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Pathology

Staff List

Professor KANNO Hiroyuki
Senior Assistant Professor SHIMOJO Hisashi

Summary of Activity

Our research goal is to elucidate molecular basis of human diseases such as cancer and chronic inflammation. To this end we are examining human pathologic specimens as well as animal models using a variety of analytical techniques including light microscopy, electron microscopy, molecular biology, biochemistry, cellular biology, microbiology, and immunology. We are also involved in diagnostic pathology service in University Hospital including surgical pathology, cytology, and autopsy. Furthermore, we are also engaged in the diagnosis of renal biopsy specimens from allied hospitals in Nagano prefecture.

Research Projects

Ongoing projects in our laboratory are as follows:
*Alteration of immune functions in Epstein-Barr virus (EBV) infection
*Mechanisms of the development of EBV-associated tumors
*Role of immunological mediators in the development of glomerulonephritis, vasculitis, and collagen diseases.
*Role of inflammatory mediators in oncogenesis.

Major Publications

1. Yoshino N, Endo M, Kanno H, Matsukawa N, Tsutsumi R, Takeshita R, Sato S. Polymyxins as novel and safe mucosal adjuvants to induce humoral immune responses in mice. PLoS One 8:e61643, 2013.

2. Shimojo H, Kobayashi M, Kamigaito T, Shimojo Y, Fukuda M, Nakayama J. Reduced glycosylation of α-dystroglycans on carcinoma cells contributes to formation of highly infiltrative histological patterns in prostate cancer. Prostate 71:1151-1157, 2011.

3. Kanno H, Segawa T, Miura Y, Miyata M, Yoshida A, Nakamura M, Sawai T. Systemic sclerosis presented as congestive heart failure: an autopsy case. Mod Rheumatol 21:423-427, 2011.

4. Kaneyama T, Kobayashi S, Aoyagi D, Ehara T. Tranilast modulates finrosis, epithelial-mesenchymal transition and peritubular capillary injury in unilateral ureteral obstruction rats. Pathology 42:564-573, 2010.

5. Yamamoto Y, Usuda N, Oghiso Y, Kuwahara Y, Fukumoto M. The uneven irradiation of a target cell and its dynamic movement can mathematically explain incubation perioid for the induction of cancer by internally deposited radionuclides. Health Physics 99:388-393, 2010.

6. YamamotoY, Chikawa J, Uegaki Y, Usuda N, Kuwahara Y, Fukumoto M. Histological type of Thorotrast-induced liver tumors associated with the translocation of deposited radionuclides. Cancer Sci 101:336-340, 2010.

7. Yoshino,N, Fujihashi K, Hagiwara Y, Kanno H, Takahashi K, Kobayashi R, Inaba N, Noda M, Sato S. Co-administration of cholera toxin and apple polyphenol extract as a novel and safe mucosal adjuvant strategy. Vaccine 27:4808-4817, 2009.

8. Watabe D, Kanno H, Inoue-Narita T, Onodera H, Izumida W, Kowata S, Sawai T, Akasaka T. A case of primary cutaneous natural killer/T-cell lymphoma, nasal type, with indolent clinical course: monoclonal expansion of Epstein-Barr virus genome correlating with the terminal aggressive behavior. Br J Dermatol 160:205-207, 2009.

9. Kanno H, Watabe D, Shimizu N, Sawai T. Adhesion of Epstein-Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines. Clin Exp Immunol 151:519-527, 2008.

GRADUATE
  • Master's Program
  • Human Sciences
  • Health Sciences (Master's Program)
  • Master's Curriculum Outline
  • Doctor's Program
  • Medical Sciences
  • Bio-regulation
  • Oncology
  • Regeneration and Reconstruction
  • Brain and Sensory Functions
  • Health and Social Medicine
  • Institute of Pathogenesis and Disease Prevention
  • Health Sciences (Doctor's Program)
  • Doctoral Curriculum Outline
  • Join us in Shinshu Med. School, NAGANO
  • Short-term Elective Training for Foreign Medical Students
  • Shinshu University
  • GET Global Education Center
  • List of Universities with Partnership Agreements