研究成果

2003年一覧

■Eizawa T, Murakami Y, Matsui K, Takahashi M, Muroi K, Amemiya M, Takano R, Kusano E, Shimada K, Ikeda U. Circulating endothelial progenitor cells are reduced in hemodialysis patients. Curr Med Res Opin 19:627-633, 2003

■Sato Y, Ajiki T, Inoue S, Hakamata Y, Murakami T, Kaneko T, Takahashi M, Kobayashi E. A novel gene therapy to the graft organ by a rapid injection of naked DNA. I. Long-lasting gene expression in a rat model of limb transplantation. Transplantation 76:1294-1298,2003

■Arakawa H, Ikeda U, Hojo Y, Ueno S, Nonaka-Sarukawa M,Yamamoto K, Shimada K. Decreased serum vascular endothelial growth factor levels in patients with congestive heart failure. Heart 89:207-208, 2003

■Kurosaki K, Ikeda U, Murakami Y, Takahashi M, Shimada K. Inhibition of rennin-angiotensin system has no effect on circulating macrophage colony-stimulating factor levels in acute myocardial infarction. J Cardiovasc Pharmacol 42: 37-41, 2003

■Hojo Y, Ikeda U, Mizuno O, Katsuki T, Shimada K. Adrenomedullin expression in coronary circulation after stent implantation as a prognositc factor for restenosis. Int J Cardiovas Inter 5:190-194, 2003

■Matsui K, Ikeda U, Murakami Y, Yoshioka T, Shimada K. Intravenous prostaglandin E1 reduces monocyte chemoattractant protein-1 levels in peripheral arterial disease. Am Heart J 145: 330-333, 2003

■Nonaka-Sarukawa M, Yamamoto K, Aoki H, Takano H, Katsuki T, Ikeda U, Shimada K. Increased urinary 15-F2t-isoprostatne levels in patients with non-ischemic congestive heart failure: a marker of oxidative stress. Heart 89: 871-874, 2003

■Matsui K, Yoshioka T, Murakami Y, Takahashi M, Shimada K, Ikeda U. Serum concentration of vascular endothelial growth factor ad monocyte-colony stimulating factor in peripheral arterial disease. Circ J 67: 660-662, 2003

■Ueno S, Ohki R, Hashimoto T, Takizawa T, Takeuchi K, Yamashita Y, Ota J, YL. Choi, Wada T, Koinuma K, Yamamoto K, Ikeda U, Shimada K, Mano M. DNA microarray analysis of in vivo progression mechanism of heart failure. Biochem Biophys Res Commun 307:771-777, 2003

■Ogata Y, Takahashi M, Takeuchi K, Ueno S, Mano H, Ookawara S, Ikeda U, Shimada K, Kobayashi E. Anti-apoptotic effect of endothelin-1 in rat cardiomyocytes in vitro. Hypertension 41: 1156-1163, 2003

■Takahashi M, Hakamata Y, Takeuchi K, Kobayashi E. Effects of different fixatives on beta-galactosidase activity. J Histochem Cytochem 51: 553-554, 2003

■Takahashi M, Hakamata Y, Murakami T, Takeda S, Kaneko T, Takeuchi K, Takahashi R, Ueda M, Kobayashi E. Establishment of lacZ-transgenic rats: a tool for regenerative research in myocardium. Biochem Biophys Res Commun 305: 904-908, 2003

■Ajiki T, Takahashi M, Inoue S, Murakami T, Kume N, Hakamata Y, Kaneko T, Kariya Y, Hoshino Y, Kobayashi E. Generation of donor hemato-lymphoid cells after rat limb composite grafting. Transplantation 75: 631-636, 2003

■Takeda S, Takahashi M, Kusano E, Kobayashi E. Mycophenolate mofetil prevents development of urinary protein in autoimmune nephritis. Kidney Int 4:365-366, 2003

■Murakami Y, Kurosaki K, Matsui K, Shimada K, Ikeda U. Serum MCP-1 and VEGF levels are not affected by inhibition of the renin-angiotensin system in patients with acute myocardial infarction. Cardiovasc Drugs Ther 17: 249-255, 2003

■Ohki R, Yamamoto K, Ueno S, Mano H, Ikeda U, Shimada K. Effects of olmesartan, an angiotensin II receptor blocker, on mechanically-modulated genes in cardiac myocytes. Cardiovasc Drugs Ther 17: 231-236, 2003

■Ikeda U, Takahashi M, Shimada K. C-reactive protein directly inhibits nitric oxide production by cytokine-stimulated vascular smooth muscle cells. J Cardiovasc Pharmacol 42: 607-611, 2003

■Shimizu H, Takahashi M, Takeda S, Tahara K, Inoue S, Hakamata Y, Kaneko T, Takeyoshi I, Morishita Y, Kobayashi E. Effect of conversion from cyclosporin A to mizoribin on transplant arteriosclerosis in rat aortic allograft models. Microsurgery 23: 454-457, 2003

■Matsui K, Ikeda U, Murakami Y, Yoshioka T, Muroi K, Kasuda H, Shimpo M, Takahashi M, Toei H, Kamisawa O, Takeuchi K, Ozawa K, Shimada K. Therapeutic angiogenesis by transplantation of autologous bone marrow and peripheral blood mononuclear cells in patients with peripheral arterial disease. Int J Angiol 12: 155-161, 2003

■Inoue S, Tahara K, Sakuma Y, Hori T, Uchida H, Hakamata Y, Murakami T, Takahashi M, Kawarazaki H, Hashizume K, Kaneko M, Kobayashi E. Impact of graft length on surgical damage after intestinal transplantation in rats. Transplant Immunol 11: 207-214, 2003

■Inoue S, Tahara K, Shimizu H, Yoshino H, Kaneko T, Hakamata Y, Takahashi M, Kaneko M, Kobayashi E. Rat liver transplantation for total vascular reconstruction, using a suture method. Microsurgery 23:470-475, 2003

■Ajiki T, Takahashi M, Hakamata Y, Murakami T, Kariya Y, Hoshino Y, Kobayashi E. Difficulty of getting a long-term graft survival of MHC disparate composite graft using CTLA4-Ig. Transplantation 76:438-439,2003

■Yoshino H, Yamauchi H, Iwai S, Endo K, Inoue S, Tahara K, Kaneko T, Hakamata Y, Takahashi M, Kobayashi E. Vascular closure staples for experimental organ transplantation. Transplantation 76:442-443,2003

■Nagata M, Takahashi M, Muramatsu S, Ueda Y, Hanazono Y, Takeuchi K, Okada K, Suzuki Y, Kondo Y, Suemori M, Ikeda U,Nakano I, Kobayashi E, Hasegawa M, Ozawa K, Nakatsuji N, Shimada K. Efficient gene transfer of a simian immunodeficiency viral vector into cardiomyocytes derived from primate embryonic stem cells. J Gene Med 5: 921-928, 2003

■Takeuchi K, Sereemaspun A, Inagaki T, Hakamata Y, Kaneko T, Murakami T, Takahashi M, Kobayashi E, Ookawara S. Morphologic characterization of green fluorescent protein-transgenic rats in embryonic, neonatal, and adult transgenic rats. Anat Rec 274A:883-886,2003

■Takahashi M, Hakamata Y, Takeda S, Kaneko T, Takeuchi K, Ikeda U, Shimada K, Kobayashi E. Green fluorescent protein-transgenic rat as a tool for study of transplantation and regeneration in myocardium. Cardiovasc Engineering 3: 63-69, 2003

■Nakamura M, Wang J, Murakami T, Ajiki T, Hakamata Y, Kaneko T, Takahashi M, Okamaoto H, Mayuki M, Kobayashi E. DNA immunization for the grafted liver by particle-mediated gene gun. Transplantation 76:1369-1375,2003

■Takahashi M, Ikeda U, Matsui K, Yoshioka T, Murakami Y, Muroi K, Ozawa K, Shimada K. Therapeutic potential and early transplantation trials of adult vascular progenitor cells for ischemic cardiovascular diseases. Progress in Gene Therapy: basic and clinical frontiers 2:161-179,2003

■Hayashi Y, Ibe T, Kawato H, Futamura N, Koyabu S, Ikeda U, Shimada K. Postpartum acute myocardial infarction induced by ergonovine administration.Intern Med 42:983-986, 2003

■Sato Y, Igarashi Y, Hakamata Y, Murakami T, Kaneko T, Takahashi M, Seo N, Kobayashi E. Establishment of Alb-DsRed2 transgenic rat for liver regeneration research.Biochem Biophys Res Commun 311:478-481, 2003

■Sato Y, Igarashi Y, Hakamata Y, Murakami T, Kaneko T, Takahashi M, Seo N, Kobayashi E. Establishment of Alb-DsRed2 transgenic rat for liver regeneration research.Biochem Biophys Res Commun 311:478-481, 2003

■Nonaka H, Ise H, Sugihara N, Hirose S, Negishi N, Kondo Y, Akaike T. Development of Highly Functional Long-Term Culture Method of Liver Slice Embeded in Polymer Scaffold for Bioartificial Liver. Cell Transplant 12: 491-498, 2003

■Kita N, Mitsushita J, Ohira S, Takagi Y, Ahida T, Kanai M, Nikaido T, Konishi I. Expression and Activation of MAP Kinases, ERK1/2, in the Human Villous Trophoblasts. Placenta 24: 164-172, 2003

■Aramaki Y, Lee I, Arima H, Sakamoto T, Magami Y, Yoshimoto T, Moriyasu F, Mizuguchi J, Koyanagi Y, Nikaido T, Tsuchiya S. Efficient Gene Transfer to Hepatoblastoma Cells through Asialoglycoprotein Receptor and Expression under the Control of the Cyclin A Promoter. Biol Pharm Bull 26:357-360, 2003

■Shimizu T, Nikaido T, Gomyo H, Yoshimura Y, Horiuchi A, Isobe K, Ebara S, Takaoka K. Electrochemotherapy for digital chondrosarcoma. J. Orthop Science 8:248-251, 2003

■Shih HC, Shiozawa T, Kato K, Imai T, Miyamoto T, Uchikawa J, Nikaido T, Konishi I. Immunohistochemical expression of cyclins, cyclin-dependent kinases, tumor-suppressor gene products, Ki-67, and sex steroid receptors in endometrial carcinoma: Positive staining for cyclin A as a poor prognostic indicator. Hum Pathol 34:471-478, 2003.

■Wei JP, Zang TS, Kawa S, Aizawa T, Ota M, Akaike T, Kato K, Konishi I, Nikaido T. Human amnion-isolated cells normalize blood glucose in streptozotocin-induced diabetic mice. Cell Transplant 12: 545-552, 2003

■Horiuchi A, Imai T, Wang C, Ohira S, Feng Y, Nikaido T, Konishi I. Up-regulation of small GTPases, Rho A and Rho C, is associated with tumor pregression in ovarian carcinoma. Lab invest 83:861-870.2003

■Ikeda U, Shimada K. Matrix metalloproteinases and coronary artery diseases. Clin Cardiol 26: 55-59, 2003.

■Ikeda U. Inflammation and coronary artery disease. Current Vascular Pharmacology 1: 65-70, 2003.

■Ito T, Ikeda U. Inflammatory cytokines and cardiovascular disease. Current Drug Target- Inflammation and Allergy 2: 257-265, 2003.

■Yamamoto K, Ikeda U, Shimada K. Role of mechanical stress in monocytes/macrophages: Implications for atherosclereosis. Current Vascular Pharmacology 1: 315-319, 2003.

■Ogata Y, Takahashi M. Bcl-xL as an anti-apoptotic molecule for cardiaomyocytes. Drugs News & Perspectives 16:446-452,2003