The Personalized Conservative Therapeutic Monitoring for Knee Osteoarthritis Using The Biomarker of Cartilage Oligomeric Matrix Protein and 3DMRI
【Supercategory：7. DESCENTE SPORTS SCIENCE Subcategory：7.45 Vol.46】
ABSTRACT
Purpose: Measurement of serum cartilage oligomeric matrix protein（COMP） level isknown to be useful for detection and monitoring of cartilage degeneration. The present study examined the impact of physical activity in daily life on cartilage changes in patients with knee osteoarthritis （OA） by the measurement of serum COMP levels with 3D-MRI scanning.
Method: Seven patients with knee OA participated in the present study. Blood sampling and knee MRI scanning were performed, and serum COMP levels were measured. Clinical scores of Tegner activity scale （TAS）， The International Knee Documentations Committee Rating System （IKDC）， Knee Injury and Osteoarthritis Outcome Score （KOOS）， and Locomo25 were obtained. Two-step test and measurement of knee extension strength were performed. All measurements above were performed at the start of the study and after the three months observation. During the observation, physical activity such as the daily steps and walking distance were recorded. Participants received treatment including outpatient rehabilitation by a physical therapist during the observation.
Result: All cases involved low-impact sports, and the average number of steps per day was 11,579. While the change in serum COMP levels tended to be negatively correlated with the change in cartilage volume, no correlation was found with other parameters regarding daily living activities, clinical evaluation, or muscle strength. Conclusion: The present study showed the possibility that the serum COMP levels could be effective even in predicting only a minor change in cartilage degeneration as shown by 3DMRI.
DECENTE SPORTS SCIENCE Vol.46/The DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
Purpose: Measurement of serum cartilage oligomeric matrix protein（COMP） level isknown to be useful for detection and monitoring of cartilage degeneration. The present study examined the impact of physical activity in daily life on cartilage changes in patients with knee osteoarthritis （OA） by the measurement of serum COMP levels with 3D-MRI scanning.
Method: Seven patients with knee OA participated in the present study. Blood sampling and knee MRI scanning were performed, and serum COMP levels were measured. Clinical scores of Tegner activity scale （TAS）， The International Knee Documentations Committee Rating System （IKDC）， Knee Injury and Osteoarthritis Outcome Score （KOOS）， and Locomo25 were obtained. Two-step test and measurement of knee extension strength were performed. All measurements above were performed at the start of the study and after the three months observation. During the observation, physical activity such as the daily steps and walking distance were recorded. Participants received treatment including outpatient rehabilitation by a physical therapist during the observation.
Result: All cases involved low-impact sports, and the average number of steps per day was 11,579. While the change in serum COMP levels tended to be negatively correlated with the change in cartilage volume, no correlation was found with other parameters regarding daily living activities, clinical evaluation, or muscle strength. Conclusion: The present study showed the possibility that the serum COMP levels could be effective even in predicting only a minor change in cartilage degeneration as shown by 3DMRI.
DECENTE SPORTS SCIENCE Vol.46/The DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
| Researcher | Yusuke Hashimoto*1, Etsuko Maeshima*1, Kazuya Nishio*2, Ken Iida*2, Kumi Ogi*2 |
|---|---|
| University or institution | *1 Osaka University of Health and Sports Science, *2 Osaka Metropolitan University |
Keywords
exercise therapy, serum COMP, cartilage volume, Personalized conservative therapeutic Monitoring