Studies on the Relationship between Physical Immunity - Effects of Opioid Peptides on Immunity in Trained and Training and Untrained Rats -
【Supercategory：7. DESCENTE SPORTS SCIENCE Subcategory：7.10 Vol.10】
The purpose of this study was to determine the role of β-endorphin on the effectiveness of immunity after long-term physical training.
Fifty μg/kg of β-endorphin was intraperitoneally injected in both trained and sedentary rats. Three hours after injection, spleens were dissociated into a single-cell suspension and natural killer cytotoxicity was measured, and the numbers of peripheral total leucocytes and lymphocytes and the levels of lymphocyte transformation response to concanavalin A were determined.
The following results were obtained.
1. There was no change in the number of total leucocytes or lymphocytes in both groups.
2. Natural killer cytotoxicity and the response of lymphocytes to concanavalin A were significantly higher in trained rats than in sedentary rats. These results suggest that β-endorphin plays a role in effectiveness of immunity after physical training.
DESCENTE SPORTS SCIENCE Vol.10/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
Fifty μg/kg of β-endorphin was intraperitoneally injected in both trained and sedentary rats. Three hours after injection, spleens were dissociated into a single-cell suspension and natural killer cytotoxicity was measured, and the numbers of peripheral total leucocytes and lymphocytes and the levels of lymphocyte transformation response to concanavalin A were determined.
The following results were obtained.
1. There was no change in the number of total leucocytes or lymphocytes in both groups.
2. Natural killer cytotoxicity and the response of lymphocytes to concanavalin A were significantly higher in trained rats than in sedentary rats. These results suggest that β-endorphin plays a role in effectiveness of immunity after physical training.
DESCENTE SPORTS SCIENCE Vol.10/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
| Researcher | Yoshiharu Oshida*1 , Yuzo Sato*1, Isao Osawa*2 |
|---|---|
| University or institution | *1 Research Center of Health, Physical Fitness and Sports, Nagoya University, *2 The Third Department of Internal Medicine, School of Medicine Nagoya University |
Keywords
β-endorphin, immunity, physical training, natural killer cytotoxicity