M, Tamura T, Inoue M. Oxidative cellular damage associated with transformation of helicobacter pylori from a bacillary to a coccoid form. Free Radic Biol Med. 28: 1611-8.

Kikuchi T, Ichikawa M, Arai J, Tateiwa H, Fu L, Higuchi K, Yoshimura N. Molecular cloning and characterization of a new neuron-specific homologue of rat polypyrimidine tract binding protein. J Biochem (Tokyo) 128: 811-21.

Shoji M, Matsushita T, Higuchi K, Honda Y, Hosokawa M: Related Articles Senile ocular amyloidosis in SAM and BALB/c strains of mice. Mech Ageing Dev 120: 87-94.

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Chiba T, Kogishi K, Wang J, Xia C, Matsushita T, Miyazaki J, Saito I, Hosokawa M, Higuchi K. Mouse senile amyloid deposition is suppressed by adenovirus-mediated overexpression of amyloid-resistant apolipoprotein A-II. Am J Pathol 155: 1319-26.

Higuchi K, Hosokawa M, Takeda T. The Senescence-Accelerated Mouse. Methods Enzymol 309: 674-86.

Xia C, Higuchi K, Shimizu M, Matsushita T, Kogishi K, Wang J, Chiba T, Festing MF, Hosokawa M. Genetic typing of the senescence-accelerated mouse (SAM) strains with microsatellite markers. Mamm Genome 10: 235-8.

Shimizu M, Higuchi K, Bennett B, Xia C, Tsuboyama T, Kasai S, Chiba T, Fujisawa H, Kogishi K, Kitado K, Kimoto M, Matsusita M, Okumura H, Serikawa T, Nakanura T, Johnson TE, Hosokawa M. Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain. Mamm Genome 10: 81-7.

Takeda M, Tsuboyama T, Kasai R, Shimizu M, Nakamura T, Higuchi K, Hosokawa M. Expression of c-fos gene induced by parathyroid hormone in bones of SAMP6 mice, a murine model for senile osteoporosis. Mech Ageing Dev 108: 87-97.

Fujisawa H, Nishizawa T, Zhu BH, Nishimura Y, Shimizu M, Kimoto M, Higuchi K, Hosokawa M. Aminoguanidine supplementation delays the onset of senescence in vitro in dermal fibroblast-like cells from Senescence-accelerated mice. J Gerontol 54: B276-82.

Mori M, Nishikawa T, Higuchi K, Nishimura. Deletion in the beige rat owing to recombination between LINE1s. Mamm Genome 10: 692-5.

Nakamura A, Yasuda K, Nakamoto H, Adachi H, Akurai Y, Ishii N, Goto S. A vitellogenin-6 is a major carbonylated protein in aged nematoda, C-elegans. Biophys Res Commun 264: 580-3.

Sakata C, Tanaka H, Takemura S, Miyaa Y, Nakamura A, Katsuragi K, Huang H, Kubo S, Kinoshita H. Effect of intraportal infusion of adenosine on hepatic blood flow and injury after ischemia and reperfusion of canine liver. Transplant 31: 1027-8.

$B!H(BAmyloid and Amyloidosis 1998$B!I(B Kyle RA, Gertz. Eds, Parthenon Publishing, New York.

1. Higuchi K, Kogishi, Wang J, Chen X, Chiba T, Matsushita T, Hoshi H, Kawano T, Ishihara T, Hosokawa M. Fibrization in mouse senile amyloidosis is fibril conformation dependent. 
pp. 47-9.

2. Chiba T, Kogishi K, Wang J, Xia C, Matsushita T, Hosokawa M, MIyazaki J, Saito I, Sasai Y, Higuchi K. AApoAII amyloid deposition is suppress by adenovirus-mediated overexpression of type B apolipoprotein A-II gene in the mice. pp. 56-58.

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Goto S, Nakamura A, Radak Z, Nakamoto H, Takahashi R, Yasuda K, Sakurai Y, Ishii N. Carbonylated proteins in aging and exercise: immunoblot approaches. Mech Aging Dev 107: 245-53.

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