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Staff List

Professor OKUYAMA Ryuhei
Associate Professor HAYASHI Koichi
Senior Assistant Professor KINIWA Yukiko, KOGA Hiroshi
Assistant Professor OGAWA Eisaku, ASHIDA Atsuko, SATO Yuki


E-mail : derma(at)
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Summary of Activity

Research in the Department of Dermatology centers on melanoma.

Research Projects

The major themes in the laboratory are:
Dermoscopy: Dermoscopy is a noninvasive method, which enhances our diagnostic ability of pigmented skin lesions. We are the first to report the characteristic dermoscopic patterns of melanocytic lesions on acral volar skin. We are now establishing a simple but effective algorithm for management of pigmented lesions on acral volar skin based on dermoscopic patterns.
Acral melanoma: Acral melanoma is a unique type of cutaneous melanoma, which is most prevalent in non-Caucasian populations, such as the Japanese. We are investigating molecular and biological characteristics of acral melanoma. The studies include the establishment of novel acral melanoma cell lines and defining signal transduction pathways that are constitutively activated in acral melanomas.
Genetic diagnosis of melanocytic tumors: Histopathological diagnosis of melanocytic tumor can be very difficult. We are trying to establish an adjunctive diagnostic system for melanocytic neoplasms by using gene sequence, FISH and multiplex ligation-dependent probe amplification.
Histogenesis of melanocytic nevus: Melanocytic nevus is the most common benign neoplasm in humans. We are investigating the histogenesis of melanocytic nevus by using BRAF gene mutations as a molecular marker. We are now doing clonality analysis of acquired melanocytic nevus.

Major Publications

1. Uhara H, Ashida A, Koga H, Uchiyama A, Uchiyama R, Hayashi K, Kiniwa Y, Okuyama R. NRAS mutations in primary and metastatic melanomas of Japanese patients. Int J Clin Oncol in press.

2. Minagawa A, Koga H, Uhara H, Yoshiharu Yokokawa Okuyama R. Age-related prevalence of dermoscopic patterns in acquired melanocytic nevus on acral volar skin. JAMA Dermatol in press.

3. Uhara H, Saiki M, Kawachi S, Ashida A, Oguchi S, Okuyama R.  Clinical courses of drug-induced hypersensitivity syndrome treated without systemic corticosteroids. J Eur Acad Derm Venereol 27: 722-726, 2013.

4. Ishikawa Y, Hosogane M, Okuyama R, Aoyama S, Onoyama I, Nakayama K, Nakayama K.  Opposing functions of Fbxw7 in keratinocyte growth-differentiation and skin tumorigesis mediated through negative regulation of c-Myc and Notch. Oncogene 32: 1921-1932, 2013.

5. MiyakeT, Ogawa E, Mikoshiba Y , Kobayasi A, Hosoe H, Kashiwabara S, Uhara H, Owada Y, Okuyama R. Epidermal-type FABP is a predictive marker of clinical response to systemic treatment and ultraviolet therapy in psoriatic skin lesions. J Dermatol Sci, 68:199-202, 2012.

6. Sakaizawa K, Goto Y, Kiniwa Y, Uchiyama A, Harada K, Shimada S, Saida T, Ferrone S, Takata M, Uhara H, Okuyama R. Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level. Br J Cancer, 106:939-946, 2012.

7. Ashida A, Uhara H, Kiniwa Y, Oguchi M, Murata H, Goto Y, Uchiyama A, Ogawa E, Hayashi K, Koga H, Okuyama R. Assessment of BRAF and KIT mutations in Japanese melanoma patients. J Dermatol Sci, 66:240-242, 2012.

8. Hayashi K, Uhara H, Koga H, Okuyama R, Saida T. Surgical treatment of nail apparatus melanoma in situ: The use of artificial dermis in reconstruction. Dermatol Surg 38: 692-694, 2012.

9. Ogawa E, Owada Y, Ikawa S, Adachi Y, Egawa T, Nemoto K, Suzuki K, Hishinuma T, Kawashima H, Kondo H, Muto M, Aiba S, Okuyama R. Epidermal FABP (FABP5)  regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. J Invest Dermatol, 131:604-612, 2011.

10. Uhara H, Kamijo F, Okuyama R, Saida T. The open pores with plugs in porokeratosis clearly visualized with the dermoscopic furrow ink test: Report of 3 cases. Arch Dermatol 147: 866-868, 2011.

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