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E-brochureMolecular and Cellular Immunology

Master's Program Human Sciences, Graduate School of Medicine
Doctor's Program Medical Science Division, Department of Medical Science, Graduate School of Medicine, Science and Technology

Staff List

Associate Professor SANJO Hideki

Summary of Activity

One of our body's activities essential to live healthy is the immune system. This system has to work properly, and with too weak immunity we are vulnerable to infections and cancers, while too strong immunity leads to allergies and autoimmune diseases. In order to understand how the immune system works, our laboratory pursues the mechanisms by which to generate various cells in the immune system and to make them work appropriately. These studies will contribute to the prevention and cure of various diseases.

Research Subject

  • ・Transcription factors for switching various genes in immune cells on/off in a timely fashion.
  • ・ Signal transduction molecules that convey various intracellular signals for the functions of immune cells.

Outlook for Research

Today, in the field of immunology, growing numbers of new therapies are brought forth for cancers and immune-related diseases such as rheumatoid arthritis. Also uncovered recently is the contribution of the immune system to the regulation of good relationship between our health and bacteria living in the gut and skin. Deeper understanding of the immune system will hence provide us with valuable hints on not only improvement of disease diagnosis and therapies, but also better life styles to keep ourselves healthy.

Major Publications

1. Sanjo H, Tokumaru S, Akira S, Taki S. (2015) Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCRαβ+ Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis. PLoS One,10(7):e0128761.

2. Minamoto K, Takahara K, Adachi T, Nagaoka K, Iyoda T, Taki S, Inaba K (2012) IRF-2 regulates B cell proliferation and antibody production through distinct mechanisms. Int Immunol. 24(9):573-581

3. Notake T, Horisawa S, Sanjo H, Miyagawa S, Hida S, Taki S. (2012) Differential requirements for IFN regulatory factor-2 in generation of CD1d-independent T cells bearing NK cell receptors. J. Immunol. 188: 4838-4845.

4. Yoshizawa K, Nakajima S, Notake S, Miyagawa S, Hida S, Taki, S (2011) IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/- mice. J. Immunol.187: 5162-5169.

5. Hida, S,. Yamasaki, S., Sakamoto, Y., Takamoto, M., Obata, K., Takai, T., Karasuyama, H., Sugane, K., Saito, T., Taki, S. (2009) Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nature Immunol. 10:214-222.

6. Nakajima, S., Hida, S. and Taki, S. (2008) IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1+B220+ NK cells. Biochem. Biophys. Res. Commun.369:1139-1143.

7. Arakura, F., Hida, S., Ichikawa, E., Yajima, C., Nakajima, S., Saida, T. and Taki., S.(2007) Genetic control directed towards spontaneous IFN-α/β responses and downstream IFN-γ expression influences the pathogenesis of a murine psoriasis-like skin disease. J. Immunol. 179 (17):3249-3257.

8. Hida, S., Tadachi, M., Saito, T. and Taki, S. (2005) Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood 106 (6): 2011-2017.

9. Taki, S., Nakajima, S., Ichikawa, E., Saito, T. and Hida, S. (2005) IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral natural killer cells. J. Immunol. 174: 6005-6012.

10. Ichikawa, E., Hida, S., Omatsu, Y., Shimoyama, S., Takahara, K., Miyagawa, S., Inaba, K., and Taki, S. (2004) Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for interferon regulatory factor-2. Proc. Natl. Acad. Sci., U.S.A.101:3909-3914.

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