Web of Science 収録学術誌
「*」印：責任著者／「*」Corresponding author

80. Oshima, S., Namai, F., Sato, T.* & Shimosato, T.*
Development of a single-chain fragment variable that binds to the SARS-CoV-2 spike protein produced by genetically modified lactic acid bacteria
Molecular Biotechnology, 66(1), 151-160, 2024.
DOI:10.1007/s12033-023-00741-y

79. Murakami, A., Toyomoto, K., Namai, F., Sato, T., Fujii, T., Tochio, T. & Shimosato, T.*
Oral administration of Brevibacterium linens from washed cheese increases short-chain fatty acid-producing bacteria and lactobacilli in the gut microbiota of mice
Animal Science Journal, 94(1):e13905, 2023.
DOI: 10.1111/asj.13905

78. Ishioka, M., Nihashi, Y., Sunagawa, Y., Umezawa, K., Shimosato, T., Kagami, H., Morimoto, T. & Takaya, T.*
Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells
International Journal of Molecular Sciences, 24(18):14380, 2023.
DOI:10.3390/ijms241814380

77. Sirisopapong, M., Shimosato, T. Okrathok, S. & Khempaka, S.*
Assessment of lactic acid bacteria isolated from the chicken digestive tract for potential use as poultry probiotics
Animal Bioscience, 36(8):1209-1220, 2023.
DOI:10.5713/ab.22.0455

76. Namai, F., Sumiya, S., Nomura, N., Sato, T.* & Shimosato, T.*
Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
AMB Express, 13:4, 2023.
DOI:10.1186/s13568-023-01509-y

75. Nihashi, Y., Yamamoto, M., Shimosato, T. & Takaya, T.*
Myogenetic oligodeoxynucleotides restores differentiation and reverses inflammation of myoblasts aggravated by cancer-conditioned medium
Muscles, 1:111-120, 2022.
DOI:

74. Nohira, N., Shinji, S., Nakamura, S., Nihashi., Shimosato, T. & Takaya, T.*
Myogenetic oligodeoxynucleotides as anti-nucleolin aptamers inhibit the growth of embryonal rhabdomyosarcoma cells
Biomedicines,10(11):2691, 2022.
DOI: 10.3390/biomedicines10112691

73. Nihashi, Y., Miyoshi, M., Umezawa, K., Shimosato, T. & Takaya, T.*
Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner.
Nanomaterials,12(10):1680, 2022.
DOI: 10.3390/nano12101680

72. Okajima, T., Shigemori, S.*, Namai, F., Ogita, T., Sato, T. & Shimosato, T.*
Free feeding of CpG-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice
Frontiers in Immunology, 12:738041, 2021.
DOI:10.3389/fimmu.2021.738041

71. Ogita, T., Namai, F., Mikami, A., Ishiguro, T., Umezawa, K., Uyeno, Y. & Shimosato, T.*
A soybean resistant protein-containing diet increased the production of Reg3γ through the regulation of the gut microbiota and enhanced the intestinal barrier function in mice
Frontiers in Nutrition, 8:701466, 2021.
DOI:10.3389/fnut.2021.701466

70. Nihashi, Y., Shinji, S., Umezawa, K., Shimosato, T., Ono, T., Kagami, H. & Takaya, T.*
Myogenetic oligodeoxynucleotide (myoDN) complexed with berberine promotes differentiation of chicken myoblasts
Animal Science Journal, 92(1):e13597, 2021.
DOI:10.1111/asj.13597

69. Nakamura, S., Yonekura, S., Shimosato, T. & Takaya, T.*
Myogenetic Oligodeoxynucleotide (myoDN) Recovers the Differentiation of Skeletal Muscle Myoblasts Deteriorated by Diabetes Mellitus
Frontiers in Physiology, 12:679152, 2021.
DOI:10.3389/fphys.2021.679152

68. Mikami, A., Ogita, T., Namai, F., Shigemori, S., Sato, T. & Shimosato, T.*
Oral administration of Flavonifractor plautii, a bacteria increased with green tea consumption, promotes recovery from acute colitis in mice via suppression of IL-17
Frontiers in Nutrition, 7:610946, 2021.
DOI:10.3389/fnut.2020.610946

67. Shinji, S., Umezawa, K., Nihashi, Y., Nakamura, S., Shimosato, T. & Takaya, T.*
Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin
Frontiers in Cell and Developmental Biology, 6:616706, 2021.
DOI: 10.3389/fcell.2020.616706

66. Yumoto, K., Sato, T.*, Nakashima, K., Namai, F., Shigemori, S., Shimosato, T. & Kaneko, T.
Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema
Antioxidants, 9:1049, 2020.
DOI:10.3390/antiox9111049

65. Namai, F., Murakami, A., Ueda, A., Tsukagoshi, M., Shigemori, S., Ogita, T., Sato, T. & Shimosato, T.*
Construction of genetically modified Lactococcus lactis producing anti–human-CTLA-4 single-chain fragment variable
Molecular Biotechnology, 62(11-12):572-579, 2020.
DOI:10.1007/s12033-020-00274-8

64. Shigemori, S., Namai, F., Ogita, T., Sato, T. & Shimosato, T.*
Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate-induced acute colitis in mice
Animal Science Journal, 91(1):e13468, 2020.
DOI:10.1111/asj.13468

63. Namai, F., Shigemori, S., Ogita, T., Sato, T. & Shimosato, T.*
Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable
Molecular Biology Reports, 47(9):7039-7047, 2020.
DOI:10.1007/s11033-020-05765-0

62. Ishida, M., Namai, F., Shigemori, S., Kajikawa, S., Tsukagoshi, M., Sato, T., Ogita, T. & Shimosato, T.*
Ribosome-engineered Lacticaseibacillus rhamnosus GG exhibits cell surface GAPDH accumulation and enhanced adhesion to human colonic mucin
Applied and Environmental Microbiology, 86(20):e01448-20, 2020.
DOI:10.1128/AEM.01448-20

61. Namai, F., Shigemori, S., Ogita, T., Sato, T. & Shimosato, T.*
Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
Experimental and Molecular Medicine, 52(9):1627-1636, 2020.
DOI:10.1038/s12276-020-005707-5

60. Mikami, A., Ogita, T., Namai, F., Shigemori, S., Sato, T. & Shimosato, T.*
Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue
Molecular Biology Reports, 47(9):6717-6725, 2020.
DOI :10.1007/s11033-020-05727-6

59. Tsukagoshi, M., Sirisopapong, M., Namai, F., Ishida, M., Okrathok, S., Shigemori, S., Ogita, T., Sato, T., Khempaka, S.* & Shimosato, T.*
Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS-stimulated mouse macrophages
Animal Science Journal, 91:e13436, 2020.
DOI:10.1111/asj.13436

58. Ogita, T., Yamamoto, Y., Mikami, A., Shigemori, S., Sato, T. & Shimosato, T.*
Oral administration of Flavonifractor plautii strongly suppresses Th2 immune responses in mice
Frontiers in Immunology, 11:379, 2020.
DOI:10.3389/fimmu.2020.00379

57. Nigar, S. & Shimosato, T.*
Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators
Frontiers in Nutrition, 6:140, 2019.
DOI:10.3389/fnut.2019.00140

56. Koyama, S., Fujita, H.*, Shimosato, T., Kamijo, A., Ishiyama, Y., Yamamoto, E., Ishii, Y., Hattori, Y., Hagiwara, M., Yamazaki, E., Tomita, N. & Nakajima, H.
Septicemia from Lactobacillus rhamnosus GG, from a Probiotic Enriched Yogurt, in a Patient with Autologous Stem Cell Transplantation
Probiotics and Antimicrobial Proteins, 11(1), 295-298, 2019.
DOI:10.1007/s12602-018-9399-6

55. Sato, T., Shimosato, T. & Klinman, DM.*
Silicosis and lung cancer: current perspectives
Lung Cancer-Targets and Therapy, 9, 91-101, 2018.
DOI:10.2147/LCTT.S156376

54. Namai, F., Yamamoto, Y., Sato, T., Ogita, T. & Shimosato, T.*
Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
Animal Science Journal, 89(12), 1707-1711, 2018. DOI:10.1111/asj.13115

53. Nigar, S., Yamamoto, Y., Okajima, T., Sato, T., Ogita, T. & Shimosato, T.*
Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components
Animal Science Journal, 89(10), 1504-1511, 2018.
DOI: 10.1111/asj.13082

52. Nakashima, K., Sato, T.*, Shigemori, S., Shimosato, T., Shinkai, M., Kaneko, T.
Regulatory Role of Heme Oxygenase-1 in Silica-induced Lung Injury
Respiratory Research, 19:144, 2018.
DOI: 10.1186/s12931-018-0852-6

51. Namai, F., Shigemori, S., Sudo, K., Sato, T., Yamamoto, Y., Nigar, S., Ogita, T. & Shimosato, T.*
Recombinant mouse osteocalcin secreted by Lactococcus lactis promotes glucagon-like peptide-1 induction in STC-1 cells
Current Microbiology, 75(1), 92-98, 2018.
DOI:10.1007/s00284-017-1354-3

50. Nigar, S., Yamamoto, Y., Okajima, T., Shigemori, S., Sato, T., Ogita, T. & Shimosato, T.*
Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
BMC Immunology, 18(1):44, 2017.
DOI:10.1186/s12865-017-0227-7

49. Yamamoto, Y., Sugimura, R., Watanabe, T., Shigemori, S., Okajima, T., Nigar, S., Namai, F., Sato, T., Ogita, T. & Shimosato, T.*
Class A CpG oligonucleotide priming rescues mice from septic shock via activation of platelet-activating factor acetylhydrolase
Frontiers in Immunology, 8, ID:1049, 2017.
DOI:10.3389/fimmu.2017.01049

48. Shigemori, S., Namai, F., Yamamoto, Y., Nigar, S., Sato, T., Ogita, T. & Shimosato, T.*
Genetically modified Lactococcus lactis producing a green fluorescence protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in LPS-stimulated RAW 264.7
Journal of Dairy Science, 100(9), 7007-7015, 2017.
◎ Editor's choice（特集論文）

47. Shigemori, S. & Shimosato, T.*
Applications of genetically modified immunobiotics with high immunoregulatory capacity for treatment of inflammatory bowel diseases
Frontiers in Immunology, 8, 22, 2017.
DOI:10.3389/fimmu.2017.00022

46. Shigemori, S., Ihara, M., Sato, T., Yamamoto, Y., Nigar, S., Ogita, T. & Shimosato, T.*
Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
Applied Microbiology and Biotechnology, 101(1), 341-349, 2017.
DOI:10.1007/s00253-016-7907-8

45. Klinman, D.M.*, Sato, T. & Shimosato, T.
The use of nanoparticles to delivery immunomodulatory oligonucleotides
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 8(4), 631-637, 2016.（総説）
DOI:10.1002/wnan.1382

44. Yamamoto, Y., Shigemori, S., Nigar, S., Oshiro, K., Wang, Y., Sato, T. & Shimosato, T.*
Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
Animal Science Journal, 87(5), 710-717, 2016.
DOI:10.1111/asj.12479

43. Shigemori, S., Watanabe, T., Kudo, K., Ihara, M., Nigar, S., Yamamoto, Y., Sato, T., Kitazawa, H., & Shimosato, T. *
Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
Microbial Cell Factories, 14(1), 189, 2015.
DOI:10.1186/s12934-015-0378-2

42. Sato, T., Shimosato, T., Ueda, A., Ishigatsubo, Y. & Klinman, D.M.*
Intrapulmonary delivery of CpG microparticles eliminates lung tumors
Molecular Cancer Therapeutics, 14(10), 2198-2205, 2015.
DOI:10.1158/1535-7163.MCT-15-0401

41. Uyeno, Y.*, Shigemori, S. & Shimosato, T.
Effect of probiotics/prebiotics on cattle health and productivity
Microbes and Environments, 30(2), 126-132, 2015. （総説）
DOI:10.1264/jsme2.ME14176

40. Tokutake, Y., Gushima, K., Miyazaki, H., Shimosato, T. & Yonekura S.*
ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation
Biochemical and Biophysical Research Communications, 460(3), 831-837, 2015.
DOI:10.1016/j.bbrc.2015.03.118

39. Wang, Y., Yamamoto, Y., Shigemori, S., Watanabe, T., Oshiro, K., Wang, X., Wang, P., Sato, T., Yonekura, S., Tanaka, S., Kitazawa, H. & Shimosato, T. *
Inhibitory/Suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice
Molecular Therapy, 23(2), 297-309, 2015.
DOI:10.1038/mt.2014.239
Featured Articles（特集論文）. DOI:10.1038/mt.2014.249

38. Shigemori, S., Ohshiro, K., Wang, P., Yamamoto, Y., Wang, Y., Sato, T., Uyeno, Y. & Shimosato, T.*
Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis
BioMed Research International, 2014:393598, 2014.
DOI:10.1155/2014/393598

37. Shimosato, T.*, Kanoh, J. & Otani, H.
Oral administration of a fruiting body extract of Boletopsis leucomelas enhances intestinal IgA production in LPS-challenged mice
Food and Agricultural Immunology, 25(4), 510-522, 2014. DOI:10.1080/09540105.2013.847064

36. Watanabe, T., Nishimura, K., Hosaka, Y., Shimosato, T., Yonekura, S., Suzuki, D., Takemoto, C., Monir, MM. & Hiramatsu, K.*
Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas
Cell and Tissue Research, 357(1), 55-61, 2014.
DOI: 10.1007/s00441-014-1836-6.

35. Shigemori, S., Yonekura, S., Sato, T., Otani, H. & Shimosato, T.*
Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
Applied Microbiology and Biotechnology, 97(8), 3603-3611, 2013.
DOI: 10.1007/s00253-012-4608-9

34. Takahashi, R., Sato, T., Klinman, DM., Shimosato, T., Kaneko, T. & Ishigatsubo, Y.*
Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
International Journal of Oncology, 42(2), 429-436, 2013.
DOI:10.3892/ijo.2012.1755

33. Ito, Y., Shigemori, S., Sato, T., Shimazu, T., Konomi, H., Otani, H., Kitazawa, H. & Shimosato, T.*
Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
FEBS Open Bio, 3, 41-45, 2013.
DOI: 10.1016/j.fob.2012.11.002

32. Sato, T., Saito, Y., Inoue, S., Shimosato, T., Takagi, S., Kaneko, T. & Ishigatsubo, Y.*
Serum heme oxygenase-1 as a marker of lung function decline in patients with chronic silicosis
Journal of Occupational and Environmental Medicine, 54, 1461-1466, 2012.
DOI: 10.1097/JOM.0b013e3182636e93

31. Ikuno, Y., Banno, M., Shimosato, T. & Otani H.*
Oral administration of a casein phosphopeptide and phosphorylated dextrin preparations enhances intestinal IgA production and gene expression relating to the IgA production and calcium absorption in mice
Milchwissenschaft-Milk Science International, 67, 289-292, 2012.

30. Shigemori, S., Yonekura, S., Sato, T., Nakanishi, M., Otani, H. & Shimosato, T.*
Expression of a biologically active GFP-αS1-casein fusion protein in Lactococcus lactis
Current Microbiology, 64(6), 569-575, 2012.
DOI: 10.1007/s00284-012-0111-x

29. Shimazu, T., Villena, J., Tohno, M., Fujie, H., Hosoya, S., Shimosato, T., Aso, H., Suda, Y., Kawai, Y., Saito, T., Makino, S., Ikegami, S., Itoh, H. & Kitazawa, H.*
Immunobiotic Lactobacillus jensenii elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the Toll-like receptor signaling pathway
Infection and Immunity, 80, 276-288, 2012.
DOI: 10.1128/IAI.05729-11

28. Tohno, M., Shimosato, T., Aso, H. & Kitazawa, H.*
Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut-associated lymphoid tissues
Veterinary Immunology and Immunopathology
144, 410-416, 2011.
DOI: 10.1016/j.vetimm.2011.09.010

27. Shimosato, T.*, Tomida, K. & Otani, H.
Effect of Lactobacillus pentosus ONRIC b0240 on intestinal IgA production in mice fed differing levels of protein
Journal of Agricultural and Food Chemistry
59, 2646-2651, 2011.
DOI: 10.1021/jf104240d

26. Sekimura, Y., Shimosato, T. & Otani, H.* Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat's milk immunoglobulin G rich fraction on ovalbumin sensitized BALB/c mice
Milchwissenschaft-Milk Science International, 66, 7-10, 2011.

25. Hosoya, S., Villena, J., Shimazu, T., Tohno, M., Fujie, H., Chiba, E., Shimosato, T., Aso, H., Suda, Y., Kawai, Y., Saito, T., Alvarez, S., Ikegami, S., Itoh, H. & Kitazawa, H.*
Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells
Veterinary Research, 42, 111, 2011.
DOI: 10.1186/1297-9716-42-111

24. Fujie, H., Villena, J., Tohno, M., Morie, K., Shimazu, T., Aso, H., Suda, Y., Shimosato, T., Iwabuchi, N., Xiao, J. Z., Yaeshima, T., Iwatsuki, K., Saito, T., Numasaki, M. & Kitazawa, H.
Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics
FEMS Immunology and Medical Microbiology, 63, 129-39, 2011.
DOI: 10.1111/j.1574-695X.2011.00837.x

23. Shimosato, T.*, Fujimoto, M., Tohno, M., Sato, T., Tateo, M., Otani, H. & Kitazawa, H.
CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9.
Biochemical and Biophysical Research Communications, 394, 81-86, 2010.
DOI: 10.1016/j.bbrc.2010.02.110

22. Sato, T., Yamamoto, M., Shimosato, T. & Klinman, D.M.*
Accelerated wound healing mediated by activation of Toll-like receptor 9
Wound Repair and Regeneration, 18, 586-593, 2010.
DOI: 10.1111/j.1524-475X.2010.00632.x

21. Nagasawa, C., Nishimura-Uemura, J., Tohno, M., Shimosato, T., Kawai, Y., Ikegami, S., Oda, M., Saito, T. & Kitazawa, H.*
Oral Administration of Phosphorylated Dextran Regulates Immune Response in Ovalbumin-Immunized Mice
Asian-Australasian Journal of Animal Sciences, 23, 106-115, 2010.

20. Shimosato, T.*, Tohno, M., Sato, T., Nishimura, J., Kawai, Y., Saito, T. & Kitazawa, H.
Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
Animal Science Journal, 80, 597-604, 2009.
DOI: 10.1111/j.1740-0929.2009.00680.x

19. Shimazu, T., Tohno, M., Katoh, S., Shimosato, T., Aso, H., Kawai, Y., Saito, T. & Kitazawa, H.*
Utilization of the porcine system to study lymphotoxin-beta regulation in intestinal lymphoid tissue
Biochemical Genetics, 47, 126-136, 2009.
DOI: 10.1007/s10528-008-9212-4

18. Kitazawa, H.*, Tohno, M., Shimosato, T. & Saito T.
Development of molecular immunoassay system for probiotics via toll-like receptors based on food immunology
Animal Science Journal, 79(1): 11-21, 2008. （総説）

17. Sato, T., Shimosato, T., Alvord, W. G. & Klinman, D. M.*
Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation
Journal of Immunology, 180, 7648-7654, 2008.

16. Iliev, I. D., Tohno, M., Kurosaki, D., Shimosato, T., He, F., Hosoda, M., Saito, T. & Kitazawa, H.*
Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA-specific IgE production in mice
Scandinavian Journal of Immunology, 67, 370-376, 2008.

15. Tohno, M., Shimosato, T., Kawai, Y., Aso, H., Ikegami, S., Taketomo, N., Saito, T. & Kitazawa, H.*
Advanced molecular immunoassay system for immunobiotic lactic acid bacteria using a transfectant of Toll-like receptor 2
Animal Science Journal, 78, 195-205, 2007.

14. Kitazawa, H.*, Yonezawa, K., Tohno, M., Shimosato, T., Kawai, Y., Saito, T. & Wang, J. M.
Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages
International Immunopharmacology, 7, 1150-1159, 2007.

13. Tohno, M., Shimosato, T., Moue, M., Aso, H., Watanabe, K., Kawai, Y., Yamaguchi, T., Saito, T. & Kitazawa, H.*
Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine
Veterinary Research, 37, 791-812, 2006.

12. Takahashi, N., Kitazawa, H.*, Shimosato, T., Iwabuchi, N., Xiao, J. Z., Iwatsuki, K., Kokubo, S. & Saito, T.
An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro
FEMS Immunology and Medical Microbiology, 46, 461-469, 2006.

11. Shimosato, T., Kimura, T., Tohno, M., Iliev, I. D., Katoh, S., Ito, Y., Kawai, Y., Sasaki, T., Saito, T. & Kitazawa, H.*
Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5 '-C...G-3 ' stem structure
Cellular Microbiology, 8, 485-495, 2006.

10. Tohno, M., Shimosato, T.(co-first author), Kitazawa, H.*, Katoh, S., Iliev, I. D., Kimura, T., Kawai, Y., Watanabe, K., Aso, H., Yamaguchi, T. & Saito, T.
Toll-like receptor 2 is expressed on the intestinal M cells in swine
Biochemical and Biophysical Research Communications, 330, 547-554, 2005.

9. Tohno, M., Kitazawa, H.*, Shimosato, T., Matsumoto, M., Katoh, S., Kawai, Y. & Saito, T.
A swine toll-like receptor 2-expressing transfectant as a potential primary screening system for immunobiotic microorganisms
FEMS Immunology and Medical Microbiology, 44, 283-288, 2005.

8. Shimosato, T., Tohno, M., Kitazawa, H.*, Katoh, S., Watanabe, K., Kawai, Y., Aso, H., Yamaguchi, T. & Saito, T.
Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer's patches
Immunology Letters, 98, 83-89, 2005.

7. Shimosato, T., Kitazawa, H.*, Katoh, S., Tohno, M., Iliev, I. D., Nagasawa, C., Kimura, T., Kawai, Y. & Saito, T.
Augmentation of TH-1 type response by immunoactive AT oligonucleotide from lactic acid bacteria via Toll-like receptor 9 signaling.
Biochemical and Biophysical Research Communications, 326, 782-787, 2005.

6. Iliev, I. D., Kitazawa, H.*, Shimosato, T., Katoh, S., Morita, H., He, F., Hosoda, M. & Saito, T.
Strong immunostimulation in murine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern
Cellular Microbiology, 7, 403-414, 2005.

5. Shimosato, T., Kitazawa, H.*, Tohno, M., Katoh, S., Kawai, Y. & Saito, T.
Development of immune assay system for both CpG and non-CpG DNA from lactic acid bacteria using a transfectant of swine Toll-like receptor 9
Animal Science Journal, 75, 377-382, 2004.

4. Sato, T., Nishimura-Uemura, J., Shimosato, T., Kawai, Y., Kitazawa, H. & Saito, T.*
Dextran from Leuconostoc mesenteroides augments immunostimulatory effects by the introduction of phosphate groups
Journal of Food Protection, 67, 1719-1724, 2004.

3. Katoh, S., Kitazawa, H.*, Shimosato, T., Tohno, M., Kawai, Y. & Saito, T.
Cloning and characterization of swine interleukin-17, preferentially expressed in the intestines
Journal of Interferon and Cytokine Research, 24, 553-559, 2004.

2. Shimosato, T., Kitazawa, H.*, Katoh, S., Tomioka, Y., Karima, R., Ueha, S., Kawai, Y., Hishinuma, T., Matsushima, K. & Saito, T.
Swine Toll-like receptor 9 recognizes CpG motifs of human cell stimulant
Biochimica et Biophysica Acta-Gene Structure and Expression, 1627, 56-61, 2003.

1. Kitazawa, H.*, Watanabe, H., Shimosato, T., Kawai, Y., Itoh, T. & Saito, T.
Immunostimulatory oligonucleotide, CpG-like motif exists in Lactobacillus delbrueckii ssp bulgaricus NIAI B6
International Journal of Food Microbiology, 85, 11-21, 2003.

6. 食品免疫学事典, 朝倉書店, 2021年11月発行.（編集委員長：上野川修一）
『細胞性免疫にかかわるサイトカイン』
下里剛士, Page 134-135.

5. 乳酸菌の機能と産業利用, 株式会社シーエムシー出版, 2021年3月発行.（監修：木下英樹・井越敬司）
『乳酸菌組換え体研究の最前線と将来展望』
重盛駿・下里剛士, Page 48-54.

4.月刊BIOINDUSTRY,株式会社シーエムシー出版, 2020年5月発行.
『乳酸菌組換え体を用いたバイオ医薬品の創製と課題』
重盛駿・下里剛士, Vol.37, No.8, Page 53-59.

3.月刊BIOINDUSTRY,株式会社シーエムシー出版,2015年8月12日発行.
『機能性オリゴDNAの経口投与を可能にする「DNAナノカプセル」の開発』
下里剛士, Vol.32, No.8, Page61-65.

2.PROBIOTICS: IMMUNOBIOTICS AND IMMUNOGENICS, CRC Press, 24-Sep-2013.
Chapter 13: Immunogenics: immunostimulatory oligodeoxynucleotides from probiotics,
Takeshi Shimosato & Haruki Kitazawa, Page 336-353.
Print ISBN: 978-1-4822-0684-5
eBook ISBN: 978-1-4822-0685-2
DOI: 10.1201/b15532-14

1.アジュバント開発研究の新展開,株式会社シーエムシー出版,2011年8月24日第１刷発行.
監修：石井健, 山西弘一
「プロバイオティック乳酸菌を利用した経口ワクチン・アジュバント研究の新展開」
下里剛士, 北澤春樹,Page100-106.
ISBN978-4-713-0405-2C3047.

2024年03月：信州大学農学部長賞（研究業績）（受賞者：野村奈津実）
2024年03月：信州大学農学部長賞（研究業績）（受賞者：Jamiyanpurev Soyolmaa）
2024年03月：信州大学農学部後援会長賞（卒業論文発表会優秀発表賞）（受賞者：梶村彩香）
2024年03月：信州大学農学部後援会長賞（修士発表会優秀発表賞）（受賞者：髙瀨渉吾）

2023年09月：日本畜産学会第131回大会優秀発表賞（受賞者：Jamiyanpurev Soyolmaa）
2023年09月：日本酪農科学シンポジウム2023・若手優秀発表賞（受賞者：野村奈津実）
2023年05月：ATS2023 Abstract Scholarship（受賞者：野村奈津実）
2023年03月：信州大学農学部長賞（研究業績）（受賞者：角谷駿介）

2022年09月：日本畜産学会第130回大会English Presentation Award（受賞者：野村奈津実）
2022年09月：日本畜産学会第130回大会English Presentation Award（受賞者：髙瀨渉吾）
2022年09月：日本畜産学会第130回大会English Presentation Award（受賞者：Jamiyanpurev Soyolmaa）
2022年09月：日本畜産学会第130回大会English Presentation Award（受賞者：大島涼香）
2022年09月：酪農科学シンポジウム2022若手優秀ポスター賞（受賞者：角谷駿介）
2022年07月：日本乳酸菌学会2022年度大会若手優秀発表賞-ロング講演部門-（受賞者：生井楓）
2022年03月：日本畜産学会優秀学生賞（受賞者：野村奈津実）
2022年03月：信州大学農学部長賞（4年次首席）（受賞者：野村奈津実）
2022年03月：信州大学農学部長賞（研究業績）（受賞者：鳥居創）
2022年03月：信州大学農学部同窓会長賞（ゆりのき賞）（4年次次席）（受賞者：ソヨルマー）

2021年09月：酪農科学シンポジウム2021若手優秀発表賞（受賞者：鳥居創）
2021年09月：日本畜産学会第129回大会English Presentation Award（受賞者：塚越まさ実）
2021年09月：日本畜産学会第129回大会English Presentation Award（受賞者：村上愛斗）
2021年03月：日本畜産学会優秀学生賞（受賞者：樋本小春）
2021年03月：信州大学農学部長賞（首席）（受賞者：樋本小春）
2021年03月：信州大学農学部後援会長賞（卒業論文発表会優秀発表賞）（受賞者：大島涼香）
2021年03月：信州大学農学部同窓会長賞（からまつ賞）（3年次首席）（受賞者：野村奈津実）

2020年03月：日本畜産学会優秀学生賞（受賞者：塚越まさ実）
2020年03月：信州大学農学部長賞（首席）（受賞者：塚越まさ実）
2020年03月：信州大学農学部長賞（研究業績）（受賞者：三上彩音）
2020年03月：信州大学農学部後援会長賞（卒業論文発表会優秀発表賞）（受賞者：村上愛斗）
2020年03月：信州大学農学部同窓会長賞（からまつ賞）（3年次首席）（受賞者：樋本小春）

2019年11月：日本食品免疫学会ポスター賞（受賞者：三上彩音）
2019年09月：日本畜産学会第126回大会優秀発表賞（受賞者：生井楓）
2019年08月：2019年度酪農科学シンポジウム若手優秀ポスター賞（受賞者：村上愛斗）
2019年07月：The Best Oral Presentation Award of TASP 2019（受賞者：生井楓）
2019年03月：日本畜産学会優秀学生賞（受賞者：三上彩音）
2019年03月：信州大学農学部長賞（受賞者：生井楓）
2019年03月：信州大学農学部長賞（首席）（受賞者：三上彩音）
2019年03月：信州大学農学部後援会長賞（修士論文発表会優秀発表賞）（受賞者：生井楓）
2019年03月：信州大学農学部後援会長賞（修士論文発表会優秀発表賞）（受賞者：三上彩音）
2019年03月：信州大学農学部同窓会長賞（ゆりのき賞）（4年次次席）（受賞者：深澤知夏）

2018年11月：2018 International Scymposium of the Korean Sciety for Lactic Acid Bacteria and Probiotics, Young Scientist Award for Oral Competition（受賞者：三上彩音）
2018年11月：2018 International Scymposium of the Korean Sciety for Lactic Acid Bacteria and Probiotics, Young Scientist Award for Poster Presentation（受賞者：杉村隆）
2018年09月：酪農科学シンポジウム2018若手優秀ポスター賞（受賞者：生井楓）
2018年03月：信州大学農学部長賞（受賞者：山本祥也）
2018年03月：信州大学農学部後援会長賞（修士論文発表会優秀発表賞）（受賞者：岡島拓真）
2018年03月：信州大学農学部後援会長賞（卒業論文発表会優秀発表賞）（受賞者：石田みのり）
2018年03月：信州大学農学部同窓会長賞（からまつ賞）（3年次首席）（受賞者：塚越まさ美）

2017年10月：農林水産省 若手農林水産研究者表彰・農林水産技術会議会長賞「乳酸菌オリゴDNAを腸まで届ける経口用ナノカプセルの開発」（受賞者：下里剛士）
2017年03月：信州大学農学部長賞（受賞者：岡島拓真）
2017年03月：信州大学農学部後援会長賞（卒業論文発表会優秀発表賞）（受賞者：生井楓）

2016年08月：17th AAAP congress Young Scientists Award/JSAS Excellent Presentation Award（受賞者：岡島拓真）
2016年03月：信州大学農学部後援会長賞（卒業論文発表会優秀発表賞）（受賞者：岡島拓真）
2016年03月：信州大学農学部後援会長賞（受賞者：大城和士）

2015年11月：第14回日本農学進歩賞「乳酸菌オリゴDNAの腸管送達系の構築と免疫制御に関する研究」（受賞者：下里剛士）
2015年09月：2015年度酪農科学シンポジウム若手優秀ポスター賞「乳酸菌由来オリゴ核酸のアナフィラキシーショック亢進メカニズム」（受賞者：山本祥也）
2015年09月：日本畜産学会第120回大会優秀発表賞「ヘムオキシゲナーゼ-1 を分泌する乳酸菌組換え体はマウスにおける急性大腸炎を軽減する」（受賞者：重盛駿）
2015年03月：信州大学農学部後援会長賞（受賞者：山本祥也）

2014年11月：JSAS 第 16 回 AAAP 大会プレゼンテーションアワード「Strong Immunostimulatory Activity of Oligodeoxynucleotide Motifs from Lactic Acid Bacteria」（受賞者：山本祥也）
2014年09月：酪農科学シンポジウム2014若手優秀ポスター賞「インターロイキン6特異的抗体を分泌する乳酸菌組換え体の構築」（受賞者：重盛駿）
2014年03月：信州大学農学部賞（受賞者：重盛駿）

2011年03月：日本畜産学会奨励賞「微生物由来免疫刺激性オリゴヌクレオチドの新規構造と機能特性」（受賞者：下里剛士）
2011年03月：Animal Science Journal Excellent Paper Award 2011（Animal Science Journal 2007, 78(2):195-205.）（受賞者：Tohno M,Shimosato T, Kawai Y, Aso H, Ikegami S, Taketomo N, Saito T, Kitazawa H.）

2008年03月：Animal Science Journal Excellent Paper Award 2008（Animal Science Journal 75, 377-382, 2004)（受賞者：Shimosato T, Kitazawa H, Tohno M, Katoh S, Kawai Y, Saito T.）

2005年08月：日本酪農科学会奨励賞「プロバイオティック乳酸菌由来DNAの腸管免疫賦活化機構の解明に関する研究」（受賞者：下里剛士）

2004年03月：日本畜産学会第103回大会優秀発表賞「ブタ TLR 9トランスフェクタントによる乳酸菌DNAの免疫評価系の構築」（受賞者：下里剛士）

18. 生井楓，下里剛士
機能強化乳酸菌の創製研究
日本乳酸菌学会誌 Vol. 33, No.1, Page 5-11, 2022

17. Julio Villena, Takeshi Shimosato, Maria Guadalupe Vizoso Pinto, Haruki Kitazawa.
Editorial: Nutrition, Immunity and Viral Infections.
Frontiers in Nutrition, 7:125, 2020.
DOI: 10.3389/fnut.2020.00125

16. 下里剛士. 乳酸菌オリゴDNAを腸まで届ける経口用ナノカプセルの開発. JATAFFジャーナル, vol. 6, No. 3, page 27-33, 2018.

15. Okajima, T.,Yamamoto, Y.,Ogita, T. & Shimosato T.
CpG oligodeoxynucleotide from Streoptococcus thermophilus induces type 2 innate lymphoid cells
Proceedings of the 17th AAAP Congress, 82-84, 2016.
Focus Session: Poultry Science, Dairy Science & Industry

14. Shigemori, S., Ogita, T. & Shimosato T.
Dose-comparison study of Lactococcus lactis producing heme oxygenase-1 for treatment of dextran sulfate sodium-induced acute colitis in mice
Proceedings of the 17th AAAP Congress, 579-581, 2016.

13. Yamamoto, Y.,Okajima, T.,Ogita, T. & Shimosato T. An immunostimulatory oligodeoxynucleotide from lactic acid bacteria promotes anaphylaxis to ovalbumin in mice
Proceedings of the 17th AAAP Congress, 582-584, 2016.

12. Nigar, S., Shimosato, T. & Md. Abdur, R.A.T.
Effect of Fishery Related Activities on the Food and Nutrition Situation of Indigenous Community : A Study of Adolescent girl
Proceedings of the 17th AAAP Congress, 919-923, 2016.

11. Yamamoto, Y., Shigemori, S., Wang, P., Wang, Y. & Shimosato T.
Strongimmunostimulatory activity of oligodeoxynucleotide motifs from lactic acid bacteria
Proceedings of the 16th AAAP Congress, 2, 854-857, 2014.

10. Shigemori, S.,Yamamoto, Y.,Wang, P., Wang, Y. & Shimosato T.
Intracellular expression of cow’s milk allergensin genetically modified Lactococcus lactis
Proceedings of the 16th AAAPCongress, 2, 851-853, 2014.

9. 森崎健太郎，松田孝裕，須賀正喜，荻田佑，平松浩二，下里剛士，大谷元
ビール酵母とその牛乳抗体のマウスにおけるアレルギー軽減作用と急性毒性に関する検討
北信越畜産学会報, 106, 35-47, 2013.

8. 下里剛士, 北澤春樹
イムノジェニクスとしての免疫刺激性DNA研究の最前線
北信越畜産学会報, 100, 1-9, 2010.

7. 下里剛士
免疫刺激性オリゴヌクレオチドの2次構造特性
信州大学農学部紀要, 46(1-2), 1-5, 2010.

6. Sekimura, Y., Onodera, N., Banno, M., Hata, I., Hamano, K.,Shimosato, T. & Otani, H.
Preparation of goat milk anti-Saccharomyces cerevisiae immunoglobulin G (IgG)-rich fraction and immunological functions of mice orally administered a mixture of the antigen and its specific IgG-rich fraction.
Milk Science, 58, 119-128, 2009.

5. 下里剛士，北澤春樹
イムノバイオティクス由来の新規免疫刺激性DNAモチーフの発見とその将来性
ミルクサイエンス,57(3), 103-107, 2008.

4. Kitazawa, H., Shimosato, T., Tohno, M. & Saito, T.
Swine intestinal immunity via Toll-like Receptors and its advanced application to food immunology
Journal of Integrated Field Science（東北大学紀要）, 3, 9-14, 2006.

3. 北澤春樹, 遠野雅徳, 下里剛士, 齋藤忠夫
豚腸管におけるToll様受容体の機能発現と食品免疫学への応用
獣医畜産新報, 59(7), 559-561, 2006.

2. Kitazawa, H., Shimosato, T., Tohno, M. & Saito, T.
Immunostimulatory Activities of Lactic Acid Bacteria via Toll-like Receptors.
Japanese Journal of Lactic Acid Bacteria, 16(1), 11-20, 2005.

1. 下里剛士，北澤春樹，齋藤忠夫
Toll様受容体9を介するイムノバイオティック乳酸菌DNAの免疫活性とその将来性
ミルクサイエンス, 54(1), 9-15, 2005.