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Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, TW., Sawamura,
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●
● Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka,
H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T., Nakamura, T.: Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis. Arthritis Rheum, 64:1024-1034, 2012
● Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R., Sawamura, T.:
Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement
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● Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R., Sawamura, T.: An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment. J Atheroscler Thromb, 18:818-828, 2011
● Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto,
R., Sawamura, T.: Procyanidins are potent inhibitors of LOX-1: a new player
in the French Paradox. Proc Jpn Acad Ser B Phys Biol Sci, 87:104-113, 2011
● Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida,
A., Miwa, K., Hayashi, H., Mitsunami, K., Horie, M.: Pitavastatin reduces
lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic
humans. Lipids, 45:329-335, 2010
● Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H., Sawamura, T.: LOX-1
mediates vascular lipid retention under hypertensive state. J Hypertens,
28:1273-1280, 2010
● Takaya, T., Wada, H., Morimoto, T., Sunagawa, Y., Kawamura, T., Takanabe-Mori, R., Shimatsu, A., Fujita, Y., Sato, Y., Fujita, M., Kimura, T., Sawamura, T., Hasegawa, K.: Left ventricular
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● Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R., Sawamura, T.: LOX index, a novel predictive biochemical marker for coronary heart disease and stroke. Clin Chem, 56:550-558, 2010
● Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R., Sawamura,
T.: C-reactive protein uptake by macrophage cell line via class-A scavenger
receptor. Clin Chem, 56:478-481, 2010
● Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita,
H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y.,
Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y., Takeishi, Y.: LOX-1-MT1-MMP axis
is crucial for RhoA and Rac1 activation induced by oxidized low-density
lipoprotein in endothelial cells. Cardiovasc Res, 84:127-136, 2009
● Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini,
L., Delneste, Y., Matsuda, H., Sawamura, T.: Oxidized LDL receptor LOX-1
binds to C-reactive protein and mediates its vascular effects. Clin Chem,
55:285-294, 2009
● Hu, C., Chen, J., Dandapat, A., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Li, D., Hermonat, P.L., Sawamura, T., Mehta, J.L.: LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice. J Mol Cell Cardiol, 44:76-83, 2008
● Izawa, Y., Yoshizumi, M., Ishizawa, K., Fujita, Y., Kondo, S., Kagami, S., Kawazoe, K., Tsuchiya, K., Tomita, S., Tamaki,
T.: Big mitogen-activated protein kinase 1 (BMK1)/extracellular signal
regulated kinase 5 (ERK5) is involved in platelet-derived growth factor
(PDGF)-induced vascular smooth muscle cell migration. Hypertens Res, 30:1107-1117,
2007
● Hu, C., Dandapat, A., Chen, J., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Sawamura, T., Mehta, J.L.: LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion. Cardiovasc Res, 76:292-302, 2007
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K., Tsuchiya, K., Tamaki, T.: Transactivation of fetal liver kinase-1/kinase-insert
domain-containing receptor by lysophosphatidylcholine induces vascular
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in neointimal hyperplasia after balloon arterial injury in a rat model.
Cardiovasc Res, 69:263-271, 2006
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Aldosterone stimulates vascular smooth muscle cell proliferation via big
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2005
● Ali, N., Yoshizumi, M., Fujita, Y., Izawa, Y., Kanematsu, Y., Ishizawa, K., Tsuchiya, K., Yano, S., Sone,S., Tamaki, T.: A novel Src kinase inhibitor, M475271, inhibits VEGF-induced human umbilical vein endothelial cell proliferation and migration. J Pharmacol Sci, 98:130-141, 2005
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● Kyaw, M., Yoshizumi, M., Tsuchiya, K., Izawa, Y., Kanematsu, Y., Fujita, Y., Ali, N., Ishizawa, K., Yamauchi, A., Tamaki, T.: Antioxidant effects
of stereoisomers of N-acetylcysteine (NAC), L-NAC and D-NAC, on angiotensin
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Cas are essentially but differentially involved in angiotensin II-stimulated
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2004
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● Yoshizumi, M., Fujita, Y., Izawa, Y., Suzaki, Y., Kyaw, M., Ali, N., Tsuchiya, K., Kagami, S., Yano,
S., Sone, S., Tamaki, T.: Ebselen inhibits tumor necrosis factor-alpha-induced
c-Jun N-terminal kinase activation and adhesion molecule expression in
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● Yoshizumi, M., Kogame, T., Suzaki, Y., Fujita, Y., Kyaw, M., Kirima, K., Ishizawa, K., Tsuchiya, K., Kagami, S., Tamaki,
T.: Ebselen attenuates oxidative stress-induced apoptosis via the inhibition
of the c-Jun N-terminal kinase and activator protein-1 signalling pathway
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