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2017”N“x

2016”N“x

Transgenic monkey model of the polyglutamine diseases recapitulating progressive neurological symptoms
Ikuo Tomioka, Hidetoshi Ishibashi, Eiko Minakawa, Hideyuki Motohashi, Osamu Takayama, Yuko Saito, H. Popiel, Sandra Puentes, Kensuke Owari, Terumi Nakatani, Naotake Nogami, Kazuhiro Yamamoto, Satoru Noguchi, Takahiro Yonekawa, Yoko Tanaka, Naoko Fujita, Hikaru Suzuki, Hisae Kikuchi, Shu Aizawa, Seiichi Nagano, Daisuke Yamada, Ichizo Nishino, Noritaka Ichinohe, Keiji Wada, Shinichi Kohsaka, Yoshitaka Nagai, and Kazuhiko Seki
eNeuro, 4(2) e0250-16, 2017.

2014”NˆÈ‘O

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2017”N“x

Ikuo Tomioka, Naotake Nogami, Naoko Fujita, Kensuke Owari, Terumi Nakatani, Hideyuki Motohashi, Osamu Takayama, Yoshitaka Nagai, Kazuhiko Seki. Generation of transgenic monkey with tetracyclin-inducible gene expression system for neurodegenerative disease model. Fourth World Congress of Reproductive Biology (WCRB), Okinawa, 2017.09.29.

Y. Nagai, I. Tomioka, H. Ishibashi, E.N. Minakawa, H. Motohashi, O. Takayama, Y. Saito, H.A. Popiel, S. Puentes, K. Owari, T. Nakatani, N. Nogami, K. Yamamoto, S. Noguchi, S. Nagano, I. Nishino, N. Ichinohe, K. Wada, S. Kohsaka, K. Seki. TRANSGENIC MONKEY MODEL OF THE POLYGLUTAMINE DISEASES RECAPITULATING PROGRESSIVE NEUROLOGICAL SYMPTOMS AND POLYGLUTAMINE PROTEIN INCLUSIONS. XXIII World Congress of Neurology, Kyoto, 2017.09.17

Î‘q‰ÄŽ÷AŽs‰ªŽ÷A—Ñ’m—mA•x‰ªˆè•vA‚–Ø—D“ñAà_–ìŒõˆêA‘–‰·«”­Œ»ƒEƒV¸Žq‚̉^“®«‚ƃJƒ‹ƒVƒEƒ€‚̕ω»A–kM‰z’{ŽYŠw‰ï‘æ66‰ñ‘å‰ïAMB‘åŠw”_Šw•”A’·–ìA2017.09.08

ˆÀ“c“µ”üA²“¡Œ’‘¾A•x‰ªˆè•vA‚–Ø—D“ñAà_–ìŒõˆêAƒEƒV¸Žq‚Ì‘–‰·«‚É‚¨‚¯‚éƒJƒ‹ƒVƒEƒ€‚ÌŠÖ—^A–kM‰z’{ŽYŠw‰ï‘æ66‰ñ‘å‰ïAMB‘åŠw”_Šw•”A’·–ìA2017.09.08

’I‹´—R‰ÀAûüžÄŒ’‘¾˜YA’†‘º‰Ø“ÞŽqA’†“c‰YA“¡ˆä”ŽA•x‰ªˆè•vACRISPR/Cas9ƒVƒXƒeƒ€‚ð—p‚¢‚½FXRƒmƒbƒNƒAƒEƒgƒ}ƒEƒX‚̍ìoA–kM‰z’{ŽYŠw‰ï‘æ66‰ñ‘å‰ïAMB‘åŠw”_Šw•”A’·–ìA2017.09.08

L£ŠC—¢AŠÖŒûŒ’ŽiA•x‰ªˆè•vA‚“‡½ŽiAà_–ìŒõŽsA‚–Ø—D“ñAFG-beads‚É‚æ‚鐬n¸‘ƒ‚©‚ç‚̐¸Œ´×–E‚Ì’P—£A‘æ123‰ñ“ú–{’{ŽYŠw‰ï‘å‰ïAMB‘åŠw”_Šw•”A’·–ìA2017.0.07

–ìã®•A”ö’£Œ’‰îA’†’J‹P”üA¬ò¹ŽiA²‰ê—m‰îAì–ì粓N‘ãAÖ“¡—TŽqA•x‰ªˆè•vAŠÖ˜a•FAƒ|ƒŠƒOƒ‹ƒ^ƒ~ƒ“•aƒ‚ƒfƒ‹ƒ}[ƒ‚ƒZƒbƒg‚̍ìo‚Æ•a‘Ô‰ðÍA‘æ123‰ñ“ú–{’{ŽYŠw‰ï‘å‰ïAMB‘åŠw”_Šw•”A’·–ìA2017.09.07

‚žÄŒ’‘¾˜YA’†“c‰YA’I‹´—R‰ÀAŒ‘ñ–A”~àVŒö“ñA“¡ˆä”ŽA•x‰ªˆè•vAFXR‚ð‰î‚µ‚½«ƒzƒ‹ƒ‚ƒ“‡¬‚̐V‹K§ŒäƒƒJƒjƒYƒ€‰ðÍA‘æ123‰ñ“ú–{’{ŽYŠw‰ï‘å‰ïAMB‘åŠw”_Šw•”A’·–ìA2017.09.06

’†‘º‰Ø“ÞŽqA‚žÄŒ’‘¾˜YA’†“c‰YA’I‹´—R‰ÀA“¡ˆä”ŽA•x‰ªˆè•vA—‘‘ƒ‚É‚¨‚¯‚éFXR‚̓^ƒEƒŠƒ“‡¬y‘fCdo1‚𐧌䂷‚éA‘æ123‰ñ“ú–{’{ŽYŠw‰ï‘å‰ïAMB‘åŠw”_Šw•”A’·–ìA2017.09.06

–ìã®•A”ö’£Œ’‰îA’†’J‹P”üA¬ò¹ŽiA²‰ê—m‰îAì–ì粓N‘ãA‰iˆä‹`—²A•x‰ªˆè•vAŠÖ˜a•FAƒ|ƒŠƒOƒ‹ƒ^ƒ~ƒ“•aƒ‚ƒfƒ‹ƒ}[ƒ‚ƒZƒbƒg‚̃‰ƒCƒ“‰»‹y‚Ñ•\Œ»Œ^‰ðÍA‘æ39‰ñ“ú–{_Œo‰ÈŠw‘å‰ïAƒpƒVƒtƒBƒR‰¡•lA_“ސìA2017.07.22

Ikuo Tomioka, Kentaro Takae, Mizuho Nakata, Kanako Nakamura, Takafumi Watanabe, Hiroshi Fujii. FXR regulates the steroidogenesis in ovarian granulosa cells via induction of SHP and FABP6 gene expressions. 50th Annual Meeting, Society for the Study of Reproduction, Washington DC, 2017.07.13-16.

ŠÖ˜a•FA•x‰ªˆè•vA‰iˆä‹`—²AÖ“¡—TŽqAÎ‹´‰prA‰Ôì—²A”ö’£Œ’‰îA–ìã®•A¬ò¹ŽiAŠFì‰hŽqA’†’J‹P”üAì–ì粓N‘ãAˆâ“`Žq‰ü•Ï‹Zp‚ð—p‚¢‚½¸_E_ŒoŽ¾Š³ƒ‚ƒfƒ‹—ì’·—ނ̍ìo‚Æ•]‰¿AƒVƒ“ƒ|ƒWƒEƒ€Iu“®•¨‚̐_Œo•Ï«Ž¾Š³ ?Ž©‘R”­Ç‚©‚çˆâ“`Žq‰ü•Ï‚܂Ł[vA‘æ58‰ñ“ú–{_Œo•a—Šw‰ï‘‰ïŠwpŒ¤‹†‰ïAŠwp‘‡ƒZƒ“ƒ^[iˆê‹´u“°jA“Œ‹žA2017.06.22

2016”N“x

1D‚žÄŒ’‘¾˜YE•x‰ªˆè•vA—‘‘ƒ‚É‚¨‚¯‚éFXRiFarnesoid X Receptorj‚Ì‹@”\‰ðÍAMBŽÀŒ±“®•¨Œ¤‹†‰ïE‘æ35‰ñŒ¤‹†”­•\‰ïAMB‘åŠw”_Šw•”A’·–쌧A2017”N3ŒŽ3“ú

2D•x‰ªˆè•vEŠFì‰hŽqE”ö’£Œ’‰îE’†’J‹P”üE–ìã®•E‰iˆä‹`—²EŠÖ˜a•FAƒgƒ‰ƒ“ƒXƒWƒFƒjƒbƒN‹Zp‚ð—p‚¢‚½_Œo•Ï«Ž¾Š³ƒ‚ƒfƒ‹—ì’·—ނ̍ìoA‘æ65‰ñ–kM‰z’{ŽYŠw‰ï‘å‰ïAVŠƒŽsA2016”N11ŒŽ10“ú

3D•x‰ªˆè•vAƒ}[ƒ‚ƒZƒbƒg‚É‚¨‚¯‚éˆâ“`Žq‘gŠ·‚¦“®•¨ì»‚ÌŽÀÛ‚Æ‚»‚̉”\«‚ɂ‚¢‚āA‘æ50‰ñ“ú–{ŽÀŒ±“®•¨‹ZpŽÒ‹¦‰ï‘‰ïAì‰zA2016”N9ŒŽ29“ú`10ŒŽ1“úAiƒVƒ“ƒ|ƒWƒEƒ€2uŽÀŒ±“®•¨‚É‚¨‚¯‚éˆâ“`Žq‰ü•Ï‹Zp‚ÌŽÀÛ‚Æ‚»‚̉”\«vj

4D’†“c‰YE‚žÄŒ’‘¾˜YE“¡ˆä”ŽE•x‰ªˆè•vA—‘‘ƒ‚É‚¨‚¯‚éFXR(Farnesoid X Receptor)‚Ì‹@”\‰ðÍA‘æ109‰ñ“ú–{”ɐB¶•¨Šw‰ï‘å‰ïA–ƒ•z‘åŠwA‘Š–ÍŒ´ŽsA2016”N9ŒŽ14“ú

5D•x‰ªˆè•vEŠFì‰hŽqE”ö’£Œ’‰îE’†’J‹P”üE–ìã®•E‰iˆä‹`—²EŠÖ˜a•FAƒ|ƒŠƒOƒ‹ƒ^ƒ~ƒ“•aƒ‚ƒfƒ‹ƒ}[ƒ‚ƒZƒbƒg‚̍ìoA‘æ109‰ñ“ú–{”ɐB¶•¨Šw‰ï‘å‰ïA–ƒ•z‘åŠwA‘Š–ÍŒ´ŽsA2016”N9ŒŽ14“ú

6D•x‰ªˆè•vASCA3ƒ‚ƒfƒ‹ƒ}[ƒ‚ƒZƒbƒg‚̍ìoA‘æ57‰ñ“ú–{_ŒoŠw‰ïŠwp‘å‰ïA_ŒËA2016”N5ŒŽ20“úAiƒzƒbƒgƒgƒsƒbƒNƒX11ƒVƒ“ƒ|ƒWƒEƒ€u‚Ç‚±‚܂ŋ߂¢‚½‚©AÒ‘¬”]•Ï«Ç‚ÌŽ¡—Ö@ŠJ”­vj

7D•x‰ªˆè•vAŽÀŒ±“®•¨‚Æ‚µ‚Ẵ}[ƒ‚ƒZƒbƒgA‘æ36‰ñMBŽÀŒ±“®•¨Œ¤‹†‰ï‘‰ïAMB‘åŠwA2016”N3ŒŽ4“úAŒû“ª”­•\


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2016”N“x

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