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œ Okamoto C, Hayakawa Y, Aoyama T, Komaki H, Minatoguchi S, Iwasa M, Yamada Y, Kanamori H, Kawasaki M, Nishigaki K, Mikami A, Minatoguchi S. Excessively low salt diet damages the heart through activation of cardiac (pro) renin receptor, renin-angiotensin-aldosterone, and sympatho-adrenal systems in spontaneously hypertensive rats. PLoS One. 12(12):e0189099. 2017.
œYokoyama C, Aoyama T, Ido T, Kakino A, Shiraki T, Tanaka T, Nishigaki K, Hasegawa A, Fujita Y, Sawamura T, Minatoguchi S. Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin. PLoS One. 11(5):e0154994. 2016 (Ó”C’˜ŽÒ)
œHayakawa Y, Aoyama T, Yokoyama C, Okamoto C, Komaki H, Minatoguchi S, Iwasa M, Yamada Y, Kawamura I, Kawasaki M, Nishigaki K, Mikami A, Suzuki F, Minatoguchi S. High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension. PLoS One. 10(3):e0120453. 2015.
œShiraki T, Aoyama T, Yokoyama C, Hayakawa Y, Tanaka T, Nishigaki K, Sawamura T, Minatoguchi S. LOX-1 plays an important role in ischemia-induced angiogenesis of limbs. PLoS One. 9(12):e114542. 2014. (Ó”C’˜ŽÒ)
œTakahashi S, Kawasaki M, Miyata S, Suzuki K, Yamaura M, Ido T, Aoyama T, Fujiwara H, Minatoguchi S. Feasibility of tissue characterization of coronary plaques using 320-detector row computed tomography: comparison with integrated backscatter intravascular ultrasound. Heart Vessels. 31(1):29-37. 2014
œHattori A, Kawamura I, Yamada Y, Kanamori H, Aoyama T, Ushikoshi H, Kawasaki M, Nishigaki K, Tamemura G, Minatoguchi S. Elevated plasma GLP-1 levels and enhanced expression of cardiac GLP-1 receptors as markers of left ventricular systolic dysfunction: a cross-sectional study. BMJ Open. 3(9):e003201. 2013
œMinatoguchi S, Aoyama T, Kawai N, Iwasa M, Oda M, Kida K, Kojima S, Goto N, Goto M, Sugishita F, Takai K, Tanaka R, Hiei K, Minagawa T, Yamamoto N, Watanabe I, Yasue T, Kobayashi H. Comparative effect of candesartan and amlodipine, and effect of switching from valsartan, losartan, telmisartan and olmesartan to candesartan, on early morning hypertension and heart rate. Blood Press.:29-37. 2013
œYamada Y, Kobayashi H, Iwasa M, Sumi S, Ushikoshi H, Aoyama T, Nishigaki K, Takemura G, Fujiwara T, Fujiwara H, Kiso M, Minatoguchi S. Postinfarct active cardiac-targeted delivery of erythropoietin by liposomes with sialyl Lewis X repairs infarcted myocardium in rabbits. Am J Physiol Heart Circ Physiol. 304(8):H1124-33. 2013
œIwasa M, Yamada Y, Kobayashi H, Yasuda S, Kawamura I, Sumi S, Shiraki T, Yamaki T, Ushikoshi H, Hattori A, Aoyama T, Nishigaki K, Takemura G, Fujiwara H, Minatoguchi S. Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits. Br J Pharmacol. 164(1):119-31. 201
œKawamura I, Takemura G, Kanamori H, Takeyama T, Kawaguchi T, Tsujimoto A, Goto K, Maruyama R, Watanabe T, Shiraki T, Aoyama T, Fujiwara T, Fujiwara H, Minatoguchi S. Repeated phlebotomy augments angiogenesis to improve blood flow in murine ischemic legs. Am J Physiol Heart Circ Physiol. H372-8. 2010
œAoyama T, Matsui T, Novikov M, Park J, Hemmings B, Rosenzweig A. Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response. Circulation. 111(13):1652-9. 2005 i•M“ª’˜ŽÒj
œNagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, del Monte F, Gwathmey JK, Grazette L, Hemmings B, Kass DA, Champion HC, Rosenzweig A. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest. 115(8):2128-38. 2005
œAoyama T, Takemura G, Maruyama R, Kosai K, Takahashi T, Koda M, Hayakawa K, Kawase Y, Minatoguchi S, Fujiwara H. Molecular mechanisms of non-apoptosis by Fas stimulation alone versus apoptosis with an additional actinomycin D in cultured cardiomyocytes. Cardiovasc Res. 55(4):787-98. 2002 i•M“ª’˜ŽÒj
œAoyama T. Chen, M. Fujiwara, H Masaki, T. Sawamura, T. LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells. FEBS Lett 467: 217-20. 2000 i•M“ª’˜ŽÒj
œAoyama T. Fujiwara, H. Masaki, T. Sawamura, T. Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells. J Mol Cell Cardiol 31: 2101-14. 1999 i•M“ª’˜ŽÒj
œAoyama T. Sawamura, T. Furutani, Y. Matsuoka, R. Yoshida, M. C. Fujiwara, H. Masaki, T. Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene. Biochem J 339: 177-84. 1999 i•M“ª’˜ŽÒj
œKanoh, M. Takemura, G. Misao, J. Hayakawa, Y. Aoyama T. Nishigaki, K. Noda, T. Fujiwara, T. Fukuda, K. Minatoguchi, S. Fujiwara, H.  Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy: not apoptosis but DNA repair. Circulation. 99: 2757-64. 1999
œMoriwaki, H. Kume, N. Sawamura, T. Aoyama T. Hoshikawa, H. Ochi, H. Nishi, E. Masaki, T. Kita, T. Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein. Arterioscler Thromb Vasc Biol 18: 1541-7. 1998
œKume, N. Murase, T. Moriwaki, H. Aoyama T. Sawamura, T. Masaki, T. Kita, T. Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res 83: 322-7. 1998
œSawamura, T. Kume, N. Aoyama T. Moriwaki, H. Hoshikawa, H. Aiba, Y. Tanaka, T. Miwa, S. Katsura, Y. Kita, T. Masaki, T. An endothelial receptor for oxidized low-density lipoprotein. Nature 386: 73-7. 199


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