Medicine (Diabetes, Endocrinology and Metabolism）

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Summary of Activity

The medical care required in the world is changing from "to cure diseases" to "to make people not get illness". The Diabetes and life style related disease which continue to be spread all over the world can become trigger to many serious diseases. We encourage basic and clinical research in order to contribute to realize the extension of healthy life span. And we are also conducting endocrinological reserch actively connecting to life style related disease.

Research Subject

• ・Investigation into mechanism of secretion of insulin hormone.
• ・Relations between thyroid hormone and life style related disease.
• ・Investigation of trend of blood glucose level using artificial pancreas.
• ・Development of an apparatus to measure blood glucose level with ray beam. (in collaboration with SEIKO EPSON corporation)

Outlook for Research

To research pathology of diabetes, endocrinology and metabolism can lead to establishment of cause-based rather than symptomatic treatment, and this will open the gate of a hopeful future where people will be all healthy and live long.

Major Publications

1. Komatsu M, Watada H, Kaneko S, Ross Agner BF, Nishida T, Kaku K. J Efficacy and safety of the fixed-ratio combination of insulin degludec and liraglutide by baseline glycated hemoglobin, body mass index and age in Japanese individuals with type 2 diabetes: A subgroup analysis of two phase III trials. J Diabetes Investig. 2021 Sep;12(9):1610-1618

2. Sekido K, Sekido T, Ohkubo Y, Shibata Y, Kawata I, Yamaguchi T, Sato A, Sato Y, Komatsu M. Exploring hidden atrial fibrillation in patients with type 2 diabetes mellitus admitted to Shinshu University Hospital. Shinshu Med J. 2021 69(2):75-81

3. Komatsu M, Ekelund M, Horio H, Kadowaki T. Efficacy and safety of fast-acting insulin aspart compared with insulin aspart in combination with insulin degludec in Japanese adults with type 1 diabetes: a subgroup analysis of the randomized onset 8 trial. Endocr J. 2021 Apr 28;68(4):429-440

4. Shibata Y, Yamazaki M, Kitahara J, Okubo Y, Oiwa A, Sato A, Komatsu M. Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes. Medicine (Baltimore) 100: e27420, 2021.

5. Asano Y, Koshi T, Sano A, Maruno T, Kosaka M, Yamazaki Y, Oiwa A, Nishii Y. A patient with mild respiratory COVID-19 infection who developed bilateral non-hemorrhagic adrenal infarction. Nagoya J Med Sci. 2021 Nov;83(4):883-891.

6. Shimada Y, Nakasone Y, Hirabayashi K, Sakuma T, Koike H, Oguchi T, Yamashita K, Uchimido R, Moriya T, Komatsu M, Aizawa T. Development of glomerular hyperfiltration, a multiphasic phenomenon. Am J Physiol Renal Physiol. 2020 Dec 1;319(6):F1037-F1041

7. Kitahara J, Ohkubo Y, Kitajima K, Nishio S, Oiwa A, Sato A, Yamazaki M, Sakuma T, Sano A, Nishii Y, Komatsu M. Aldosterone to Potassium Ratio after Adrenocorticotropin Stimulation in Unilateral Primary Aldosteronism Diagnosis. Shinshu Med J. 2020 68 (3):159-168

8. Watada H, Kaneko S, Komatsu M, Agner BR, Nishida T, Ranthe M, Nakamura J. Superior HbA1c control with the fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with a maximum dose of 50 units of insulin degludec in Japanese individuals with type 2 diabetes in a phase 3, double-blind, randomized trial. Diabetes Obes Metab. 2019 Dec;21(12):2694-2703.

9. Ohkubo Y, Sekido T, Nishio SI, Sekido K, Kitahara J, Suzuki S, Komatsu M. Loss of μ-crystallin causes PPARγ activation and obesity in high-fat diet-fed mice. Biochem Biophys Res Commun. 2019 Jan 15;508(3):914-920

10. Oiwa A, Minemura K, Nishio SI, Yamazaki M, Komatsu M. Implications of thyroid autoimmunity in infertile women with subclinical hypothyroidism in the absence of both goiter and anti-thyroid antibodies: lessons from three cases. Endocr J. 2019 Feb 28;66(2):193-198

11. Sato A, Takei M, Hiramatsu K, Takeda T, Miyamoto T, Yamazaki M, Sato Y, Komatsu M. Effects of Sitagliptin on Pancreatic Beta-Cells in Type 2 Diabetes With Sulfonylurea Treatment: A Prospective Randomized Study. J Clin Med Res. 2019 Jan;11(1):15-20

12. Sekido T, Nishio S, Ohkubo Y, Sekido K, Kitahara J, Miyamoto T, Komatsu M. Repression of insulin gene transcription by indirect genomic signaling via the estrogen receptor in pancreatic beta cells. In Vitro Cell Dev Biol Anim. 2019 Apr;55(4):226-236