Graduate School of Medicine ＞ Human Science
＞Metabolic Regulation

Professor: AOYAMA TOSHIFUMI
Associate Professor: HARA ATSUSHI
Assistant Professor: NAKAJIMA TAKERO, TANAKA NAOKI

Summary of Activity
This laboratory has examined the physiological, pharmacological, and toxicological roles of PPAR (peroxisomal proliferator-activated receptor) in many kinds of organs and tissues.
This laboratory has also developed the analytical method for sulfatides and examined its relation with specific diseases.


Research Projects
Roles of PPARα activation in the development of HCC with HCV infection
Development of preventive methods against HCC appearance with HCV infection
Roles of PPARα activation in the development of inflammation in kidney abnormalities
Roles of PPARα activation in cholesterol / bile acids metabolism
Roles of PPARα activation in the development of NASH and ASH
Roles of PPARα activation in hepatic triglyceride homeostasis
Roles of PPARα activation in renal triglyceride homeostasis
Roles of PPARα activation in cardiac triglyceride homeostasis
Roles of PPARα activation in testicular cholesterol homeostasis
Roles of sulfatides in coagulation
Roles of sulfatides as oxidative stress scavenger
Roles of sulfatides in sulfur metabolism

References
  1. Nagaya, T., ---, Aoyama, T. (2010) Down-regulation of SREBP-1c is associated with the development of burned-out NASH. J Hepatol. (in press).

  2. Okiyama, W., ---, Aoyama, T. (2009) Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress. J Hepatol. 50: 1236-1246.

  3. Tanaka, N., --- , Aoyama T. (2008) PPARα activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. J Clin. Invest. 118: 683-694.

  4. Kamijo, Y., --- , Aoyama, T. (2007) PPAR alpha protects proximal tubular cells from acute fatty acid toxicity. J Am Soc Nephrol. 18: 3089-3100.

  5. Kamijo, Y., --- , Aoyama, T. (2007) PPARα protects against glomerulonephritis induced by long-term exposure to the plasticizer di-(2-ethylhexyl) phthalate. J Am Soc Nephrol. 18: 176-188.