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Medicine(Rheumatology, Clinical Immunology)

Staff List

Associate Professor SEKIJIMA Yoshiki, SHIMOJIMA Yasuhiro
Senior Assistant Professor KATO Nagaaki, MIYAZAKI Daigo, HINENO Akiyo
Assistant Professor KISHIDA Dai, KODAIRA Minori

Contact

E-mail : sannai(at)shinshu-u.ac.jp
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Summary of Activity

Our department has the purpose of developing practical therapeutic strategies and investigating the pathogenic mechanisms in the field of neurology, rheumatology and clinical immunology. We also have been working on the clinical and basic researches in metabolic disorders and amyloidosis. We are additionally managing the general medicine at Shinshu University Hospital. These performances of clinical practice and research in our department are not only focusing on elucidating the pathogenesis of intractable disorders associated with neurology, clinical immunology, metabolic disease and amyloidosis, but also playing an important role of fostering a hopeful medical scientist.

Research Projects

Our research interests are as follows :

1) Elucidation of pathophysiology in cerebrovascular disease.

2) High-dose intravenous administration of melphalan with autologous peripheral blood stem cell transplantation for primary AL amyloidosis patients.

3) Improvement of the therapeutic approach to intractable neuroimmunological disorders.

4) Gene diagnosis of hereditary spinocerebellar degeneration.

5) Establishment of new therapeutic approach and gene diagnosis for muscular dystrophy.

6) Elucidation of pathophysiology in neurological disorders using neurophysiological examination.

7) Liver transplantation and new drug therapies for familial amyloid polyneuropathy patients.

8) Establishment of therapeutic approaches to adult-onset citrullinemia patients.

9) Gene diagnosis and immunological investigation of familial Mediterranean fever.

10) Biopharmaceutical therapy for visceral disorders associated with rheumatoid arthritis.

11) Establishment of new therapeutic strategy with immunosuppressive agents for intractable dermatomyositis.

12) Elucidation of immunological mechanisms in autoimmune diseases using flow cytometry analysis.


Fig.1 Cerebral angiography



Fig.2 Myelography


Major Publications

1. Nakagawa M, Sekijima Y, Tojo K, Ikeda S. High prevalence of ATTR amyloidosis in endomyocardial biopsy-proven cardiac amyloidosis patients. Amyloid 2013;20:138-140.

2. Tachibana N, Kinoshita M, Saito Y, Ikeda S. Identification of the N-methyl-D   -aspartate receptor (NMDAR)-related epitope, NR2B, in the normal human ovary: implication for the pathogenesis of anti-NMDAR encephalitis. Tohoku J Exp Med 2013;230:13-16. 
 
3. Naito K, Fukushima K, Suzuki S, Kuwahara M, Morita H, Kusunoki S, Ikeda S. Intravenous immunoglobulin (IVIg) with methylpredonisolone pulse therapy for motor impairment of neuralgic amyotrophy: clinical observations in 10 cases. Intern Med 2012;51:1493-1500.

4. Ikeda S, Sekijima Y, Tojo K, Koyama J. Diagnostic value of abdominal wall fat biopsy in senile systemic amyloidosis. Amyloid 2011;18:211-215.

5. Sekijima Y, Uchiyama S, Tojo K, Sano K, Shimizu Y, Imaeda T, Hoshii Y, Kato H, Ikeda S. High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly. Hum Pathol 2011;42:1785-1791.

6. Kodaira M, Morita H, Shimojima Y. Ikeda S. Electrophysiological features of familial amyloid polyneuropathy. Amyloid 2011;18:10-18.

7. Tsuchiya-Suzuki A, Yazaki M, Kametani F, Sekijima Y, Ikeda SI. Wild-type trans-thyretin significantly contributes to the formation of amyloid fibrils in familial amyloid polyneuropathy with amyloidogenic transthyretin Val30Met. Hum Pathol 2011;42:236-243.

8. Ikeda S, Sekijima Y, Tojo K, Koyama J. Diagnostic value of abdominal wall fat biopsy in senile systemic amyloidosis. Amyloid 18: 211-215, 2011.

9.Tsuchiya-Suzuki A, Yazaki M, Kametani F, Sekijima Y, Ikeda S. Wild-type transthyretin significantly contributes to the formation of amyloid fibrils in familial amyloid polyneuropathy patients with amyloidogenic transthyretin Val30Met. Hum Pathol 42:236-243, 2011.

10. Kodaira M, Morita H, Shimojima Y, Ikeda S. Electrophysiological features of familial amyloid polyneuropathy in endemic area. Amyloid 18:10-18, 2011.


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