Publications

Papers | Reviews | Books | Patents | Others | Presentations/Lectures

Peer-Reviewed Papers

60. Prakash Parvatkar, Nobuo Kato, Motonari Uesugi, Shin-ichi Sato, Junko Ohkanda*
"Intracellular generation of a diterpene-peptide conjugate that inhibits 14-3-3-mediated interactions"
J. Am. Chem. Soc., 2015, 137, 15624-15627 (Communication).
59. Kazuo Harada*, Shoko Aoyama, Akimasa Matsugami, Penmetcha K. R. Kumar, Masato Katahira, Nobuo Kato, Junko Ohkanda
"RNA-directed amino acid coupling as a model reaction for primitive coded translation"
ChemBioChem., 2014, 15,794-798.
58.Junko Ohkanda
"Module assembly for designing multivalent mid-sized inhibitors of protein-protein interactions"
The Chemical Record, 2013, 13, 561-575.
57.Manuela Molzan, Stefan Kasper, Lars Röglin, Malgorzata Skwarczynska, Takeshi Sassa, Takatsugu Inoue, Frank Breitenbuecher, Junko Ohkanda, Nobuo Kato, Martin Schuler, Christian Ottmann
"Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for Ras mutant cancers"
ACS Chem. Biol., 2013, 8, 1869-1875.
56.Daisuke Hayashi, Nobuo Kato, Tomohisa Kuzuyama, Yasuo Sato, Junko Ohkanda*
"Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase"
Chem. Commun., 2013, 49,5535-5537.
55.Carolin Anders, Yusuke Higuchi, Kristin Koschinsky, Maria Bartel, Benjamin Schumacher, Philipp Thiel, Hajime Nitta, Regina Preisig-Müller, Günter Schlichthörl, Vijay Renigunta, Junko Ohkanda, Jürgen Daut, Nobuo Kato, Christian Ottmann
A semi-synthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface"
Chem. Biol., 2013, 20, 583-593.
54.Toshio Maki, Akie Kawamura, Nobuo Kato, Junko Ohkanda*
"Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein"
Mol. BioSyst., 2013, 9,940-943.
53.Shinnosuke Machida, Mai Tsubamoto, Nobuo Kato, Kazuo Harada, Junko Ohkanda*
"Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors"
Bioorg. Med. Chem., 2013, 21,4004-4010.
52. Koshi Kawakami, Miho Hattori, Takatsugu Inoue, Yuriko Maruyama, Junko Ohkanda, Nobuo Kato, Miki Tongu, Takaya Yamada, Miho Akimoto, Keizo Takenaga, Takeshi Sassa, Junji Szumiya, Yoshio Honma
"A novel fusicoccin derivative preferentially targets hypoxic tumor cells and inhibits tumor growth in xenografts"
Anticancer Agents Med. Chem., 2012, 12,791-800.
51. Yoshinobu Yamaguchi, Nobuo Kato, Hideki Azuma, Takeshi Nagasaki, Junko Ohkanda*
"Protein recognition of hetero-/homoleptic ruthenium (II) tris(bipyridine)s for alpha-chymotrypsin and cytochrome c"
Bioorg. Med. Chem. Lett., 2012, 22, 2354-2358.
50. Michiko Takahashi, Akie Kawamura, Nobuo Kato, Tsuyoshi Nishi, Itaru Hamachi, Junko Ohkanda*
"Phosphopeptide-dependent labeling of 14-3-3zeta proteins by fusicoccin-based fluorescent probes"
Angew. Chem. Int. Ed., 2012, 51, 509-512.
49. Shinnosuke Machida, Nobuo Kato, Kazuo Harada, Junko Ohkanda*
"Bivalent inhibitors for disrupting protein surface-substrate interactions and for dual inhibition of protein prenyltransferases"
J. Am. Chem. Soc., 2011,133, 958-963.
48. Junko Ohkanda*, Ritsuko Satoh, Nobuo Kato
"Protein surface recognition by dendritic ruthenium(II) tris(bipyridine) complexes"
Chem. Commun., 2009, 6949-6951.
47. Tomonobu Toyomasu, Mai Tsukahara, Hiromichi Kenmoku, Masahide Anada, Hajime Nitta, Junko Ohkanda, Wataru Mitsuhashi, Takeshi Sassa, Nobuo Kato*
"Transannular proton transfer in the cyclization of geranylgeranyl diphosphate to fusicoccadiene, a biosynthetic intermediate of fusicoccins" Org. Lett., 2009, 11, 3044-3047.
46. Praveen Kumar Suryadevara, Srinivas Olepu, Jeffrey W. Lockman, Junko Ohkanda, Mandana Karimi, Christophe L. M. J. Verlinde, James M. Kraus, Jan Schoepe, Wesley C. Van Voorhis, Andrew D. Hamilton, Frederick S. Buckner, Michael H. Gelb
"Structurally simple inhibitors of lanosterol 14a-demethylase are efficacious in a rodent model of acute Chagas disease"
J. Med. Chem., 2009, 52, 3703-3715.
45. Shinnosuke Machida, Kakeru Usuba, Michelle A. Blaskovich, Akiko Yano, Kazuo Harada, Saïd M. Sebti, Nobuo Kato, Junko Ohkanda*
"Module assembly for protein-surface recognition: Geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces."
Chem. Eur. J., 2008, 14, 1392-1401.
44. Frederik L. Delarue, Jalila Adnane, B. Joshi, Michelle A. Blaskovich, De-an Wang, James Hawker, Frank Bizouarn, Junko Ohkanda, Kuichun Zhu, Andrew D. Hamilton, Srikumar Chellappan, Saïd M. Sebti
"Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter."
Oncogene, 2007, 26, 633-640.
43. Junko Ohkanda, Corey L. Strickland, Michelle A. Blaskovich, Dora Carrico, Jeffrey W. Lockman, Andreas Vogt, Cynthia J. Bucher, Jiazhi Sun, Yimin Qian, David Knowles, Erin E. Pusateri, Saïd M. Sebti, Andrew D. Hamilton.
"Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase."
Org. Biomol. Chem., 2006, 4, 482-492.
42. Dora Carrico, Junko Ohkanda, Howard Kendrick, Kohei Yokoyama, Michelle A.Blaskovich, Cynthia J. Bucher, Frederick S. Buckner,Wesley C. Van Voorhis, Simon L.Croft, Michael H. Gelb, Saïd M. Sebti, and Andrew D. Hamilton
"In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability."
Bioorg. Med. Chem., 2004, 12, 6517-6526.
41. Junko Ohkanda, Frederick S. Buckner, Jeffrey W. Lockman, Kohei Yokoyama, Dora Carrico, Richard Eastman, Kate de Luca-Fradley, Wendy Davies, Simon L. Croft, Wesley C. Van Voorhis, Michael H. Gelb, Saïd M. Sebti, Andrew D. Hamilton
"Design and synthesis of peptidomimetics protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents"
J. Med. Chem., 2004, 47, 432-445.
40. Frederick Buckner, Kohei Yokoyama, Jeffrey Lockman, Kendra Aikenhead, Junko Ohkanda, Martin Sadilek, Wesley Van Voorhis, Andrew D. Hamilton, Michael H. Gelb
"A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents"
Proc. Natl. Acad. Sci. U.S.A., 2003, 100, 15149-15153.
39. Jiazhi Sun, Junko Ohkanda, Domenico Coppola, Hang Yin, Mohit Kothare, Brian Busiglio, Andrew D. Hamilton, Saïd M. Sebti
"Geranylgeranyltransferase I inhibitor, GGTI-2154, induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice."
Cancer Res., 2003,63, 8922-8929.
38. Bruno B. Bordier, Junko Ohkanda, Ping Liu, So-Young Lee, F. H. Salazar, Patricia L. Marion, Kazuo Ohashi, Leonard Meuse, Mark A. Kay, John L. Casey, Saïd M. Sebti, Andrew D. Hamilton, Jeffrey S. Glenn
"In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus (HDV)."
J. Clinic. Invest., 2003, 112(3), 407-414.
37. S. C. E. Bolick, T. H. Landowski, D. Boulware, M. M. Oshiro, J. Ohkanda, A. D. Hamilton, S. M. Sebti, W. S. Dalton
"The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells."
Leukemia, 2003, 17, 451-457.
36. Akira Katoh, Yuichi Inoue, Hitoshi Nagashima, Yasushi Hikita, Junko Ohkanda, Ryota Saito.
"Synthesis of linear and cyclic hexapeptides with N-(1,2-dihydro-1-hydroxy-2-oxopyrimidin-4-yl)-L-lysyl-b-alanyl as the repeating unit and properties of their iron(III) complexes."
Heterocycles, 2002, 58, 371-381.
35. Nichole C. Crespo, Frederic Delarue, Junko Ohkanda, Dora Carrico, Andrew D. Hamilton, Saïd M. Sebti
"The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status."
Cell Death and Differentiation, 2002, 9, 702-709.
34. Junko Ohkanda, Jeffrey W. Lockman, Mohit A. Kothare, Yimin Qian, Michelle A. Blaskovich, Saïd M. Sebti, Andrew D. Hamilton
“Design and synthesis of potent non-peptidic farnesyltransferase inhibitors based on a terphenyl scaffold."
J. Med. Chem., 2002, 45, 177-188.
33. Akira Katoh, Yasushi Hikita, Manabu Harata, Junko Ohkanda, Taro Tsubomura, Akon Higuchi, Ryota Saito, Kazuo Harada
"3-Hydroxy-4(1H)-pyridinone-containing linear and cyclic hexapeptides and their Iron(III) complexes-synthesis, property, and the growth-promotion activity-"
Heterocycles, 2001, 55, 2171-2187.
32. Junko Ohkanda, Jeffrey W. Lockman, Kohei Yokoyama, Michael H. Gelb, Simon L. Croft, Howard Kendrick, Maria Isabel Harrell, Jean E. Feagin, Michelle A. Blaskovich, Saïd M. Sebti, Andrew D. Hamilton
"Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity”
Bioorg. Med. Chem. Lett., 2001, 11, 761-764.
31. Nichole Crespo, Junko Ohkanda, Timothy Yen, Andrew D. Hamilton, Saïd M. Sebti
"The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells"
J. Biol. Chem., 2001, 276, 16161-16167.
30. Jalila Adnane, Francisco A. Bizouarn, Zhi Chen, Junko Ohkanda, Andrew D. Hamilton, Teresita Munoz-Antonia, Saïd M. Sebti.
"Inhibition of Farnesyltransferase Increases TGFb type II Receptor Expression and Enhances the Responsiveness of Human Cancer Cells to TGFb"
Oncogene, 2000, 19, 5525-5533.
29. Mohit A. Kothare, Junko Ohkanda, Jeffrey W. Lockman, Yimin Qian, Michelle A. Blaskovich, Saïd M. Sebti, Andrew D. Hamilton
"Development of a tripeptide mimetic strategy for the inhibition of protein farnesyltransferase"
Tetrahedron, 2000, 56, 9833-9841.
28. Akira Katoh, Tohru Yoshida, Junko Ohkanda
"Synthesis of quinoxaline derivatives bearing the styryl and phenylethynyl groups and application to a fluorescence derivatization reagent."
Heterocycles, 2000, 52, 911-920.
27. Laura E. Lantry, Zhongqiu Zhang, Rusheng Yao, Keith A. Crist, Yian Wang, Junko Ohkanda, Andrew D. Hamilton, Saïd M. Sebti, Ronald A. Lubet, Ming You
"Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone."
Carcinogenesis, 2000, 21, 113-116.
26. Jiazhi Sun, Michelle A. Blaskovich, David Knowles, Yimin Qian, Junko Ohkanda, Ratna D. Balley, Andrew D. Hamilton, and Saïd M. Sebti
"Antitumor efficacy of a novel class of non-rhiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents Cisplatin, Taxol, and Gemcitabine."
Cancer Res., 1999, 59, 4919-4926.
25. Anil Vasudevan, Yimin Qian, Andreas Vogt, Michelle Blaskovich, Junko Ohkanda, Saïd M. Sebti, and Andrew D. Hamilton
“Potent, highly selective and non-thiol inhibitors of protein geranylgeranyltransferase-I."
J. Med. Chem., 1999, 42, 1333-1340.
24. Akira Katoh, Takeshi Fujimoto, Motoki Takahashi, and Junko Ohkanda
“Synthesis of 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline and application to new fluorescence derivatization reaction of fatty acids for the high-performance liquid chromatographic analysis."
Heterocycles, 1999, 50, 299-308.
23. Umberto Kucich, Joan C. Rosenbloom, Gloria Shen, William R. Abrams, Michelle A. Blaskovich, Andrew D. Hamilton, Junko Ohkanda, Saïd M. Sebti, and Joel Rosenbloom
“Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-b-stimulated pathway leading to elastin mRNA stabilization"
Biol. Phys. Res. Commun, 1998, 252, 111-116.
22. Akira Katoh, Yoshihiko Kitamura, Hideyuki Fujii, Yumi Horie, Tetsuji Satoh, and Junko Ohkanda
"Synthesis of new 2,2’- bipyridines bearing amino or carboxyl group at the side chain and physical properties of their ruthenium(II) complexes"
Heterocycles, 1998, 49, 281-296.
21. Akira Katoh, Yoko Hida, Jun Kamitani, and Junko Ohkanda
“New hexadentate ligands composed of 1-Hydroxy-2(1H)-pyrimidinone,a,w-diamine, and tris-(carboxybutyl)isocyanurate. Synthesis and characterization of their iron(III) complexes."
J. Chem. Soc., Dalton Trans., 1998, 3859-3864.
20. Junko Ohkanda, Hiroyuki Shibui, Akira Katoh
“N-Hydroxypyrazinone bearing homotrioxacalix[3]arene: Its cooperative molecular recognition by metal complexation."
Chem. Commun., 1998, 375-376.
19. Akira Katoh, Shoichiro Naruse, Junko Ohkanda, Hiroshi Yamamoto
"Synthesis of 1,3-linked 1,4-dihydropyridines containing the L-tyrosine residue and the Influence of their structures upon the enantioselective reduction."
Heterocycles, 1997, 45, 1441-1446.
18. Junko Ohkanda, Jun Kamitani, Takeshi Tokumitsu, Yoko Hida, Takeo Konakahara, Akira Katoh
"Novel iron sequestering agents: Synthesis and iron-chelating properties of hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, w-aminocarboxylic acid, and tris(2-aminoethyl)amine"
J. Org. Chem., 1997, 62, 3618-3624.
17. Akira Katoh, Tohru Yoshida, Junko Ohkanda, Takehiko Nishio
"Structural analysis of N-(w-phenylalkyl)substituted quinoxalin-2(1H)-ones and -tiones."
Heterocycles, 1997, 44, 357-366.
16. Akira Katoh, Motoki Takahashi, Junko Ohkanda
"Synthesis of 2,3-substituted 6-aminoquinoxalines and their application to new fluorescence derivatization reagents for carboxylic acids."
Chem. Lett., 1996, 369-370.
15. Akira Katoh, Shin-ichi Ishida, Junko Ohkanda, Masao Washizu
“Synthesis of novel amphiphilic compounds containing aza-12-crown-4 or D-glucosamine and their ion permeability."
Heterocycles, 1996,43, 589-599.
14. Junko Ohkanda and Akira Katoh
"The influence of the chirality of synthetic iron chelators bearing N-hydroxy-2(1H)-pyrazinones and amino acid residues upon iron removal from human transferrin."
Chem. Lett.,1996, 423-424.
13. Junko Ohkanda, Toshihiko Kumasaka, Aki Takasu, Tadashi Hasegawa, Akira Katoh
"N-Hydroxyamide-containing heterocycles. Part 7. Preparation and photochemical behavior of 1-benzyloxy-2(1H)-pyrazinones."
Heterocycles, 1996, 43, 883-889.
12. Akira Katoh, Syoichi Kondoh, Junko Ohkanda
"N-Hydroxyamide-containing heterocycles. Part 6. Application of 1-hydroxy-4,6-dimethyl-2(1H)-pyrimidinone to a new benzyloxy-carbonylating agent."
Heterocyclic Commun., 1996, 2, 141-144.
11. Junko Ohkanda and Akira Katoh
“N-Hydroxyamide-containing heterocycles. Part 5. Synthesis of novel hexadentate ligands composed of N-hydroxypyrazinone, aliphatic diamine, and 1,1,1-tris(carboxyethoxymethyl)ethane and spectroscopic study of their ferric complexes."
Tetrahedron, 1995, 51, 12995-13002.
10. Junko Ohkanda and Akira Katoh
"N-Hydroxyamide-containing heterocycles. Part 4. Synthesis and Fe(III)-chelating properties of novel hexadentate ligands composed of N-hydroxy-2(1H)-pyrazinone, amino acid residues, and tris(2-aminoethyl)amine."
J. Org. Chem., 1995, 60, 1583-1589.
9. Akira Katoh, Mika Inokawa, Junko Ohkanda, Keiryo Mitsuhashi
"Synthesis of 2(1H)-pyrimidinone-containing a-amino acid derivatives by chemical modification of L-glutamic acid."
Chem. Pharm. Bull.,1994, 42, 1514-1517.
8. Akira Katoh, Junko Ohkanda, Atsushi Tamura, Yuji Yoshiike, Keiryo Mitsuhashi
"N-Hydroxyamide-containing heterocycles. Part 3. The ring transformation of 1-benzyloxy-2(1H)-pyrimidinone into 2-isoxazolines with hydroxylamine."
Heterocycles, 1994, 37, 1141-1146.
7. Akira Katoh, Junko Ohkanda, Hiroshi Sato, Tsuyoshi Sakamoto, Keiryo Mitsuhashi
"A convenient synthesis of 3-(aryl)substituted 2,4(1H, 3H)-pteridinediones and their absorption and fluorescence spectroscopic characteristics."
Heterocycles, 1993, 35, 949-954.
6. Junko Ohkanda, Takeshi Tokumitsu, Keiryo Mitsuhashi, Akira Katoh
"N-Hydroxyamide-containing heterocycles. Part 2. Synthesis and iron(III) complex-forming tendency of 1-Hydroxy-2(1H)-pyrimidinone and -pyrazinone."
Bull. Chem. Soc. Jpn., 1993, 66, 841-847.
5. Akira Katoh, Junko Ohkanda, Yoshifumi Itoh, Keiryo Mitsuhashi
"N-Hydroxyamide-containing heterocycles. New effective additives for peptide synthesis by the dicyclohexylcarbodiimide method."
Chem. Lett., 1992, 2009-2012.
4. Akira Katoh, Shuhei Ueda, Junko Ohkanda, Mutsumi Hirota, Motohiro Komine, Keiryo Mitsuhashi
"Isolation of the intermediates and improved synthesis of pyrido [1',2':1,2]imidazo[4,5-b]pyrazines and quinoxalines."
Heterocycles, 1992, 34,1965-1972.
3. Junko Ohkanda, Yukie Mori, Koko Maeda, Eiji Osawa
"Structural aspects of the mechanical and thermal dissociation of the central bond in 2,2'-bis(2,3,4-triarylchromenyl)s."
J. Chem. Soc. Perkin Trans. 2,1992, 59-63.
2. Tadashi Hasegawa, Junko Ohkanda, Mariko Kobayashi, Michikazu Yoshioka
"Unusual substituent effect by the a-acetyl group on the type II photoreaction of valerophenones: Strong wavelength dependence of quantum yields."
J. Photochem. Photobiol. A: Chem., 1992, 64, 299-306.
1. Tadashi Hasegawa, Junko Ohkanda, Toyokazu Usui
"Cis-trans isomerization of stilbene by illumination of sun-light-teaching material for photochemical experiment in high school."
Kagaku to Kyoiku, 1990, 38, 448-451.

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Reviews

8. Junko Ohkanda
"Intracellular synthesis of bioactive molecules induced by a targeted protein"
Kagaku to Seibutsu, 2017, in press.
7. Junko Ohkanda
"Molecules that recognize interfaces onf protein protein interactions"
Journal of Synthetic Organic Chemistry, 2017, 75, 735-745.
6. Junko Ohkanda
"Protein-guided self-assembly for controlling protein-protein interactions"
Journal of the Society of Japanese Women Scientists, 2017, 17, 1-7.
5. Junko Ohkanda
"Synthetic inhibitors targeting protein surfaces." (Perspective)
SAR News, 2007, 13, 2-7.
4. Junko Ohkanda, David B. Knowles, Michelle A. Blaskovich, Saïd M. Sebti, Andrew D. Hamilton
"Inhibitors of protein farnesyltransferase as novel anticancer agents."
Curr.Top. Med. Chem., 2002, 2, 303-323.
3. Junko Ohkanda
"CAAX peptidomimetics: Their farnesyltransferase inhibition activity and antitumor effect."
Seikagaku, 2002, 74, 46-50.
2. Junko Ohkanda and Akira Katoh
"N-Hydroxyamide-containing heterocycles. -Synthesis, reactivities, and iron(III)-chelating properties-."
Rev. Heteroatom Chem., 1998, 18, 87-118.
1. Junko Ohkanda, Akira Katoh
"Synthesis, reactivities, and metal-chelating properties of functionalized N-hydroxyamide-containing heterocycles"
Yuukigousei Kagaku Kyoukai Shi, 1997, 55, 524-534.

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Books

3. Junko Ohkanda
"Self-assembled receptors for protein surface recognition"
Comprehensive Supramolecular Chemistry II, Atwookd, J. L. (ed.), Vol. 4, pp 351-368, Elsevier, Oxford, 2017.
2. Junko Ohkanda, Michelle A. Blaskovich, Saïd M. Sebti, Andrew D. Hamilton
"The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents."
Progress in Cell Cycle Research, Vol. 5, Eds. Meijer, L., Jezequel, A., Roberge, M., 2003, 211-213.
1. M. Gelb, F. S. Buckner, K. Yokoyama, J. Ohkanda, A. D. Hamilton, L. Nguyen, S. M. Sebti, W. C. Van Voorhis
"Protein prenylation in Trypanosomatids: A new Piggy-Back medicinal chemistry target for the development of agents against tropical diseases"
Cancer Drug Discovery and Development, 221-232. : Farnesyltransferase Inhibitors in Cancer Therapy, Ed. Saïd M. Sebti and Andrew D. Hamilton, Humana Press Inc., Totowa, NJ. 2000.

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Patents

6. Nobuo Kato, Masamitsu Hiraoka, Junko Ohkanda, Tomikazu Kono, Akito Yamaguchi, Takahiro Hirata, Kunihiko Nishino, Shigeyuki Ebisu, Bonnie L. Bassler.
"3,6-Dioxa-1-azaspiro[4.4]nonan-2-ones and their use for autoinducer 2 receptor antagonists, biofilm formation inhibitors, and dental plaque formation inhibitors, and biofilm formation-inhibiting method"
Jpn. Kokai Tokkyo Koho, 2008, 53 pp. JP2008214296
5. Phadke, Avinashi; Chen, Dawei; Deshpande, Milind; Thurkauf, Andrew; Wang, Xiangzhu; Shen, Yiping; Liu, Cuixian; Quinn, Jesse; Okanda, Junko; Lee, Shouming.
"Aryl acyl thioharnstoff and the related chemical compound which are substituted; inhibitor of virus duplication."
Jpn. Kokai Tokkyo Koho, 2005, 186 pp. JP2005330284
4. Phadke, Avinash; Quinn, Jesse; Ohkanda, Junko; Thurkauf, Andrew; Shen, Yiping; Liu, Cuixian; Chen, Dawei; Li, Shouming
"Preparation of substituted arylthioureas as inhibitors of viral replication.".
PCT Int. Appl., 2005, 80 pp. WO 2005007601
3. Chen, Dawei; Deshpande, Milind; Thurkauf, Andrew; Phadke, Avinash; Wang, Xiangzhu; Shen Yiping; Liu, Cuixian; Quinn, Jesse; Ohkanda, Junko; Li, Shouming.
"Substituted aryl thioureas and related compounds; Inhibitors of viral replication."
PCT Int. Appl., 2004, 218pp.WO2004046095
2. Hamilton, Andrew D.; Van Voorhis, Wesley C.; Yokoyama, Kohei; Buckner, Frederick S.; Ohkanda, Junko; Gelb, Michael.
"Preparation of imidazolemethanamines and methods for the inhibition of protozoal, fungal and/or bacterial agents such as Trypanosoma cruzi."
PCT Int. Appl., 2003, 59 pp. WO2003006012
1. Takahashi, Junichi; Horiguchi, Hiroyuki; Ozaki, Motomi; Watanabe, Yoshio; Suzuki, Eiko; Okanda, Junko.
"Manufacture of shape-monitoring stylus for scanning-force microscopy."
Jpn. Kokai Tokkyo Koho, 1992, 5 pp, JP04353712

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Others

12. Junko Ohkanda
News Letter, Chemical Biology using Bioactive Natural Products as Specific Ligands 2013, 3, 12.
11. Junko Ohkanda
News Letter by Institute for Chemical Research, Kyoto University 2013,39, 7.
10. Junko Ohkanda
"Low-molecular-weight agents for disrupting protein-protein interactions"
Roadmap of Chemical Research in 30 years, The Chemical Society of Japan 2012, 46.
9. Junko Ohkanda
Academic Achievements 2010-2011, 100 papers selection, Annual Report of Osaka University, 2012, 42.
8. Junko Ohkanda
"Double whammy-type antimalarial agents for chloroquine-resistant P. falciparum"
Pharmacia 2010, 46, 80-81.
7. Junko Ohkanda
"Design of organic agents for disrupting protein-protein interactions"
Bulletin of Naito Memorial Foundation 2009, 84, 55.
6. Junko Ohkanda
"Module assembly: Design of protein surface-directed inhibitors"
Peptide NewsLetter Japan 2009, 72, 1-3.
5. Junko Ohkanda
"Design, synthesis, and functional evaluation of inhibitors for protein-protein interaction: From peptidomimetics to module assembly"
Letters of Forum on Biomolecular Chemistry 2008, 27, 4-9.
4. Junko Ohkanda
"Rational design and functional evaluation of antitumor activity of peptidomimetic prenyltransferase inhibitors "
News Letter of Division of Biofunctional Chemistry, The Chemical Society of Japan, 2007, 21, 25-28.
3. Junko Ohkanda
Letters of Forum on Biomolecular Chemistry 2004, 16, 26-29. [PDF]
2. Junko Ohkanda.
Jujiro, Yukigousei Kagaku Kyokaishi, 1997, 55, 574.
1. Junko Ohkanda
"Final stage of the lab.work. -Cleaning a lab. up-"
Kagaku to Kyoiku, 1993, 41, 526-528.

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Invited Presentations/Lectures

70. Synthetic Organic Chemistry Kansai Satelite Symposium, February 1, 2017
69. 42nd Alliance Symposium in Kyushu Institute of Technology, Kokura, December 9, 2016
68.Post-conference Syposium, FBC annual conference,Yamaguchi, August 3, 2016
67. Tokyo Institute of Technology, Yokohama, June 25, 2016
66. 16th Akabori Conference, Rokko, May 23, 2016
65. The 21st Incentive Award, The Society of Japanese Women Scientist, Kanda, May 22, 2016
64. Nadeshiko-Science Talk, Konan University, April 27, 2016
63. Department of Education, Kagawa University, Takamatsu, February 17, 2016
62. Department of Chemistry, Ochanomizu University, Tokyo, February 12, 2016
61. Asian Chemical Biology Initiative, Jakarta, Indonesia • January 30, 2016
60. Pacifichem2015, Hawaii, USA • December 15, 2015
59. The Seventh Peptide Engineering Meeting PEM7 • Indian Institute of Science Education and Research •Pune, India • December 5 to 7, 2015
58. Chugai Pharmaceuticals, Kamakura Research Institute • October 7, 2015
57. Sohyaku-konwa-kai, Tokushima • July 2, 2015
56. Gifu Pharmaceutical University • May 22, 2015
55. 135th Annual meeting of the Pharmaceutical Society of Japan, Kobe • March 2, 2015
54. The Regional Meeting of the Chemical Biology of Natural Products • Sendai • March 28, 2015
53. Department Seminar, National University of Singapore • Singapore • December 12,2014
52. The 4th Asian Chemical Biology Initiative • Hangzhou, China • November 24, 2014
51. Sino-Japan Workshop on Chemical Biology • Beijing, China • October 12, 2014
50. Recent Advances in Nanobiotechnology and Chemical Biology 2014 • Seoul National University, Korea • August 21, 2014
49. Osaka University • July 10, 2014
48. 94th CSJ Meeting •Nagoya • March 27, 2014
47. 2014 Queenstown Molecular Biology Meetings in Shanghai –Drug Discovery and International Collaboration • Shanghai, China • March 14,2014
46. The 3nd Asian Chemical Biology Initiative • Manila, Philippines • January 25, 2014
45. Junko Ohkanda, Nara Institute of Science and Technology, November 7, 2013
44. Junko Ohkanda,Graduate School of Engineering, Tokyo University of Science, October 30, 2013
43. Junko Ohkanda,The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, October 29, 2013
42. Junko Ohkanda,Department of Pharmacy, Nagasaki International University, July 26, Sasebo, 2013
41. Junko Ohkanda, Department of Pharmacy, Kyushu University, July 25, 2013
40. Junko Ohkanda, 4th SANKEN Techno-Salon ~Ideas and Synergy~, ISIR, Osaka University, February 1, 2013
39. Junko Ohkanda,Graduate School of Engineering, Tokyo University of Science, October 31, 2012
38. Junko Ohkanda,CTC Seminar, Tokyo University of Science, October 30, 2012
37. Junko Ohkanda, G3 Alliance Meeting, Tokyo Institute of Technology, October 12, 2012
36. Junko Ohkanda, Department of Pharmaceutical Sciences of College of Pharmacy, University of South Florida, Tampa, USA, October 8, 2012
35. Junko Ohkanda, 6th Peptide Engineering Meeting PEM6, Emory University Conference Center, Atlanta, USA, October 4, 2012
34. Junko Ohkanda,Institute for Chemical Research, Kyoto University, July 18, 2012
33. Junko Ohkanda,2012 Asian Chemical Biology Conference, July 4, 2012.
32. Junko Ohkanda,Department of Chemistry, University of Minnesota, June 7, 2012.
31. Junko Ohkanda,Department of Cellular and Moelcular Pharmacology,UCSF, USA, June 5, 2012..
30. Junko Ohkanda, Graduate School of Engineering, Osaka University, February 1, 2012.
29. Junko Ohkanda, 14th Asian Chemical Congress, Bangkok, Thailand, September 5-8, 2011.
28. Junko Ohkanda, Kagaku Senichiya, The society of Synthetic Organic Chemistry, Japan (Kansai satelite), Kao Inc., Wakayama, July 29-30, 2011.
27. Junko Ohkanda, RIKEN Chemical Biology Seminar, RIKEN, April 27, 2011.
26. Junko Ohkanda, Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore, March 9, 2011.
25. Junko Ohkanda, Kickoff Colloquium for Global Interdisciplinary Research on Life/Ecological Innovations, Nara Insititute of Science and Technology, December 9-11, 2010.
24. Junko Ohkanda, Institute for Materials Chemistry and Engineering, Kyushu University, October 8, 2010.
23. Junko Ohkanda, Forum of Peptide Science for Young Chemists, Hyogo, August 1-3, 2010.
22. Junko Ohkanda, "Module assembly for disruption and detection of protein-protein interactions", Gordon Research Conference, Bioorganic Chemistry, Andover, NH, USA, June 12-18, 2010.
21. Junko Ohkanda, 130th Medicinal Chemistry National Meeting,Okayama, March 29, 2010.
20. Junko Ohkanda, 58th Polymer Science Meeting, Kumamoto University, Kumamoto, September 16-18, 2009.
19. Junko Ohkanda, 2nd Switzerland-Japan Biomolecular Chemistry Symposium, University of Tokyo, Tokyo, September 11-12, 2009.
18. Junko Ohkanda, 36th Organic Reaction Forum, Kansei Gakuin University, Hyogo, August 3, 2009.
17. Junko Ohkanda, Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Miyagi, May 22, 2009.
16. Junko Ohkanda, Symposium on Frontier Science, Hokuriku University, Ishikawa, March 10, 2009.
15. Junko Ohkanda, IUMRS-ICA2008, December 9, Nagoya, 2008.
14. Junko Ohkanda, 64th Symposium of The Institute of Scientific and Industrial Research, Osaka University, Osaka, December 1, 2008.
13. Junko Ohkanda, 22nd Symposium of the Pharmaceutical Society of Japan, Kanto Satellite, Tokyo, November 15, 2008.
12. Junko Ohkanda, Ochanomizu University, Department of Chemistry, Research Seminar, Tokyo, October 11, 2008.
11. Junko Ohkanda, Shinnosuke Machida, Toshio Maki, Kohei Fujii, Akie Kawamura, Nobuo Kato, (Invited presentation) 27th Japan Combinatorial Chemistry Forum, Tokyo, September 25, 2008.
10. Junko Ohkanda, University of Tokyo, Biothechnology Research Center, Research Seminar, Tokyo, July 3, 2008.
9. Junko Ohkanda, Invited lecture, "Synthetic agents for targeting protein surfaces: Peptidomimetics and module assembly." Chem-Bio Informatics Society, 277th Research Seminar, Tokyo, August 10, 2007.
8. Junko Ohkanda, "A new medicinal chemical approach to target protein-protein interactions." 3rd Japanese-German Frontiers of Science Symposium, Heidelberg, Germany, November 2-5, 2006.
7. Junko Ohkanda, "Prenyltransferase inhibitors based on peptidomimetics." 8th Heterocyclic Chemistry Forum, Osaka, October 28, 2005.
6. Junko Ohkanda, "Mammalian GGTase-I inhibitors: A solution phase combinatorial approach and structure-based design of hybrid inhibitors." 21st Conference on Combinatorial Chemistry, Japan, Tokyo, Sep. 21, 2005.
5. Junko Ohkanda, "Farnesyltransferase inhibitors as antitumor and antiparasitic agents. -Rational design based on CAAX tetrapeptide." Medicinal Chemistry Research Labs, Meiji Seika Kaisha, Ltd., Yokohama, July 26, 2005.
4. Junko Ohkanda, "Design and synthesis of prenyltransferase inhibitors based on peptidomimetics." School of Pharmaceutical Science, Kitasato University, Tokyo, April 27, 2005.
3. Junko Ohkanda, "Application of peptidomimetics toward prenyltransferase inhibitors." The Symposium for Young Organic Synthetic Chemists. Tokyo,Oct. 30, 2004.
2. Junko Ohkanda, "Peptidomimetic prenyltransferase inhibitors as antitumor and antiparasitic agents." Department of Applied Chemistry, Seikei University, Tokyo, Dec 25, 2002.
1. Junko Ohkanda, The Symposium for Young Organic Synthetic Chemists. Tokyo, Nov. 1995.

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