graduate image

E-brochureMedicine (Gastroenterology, Nephrology)

Master's Program Human Sciences, Graduate School of Medicine
Doctor's Program Medical Science Division, Department of Medical Science, Graduate School of Medicine, Science and Technology

Staff List

Professor UMEMURA Takeji
Associate Professor KAMIJO Yuji (Nephrology), JOSHITA Satoru (Gastroenterology), NAGAYA Tadanobu (Gastroenterology), IWAYA Yugo (Gastroenterology)
Senior Assistant Professor HASHIMOTO Koji (Nephrology)
Assistant Professor KIMURA Takefumi (Gastroenterology), OGUCHI Takaya (Gastroenterology), OKAMURA Takuma (Gastroenterology)


E-mail : yujibeat(at)
※ Change (at) to @ when you send an e-mail.

Summary of Activity

Our gastroenterology, nephrology divisions perform clinical treatment, education, and research to create generations of skilled clinicians. During training, students and residents learn to act as valuable members of the medical team. In clinical practice, we make the medical environment bright and provide a sense of accomplishment.

The division of gastroenterology is divided into the liver, stomach and intestine, and biliary tract and pancreas teams. Each team provides specialized medical treatment to people in need.The division of nephrology concentrates on not only kidney transplantation, but also the treatment of nephritis and blood purification therapy. Together, we perform research in key fields that are decided by each study group. We strive to share our ideas, skills, and research findings to the world.


1. Gastroenterology: Liver
2. Gastroenterology: Stomach and intestine
3. Gastroenterology: Biliary tract and pancreas
4. Nephrology

Major Publications

1. Umemura T, Zen Y, Hamano H, Kawa S, Nakanuma Y, Kiyosawa K: Immunoglobin G4-hepatopathy: association of immunoglobin G4-bearing plasma cells in liver with autoimmune pancreatitis. Hepatology 46: 463-471, 2007.

2. Kamijo Y, Hora K, Nakajima T, Kono K, Takahashi K, Ito Y, Higuchi M, Kiyosawa K, Shigematsu H, Gonzalez FJ, Aoyama T: Peroxisome proliferator-activated receptor alpha protects against glomerulonephritis induced by long-term exposure to the plasticizer di-(2-ethylhexyl)phthalate. J Am Soc Nephrol 18:176-188, 2007.

3. Kamijo Y, Hora K, Kono K, Takahashi K, Higuchi M, Ehara T, Kiyosawa K, Shigematsu H, Gonzalez FJ, Aoyama T: PPARalpha protects proximal tubular cells from acute fatty acid toxicity. J Am Soc Nephrol 18:3089-3100, 2007.

4. Joshita S, Umemura T, Yoshizawa K, Katsuyama Y, Tanaka E, Nakamura M, Ishibashi H, Ota M. Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients. J Hepatol 53:537-41. 2010.

5. Nagaya T, Tanaka N, Suzuki T, Sano K, Horiuchi A, Komatsu M, Nakajima T, Nishizawa T, Joshita S, Umemura T, Ichijo T, Matsumoto A, Yoshizawa K, Nakayama J, Tanaka E, and Aoyama T. Down-regulation of SREBP-1c is associated with the development of burned-out NASH. J. Hepatol. 53: 724-731, 2010.

6. Umemura T, Joshita S, Ichijo T, Yoshizawa K, Katsuyama Y, Tanaka E, Ota M. Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis. Hepatology 55:506-11. 2012.

7. Umemura T, Joshita S, Sekiguchi T, Usami Y, Shibata S, Kimura T, Komatsu M, Matsumoto A, Ota M, Tanaka E. Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein Level Predicts Liver Fibrosis and Prognosis in Primary Biliary Cirrhosis. Am J Gastroenterol 110:857-64. 2015.

8. Sato K, Sato N, Xu B, Nakamura Y, Nagaya T, Choyke PL, Hasegawa Y, Kobayashi H. Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy. Sci Transl Med. 8: 352ra110, 2016.

9. Nani RR, Gorka AP, Nagaya T, Yamamoto T, Ivanic J, Kobayashi H, Schnermann MJ. In Vivo Activation of Duocarmycin-Antibody Conjugates by Near-Infrared Light. ACS Cent Sci. 3: 329-337, 2017.

10. Song WM, Joshita S, Zhou Y, Ulland TK, Gilfillan S, Colonna M. Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism. J Exp Med 215:745-760. 2018.

11. Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science 359:1269-1273. 2018.

12. Kawakami T, Sekiguchi N, Kobayashi J, Imi T, Matsuda K, Yamane T, Nishina S, Senoo Y, Sakai H, Ito T, Koizumi T, Hirokawa M, Nakao S, Nakazawa H, Ishida F. Blood Adv. 23:2704-12, 2018.

  • Join us in Shinshu Med. School, NAGANO
  • Short-term Elective Training for Foreign Medical Students
  • Shinshu University
  • GET Global Education Center
  • List of Universities with Partnership Agreements