核磁気共鳴NMRを用いた高分子の構造解析に関する基礎的研究、ならびに、それを絹の構造解析に適用、得られた知見の蓄積を背景に、絹を用いた再生医療材料(小口径人工血管)の開発を行っている。

【主要参考文献】
1. Asakura, T.; Suzuki, Y.; Yazawa, K.; Aoki, A.; Nishiyama, Y.; Nishimura, K.; Suzuki, F.; Kaji, H., Determination of Accurate 1H Positions of (Ala-Gly)n as a Sequential Peptide Model of Bombyx mori Silk Fibroin before Spinning (Silk?). Macromolecules, 46(19), 8046-8050 (2013)
2013_Macromolecules46_8046
2. Asakura, T., Suzuki, Y., Nagano, A., Knight, D.P., Kamiya, M., Demura, M., Synthesis and Characterization of Water-Soluble Silk Peptides and Recombinant Silk Protein Containing Polyalanine, the Integrin Binding Site, and Two Glutamic Acids at Each Terminal Site as a Possible Candidate for Use in Bone Repair Materials, Biomacromolecules, 14(10), 3731-3741 (2013)
2013_Biomacromorecules14_3731
3. Aytemiz, D.; Sakiyama, W.; Suzuki, Y.; Nakaizumi, N.; Tanaka, R.; Ogawa, Y.; Takagi, Y.; Nakazawa, Y.; Asakura, T., Small-diameter knitted silk vascular grafts (3mm diameter) with a double-raschel knitted silk tube coated with silk fibroin sponge, Adv. Healthcare Mater., 2, 361-368 (2013)
2013_AdvHealthcareMater2_361
4. Asakura, T.; Okonogi, M.; Horiguchi, K.; Aoki, A.; Saito, H.;Knight D.P.; Williamson M.P.; Two Different packing arrangements of antiparallel polyalanine, Angew.Chem.Int. Edit., 51, 1212-1215 (2012).
2012_Andewandte_Chemi51_1212
5. Nagano, A.; Sato, H.; Tanioka, Y.; Nakazawa, Y.; Knight,D.P.; Asakura, T.; Characterization of a Ca binding-amphipathic silk-like protein and peptide with the sequence, (Glu)8(Ala-Gly-Ser-Gly-Ala-Gly)4 with potential for bone repair, Soft Matter, 8, 741-748 (2012).
2012_SoftMatter8_741
6. Asakura, T.; Nishi, H.; Nagano, A.; Yoshida, A.; Nakazawa, Y.; Kamiya, M.; Demura,M.; NMR analysis of the fibronection cell-adhesive sequence, Arg-Gly-Asp, in a recombinant silk-like protein and a model peptide, Biomacromolecules, 12, 3910-3916 (2011).
2011_Biomacromolecules12_3910
7. Nagano, A.; Tanioka, Y.; Sakurai, N.; Sezutsu, H.; Kuboyama, N.; Kiba, H.; Tanimoto, Y.; Nishiyama, N.; Asakura, T.; Regeneration of the femoral epicondyle on calcium-binding silk scaffolds developed using transgenic silk fibroin produced by transgenic silkworm, Acta Biomaterialia , 7, 1192-1201 (2011) .
2011_ActaBiomaterialia7_1192
8. Yagi, T.; Sato, M.; Nakazawa, Y.; Tanaka, K.; Sata, M.; Itoh, K.; Takagi, Y.; Asakura, T.; Preparation of double-raschel knitted silk vascular grafts and evaluation of short-term function in a rat abdominal aorta, J. Artif. Organs, 14, 89-99 (2011)
2011_JArtifOrgans14_89
9. Nakazawa, Y.; Sato, M.; Takahashi, R.; Aytemiz, D.; Takabayashi, C.; Tamura, T.; Enomoto, S.; Sata, M.; Asakura, T.; Development of Small-Diameter Vascular Grafts Based on Silk Fibroin Fibers from Bombyx mori for Vascular Regeneration, J. Biomat. Sci-Polym. E., 22, 195-206 (2011)
2011_JBiomaterialsScience22_195
10. Enomoto, S.; Sumi, M.; Kajimoto, K.; Nakazawa, Y.;Takahashi, R.; Takabayashi, C.; Asakura, T.; Sata, M.; Long-term Patency of Small-diameter Vascular Graft Made from Fibroin, a Silk-based Biodegradable Material, J. Vasc. Surg., 51, 155-164 (2010)
2010_JVascSurg51_155

アンケート調査（2014年）/信州大学繊維学部Fii