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Urology (Clinical Urologic and Pharmacologic Research)

Staff List

Professor ISHIZUKA Osamu
Associate Professor OGAWA Teruyuki
Senior Assistant Professor MINAGAWA Tomonori
Assistant Professor IMAMURA Tetsuya, OGAWA Noriyuki, NAGAI Takashi , DOUMEN Takahisa


E-mail : urology(at)
※ Change (at) to @ when you send an e-mail.

Summary of Activity

We perform minimal invasive surgery, especially robotic, laparoscopic and laser surgery for benign prostatic hypertrophy and urolithiasis, and improving the operation technique day by day. We have the good transplantation result with the collaboration of physicians. We also have the high level of basic tissue engineering of lower urinary tract, we will be able to apply into the clinical field near future. Our department is famous for its long traditional high research level for Neurourology. Our department is the urological cancer center in Nagano prefecture.

Research Projects

1, The research of new drugs and new treatments for lower urinary dysfunction (difficulty, frequency, incontinence).

2, Tissue engineering of lower urinary tract (bladder, urethral sphincter) using bone-marrow stem cells, adipose-tissue derived stem cell and stem cell sheets.



3, Epidemiology and clinical trials of renal cancer and prostate cancer in Nagano prefecture.

4, Study for good operation techniques for renal transplantation.

5, Skill up study for robotic surgery, laparoscopic surgery and laser surgery.



Major Publications

1. Sudha, G.S., Imamura, T., Ishizuka, O., Zhang, L., Yamagishi, T., Yokoyama, H., Minagawa, T., Ogawa, T., Kurizaki, Y., Kato, H., Nishizawa, O.: Implantation of autologous adipose-derived cells reconstructs functional urethral sphincters in rabbit cryo-injured urethra. Tissue Eng. Part A. 2014 Mar 25 [Epub ahead of print]

2. Imamura, T., Ishizuka, O., Ogawa, T., Yamagishi, T., Yokoyama, H., Minagawa, T., Nakazawa, M., Sudha,S.G., Nishizawa, O.: Muscarinic receptors mediate cold stress-induced detrusor overactivity in type 2 diabetes mellitus rats. IJU 2014 May 8. Doi: 10.1111/iju.12475.[Epub ahead of print]

3. Suzuki,H., Suzuki,T., Ishizuka,O., Nishizawa, O., Ueno,M. (2014) Efficacy and safety of advanced renal cell carcinoma patients treated with sorefenib: roles of cytokine pretreatment. I.J.Clin.Oncol. 19: 686-692.

4. Ishizuka, O., Nishizawa, O., Nishizawa, S., Satoh, T., Wajiki, M., Kiyokawa, H., Inoue, Y., Kobayashi, S., Mizusawa, H., Nakagawa, T. (2013) Comparison of efficacy and safety of one- and three-month luteinizing hormone-releasing hormone agonist depots as initial therapies for prostate cancer. I.J.Clin.Oncol. 18: 524-530.

5. Kurizaki, Y., Ishizuka, O., Imamura, T., Nishizawa, O., Andersson,K.-E. (2013)  Relationship between expression of 3-adrencoceptor mRNA in bladder mucosa and urodynaic findings in men with lower urinary tract symptoms. Neurourol. Urodyn. 32: 88-91.

6. Ishizuka, O., Matsuyama, H., Sakai, H., Matsubara, A., Nagaoka, A., Takahashi, S., Takeda, M., Ozono,S., Shiroki,R., Shuin, T., Hara, I., Kakizaki, H., Tsukamoto, T., Yamanishi, T., Yokoyama, O., Kakehi, Y., Nishizawa, O. (2013) Nocturia potentially influences maintenance of sexual function in elderly men with benign prostatic hyperplasia. LUTS 5(2): 75-81.

7. Imamura, T., Ishizuka, O., Sudha, G.S., Lei, Z., Hosada, T., Noguchi, W., Yamagishi, T., Kurizaki, Y., Nishizawa, O. (2013) A galenical produced from Ba-Wei-Huang-Wan (THC-002) provide resistance to the cold stress-induced detrusor overactivity in conscious rats. Neurourol. Urodyn. 32:486-492.

8. Lei, Z., , Ishizuka, O., Imamura , T., Noguchi, Q., Yamagishi , T., Yokoyama, H., Kurizaki, Y., Sudha, G.S., Hosoda, T., Nishizawa, O., Andersson, K.E (2013) Functional roles of transient receptor potentila melastatin 8 (TRPM8) in the cold stress-induced detrusor overactivity pathways in conscious rats. Neurourol. Urodyn. 32:500-504.

9. Noguchi,W., Ishizuka,O., Imamura, T., Kurizaki, Y., Yamagishi, T., Yokoyama, H., Zhang, L., Sudha, GS, Nishizawa,O., Andersson,KE (2013) The relationship between alpha1-adrenergic receptors and TRPM8 channels in detrusor overactivity induced by cold stress in ovariectomized rats. J.Urol. 189(5): 1975-1981.

10.Imamura, T., Ishizuka, O., Zhang, L., Hida, S., Sudha, G.S., Kato, H., Nishizawa, O. (2012) Bone marrow-derived cells implanted into radiation-injured urinary bladders reconstructe functional bladder tissues in rats. Tissue Eng Part A. 18(15-16): 1698-709.

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