Works

業績一覧

1. Amano Y., Akazawa Y., Yasuda J., Yoshino K., Kojima K., Kobayashi N., Matsuzaki S., Nagasaki M., Kawai Y., Minegishi N., Ishida N, Motoki N., Hachiya A., Nakazawa Y., Yamamoto M., Koike K., Takeshita T.:A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease.

2. Nakada T., Kashihara T., Komatsu M., Kojima K., Takeshita, T., Yamada, M.:Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction.

3. Kashihara T., Nakada T., Kojima K., Takeshita, T., Yamada, M.:Angiotensin II activates Ca(V)1.2 Ca2+ channels through beta-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.

4. Funadani R., Sogame Y.,Kojima K., Takeshita T.,Yamamoto K, Tsujizono T., Suizu F., Miyata S.,Yagyu KI., Suzuki T., Arikawa M., Matsuoka, T .:Morphogenetic and molecular analyses of cyst wall components in the ciliated protozoan Colpoda cucullus Nag-1 .

5. Kojima K., Amano Y., Yoshino K., Tanaka N., Sugamura K., Takeshita T.:ESCRT-0 Protein Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (Hrs) Is Targeted to Endosomes Independently of Signal-transducing Adaptor Molecule (STAM) and the Complex Formation with STAM Promotes Its Endosomal Dissociation.

6. Amano Y, Yoshino K, Kojima K, Takeshita T: A hydrophobic amino acid cluster inserted into the C-terminus of a recycling cell surface receptor functions as an endosomal sorting signal.

7. Sogame Y, Kojima K, Takeshita T, Kinoshita E, Matsuoka T.: Identification of Differentially Expressed Water-insoluble Proteins in the Encystment Process of Colpoda cucullus by Two-dimensional Electrophoresis and LC-MS/MS Analysis.

8. Sogame Y, Kojima K, Takeshita T, Kinoshita E, Funadani R, Matsuoka T.: Excystment-dependent alteration of protein expression in terrestrial ciliate Colpoda cucullus.

9. Sogame Y, Kojima K, Takeshita T, Kinoshita E, Matsuoka T.:EF-1α and mitochondrial ATP synthase β chain: alteration of their expression in encystment-induced Colpoda cucullus.

10. Sogame Y, Kojima K, Takeshita T, Fujiwara S, Miyata S, Kinoshita E, Matsuoka T.:Protein phosphorylation in encystment-induced Colpoda cucullus: localization and identification of phosphoproteins.

11. Amano Y, Yamashita Y, Kojima K, Yoshino K, Tanaka N, Sugamura K, Takeshita T.:Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting.

12. Yamada K, Tsukahara T, Yoshino K, Kojima K, Agawa H, Yamashita Y, Amano Y, Hatta M, Matsuzaki Y, Kurotori N, Wakui K, Fukushima Y, Osada R, Shiozawa T, Sakashita K, Koike K, Kumaki S, Tanaka N. and Takeshita T.: Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus.

13. Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T.: Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor β chain.

14. Kyuuma M, Kikuchi K, Kojima K, Sugawara Y, Sato M, Mano N, Goto J, Takeshita T, Yamamoto A, Sugamura K, Tanaka N.: AMSH, an ESCRT-III Associated Enzyme, Deubiquitinates Cargo on MVB/Late Endosomes.

15. Tsukahara T, Agawa H, Matsumoto S, Matsuda M, Ueno S, Yamashita Y, Yamada K, Tanaka N, Kojima K, and Takeshita T.: Murine leukemia virus vector integration favors promoter regions and regional hot spots in a human T-cell line.

16. Brancho D, Tanaka N, Jaeschke A, Ventura J.-J, Kelkar N, Tanaka Y, Kyuuma M, Takeshita T, Flavell R.A, Davis R.J.: Mechanism of p38 MAP kinase activation in vivo.

17. Yamada, M, Takeshita, T, Miura, S, Murata, K, Kimura, Y, Ishii, N, Nose, M, Sakagami, H, Kondo, H, Tashiro, F, Miyazaki, J, Sasaki, H, and Sugamura, K.: Loss of hippocampal CA3 pyramidal neurons in mice acking STAM1.

18. Kikuchi, K, Kawasaki, Y, Ishii, N, Sasaki, Y, Asao, H, Takeshita, T, Miyoshi, I, Kasai, N, and Sugamura, K.:Suppression of thymic development by the dominant-negative form of Gads.

19. Miura, S, Takeshita, T, Kimura, Y, Kasai, H, Murata, K, Sasaki, Y, Asao, H, Hanami, J-I, Beppu, H, Tsukazaki, T, Wrana, J.L, Miyazono, K, and Sugamura, K.: Hgs(Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.

20. Endo, K, Takeshita, T, Kasai, H, Sasaki, Y, Tanaka, N, Asao, H, Kikuchi, K, Yamada, M, Chen, M, O'Shea, J. J, and Sugamura, K.:STAM2, a new member of the STAM family, binding to the Janus kinases.

21. Tanaka, N, Kaneko, K, Asao, H, Kasai, H, Endo, Y, Fujita, T, Takeshita, T, and Sugamura, K.: Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines.

22. Asada, H, Ishii, N, Sasaki, Y, Endo, K, Kasai, H, Tanaka, N, Takeshita, T, Tsuchiya, S, Konno, T, and Sugamura, K.:Grf40, A novel grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.

23. Yamada, A, Kubo, K, Takeshita, T, Harashima, N, Kawano, K, . Mine, T, Sagawa, K, Sugamura, K, and Itoh, K.:Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108.

24. Abe, H, Takeshita, T, Nagata, K, Arita, T, Endo, Y, Fujita, T, Takayama, H, Kubo, M, and Sugamura, K.: Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family.

25. Yasuda, K, Nemoto, T, Ohashi, Y, Satomi, S, Murata, K, Ishii, N, Takeshita, T, and Sugamura, K.: Prolongation of allograft survival by administration of mAb specefic for the three subunits of IL-2 receptor.

26. Asao, H, Sasaki, Y, Arita, T, Tanaka, N, Endo, K, Kasai, H, Takeshita, T, Endo, Y, Fujita, T. and Sugamura, K.: Hrs is associated with STAM, signal-transducing adaptor molecule.

27. Takeshita, T, Arita, T, Higuchi, M, Asao, H, Endo, K, Kuroda, H, Tanaka, N, Murata, K, Ishii, N. and Sugamura, K.: STAM, signal transducing adaptor molecule, is associated with janus kinases and involved in signaling for cell growth and c-myc induction.

28. Sugamura, K, Asao, H, Kondo, M, Tanaka, N, Ishii, N, Ohbo, K, Nakamura, M. and Takeshita, T.: The interleukin-2 receptor γ chain : its role in the multiple cytokine receptor complexes and T cell development in XSCID.

29. Takeshita, T, Arita, T, Asao, H, Tanaka, N, Higuchi, M, Kuroda, H, Endo, Y, Fujita, T. and Sugamura, K. : Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM.

30. Higuchi, M, Asao, H, Tanaka, N, Oda, K, Takeshita, T, Nakamura, M, Snick, J. V, and Sugamura, K. : Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line.

31. Sugamura, K, Asao, H, Kondo, M, Tanaka, N, Ishii, N, Nakamura, M. and Takeshita, T.: The Common γ-chain for multiple cytokine receptors.

32. Ishii, N, Kondo, K, Takeshita, T. and Sugamura, K.: mAb specific for the γ chain of the IL-2 receptor.

33. Nemoto, Y, Takeshita, T, Ishii, N, Kondo, M, Higuchi, M, Satomi, S, Nakamura, M, Mori, S. and Sugamura, K. :Differences in tbe interleukin-2 (IL-2) receptor system in human and mouse: α chain is required for formation of the functional mouse IL-2 receptor.

34. Kimura, Y, Takeshita, T, Kondo, M, Ishii, N, Nakamura, M, Snick, J.V. and Sugamura, K.: Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex.

35. Asao, H, Tanaka, N, Ishii, N, Higuchi, M, Takeshita, T, Nakamura, M, Shirasawa, T. and Sugamura, K.: Interleukin 2-induced activation of JAK3: possible involvement in signal transduction for c-myc induction and cell proliferation.

36. Tanaka, N, Asao, H, Ohbo, K, Ishii, N, Takeshita, T, Nakamura, M. Sasaki, H. and Sugamura, K.: Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor β and γ chains.

37. Ishii, N, Asao, H, Kimura, Y, Takeshita, T, Nakamura, M, Tsuchiya, K, Konno, T, Maeda, M, Uchiyama, T. and Sugamura, K.: Impairment of ligand binding and growth signaling of mutant IL-2 receptor γ-chains in patients with X-linked severe combined immunodeficiency.

38. Ishii, N, Takeshita, T, Kimura, Y, Tada, K, Kondo, M, Nakamura, M. and Sugamura, K.: Expression of the interleukin2 receptor γ chain on various populations in human peripheral blood.

39. Kondo, M, Takeshita, T, Higuchi, M, Nakamura, M, Sudo, T, Nishikawa, S. andSugamura, K.: Functional participation of the IL-2 receptor γ chain in IL-7 receptors complexes.

40. Kondo, M, Takeshita, T, Ishii, N, Nakamura, M, Watanabe, S, Arai, K. and Sugamura, K.: Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4.

41. Matsuoka, M, Takeshita, T, Ishii, N, Nakamura, M. and Sugamura, K.: Kinetic study of IL-2 binding on the receonstituted IL-2 receptor complexes including the human γ chain.

42. Kumaki, S, Kondo, M, Takeshita, T, Asao, H, Nakamura, M. and Sugamura, K.: Cloning of the mouse interleukin 2 receptor γ chain: Demonstration of functional differences between the mouse and human receptors.

43. Asao, H, Takeshita, T, Ishii, N, Kumaki, S, Nakamura, M, and Sugamura, K.: Reconstitution of the functional IL-2 receptor complexes on fibroblastoid cells: Involvement of the cytoplasmic domain of the γ chain in two distinct signaling pathways.

44. Takeshita, T, Asao, H, Ohtani, K, Ishii N, Kumaki, S, Tanaka, N, Munakata, H, Nakamura, M. and Sugamura, K.: Cloning of the γchain of the human IL-2 receptor.

45. Kumaki, S, Asao, H, Takeshita, T, Kurahayashi, Y, Nakamura, M, Beckers, T, Engels, J. W, and Sugamura, K.: Cell type-specific activation of a tyrosine kinase associated with IL-2 receptor β chain in response to IL-2.

46. Asao, H, Kumaki, S, Takeshita, T, Nakamura, M. and Sugamura, K.: IL-2-dependent in vivo and in vitro tyrosine phosphorylation of IL-2 receptor γ chain.

47. Takeshita, T, Ohtani, K, Asao, H, Kumaki, S, Nakamura, M. and Sugamura, K.: An associated molecule, p64, with IL-2 receptor β chain: its possible involvement in formation of the functional IL-2 receptor complex.

48. Ohbo, K, Takeshita, T, Asao, H, Kurahayashi, Y, Tada, K, Mori, H, Hatakeyama, M, Taniguchi, T. and Sugamura, K.: Monoclonal antibodies defining distinct epitopes of the human IL-2 receptor β chain and their differential effects on IL-2 responses.

49. Sugamura, K, Takeshita, T, Asao, H, Kumaki, S, Ohbo, K, Ohtani, K.and Nakamura, M.: IL-2-induced signal transduction: Involvement of tyrosine kinase and IL-2 receptor γ chain.

50. Honda, M, Kitamura, K, Takeshita, T, Sugamura, K. and Tokunaga, T.: Identification of a soluble IL-2 receptor β chain from human lymphoid cell line cells.

51. Takeshita, T, Ohbo, K, Nakamura, M. Goto, Y. and Sugamura, K.: Establishment of a cyclic AMP-dependent growing human T cell line derived from an interleukin 2-dependent cell line.

52. Nishikawa, K, Saito, S, Morii, T, Kato, Y, Narita, N, Ichijo, M, Ohashi, Y, Takeshita, T. and Sugamura, K.: Differential expression of the interleukin 2 receptor β (p75) chain on human peripheral blood natural killer subsets.

53. Takeshita, T, Asao, H, Suzuki, J. and Sugamura, K.: An associated molecule, p64, with high-affinity interleukin 2 receptor.

54. Asao, H, Takeshita, T, Nakamura, M, Nagata, K. and Sugamura, K.:The evidence for the IL-2 receptor β chain processing from p70 to p75.

55. Ortaldo, J. R, Frey, J, Farrar, W. L, Takeshita, T, and Sugamura, K.:Regulation of CD3- lymphocyte function with an antibody against the IL-2β-chain receptor: modulation of NK and LAK activity and production of IFN-γ.

56. Asao, H, Takeshita, T, Nagata, K, Nakamura, M. and Sugamura, K.: Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75.