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Welcome to Department of Molecular & Cellular Physiology, Shinshu University School of Medicine


Uemura T, Mori T, Kurihara T, Kawase S, Koike R, Satoga M, Cao X, Li X, Yanagawa T, Sakurai T, Shindo T, Tabuchi K.
Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques.
Sci Rep.6:35861.2016

Cao, X.,Tabuchi, K.
Functions of synapse adhesion molecules neurexin/neuroligins and neurodevelopmental disorders.
Neurosci Res 2016

Ito, S., Kimura, S., Warabi, E., Kawachi, Y., Yamatoji, M., Uchida, F., Ishibashi-Kanno, N., Yamagata, K., Hasegawa, S., Shoda, J., Tabuchi, K., Sakai, S., Bukawa, H., Sekido, M.,Yanagawa, T.
p62 modulates the intrinsic signaling of UVB-induced apoptosis.
J Dermatol Sci 83(3):226-33.2016

Baig, D. N., Yanagawa, T.,Tabuchi, K.
Distortion of the normal function of synaptic cell adhesion molecules by genetic variants as a risk for autism spectrum disorders.
Brain Res Bull 2016

Um, J. W., Choii, G., Park, D., Kim, D., Jeon, S., Kang, H., Mori, T., Papadopoulos, T., Yoo, T., Lee, Y., Kim, E., Tabuchi, K.,Ko, J.
IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation.
J Biol Chem 291(19):10119-30.2016

Anderson, G. R., Aoto, J., Tabuchi, K., Foldy, C., Covy, J., Yee, A. X., Wu, D., Lee, S. J., Chen, L., Malenka, R. C.,Sudhof, T. C.
beta-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.
Cell 162(3):593-606.2015

Aoto, J., Foldy, C., Ilcus, S. M., Tabuchi, K.,Sudhof, T. C.
Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses.
Nat Neurosci 18(7):997-1007.2015

Ko, J. S., Pramanik, G., Um, J. W., Shim, J. S., Lee, D., Kim, K. H., Chung, G. Y., Condomitti, G., Kim, H. M., Kim, H., de Wit, J., Park, K. S., Tabuchi, K.,Ko, J.
PTPsigma functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.
Proc Natl Acad Sci U S A 112(6):1874-9.2015

Nagaoka, T., Tabuchi, K.,Kishi, M.
PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2.
Sci Rep 5:12916.2015

Azuma M, Yanagawa T, Ishibashi-Kanno N, Uchida F, Ito T, Yamagata K, Hasegawa S, Sasaki K, Adachi K, Tabuchi K, Sekido M, Bukawa H.
Mandibular reconstruction using plates prebent to fit rapid prototyping 3-dimensional printing models ameliorates contour deformity.
Head Face Med 10(1):45.2014

Isshiki M, Tanaka S, Kuriu T, Tabuchi K, Takumi T, Okabe S.
Enhanced synapse remodelling as a common phenotype in mouse models of autism.
Nat Commun 5:4742.2014

Li H, Guo Q, Inoue T, Polito VA, Tabuchi K, Hammer RE, Pautler RG, Taffet GE, Zheng H.
Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow.
Mol Neurodegener 9:28.2014

Ito T, Kimura S, Seto K, Warabi E, Kawachi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T.
Peroxiredoxin I plays a protective role against UVA irradiation through reduction of oxidative stress.
J Dermatol Sci 74(1):9-17.2014

Um JW, Pramanik G, Ko JS, Song MY, Lee D, Kim H, Park KS, Sudhof TC, Tabuchi K, Ko J.
Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.
Cell Rep 6(6):1096-109.2014

Aoto J, Martinelli DC, Malenka RC, Tabuchi K, Sudhof TC.
Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking.
Cell 154(1):75-88.2013

Budreck EC, Kwon OB, Jung JH, Baudouin S, Thommen A, Kim HS, Fukazawa Y, Harada H, Tabuchi K, Shigemoto R, Scheiffele P, Kim JH.
Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling.
Proc Natl Acad Sci U S A. 110(2):725-30.2013

Kishioka A, Uemura T, Fukushima F, Mishina M
Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum.
Mol. Brain 6; 17, 2013

Sasaki H, Togashi S, Karube R, Yanagawa T, Nakane S, Tabuchi K, Ishibashi N, Shinya Y, Ito H, Yamagata K, Onizawa K, Adachi K, Sekido M. and Bukawa H.
Presurgical nasoalveolar molding orthopedic treatment improves the outcome of primary cheiloplasty of unilateral complete cleft lip and palate, as assessed by naris morphology and cleft gap.
J Craniofac Surg. 23(6):1596-601.2012

Karube R, Sasaki H, Togashi S, Yanagawa T, Nakane S, Ishibashi N, Yamagata K, Onizawa K, Adachi K, Tabuchi K, Sekido M. and Bukawa H.
A novel method for evaluating postsurgical results of unilateral cleft lip and palate with the use of Hausdorff distance: presurgical orthopedic treatment improves nasal symmetry after primary cheiloplasty.
Oral Surg Oral Med Oral Pathol Oral Radiol. 114(6):704-11. 2012

Mishina M, Uemura T, Yasumura M, Yoshida T
Molecular mechanism of parallel fiber-Purkinje cell synapse formation.
Frontiers in Neural Circuits 6, Article90, 1-9, 2012

Yasumura M, Yoshida T, Lee SJ, Uemura T, Joo JY, Mishina M
Glutamate receptor â┬1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes.
J Neurochem , 121(5):705-716 2012

Yoshida T, Shiroshima T, Lee SJ, Yasumura M, Uemura T, Chen X, Iwakura Y, Mishina M
Receptor Accessory Protein organizes neuronal synaptogenesis as a cell adhesion molecule
J Neurosci , 32(8):2588-2600 2012

Lee SJ, Uemura T, Yoshida T, Mishina M
GluR_2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation
J Neurosci , 32(13):4688-4701 2012

Masayoshi Mishina, Takeshi Uemura, Misato Yasumura and Tomoyuki Yoshida
Molecular mechanism of parallel fiber-Purkinje cell synapse formation
Frontiers in Neural Circuits , 6(90):doi: 10.3389/fncir.2012.00090 2012

Moteki H, Nishio SY, Hashimoto S, Takumi Y, Iwasaki S, Takeichi N, Fukuda S, Usami S.
TECTA mutations in Japanese with mid-frequency hearing loss affected by zona pellucida domainprotein secretion.
J Hum Genet. , 57(9):587-592 2012

Oguchi T, Suzuki N, Hashimoto S, Chaudhry GA, Chaudhry FA, Usami S
Ottersen OP.Inner hair cells of mice express the glutamine transporter SAT1.
Hear Res. , 292(1-2):59-63 2012

Etherton MR, Tabuchi K, Sharma M, Ko J, Sudhof TC.
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
EMBO J. , 30(14):2908-2919 2011

Etherton, M. R., Tabuchi, K., Sharma, M., Ko, J. and Sudhof, T. C.
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
EMBO J. 30(14):2908-19.2011

Etherton M, Foldy C, Sharma M, Tabuchi K, Liu X, Shamloo M, Malenka RC, Sudhof TC.
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.
Proc Natl Acad Sci U S A. , 108(33):13764-13769 2011

Joo JY, Lee SJ, Uemura T, Yoshida T, Yasumura M, Watanabe M, Mishina M
Differential Interactions of Cerebellin Precursor Protein (Cbln) Subtypes and Neurexin Variants for Synapse Formation of Cortical Neurons
Biochem Biophys Res Commun , 406(4):627-632 2011

Yoshida T, Yasumura M, Uemura T, Lee SJ, Ra M, Taguchi R, Iwakura Y, Mishina M
IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase â┬
J Neurosci , 31(88):13485-13499 2011

Uemura T, Lee SJ, Yasumura M, Takeuchi T, Yoshida T, Ra M, Taguchi R, Sakimura K, Mishina M
Trans-synaptic interaction of GluRâ┬2 and neurexin through Cbln1 mediates synapse formation in the cerebellum
Cell , 141(6):1068-1079 2010

Li, H., Wang, B., Wang, Z., Guo, Q., Tabuchi, K., Hammer, R. E., Sudhof, T. C. and Zheng, H.
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.
Proc Natl Acad Sci U S A. , 107(40):17362-7.2010

Li, H., Wang, Z., Wang, B., Guo, Q., Dolios, G., Tabuchi, K., Hammer, R. E., Sudhof, T. C., Wang, R. and Zheng, H.
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.
J Biol Chem. 285(40):30598-605.2010

Fukata, Y., Lovero, K. L., Iwanaga, T., Watanabe, A., Yokoi, N., Tabuchi, K., Shigemoto, R., Nicoll, R. A. and Fukata, M.
Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy.
Proc Natl Acad Sci U S A. 107(8):3799-804.2010

Blundell, J., Blaiss, C. A., Etherton, M. R., Espinosa, F., Tabuchi, K., Walz, C., Bolliger, M. F., Sudhof, T. C. and Powell, C. M.
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior.
J Neurosci. 30(6):2115-29.2010

Tabuchi, K., Chen, G., Sudhof, T. C. and Shen, J.
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.
J Neurosci. 29(22):7290-301.2009

Blundell, J., Tabuchi, K., Bolliger, M. F., Blaiss, C. A., Brose, N., Liu, X., Sudhof, T. C. and Powell, C. M.
Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2.
Genes Brain Behav. 8(1):114-26.2009

Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M. and Sudhof, T. C.
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Science. 318(5847):71-6.2007 *Research Article.

Dudanova, I., Tabuchi, K., Rohlmann, A., Sudhof, T. C. and Missler, M.
Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.
J Comp Neurol. 502(2):261-74.2007

Yanagawa, T., Yoshida, H., Yamagata, K., Onizawa, K., Tabuchi, K., Koyama, Y., Iwasa, S., Shimoyamada, H., Harada, H. and Omura, K.
Loss of cytokeratin 13 expression in squamous cell carcinoma of the tongue is a possible sign for local recurrence.
J Exp Clin Cancer Res. 26(2):215-20.2007

Ho, A., Morishita, W., Atasoy, D., Liu, X., Tabuchi, K., Hammer, R. E., Malenka, R. C. and Sudhof, T. C.
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.
J Neurosci. 26(50):13089-101.2006

Shah, S., *Lee, S. F., *Tabuchi, K., *Hao, Y. H., Yu, C., LaPlant, Q., Ball, H., Dann, C. E., 3rd, Sudhof, T. and Yu, G.
Nicastrin functions as a gamma-secretase-substrate receptor.
Cell. 122(3):435-47.2005
*These authors contributed equally to this work

Yuasa, Y., Okabe, M., Yoshikawa, S., Tabuchi, K., Xiong, W. C., Hiromi, Y. and Okano, H.
Drosophila homeodomain protein REPO controls glial differentiation by cooperating with ETS and BTB transcription factors.
Development. 130(11):2419-28.2003

Tabuchi, K., Biederer, T., Butz, S. and Sudhof, T. C.
CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein.
J Neurosci. 22(11):4264-73.2002

Tabuchi, K. and Sudhof, T. C.
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.
Genomics. 79(6):849-59.2002

Honarpour, N., Tabuchi, K., Stark, J. M., Hammer, R. E., Sudhof, T. C., Parada, L. F., Wang, X., Richardson, J. A. and Herz, J.
Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.
Neuroscience. 106(2):263-74.2001

Tabuchi, K., Sawamoto, K., Suzuki, E., Ozaki, K., Sone, M., Hama, C., Tanifuji-Morimoto, T., Yuasa, Y., Yoshihara, Y., Nose, A. and Okano, H.
GAL4/UAS-WGA system as a powerful tool for tracing Drosophila transsynaptic neural pathways.
J Neurosci Res. 59(1):94-9.2000

Yanagawa, T., Harada, H., Iwasa, S., Tabuchi, K., Omura, K., Suzuki, H., Yusa, H., Yamagata, K., Onizawa, K., Ishii, T. and Yoshida, H.
c-Abl expression in oral squamous cell carcinomas.
Oral Oncol. 36(1):89-94.2000

Yanagawa, T., Iwasa, S., Ishii, T., Tabuchi, K., Yusa, H., Onizawa, K., Omura, K., Harada, H., Suzuki, H. and Yoshida, H.
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Cancer Lett. 156(1):27-35.2000

Yanagawa, T., Ishikawa, T., Ishii, T., Tabuchi, K., Iwasa, S., Bannai, S., Omura, K., Suzuki, H. and Yoshida, H.
Peroxiredoxin I expression in human thyroid tumors.
Cancer Lett. 145(1-2):127-32.1999

Yoshihara, Y., Mizuno, T., Nakahira, M., Kawasaki, M., Watanabe, Y., Kagamiyama, H., Jishage, K., Ueda, O., Suzuki, H., Tabuchi, K., Sawamoto, K., Okano, H., Noda, T. and Mori, K.
A genetic approach to visualization of multisynaptic neural pathways using plant lectin transgene.
Neuron. 22(1):33-41.1999

Tsuji, M. H., Yanagawa, T., Iwasa, S., Tabuchi, K., Onizawa, K., Bannai, S., Toyooka, H. and Yoshida, H.
Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis.
Cancer Lett. 138(1-2):53-9.1999

Tabuchi, K., Yoshikawa, S., Yuasa, Y., Sawamoto, K. and Okano, H.
A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells.
Neurosci Lett. 257(1):49-52.1998

Hamada, S., Senzaki, K., Hamaguchi-Hamada, K., Tabuchi, K., Yamamoto, H., Yamamoto, T., Yoshikawa, S., Okano, H. and Okado, N.
Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken.
Brain Res Mol Brain Res. 54(2):199-211.1998


Department of Molecular &
Cellular Physiology,
Shinshu University School of Medicine

3-1-1 Asahi, Matsumoto,
Nagano 390-8621

PHONE: +81-263-37-3775
FAX: +81-263-37-3776