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分子細胞生理学講座では、シナプス異常と精神・神経疾患の関連について研究を行っています

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論文

Mori, T., Kasem, E. A., Suzuki-Kouyama, E., Cao, X., Li, X., Kurihara, T., Uemura, T., Yanagawa, T. and Tabuchi, K.
Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by down-regulating GluN2B
Mol Psychiatry 24 (7): 1079-1092. 2019

Han, K. A., Ko, J. S., Pramanik, G., Kim, J. Y., Tabuchi, K., Um, J. W. and Ko, J.
PTPsigma Drives Excitatory Presynaptic Assembly via Various Extracellular and Intracellular Mechanisms
J Neurosci 38 (30): 6700-6721. 2018

Kasem, E., Kurihara, T. and Tabuchi, K.
Neurexins and neuropsychiatric disorders
Neurosci Res 127: 53-60. 2018

Cao, X. and Tabuchi, K.
Functions of synapse adhesion molecules neurexin/neuroligins and neurodevelopmental disorders
Neurosci Res 116: 3-9. 2017

Takahashi, H., Matsuda, K., Tabuchi, K. and Ko, J.
Central synapse, neural circuit, and brain function
Neurosci Res 116: 1-2. 2017

Baig, D. N., Yanagawa, T. and Tabuchi, K.
Distortion of the normal function of synaptic cell adhesion molecules by genetic variants as a risk for autism spectrum disorders
Brain Res Bull 129: 82-90. 2017

Miki, T., Kaufmann, W. A., Malagon, G., Gomez, L., Tabuchi, K., Watanabe, M., Shigemoto, R. and Marty, A.
Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses
Proc Natl Acad Sci U S A 114 (26): E5246-e5255. 2017

Ito, S., Kimura, S., Warabi, E., Kawachi, Y., Yamatoji, M., Uchida, F., Ishibashi-Kanno, N., Yamagata, K., Hasegawa, S., Shoda, J., Tabuchi, K., Sakai, S., Bukawa, H., Sekido, M. and Yanagawa, T.
p62 modulates the intrinsic signaling of UVB-induced apoptosis
J Dermatol Sci 83 (3): 226-33. 2016

Um, J. W., Choii, G., Park, D., Kim, D., Jeon, S., Kang, H., Mori, T., Papadopoulos, T., Yoo, T., Lee, Y., Kim, E., Tabuchi, K. and Ko, J.
IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation
J Biol Chem 291 (19): 10119-30. 2016

Uemura, T., Mori, T., Kurihara, T., Kawase, S., Koike, R., Satoga, M., Cao, X., Li, X., Yanagawa, T., Sakurai, T., Shindo, T. and Tabuchi, K.
Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
Scientific Reports 6: 35861. 2016

Zetsche, B., Gootenberg, J. S., Abudayyeh, O. O., Slaymaker, I. M., Makarova, K. S., Essletzbichler, P., Volz, S. E., Joung, J., van der Oost, J., Regev, A., Koonin, E. V. and Zhang, F.
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system
Cell 163 (3): 759-71. 2015

Anderson, G. R., Aoto, J., Tabuchi, K., Foldy, C., Covy, J., Yee, A. X., Wu, D., Lee, S. J., Chen, L., Malenka, R. C. and Sudhof, T. C.
beta-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling
Cell 162 (3): 593-606. 2015

Aoto, J., Foldy, C., Ilcus, S. M., Tabuchi, K. and Sudhof, T. C.
Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses
Nat Neurosci 18 (7): 997-1007. 2015

Ko, J. S., Pramanik, G., Um, J. W., Shim, J. S., Lee, D., Kim, K. H., Chung, G. Y., Condomitti, G., Kim, H. M., Kim, H., de Wit, J., Park, K. S., Tabuchi, K. and Ko, J.
PTPsigma functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission
Proc Natl Acad Sci U S A 112 (6): 1874-9. 2015

Nagaoka, T., Tabuchi, K. and Kishi, M.
PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2
Sci Rep 5: 12916. 2015

Azuma, M., Yanagawa, T., Ishibashi-Kanno, N., Uchida, F., Ito, T., Yamagata, K., Hasegawa, S., Sasaki, K., Adachi, K., Tabuchi, K., Sekido, M. and Bukawa, H.
Mandibular reconstruction using plates prebent to fit rapid prototyping 3-dimensional printing models ameliorates contour deformity
Head Face Med 10: 45. 2014

Um, J. W., Pramanik, G., Ko, J. S., Song, M. Y., Lee, D., Kim, H., Park, K. S., Sudhof, T. C., Tabuchi, K. and Ko, J.
Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins
Cell Rep 6 (6): 1096-109. 2014

Li, H., Guo, Q., Inoue, T., Polito, V. A., Tabuchi, K., Hammer, R. E., Pautler, R. G., Taffet, G. E. and Zheng, H.
Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
Mol Neurodegener 9: 28. 2014

Ito, T., Kimura, S., Seto, K., Warabi, E., Kawachi, Y., Shoda, J., Tabuchi, K., Yamagata, K., Hasegawa, S., Bukawa, H., Ishii, T. and Yanagawa, T.
Peroxiredoxin I plays a protective role against UVA irradiation through reduction of oxidative stress
J Dermatol Sci 74 (1): 9-17. 2014

Isshiki, M., Tanaka, S., Kuriu, T., Tabuchi, K., Takumi, T. and Okabe, S.
Enhanced synapse remodelling as a common phenotype in mouse models of autism
Nat Commun 5: 4742. 2014

Aoto, J., Martinelli, D. C., Malenka, R. C., Tabuchi, K. and Sudhof, T. C.
Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking
Cell 154 (1): 75-88. 2013

Budreck, E. C., Kwon, O. B., Jung, J. H., Baudouin, S., Thommen, A., Kim, H. S., Fukazawa, Y., Harada, H., Tabuchi, K., Shigemoto, R., Scheiffele, P. and Kim, J. H.
Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling
Proc Natl Acad Sci U S A 110 (2): 725-30. 2013

Sasaki, H., Togashi, S., Karube, R., Yanagawa, T., Nakane, S., Tabuchi, K., Ishibashi, N., Shinya, Y., Ito, H., Yamagata, K., Onizawa, K., Adachi, K., Sekido, M. and Bukawa, H.
Presurgical nasoalveolar molding orthopedic treatment improves the outcome of primary cheiloplasty of unilateral complete cleft lip and palate, as assessed by naris morphology and cleft gap
J Craniofac Surg 23 (6): 1596-601. 2012

Karube, R., Sasaki, H., Togashi, S., Yanagawa, T., Nakane, S., Ishibashi, N., Yamagata, K., Onizawa, K., Adachi, K., Tabuchi, K., Sekido, M. and Bukawa, H.
A novel method for evaluating postsurgical results of unilateral cleft lip and palate with the use of Hausdorff distance: presurgical orthopedic treatment improves nasal symmetry after primary cheiloplasty
Oral Surg Oral Med Oral Pathol Oral Radiol 114 (6): 704-11. 2012

Etherton, M. R., Tabuchi, K., Sharma, M., Ko, J. and Sudhof, T. C.
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus
EMBO J 30 (14): 2908-19. 2011

Etherton, M., Foldy, C., Sharma, M., Tabuchi, K., Liu, X., Shamloo, M., Malenka, R. C. and Sudhof, T. C.
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function
Proc Natl Acad Sci U S A 108 (33): 13764-9. 2011

Li, H., Wang, B., Wang, Z., Guo, Q., Tabuchi, K., Hammer, R. E., Sudhof, T. C. and Zheng, H.
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
Proc Natl Acad Sci U S A 107 (40): 17362-7. 2010

Li, H., Wang, Z., Wang, B., Guo, Q., Dolios, G., Tabuchi, K., Hammer, R. E., Sudhof, T. C., Wang, R. and Zheng, H.
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis
J Biol Chem 285 (40): 30598-605. 2010

Fukata, Y., Lovero, K. L., Iwanaga, T., Watanabe, A., Yokoi, N., Tabuchi, K., Shigemoto, R., Nicoll, R. A. and Fukata, M.
Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy
Proc Natl Acad Sci U S A 107 (8): 3799-804. 2010

Blundell, J., Blaiss, C. A., Etherton, M. R., Espinosa, F., Tabuchi, K., Walz, C., Bolliger, M. F., Sudhof, T. C. and Powell, C. M.
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior
J Neurosci 30 (6): 2115-29. 2010

Tabuchi, K., Chen, G., Sudhof, T. C. and Shen, J.
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration
J Neurosci 29 (22): 7290-301. 2009

Blundell, J., Tabuchi, K., Bolliger, M. F., Blaiss, C. A., Brose, N., Liu, X., Sudhof, T. C. and Powell, C. M.
Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2
Genes Brain Behav 8 (1): 114-26. 2009

Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M. and Sudhof, T. C.
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
Science 318 (5847): 71-6. 2007

Dudanova, I., Tabuchi, K., Rohlmann, A., Sudhof, T. C. and Missler, M.
Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation
J Comp Neurol 502 (2): 261-74. 2007

Yanagawa, T., Yoshida, H., Yamagata, K., Onizawa, K., Tabuchi, K., Koyama, Y., Iwasa, S., Shimoyamada, H., Harada, H. and Omura, K.
Loss of cytokeratin 13 expression in squamous cell carcinoma of the tongue is a possible sign for local recurrence
J Exp Clin Cancer Res 26 (2): 215-20. 2007

Ho, A., Morishita, W., Atasoy, D., Liu, X., Tabuchi, K., Hammer, R. E., Malenka, R. C. and Sudhof, T. C.
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family
J Neurosci 26 (50): 13089-101. 2006

Shah, S., Lee, S. F., Tabuchi, K., Hao, Y. H., Yu, C., LaPlant, Q., Ball, H., Dann, C. E., 3rd, Sudhof, T. and Yu, G.
Nicastrin functions as a gamma-secretase-substrate receptor
Cell 122 (3): 435-47. 2005

Yuasa, Y., Okabe, M., Yoshikawa, S., Tabuchi, K., Xiong, W. C., Hiromi, Y. and Okano, H.
Drosophila homeodomain protein REPO controls glial differentiation by cooperating with ETS and BTB transcription factors
Development 130 (11): 2419-28. 2003

Tabuchi, K., Biederer, T., Butz, S. and Sudhof, T. C.
CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein
J Neurosci 22 (11): 4264-73. 2002

Tabuchi, K. and Sudhof, T. C.
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing
Genomics 79 (6): 849-59. 2002

Honarpour, N., Tabuchi, K., Stark, J. M., Hammer, R. E., Sudhof, T. C., Parada, L. F., Wang, X., Richardson, J. A. and Herz, J.
Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1
Neuroscience 106 (2): 263-74. 2001

Tabuchi, K., Sawamoto, K., Suzuki, E., Ozaki, K., Sone, M., Hama, C., Tanifuji-Morimoto, T., Yuasa, Y., Yoshihara, Y., Nose, A. and Okano, H.
GAL4/UAS-WGA system as a powerful tool for tracing Drosophila transsynaptic neural pathways
J Neurosci Res 59 (1): 94-9. 2000

Yanagawa, T., Harada, H., Iwasa, S., Tabuchi, K., Omura, K., Suzuki, H., Yusa, H., Yamagata, K., Onizawa, K., Ishii, T. and Yoshida, H.
c-Abl expression in oral squamous cell carcinomas
Oral Oncol 36 (1): 89-94. 2000

Yanagawa, T., Iwasa, S., Ishii, T., Tabuchi, K., Yusa, H., Onizawa, K., Omura, K., Harada, H., Suzuki, H. and Yoshida, H.
Peroxiredoxin I expression in oral cancer: a potential new tumor marker
Cancer Lett 156 (1): 27-35. 2000

Yanagawa, T., Ishikawa, T., Ishii, T., Tabuchi, K., Iwasa, S., Bannai, S., Omura, K., Suzuki, H. and Yoshida, H.
Peroxiredoxin I expression in human thyroid tumors
Cancer Lett 145 (1-2): 127-32. 1999

Yoshihara, Y., Mizuno, T., Nakahira, M., Kawasaki, M., Watanabe, Y., Kagamiyama, H., Jishage, K., Ueda, O., Suzuki, H., Tabuchi, K., Sawamoto, K., Okano, H., Noda, T. and Mori, K.
A genetic approach to visualization of multisynaptic neural pathways using plant lectin transgene
Neuron 22 (1): 33-41. 1999

Tsuji, M. H., Yanagawa, T., Iwasa, S., Tabuchi, K., Onizawa, K., Bannai, S., Toyooka, H. and Yoshida, H.
Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis
Cancer Lett 138 (1-2): 53-9. 1999

Tabuchi, K., Yoshikawa, S., Yuasa, Y., Sawamoto, K. and Okano, H.
A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells
Neurosci Lett 257 (1): 49-52. 1998

Hamada, S., Senzaki, K., Hamaguchi-Hamada, K., Tabuchi, K., Yamamoto, H., Yamamoto, T., Yoshikawa, S., Okano, H. and Okado, N.
Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken
Brain Res Mol Brain Res 54 (2): 199-211. 1998

総説・著書

田渕克彦
シナプスと自閉症
生体の科学 65(1):3-6.2014

田渕克彦, 張文欣, Asgar NFM, Pramanik G
モデルマウスに見るシナプス成熟障害と自閉症との関係
日本神経精神薬理学雑誌(Jpn. J. Neuropsychopharmacol.) 34:1-4.2014

田渕克彦
ニューレグリン受容体(ERBB4)の異常と精神疾患
生体の科学 4(5):470-471.2013

田渕克彦
信州大学医学部神経生理学講座
神経化学 52(1):39-40.2013

植村 健
シナプスオーガナイザーによるシナプス形成の制御機構
生物物理 53、90-93, 2013

Baig DN, 柳川徹, 田渕克彦
Analysis of Neuroligin-3R451C knock-in mice as models for autistic savant.
日本生物学的精神医学会誌 23(4):281-286.2012

田渕克彦
Neuroligin
分子精神医学 11:207-208.2011

Katsuhiko Tabuchi
Neuroligins and Neurexins in Autism
American Psychiatric Publishing, Inc , Textbook of Autism Spectrum Disorders , :347-352 2011

植村健, 三品昌美
シナプス形成とグルタミン酸受容体δ2サブユニット
細胞工学 , 30(2):186-191 2011

田渕克彦
シナプス, Neuroliginと自閉症
Cognition and Dementia 8:203-208.2009

田渕克彦
自閉症とニューロリギン
Clinical Neuroscience 27:1092-1093.2009

田渕克彦
素顔のニューロサイエンティストThomas C. Sudhof
Clinical Neuroscience 27:944.2009

田渕克彦
シナプス機能と自閉症:ニューロリギン遺伝子改変マウスを用いた自閉症病理の探求
実験医学 26:543-546.2008

バナースペース

信州大学医学部
分子細胞生理学講座

〒390-8621
長野県松本市旭3−1−1

TEL: 0263-37-3775
FAX: 0263-37-3776
e-mail: seiri2@shinshu-u.ac.jp

    

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