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医学科

内科学第二 専用サイト

教室の概要

第二内科は、消化器、腎臓、血液を担当しています。診療科は医療の高度化により専門化が進み、診療科は細分化されていますが、複数診療科統合講座の体制を 変えていません。診療科毎が高度先進医療を行うと同時に、横の連携を大切にし、症例における疾病を多方面から検討し診療する事を重視しています。各診療科 がそれぞれの特色を生かし、教育・診療・研究を行い、協力、刺激しあい、それが各診療科に良い影響を与えております。

研究テーマ

消化器

B型肝炎の基礎研究と抗ウイルス療法
C型肝炎の基礎研究と抗ウイルス療法
肝癌の疫学研究と発症機序の解明
自己免疫性肝疾患の免疫遺伝学的解析と疫学
代謝性肝疾患(NASHとメタボリックシンドローム)
消化管悪性リンパ腫の非手術的治療法の確立
高校生におけるH.pylori感染状況の検討
膵胆道疾患に対する内視鏡的アプローチ法の確立
自己免疫性膵炎の病態解明

腎臓

糸球体・尿細管障害の新たな進展機序の解明
腎障害におけるPPARαの役割
慢性腎臓病患者・透析患者に対する介入治療研究
腎生検情報を用いた腎疾患病態解析
慢性腎臓病・透析患者に高頻度におきる心血管病の発症予測因子の確立

血液

造血器悪性腫瘍に対する各種移植治療成績の検討
T細胞大顆粒リンパ球白血病の病態解析
成熟NK細胞性腫瘍の病態解析
造血不全症候群の病態の解析
慢性リンパ性白血病の病態解析

主な成果

  1. Sakai H, Hosono N, Nakazawa H, Przychodzen B, Polprasert C, Carraway HE, Sekeres MA, Radivoyevitch T, Yoshida K, Sanada M, Yoshizato T, Kataoka K, Nakagawa MM, Ueno H, Nannya Y, Kon A, Shiozawa Y, Takeda J, Shiraishi Y, Chiba K, Miyano S, Singh J, Padgett RA, Ogawa S, Maciejewski JP, Makishima H. A novel genetic and morphologic phenotype of ARID2-mediated myelodysplasia.Leukemia. 2017 Nov 3. doi: 10.1038/leu.2017.319. [Epub ahead of print] No abstract
  2. Kawakami T, Nakazawa H, Kurasawa Y, Sakai H, Nishina S, Senoo N, Senoo Y, Ishida F. Intern Med. Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria. 2018 Jan 1;57(1):127-130. doi: 10.2169/internalmedicine.9151-17. Epub 2017 Oct 11.
  3. Sekiguchi N, Nishina S, Kawakami T, Sakai H, Senoo N, Senoo Y, Ito T, Saito H, Nakazawa H, Koizumi T, Ishida F. Oral cyclophosphamide was effective for Coombs-negative autoimmune hemolytic anemia in CD16+CD56- chronic lymphoproliferative disorder of NK-cells. Int J Hematol. 2017 Jun;105(6):854-858. doi: 10.1007/s12185-016-2170-4. Epub 2016 Dec 27.
  4. Andersson EI, Tanahashi T, Sekiguchi N, Gasparini VR, Bortoluzzi S, Kawakami T, Matsuda K, Mitsui T, Eldfors S, Bortoluzzi S, Coppe A, Binatti A, Lagstrom S, Ellonen P, Fukushima N, Nishina S, Senoo N, Sakai H, Nakazawa H, Kwong YL, Loughran TP, Maciejewski JP, Mustjoki S, Ishida F. High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. Blood. 2016 Nov 17;128(20):2465-2468. Epub 2016 Oct 3. No abstract available.
  5. Nakazawa H, Sakai H, Kawakami T, Hirabayashi Y, Nakazawa K, et al. An Aggressive Transformation to EBV-Positive Hodgkin Lymphoma after Bendamustine-Containing Chemotherapy for Marginal Zone Lymphoma. J Hematol Thrombo Dis 2016 4:246. doi:10.4172/2329-8790.1000246
  6. Tanahashi T, Sekiguchi N, Matsuda K, Matsumoto A, Ito T, Nakazawa H, Ishida F. A screening method with lymphocyte percentage and proportion of granular lymphocytes in the peripheral blood for large granular lymphocyte (LGL) leukemia. Int J Hematol. 2017 Jan;105(1):87-91. doi: 10.1007/s12185-016-2092-1. Epub 2016 Sep 29.
  7. Tokutake T, Baba H, Shimada Y, Takeda W, Sato K, Hiroshima Y, Kirihara T, Shimizu I, Nakazawa H, Kobayashi H, Ishida F. Exogenous Magnesium Chloride Reduces the Activated Partial Thromboplastin Times of Lupus Anticoagulant-Positive Patients. PLoS One. 2016 Jun 29;11(6):e0157835. doi: 10.1371/journal.pone.0157835. eCollection 2016.
  8. Tanahashi T, Sekiguchi N, Matsuda K, Takezawa Y, Ito T, Kobayashi H, Ichikawa N, Nishina S, Senoo N, Sakai H, Nakazawa H, Ishida F. Cell size variations of large granular lymphocyte leukemia: Implication of a small cell subtype of granular lymphocyte leukemia with STAT3 mutations. Leuk Res. 2016 Jun;45:8-13. doi: 10.1016/j.leukres.2016.04.001. Epub 2016 Apr 4.
  9. Nakazawa H, Makishima H, Ito T, Ota H, Momose K, Sekiguchi N, Yoshizawa K, Akamatsu T, Ishida F. Screening tests using serum tissue transglutaminase IgA may facilitate the identification of undiagnosed celiac disease among Japanese population. Int J Med Sci. 2014 Jun 3;11(8):819-23. doi: 10.7150/ijms.8854. eCollection 2014.
  10. Nakazawa H, Nishina S, Mimura Y, Kawakami T, Senoo Y, Sakai K, NakazawaK, Kitano K. Tumor lysis syndrome in a chronic lymphocytic leukemia patient with pleural effusion after oral fludarabine and cyclophosphamide therapy. Int J Hematol. 2014 Jun;99(6):782-5. doi: 10.1007/s12185-014-1560-8. Epub 2014 Mar 2.
  11. Ishida F, Nakazawa H, Takezawa Y, Matsuda K, Asano N, Sano K, Sakai H, Ito T. Richter transformation in the brain from chronic lymphocytic leukemia. J Clin Exp Hematop. 2013;53(2):157-60.
  12. Matsuda K, Ishida F, Ito T, Nakazawa H, Miura S, Taira C, Sueki A, Kobayashi Y, Honda T. Spliceosome-related gene mutations in myelodysplastic syndrome can be used as stable markers for monitoring minimal residual disease during follow-up. Leuk Res. 2012 Nov;36(11):1393-7. doi: 10.1016/j.leukres.2012.07.019. Epub 2012 Aug 14.
  13. Umemura T, Joshita S, Ichijo T, Yoshizawa K, Katsuyama Y, Tanaka E, Ota M; The Shinshu PBC Study Group. HLA class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis.  Hepatology 2012;55:506-511.
  14. Hashimoto K, Kamijo Y, Nakajima T, Harada M, Higuchi M, Ehara T, Shigematsu H, Aoyama T. PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling. PPAR Res. 976089, 2012
  15. Kamijo Y, Wang L, Matsumoto A, Nakajima T, Hashimoto K, Higuchi M, Kyogashima M, Aoyama T, Hara A: Long-term improvement of oxidative stress via kidney transplantation ameliorates serum sulfatide levels. Clin Exp Nephrol 16: 959-967, 2012
  16. Sekiguchi N, Asano N, Ito T, Momose K, Momose M, Ishida F: Elevated serum granulysin and its clinical relevance in mature NK-cell neoplasms. Int J Hematol 96: 461-468, 2012
  17. Ito T, Makishima H, Nakazawa H, Senoo Y, Senoo N, Ishida F: Donor lymphocyte infusion for extranodal NK/T cell lymphoma, nasal type, relapsed after allogeneic hematopoietic SCT. Bone Marrow Transplant 46: 1270-1271, 2011
  18. Umemura T, Tanaka E, Kiyosawa K, Kumada H, the Japan de novo Hepatitis B Research Group. Mortality secondary to fulminant hepatic failure in patients with prior resolution of hepatitis B virus infection in Japan. Clinical Infectious Diseases 2008;47:e52-56.
  19. Umemura T, Zen Y, Hamano H, Kawa S, Nakanuma Y, Kiyosawa K. ImmunoglobulinG4-hepatopathy: Association of IgG4-bearing plasma cells in liver with autoimmune pancreatitis. Hepatology 2007;46:463-471.
  20. Hamano H, Kawa S, Ochi Y, Unno H, Shiba N, Wajiki M, Nakazawa K, Shimojo H, Kiyosawa K. Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis. Lancet. 2002 Apr 20;359(9315):1403-4.
  21. Suga T, Akamatsu T, Kawamura Y, Saegusa H, Kajiyama M, Nakamura N, Takei M, Matsumoto A : Actual behaviour of N-butyl-2-cyanoacrylate (histoacryl) in a blood vessel: a model of the varix. Endoscopy 34 : 73-77, 2002.
  22. Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaido T, Nakayama K, Usuda N, Kiyosawa High serum IgG4 concentrations in patients with sclerosing pancreatitis. K.N Engl J Med. 2001 Mar 8;344f(10):732-8.

スタッフ

教授 田中榮司
准教授 梅村武司、濱野英明(兼務)、上條祐司(兼務)、田中直樹(兼務)、菅 智明(兼務)
講師 中澤英之、村木 崇、関口 和(兼務)、長屋匡信
助教 城下 智、橋本幸始、酒井 均、渡邉貴之、大工原誠一