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Ophthalmology (Pathogenesis of ocular neovascular diseases)

Staff List

Professor MURATA Toshinori
Senior Assistant Professor KUROKAWA Toru, MIYAHARA Teruyoshi
Assistant Professor YOSHIDA Noriko, TOKIMITSU Motoharu

Contact

E-mail : murata(at)shinshu-u.ac.jp
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Summary of Activity

Department of Ophthalmology consists of about 20 ophthalmologists and researchers. The main topic of the research is to elucidate the pathogenesis of ocular diseases such as diabetic retinopathy and age related macular degeneration. Using oxygen induced neovascularization model and various transgenic or knock out mice, we investigate the mechanisms of retinal edema, retinal and chorodial neovascularization. We also perform in vitro studies such as real time PCR, western blotting and proteomics.

Major Publications

1. Y Iesato, Y Toriyama, T Sakurai, Y Shindo, H Kawate, T Yoshizawa, T Koyama, R Uetake, L Yang, A Yamauchi, M Tanaka, K Igarashi, T Murata, T Shindo
Adrenomedullin-RAMP2 System is Crucially Involved in Retinal Angiogenesis
Am J Pathol. 182(6) 2380-2390 2013

2. Yuuka Yamamoto, Youichiro Yamamoto, Atsushi Marugame, Maki Ogura, Akira Saito, Kouichi Ohta, Manabu Fukumoto, Toshinori Murata
Age-Related Decrease of the Retinal Vasculature Area Identified with a Novel Computer-aided Analysis System
Tohoku J. Exp. Med. 228: 229-237 2012

3. Toshinori Murata, Wataru Kikushima, Akira Imai, Yuichi Toriyama, Motoharu Tokimitsu, Toru Kurokawa
Tissue-type plasminogen activator-assisted drainage of suprachoroidal hemorrhage showing a kissing configuration
Jpn J Ophthalmol 55:431-432, 2011

4. Tomoko Nakamura-Yanagidaira, Yasuko Takahashi, Kenji Sano, Toshinori Murata, Takuma Hayashi
Development of spontaneous neuropathy in NF-kBp50-deficient mice by calcineurin-signal involving impaired NF-kB activation
Molecular Vision 17:2157-2170, 2011

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