1995-2009年 業績（原著論文・総説・著書）
【2009年】
・ Benoit BN, Kobayashi M, Kawakubo M, Takeoka M, Sano K, Zou J, Itano N,
Tsutsui H, Noda T, Fukuda M, Nakayama J, Taniguchi S.
Role of ASC in the Mouse Model of Helicobacter pylori Infection.
J.Histochem & Cytochem.271:327-338, 2009
・ Sagara J, Arata T, Taniguchi S
Scapinin, the Protein Phosphatase 1 Binding Protein, Enhances Cell Spreading and
Motility by Interacting with the Actin Cytoskeleton
ＰLｏｓ ONE 4(1):e4247, 2009
・ Imamura M, Tsutsui H, Yasuda K, Yumikura-Futatsugi S, Mitani K, Uchiyama R,
Hayashi S, Akira S, Taniguchi S, Nico Van Rooijen, Jurg Tschopp, Yamamoto T,
Fujimoto J, Nakanishi K.
Contribution of TIR domain-containing adapter inducing IFN-β mediated IL-18
Release to LPS-induced liver injury in mice.
J. Hepatol. 51:333-341, 2009
・ Matsushita K, Takeoka M, Sagara J, Itano N, Kurose Y, Nakamura A,
Taniguchi S.
A Splice Variant of ASC Regulates IL-1β Release and Aggregates Differently
from Intact ASC.
Mediators Inflamm. 2009;2009:287387. Epub 2009
・ Takano H, Nakazawa S, Shigero T, Furuta K, Tsuchiya S, Morimoto K, Itano N,
Irie A, Ichikawa A, Kimata K, Nakayama K.
Involvement of CD44 in mast cell proliferation during terminal
differentiation.
Lab Invest. Apr;89(4):446-55. Epub 2009
・ Hirayama Y, Yoshimura M, Ozeki Y, Sugawara I, Udagawa T, Mizuno S, Itano N,
Kimata K, Tamaru A, Ogura H, Kobayashi K, Matsumoto S.
Mycobacteria Exploit Host Hyaluronan for Efficient Extracellular Replication.
PLoS Pathog. 2009 Oct;5(10):e1000643. Epub 2009
・ Hida S, Yamasaki S, Sakamoto Y, Takamoto M, Obata K, Takai T, Karasuyama H,
Sugane K, Saito T , Taki S.
Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-
induced IL-4 production in basophils.
Nature Immunol. 10:214-222, 2009
・ Hu T, Takamoto M, Hida S, Tagawa YI, Sugane K.,
IFN-γ deficiency worsen Pneumocystis pneumonia with Th17 development in nude mice.
Immunol Lett. 127(1), 55-59, 2009
・ 谷口俊一郎
嫌気性菌を用いた固形癌の治療
実験医学 27（2）（増刊）：191-196, 2009
・ 谷口俊一郎
腸内細菌を用いたがん治療の可能性
日本臨床腸内微生物学会誌 第11巻 第1号,2009
【2008年】
・ Ohta S, Taniguchi S, et al
Metastasis-associated gene expression profile of liver and subcutaneous lesions
derived from mouse pheochromocytoma cells.
Mol Carcinog.47:245-251, 2008
・ Koyama H, Kobayashi N, Harada M, Takeoka M, Kawai Y, Sano K, Fujimori M,
Amano, J., Ohhashi, T., Kannagi, R., Kimata, K., Taniguchi, S., and Itano, N.
Significance of Tumor-Associated Stroma in Promotion of Intratumoral
Lymphangiogenesis: Pivotal Role of a Hyaluronan-Rich Tumor Microenvironment.
Am. J. Pathol.172:179-193,2008.
・ Yanagisawa Y, Takeoka M, Ehara T, Itano N, Miyagawa S, Taniguchi S.
Reduction of Calponin h1 expression in human colon cancer blood vessels
Europ. J. Surgical Oncol. 34:531-537, 2008
・ Itano N, Zhuo L, and Kimata K.
Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and
dprogression.
Cancer Sci. 99:1720-1725. 2008.
・ Itano N.
Simple primary structure, complex turnover regulation and multiple roles of
hyaluronan
J. Biochem. 144:131-137. 2008.
・ Itano N, Kimata K.
Altered hyaluronan biosynthesis in cancer progression
Sem. Cancer Biol. 18:268-274, 2008
・ Kakizaki I, Itano ., Kimata K, Hanada K, Kon A, Yamaguchi M, Takahashi T, and
Takagaki K. Up-regulation of hyaluronan synthase genes in cultured human
epidermal keratinocytes by UVB irradiation.
Arch. Biochem. Biophys. 471:85-93. 2008.
・ Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H,
Sagara J, Nakayama J, Taniguchi S, Ikeda U.
Critical role of bone marrow apoptosis-associated speck-like protein, an
inflammasome adaptor molecule, in neointimal formation after vascular injury in
mice.
Circulation. Jun 17;117(24):3079-87,2008
・ Itano N.
Hyaluronan synthase assay.
Experimental Glycoscience Springer 70-71, 2008
・ Itano N.
Conditional transgenic mouse of hyaluronan synthase: a potential model of
Advanced breast cancer.
Experimental Glycoscience Springer 252-254, 2008
・ Nakajima S, Hida S, Taki S.
IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1+B220+ NK cells.
Biochem. Biophys. Res.Commun. 396, 1139-1143, 2008
・ 肥田重明、瀧伸介:「好塩基球を介するTh2細胞の誘導」
分子細胞治療, vol.7, no.3, p45-51 ,2008
【2007年】
・ Koyama H., Hibi T., Isogai Z., Yoneda M., Fujimori M., Amano J., Kawakubo M.,
Kannagi R., Kimata K.,Taniguchi S., Itano N.
Hyperproduction of Hyaluronan in Neu-Induced Mammary Tumor Acceletrates
Angiogenesis through Stromal Cell Recruitment: Possible Involvement of Versican
/PG-M. Am. J.Pathol. 170(3) :1086-1099,2007.
・ Yokosawa S, Yoshizawa K, Ota M, Katsuyama Y, Kawa S, Ichijo T, Umemura T,
Tanaka E, and Kiyosawa K.
A Genomic DNA Microsatellite Association Study of Japanese Patients with
Autoimmune hepatitis Type1.
Hepatology, 2007
・ Hasegawa K, Yoneda M, Kuwabara H, Miyaishi O, Itano N, Ohno A, Zako M, and
Isogai, Z.
Versican, a Major Hyaluronan-Binding Component in the Dermis, Loses its
Hyaluronan-Binding Ability in Solar Elastosis. J. Invest.
Dermatol.127(7):1657-63,2007.
・ Nobuhisa T, Nakamoto Y, Okawa T, Takaoka M, Gundz M, Nagatsuka H, Tsujigiwa H,
Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Nakajima M, Taniguchi S,
Sagara J,Dong J, and Tanaka N.
Translocation of Heparanase into Nucleus Results in Cell Differentiation.
Cancer Sci.98(4):535-40, 2007
・ Hamaji Y, Fujimori M, Sasaki T, Matsuhashi H, Matsui-Seki K, Shimatani-Shibata Y, Kano Y,
Amano J, and Taniguchi S.
Strong Enhancement of Recombinant Cytosine Deaminase Activity in Bifidobacterium
longum for Tumor Targeting Enzyme-Prodrug Therapy.
Biosci. Biotechnol Biochem;71(4):874-883 ,2007
・ Fujihara N, Yamauchi K, Hirota-Kawadobora M, Ishikawa S, Tozuka M, Ishii E,
Katsuyama T, Nobuo Okumura, Taniguchi S
In vitro expression of β-thalassemia gene (IVS1-1G>C) reveals complete
inactivation of the normal5 splice site and alternative aberrant RNA splicing.
Ann Clin Biochem. 44(Pt6):573-8,2007
・ Takahashi Y, Katai N, Murata T, Taniguchi S, Hayashi T
Development of spontaneous optic neuropathy in NF-kBp50-deficient mice;
Requirement for NF-kBp50 in ganglion cell survival.
Neuropath, Applied Neurobiol. 33(6):692-705,2007
（平成20年度松医会奨励賞受賞論文）
・ Taniguchi S, Sagara J.
Regulatory molecules involved in inflammasome formation with special reference
to a key mediator protein, ASC. (review)
Semin Immunopathol. 29(3):231-238. Epub2007
・ Hidaka A, Hamaji Y, Sasaki T, Taniguchi S, Fujimori M.
Exogeneous cytosine deaminase gene expression in bifidobacterium breve Ⅰ-53-8w
for tumor-targeting enzyme/prodrug therapy.
Biosci Biotechnol Biochem. 71(12):2921-2926,2007
・ Sakai A, Akifusa S, Itano N, Kimata K, Kawamura T, Koseki T,
Takehara T, Nishihara T.
Potential role of high molecular weight hyaluronan in the anti-Candida
activity of human oral epithelial cells.
Med Mycol. 45:73-79, 2007
・ Yana I, Sagara H, Takaki S, Takatsu K, Nakamura K, Nakao K, Katsuki M,
Taniguchi S, Aoki T, Sato H, Weiss SJ, Seiki M.
Crosstalk between neovessels and mural cells directs the site-specific expression
of MT1-MMP to endothelial tip cells.
J. Cell Sci. 1;120(9):1607-1614, 2007
・ Arakura F, Hida S, Ichikawa E, Yajima C, Nakajima S, Saida T, Taki S.
Genetic control directed towards spontaneous IFN-α/β responses and downstream IFN-γ
expression influences the pathogenesis of a murine psoriasis-like skin disease.
J. Immunol. 179, 3249-3257, 2007
・ Yokosawa S, Yoshizawa K, Ota M, Katsuyama Y, Kawa S, Ichijo T, Umemura T, Tanaka E,
Kiyosawa K.
A genomewide DNA microsatellite association study of Japanese patients with
autoimmune hepatitis type 1.
Hepatology. 45(2):384-90,2007
・ 小山洋、板野直樹 ヒアルロン酸リッチマトリックスによる腫瘍微小環境の形成と
血管新生 Functional Glycomics 9:47-53, 2007
・ 三好征司、小林宣隆、板野直樹
進行癌モニタリングのおけるヒアルロン酸リッチ腫瘍内微小環境の重要性
臨床糖鎖バイオマーカーの開発—糖鎖機能の解明とその応用
遺伝子医学MOOK11号,2007
【200６年】
・ Yu JW,Wu J, Zhang Z, Datta P, Ibrahimi I, Taniguchi S, Sagara J,
Fernandes-Alnemri T, Alnemri ES.
Cryoprin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.
Cell Death Differ. 13: 236-249 , 2006
・ Ohta S, Edwin W.Lai, Taniguchi S, Arthur S.Tischler, Salvatore Alesci,
Karel Pacak.
Animal models of pheochromocytoma including NIH initial experience.
Ann N Y Acad Sci. 1073:300-305, 2006
・ Ota Machida E Malcolm V. Brock, Craig M. Hooker, Nakayama J, Ishida A,
Amano J, Maria A. Picchi, Steven A. Belinsky, James G. Herman, Taniguchi S,
Stephen B. Baylin
Hypermethylation of ASC/TMS1 is a Sputum Marker for Late-Stage Lung Cancer.
Cancer Res ; 66(12) : 6210-6218,2006
・ Sasaki T, Fujimori M, Hamaji Y, Hama Y, Ito K, Amano J, Taniguchi S.
Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug
therapy of autochthonous mammary tumors in rats.
Cancer Science,97(7): 649 - 657 ,2006
・ Ogura T, Kobayashi H, Ueoka Y, Okugawa K, Kato K, Hirakawa T, Hashimoto S,
Taniguchi S, Wake N, Nakano H.
Adenovirus –mediated calponin h1 gene therapy directed against peritoneal
Dissemination of ovarian cancer: bifunctional therapeutic effects on peritoneal
cell layer and cancer cells.
Clin Cancer Res.12(17):5216-23,2006
・ Hiratochi M, Nagase H, Kuramochi Y, Koh Chang-sung, Ohkawara T, Nakayama K.
The delta intracellular domain mediates TGF-1*beta*1/activin signaling through
binding to smads and has an important bi-directional function in notch-delta
signaling pathway.
Nucleic A Cids Res. 02308-W-2006.R1
・ Katsuno K, Fujimori Y, Takemura Y, Hiratochi M, Itoh F, Komatsu Y, Fujikura H,
Isaji M.
Sergliflozin, a Novel Selective Inhibitor of Low Affinity Sodium Glucose
Cotransporteer (SGLT2), Validates the Critical Role of SGLT2 in Renal Glucose
Reabsorption and Modulates Plasma Glucose Level.
J Pharmacol EXP Ther.
・ Zhuo, L., Kanamori, A., Kannagi, R., Itano, N., Wu, J., Hamaguchi, M.,
Ishiguro, N., Kimata, K.
SHAP Potentiates the CD44-mediated Leukocyte Adhesion to the Hyaluronan
Substratum. J. Biol. Chem. 281:20303-20314, 2006.
・ Aiyama Y, Itano N, Sagara J, Taniguchi S.
Molecular Basis for Nuclear Trafficking of Scapinin, a Scaffold-Associated PP1
Inhibiting Protein.
Seikagaku A11534 4P-A-045, 2006
【2005年】
・ Moriya M, Taniguchi S, Peter Wu, Edvards Liepinsh, Gottfried Otting, Sagara J.
Role of charged and hydrophobic residues in the oligomerization of the PYRIN
domain of ASC.
Biochemistry .Jan 18;44(2):575-583,2005
・ Kobayashi H, Koike T, Nakatsuka A, Kurita H, Sagara J, Taniguchi S, Kurashina K
Dihydropyrimidine dehydrogenase expression predicts survival outcome and
chemosensitivity to 5-fluorouracil in patients with oral squamous cell carcinoma.
Oral Oncology. 41:38-47, 2005
・ Hattori Y, Takeoka M, Nakajima K, Ehara T, Koyama M.
A heteroplasmic mitochondrial DNA 3310 mutation in the ND1 gene in a patient with
type 2 diabetes, hypertrophic cardiomyopathy, and mental retardation.
Exp Clin Endocrinol Diabetes. 113:313-317,2005
・ Taniguchi S.
Suppression of cancer phenotypes through a multifunction actin binding protein,
calponin,that attacks cancer cells and simultaneously protects the host from
invasion (review).
Cancer science 96:738-746,2005
・ Kanomata N, Yokose T, Kamijo T, Yonou H, Hasebe T, Itano N, Kimata K, Ochiai A.
Hyaluronan synthase expression in pleural malignant mesotheliomas.
Virchows Arch 446: 246-250 , 2005
・ 谷口俊一郎
インターロイキン１８(IL-18)ーその作用と活性化機序
信州医誌 53:33-34,2005
・ 谷口俊一郎
細胞骨格に着目した癌転移の抑制ー癌細胞と宿主の両面からー
肝転移のすべて 63-68,2005
・ Itano N, Kakizaki I, Mita S, Endo M, Takagaki K, and Kimata K.
A mechanism for 4-methylumbelliferone-mediated inhibition of hyaluronan biosynthesis.
Hyaluronan: Structure, metabolism, biological activities, therapeutic applications. .
Eds,E.A.,Balazs and V.C., Hascall 編：Hyaluronan: Structure, metabolism, biological
activities, therapeutic applications..pp 147-153, Matrix Biology Institute, 2005.
・ 板野直樹、木全弘治：ヒアルロン酸合成酵素.
川嵜敏祐編：未来を拓く糖鎖科学.
pp 176-177, 金芳堂, 京都, 2005.
・ 板野直樹：プロテオグリカン分子群の合成と構造異常がもたらす細胞機能の変化—
癌浸潤・転移の理解と克服に向けた解析—. 川嵜敏祐編：未来を拓く糖鎖科学.
pp 299-302, 金芳堂, 京都, 2005.
【2004年】
・ Yabushita H, Kishida T, Fusano K, Kanyama K, Zhuo L. Itano N, Kimata K, Noguchi M.
Role of hyaluronan and hyaluronan synthase in endometrial cancer.
Oncol Rep 13:1101-1105, 2005
・ Kobayashi H, Sagara J, Kurita H, Morifuji M, Ohishi M, Kurashina K, Taniguchi S.
Clinical significance of cellular distribution of moesin in parients with oral
squamous cell carcinoma.
Clin. Cancer Res. 10:572-580, 2004
・ Itano N, Sawai T, Atsumi F, Miyaishi O, Taniguchi S, Kannagi R, Hamaguchi M, Kimata K
Selective expression and functional characteristics of three mammalian hyaluronan
synthases in oncogenic malignant transformation.
J Biol Chem.279: 18679 -18687, 2004
・ Yamamoto M,Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M,
Akira S, Nakanishi K, Noda T, Taniguchi S.
ASC is essential for LPS-induced activation of procaspase-1 independently of
TLR- associated signal adaptor molecules.
Genes to Cells ,9(11):1055-1067,2004
・ Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, Nakayama KI, Aaronson
SA ,Lee SW
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.
Nat. Cell Biol. 6: 121-128,2004
・ 相良淳二
ASCとPYRINファミリー：新しいインターロイキン変換酵素活性化経路
信州医誌 52:305-312,2004
・ 相良淳二、谷口俊一郎
新規アポトーシス制御蛋白ASC:インターロイキン変換酵素の新しい活性化経路
臨床免疫42(3):306-312,2004
【2003年】
・ Kobayashi H, Sagara J, Masumoto J, Kurita H, Kurashita K, Taniguchi S
Shifts in cellular Jocalization of moesin in normal oral epithelium, oral epithelial
dysplasia, verrucous carcinoma and oral squamous cell carcinoma
Oral Pathology & Medicine 32:1-6,2003.
・ Koganehira Y, Takeoka M, Ehara T, Sasaki K, Murata H, Saida T, Taniguchi S
Reduced expression of actin-binding proteins , h-caldesmon and calponin h1 , in the
vascular smooth muscle inside melanoma lesions: a possible risk factor of metastasis.
British J Dermatology 148:971-980,2003.
・ Masuki S, Takeoka M, Taniguchi S, Nose H
Enhanced baroreflex sensitivity in free moving calponin knockout mice.
American J of Physiology-Heart and Circulatory Physiology, 284:H939-H946,2003.
・ Masumoto J, Weibin Zhou, Felicia F.Chen, Fengyun Su, John Y.Kuwada, Hidaka E,
Katsuyama T, Sagara J, Taniguchi S, Phuong Ngo-Hazelett, John H.Postlethwait,
Gabriel Nunez, Inohara N
Caspy:A Zebrafish caspase activated by ASC oligomerization required for pharyngeal
Arch development
J.Biol.Chem,278(6):4268-76,2003.
・ Bannai M, Yoshimoto R, Mitsui-Saito M, Hori M, Nishihara M, Takahashi K,
Yamamura H, Taniguchi S, Katsuki M
Increased locomotor activity , increased food and water intake and decreased PVN
neurons in H1 calponin gene-deficient mice.
J. Vet Med. Sci. 65(1): 153-155, 2003
・ Masumoto J, Theresa A.Dowds, Philip Schaner, Felicia F.Chen, Ogura Y,
Katsuyama T, Sagara J, Taniguchi S, Deborh L.Gumucio, Gabriel Nunez, Inohara N
ASC is an activating for caspase-8-dependent apoptosis.
BBRC 303:69-73,2003.
・ Guan X, Sagara J, Yokoyama T, Koganehira Y, Oguchi M, Saida T, Taniguchi S
ASC/TMS-1, a caspase-1 activating adaptor, is down-regulated by aberrant metylation
in human melanoma.
Int. J. Cancer 107,202-208 , 2003.
・ Hashimoto S, Takeoka M, Taniguchi S
Suppression of peritoneal dissemination through protecting mesothelial cells from
retraction by cancer cells
Int. J. Cancer 107:557-563, 2003
・ Yokoyama T, Sagara J, Guan X, Masumoto J, Takeoka M, Komiyama Y, Miyata K,
Higuchi K, Taniguchi S
Methylation of ASC/TMS1, a proapoptotic gene responsible for activating procaspase-1,
in human colorectal cancer.
Cancer Letters 202:101-108, 2003
・ Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H,
Kikuchi K, Taniguchi S.
Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the
nuclear nonchromatin structure.
J. Biol. Chem. 278:(46)45611-45619, 2003
・ Tochikura TS, Xiao S, Ego T, Sagara J, Kawai A
Further characterization of a CD99-related 21-kDa transmembrane
protein(VAP21) expressed in Syrian hamster cells and its possible involvement in
vesicular stomatitis virus production.
Microbiol Immunol.47(10):745-57, 2003
・ Stehlik C, Lee SH, Dorfleutner A, Stassinopoulos A, Sagara J, Reed JC.
Apoptosis-associated speck-like protein containing a caspase recruitment domain
is a regulator of procaspase-1 activation.
J. Immunol. 171(11):6154-63, 2003
・ Hattori Y, Nakajima K, Eizawa T, Ehara T, Koyama M, Hirai T, Fukuda Y, Kinoshita M.
Heteroplasmic mitochondrial DNA 3310 mutation in NADH dehydrogenase
subunit 1 associated with type 2 diabetes, hypertrophic cardiomyopathy, and
mental retardation in a single patient.
Diabetes Care 26:952-3,2003.
・ Masuki S, Takeoka M, Taniguchi S, Yokoyama M, Nose H
Impaired arterial pressure regulation during exercise due to enhanced muscular
vasodilation in calponin knockout mice.
J. Physiol. 553:203-212, 2003
・ 谷口俊一郎
癌転移 ー基礎と臨床アップデートー
日本臨牀61 105-110, 2003
・ 谷口俊一郎
医学大辞典、2003、医学書院
・ 谷口俊一郎
『分子生物学・免疫学キーワード辞典（第２版）』 2003、医学書院
・ 相良淳二
『分子生物学・免疫学キーワード辞典（第２版）』 2003、医学書院
【2002年】
・ Nomura K, Miyagawa S, Ayukawa K, Soeda J, Taniguchi S, Kawasaki S
Inhibition of urokinase-type plasminogen activator delays expression of c-jun,
activated transforming growth factor β1, and matrix metalloproteinase 2 during
post-hepatectomy liver regeneration in mice.
J. Hepatology 36:637-644, 2002.
・ Takeoka M, Ehara T, Sagara J,Hashimoto S, Taniguchi S
Calponin h1 induced a flattened morphology and suppressed the growth of human
fibrosarcoma HT1080 cells.
European J. Cancer 38(3):436-42,2002.
・ Fujimori M, Amano J, Taniguchi S
The genus Bifidobacterium for cancer gene therapy.
Current Opinion In Drug Discovery ＆ Development 5（2）:200-203,2002.
・ Shiohara M, Taniguchi S, Masumoto J, Yasui K, Komiyama A, Sagara J.
ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and
apoptosis in human neutrophils.
BBCR, 24;293(5):1314-8, 2002.
・ Oguchi M, Sagara J, Matsumoto K, Saida T, Taniguchi S
Expression of lamins depends on epidermal differentiation and transformation
Brit.J. Dermatology147:1-6, 2002
・ Kaneko M, Takeoka M, Oguchi M, Koganehira Y, Murata H, Ehara T, Tozuka M,
Saida T, Taniguchi S
Calponin H1 Suppresses Tumor Growth of Src-induced Transformed 3Y1 Cells in
Association with a Decrease in Angiogesis
J. Cancer Research 93(8):935-943, 2002
・ Nakamura T, Sasaki T, Fujimori M, Yazawa K, Kano Y, Amano J, Taniguchi S
Cloned cytosine deaminase gene expression of bifidobacterium longum and application
to enzyme/ pro-drug therapy of hypoxic solid tumors.
Biosci. Biotechnol. Biochem. 66(11):2362-2366, 2002.
【2001年】
・ Soeda J, Miyagawa S, Sano K, Masumoto J, Taniguchi S, Kawasaki S
Cytochrome c release into cytosol with subsequent caspase activation during warm
ischemia in rat liver.
Am. J. Physiol. Gastrointest Liver Physiol. 281:G1115-G1123, 2001.
・ Masumoto J, Taniguchi S, Nakayama K, Ayukawa K, Sagara J
Murine ortholog of ASC, a CARD-containing protein self-associates and exhibits
restricted distribution in developing mouse embryos.
Exp. Cell Res. 262:123-133, 2001.
・ Yazawa K, Fujimori M, Nakamura T, Sasaki T, Amano J, Kano Y and Taniguchi S
Bifidobacterium longum as a delivery system for gene therapy of chemically
induced rat mammary tumors.
Breast Cancer Research and Treatment 66: 165-170,2001
・ Masumoto J, Taniguchi S, Sagara J
Pyrin N-terminal homology domain-and caspase recruitment domain-dependent
oligomerization of ASC.
BBRC 280:652-655,2001.
・ Taniguchi S, Takeoka M, Ehara T, Hashimoto S, Shibuki H, Yoshimura N,
Shigematsu H, Takahashi K, Katsuki M
Structural fragility of blood vessels and peritoneum in calponin h1-deficient mice,
resulting in an increase in hematogenous metastasis and peritoneal dissemination
of malignant tumor cells.
Cancer Res. 61:7627-7634,2001.
・ Masumoto J, Taniguchi S, Nakayama J, Shiohara M, Hidaka E, Katsuyama T, Murase S,
Sagara J
Expression of apoptosis-associated speck-like protein containing a caspase
recruitment domain, a pyrin N-terminal homology domain-containing protein, in
normal human tissues.
J. Histochem Cytochem 49(10):1269-1275,2001
・ Sakashita K, Koike K, Kinoshita T, Shiihara M, Kamijo T, Taniguti S, Kuboa T.
Dynamic DNA methylation change in the CpG island region of P15 during human myeloid
development.
J.Clinical Investigation 1195-1204,2001.
・ 谷口俊一郎
地方大学の使命
SCIENTIA 3、 2001
【2000年】
・ Morifuji M, Taniguchi S, Sakai H, Nakabeppu Y, Ohishi M.
Differential expression of cytokeratin after orthotopic implantation of newly
established human tongue cancer cell lines of defined metastatic ability .
Am J Pathol 156: 1317-1326,2000.
・ Yazawa K, Fujimori M, Amano J, Nakayama J, Kano Y, Taniguchi S.
Bifidobacterium longumas a delivery system for cancer gene therapy: Selective
localization and growth in hypoxic tumors.
Cancer Gene Therapy 7:269-274, 2000.
・ Okamoto-Inoue M, Nakayama J, Hori Y, Taniguchi S.
Human malignant melanoma cells release a factor that inhibits the expression of
smooth muscleα-actin.
J.Dermatological Science 23: 170-177, 2000.
・ Kubo H, Matsumoto K, Funahashi M, Takagi H, Kitajima Y, Taniguchi S, Saida T
Sequential chemoimmunotherapy with cisplatin, interferon-β and interleukin-2
inhibits the growth of B16-F1 melanoma in syngeneic mice.
Melanoma Res. 10: 223-229, 2000.
・ Ayukawa K, Taniguchi S, Masumoto J, Hashimoto S, Sarvotham H, Hara A, Aoyama T,
Sagara J.
La autoantigen is cleaved in the COOH-terminus and loses the nuclear localization
signal (NLS) during apoptosis.
J. Biol. Chem. 275:34465-34470,2000.
・ Matthew J, Khromov A, McDuffie M, Somlyo AP, Taniguchi S, Takahashi K
Contractile properties and proteins of smooth muscles of a calponin knockout
mouse.
J. Physiol. London 529:811-824, 2000.
・ Takahashi K, Yoshimoto R, Fuchibe K, Fujishige A, Mitsui-Saito M, Hori M,
Ozaki H, Yamamura H, Awata N, Taniguchi S, Katsuki M, Tsuchiya T, Karaki H
Regulation of shortening velocity by calponin in intact contracting smooth muscles.
BBRC 279:150-157, 2000.
・ Yoshimoto R, Hori M, Takahashi K, Taniguchi S, Katsuki M, Ozaki H, Karaki H
Ca-sensitization of contraction in the h1 calponin-deficient smooth muscle.
Jpn. J. Pharmacol. 84:474-475, 2000.
・ 市川 健、齋田俊明、谷口俊一郎
ヒアルロン酸と悪性腫瘍の浸潤、転移能
医薬の門40 605-609、2000.
【1999年】
・ Yatsunami J, Tsuruta N, Fukuno Y, Kawashima M, Taniguchi S, Hayashi S.
Inhibitory effects of roxithromycin on tumor angiogenesis, growth and metastasis
of mouse B16 melanoma cells.
Clinical & Experimental Metastasis 17: 119-124,1999.
・ Horiuchi A, Nikaido T, Taniguchi S, Fujii S.
Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcoma.
J. Natl. Cancer Inst. 91: 790-796,1999.
・ Yatsunami J , Fukuno Y, Nagata M, Tsuruta N, Tominaga M, Kawashima M, Taniguchi S,
Hayashi S.
Antiangiogenic and antitumor effects of 14-membered ring macrolides on mouse B16
melanoma cells.
Clin. Exp. Metastasis 17:361-367,1999.
・ Okamoto-Inoue M, Kamada S, Kimura G, Taniguchi S.
The induction of smooth muscle α actin in a transformed rat cell line suppresses
malignant properties in vitro and in vivo.
Cancer Lett. 142:173-178,1999.
・ Yatsunami J, Fukuno Y, Nagata M, Tsuruta N, Aoki S, Tominaga M, Kawashima M,
Taniguchi S, Hayashi S.
Roxithromycin and clarithromycin, 14-membered ring macrolides, potentiate the
antitumor activity of cytotoxic agents against mouse B16 melanoma cells.
Cancer Lett. 147:17-24,1999.
・ Ichikawa T, Itano N, Sawai T, Kimata K, Koganehira Y, Saida T, Taniguchi S.
Increased synthesis of hyaluronate enhances motility of human melanoma cells.
J. Investigative Dermatol. 113:935-939,1999.
・ Masumoto J, Taniguchi S, Ayukawa K, Kishino T, Niikawa N, Hidaka E,
Katsuyama T, Higuchi T, Sagara J.
ASC, a novel 22-kDa protein containing a caspase recruitment domain (CARD),
forms a speck during apoptosis of human promyelocytic leukemia HL-60 cells.
J. Biol.Chem. 274:33835-33838,1999.
・ Yatsunami J , Fukuno Y, Nagata M, Tsuruta N , Aoki S, Tominaga M, Kawashima M,
Taniguchi S, Hayashi S.
Roxithromycin and clarithromycin, 14-membered ring macrolides, potentiate the
antitumor activity of cytotoxic agents against mouse B16 melanoma cells.
Cancer Letters 147:17-24,1999.
・ 谷口俊一郎
加齢と癌
JOHNS 15:1045-1048, 1999.
【1998年】
・ Ichikawa T, Masumoto J, Kaneko M, Saida T, Sagara J, Taniguchi S.
Moesin and CD44 expression in cutaneous melanocytic tumours.
British. J. Dermatol. 138:763-768, 1998.
・ Ichikawa T, Masumoto J, Kaneko M, Saida T, Sagara J, Taniguchi S.
Expression of moesin and its associated molecule CD44 in epithelial skin tumours.
J. Cutan. Pathol. 25:237-243, 1998.
・ Masumoto J, Sagara J, Hayama M, Hidaka E, Katsuyama T, Taniguchi S.
Differential expression of moesin in cells of hematopoietic lineage and lymphatic
systems.
Histochem. Cell Biol. 110:33-41,1998.
・ Horiuchi A, Nikaido T, Ito K, Zhai Y, Orii A, Taniguchi S, Toki T, Fujii S.
Reduced expression of calponin h1 in Leiomyosarcoma of the Uterus.
Laboratory Investigation 78:839-846,1998.
・ Go H, Taniguchi S.
Augmentation in the expression of a ribosomal protein associated with transformation.
Biochem. Mol.Biol.Int. 46:629-638,1998.
・ Yoshikawa H, Taniguchi S, Yamamura H, Mori S, Sugimoto M, Miyado K, NakamuraK,
Nakano K, Katsuki M, Shibata N, Takahashi K.
Mice lacking smooth muscle calponin display increased bone formation that is
associated with enhancement of bone morphogenetic protein responses.
Genes to Cells 3:685-695,1998.
・ Go H,Miyado K, Taniguchi S.
Genomic structure of the human ribosomal protein L41gene.
Biochem. Mol. Biol. Int. 46:1227-1234,1998.
・ Zaizen Y, Taniguchi S, Suita S.
The role of cellular motility in the invasion of human neuroblastoma cells with or
without N- myc amplification and expression.
J. Pediatric Surgery 33:1765-1770,1998.
・ 谷口俊一郎
転移を左右する宿主側因子とその遺伝子操作
実験医学増刊号 16: 32-36, 1998.
・ Taniguchi S, Miyado K.
Decreased expression of a single tropomyosin isoform, TM5/TM30nm, results in reduction in
motility of metastatic cell lines.
Hokkaido University Medical library Series 37:32-35,1998.
【1997年】
・ Miyado K, Sato M, Taniguchi S.
Transformation-related expression of a low-molecular weight tropomyosin isoform
TM5/TM30nm in transformed rat fibroblastic cell lines.
J.Can.Res.Clin.Oncol. 123:331-336,1997.
・ Tatsuka M, Ota T, Maeda M, Wada M, Yamagishi N, Taniguchi S, Seiki M, Odashima S.
A BALB/c 3T3-Transformed Cell Line Suitable For Transfection Assay of Metastasis-
Inducing Genes.
Int. J. Cancer 71: 88-93, 1997.
・ Ishidoh K, Taniguchi S, Kominami E.
Egr Family member proteins are involved in the activation of the cathepsin L gene
in v-src-Transformed cells.
BBRC 238:665-669,1997.
・ Iwamoto Y, Tanaka K, Okuyama K, Sugioka Y, Taniguchi S.
In vitro assay of the invasive potential of malignant bone and soft tissue tumours
through basement membranes.
Int. Orthopaedics 18:240-247,1997.
・ 谷口俊一郎
〈特集 細胞骨格の臨床〉 細胞骨格と転移
細胞 29: 224-227,1997.
・ 谷口俊一郎
癌転移関連分子
医学のあゆみ 182:108-113,1997.
・ 谷口俊一郎
細胞骨格と情報伝達因子①変異アクチンの検出（編集：がん転移研究会）
続〕がんの浸潤・転移研究マニュアル —実験の手技と指針—
pp244-246 , 1997, 金芳堂, 東京.
【1996年】
・ Miyado K, Kimura M, Taniguchi S.
Decreased expression of a single tropomyosin isoform , TM/TM30nm, results in
reduction in motility of highly metastatic B16-F10 mouse melanoma cells.
BBRC, 225, 427-435, 1996.
・ 谷口俊一郎
癌の遺伝子異常と転移
外科58：571-574, 1996.
・ 谷口俊一郎
癌転移関連遺伝子
血液・免疫・腫瘍 1:340-347 , 1996.
・ 谷口俊一郎
がん転移の分子機構
信州医誌 44 : 227-238, 1996.
・ Taniguchi S.
Cellular and molecular function of a variant actin(βm), which inhibits metastasis of mouse
B16 melanoma. in Melanogenesis and malignant melanoma：Biochemistry, Cell Biology,
Molecular Biology, Pathophysiology, Diagnosis and Treatment. Edited by Y. Hori, V.J.
Hearing, J. Nakayama.pp169-183, Excerpta Medica (New York), 1996.
【1995年】
・ Yoshimura M, Nishikawa A, Ihara Y, Taniguchi S, Taniguchi N.
Suppression of Lung Metastasis of B16 Mouse Melanoma by
N- Acetylglucosaminyltransferase III Gene Transfection.
Proc. Natl. Acad. Sci. USA, 92: 8754-8758, 1995.
・ Nakayama J, Urabe K, Tsuchida T, Urabe A, Terao H, Taniguchi S, Hori Y.
Differential cell- and immuno-biological properties of murine B16-F1
and F10 melanomas: oncogene c-fos expression, sensitivity to LAK
cells and/or IL-2, and components of gangliosides.
J. Dermatol. 22(8):549-59,1995
・ 谷口俊一郎
転移を制御する遺伝子
Molecular Medichine, 32(4): 414-420, 1995.
・ 谷口俊一郎
転移性肺腫瘍：転移腫瘍のモデルと転移抑制.
THE LUNG perspectives, 3(4), 393-396, 1995.
・ 谷口俊一郎
消化器癌の転移機構：細胞骨格と転移
G.I. Research, Journal of Gastrointestinal Research, 508-513, 1995.
・ 谷口俊一郎
分子生物学的アプローチによる癌研究プロトコール
転移のin vitroアッセイ（運動能）
実験医学別冊、バイオマニュアルUPシリーズ pp217-221,1995. 10月20日発行
羊土社、東京.
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