Inresearchactivities,werepeatinvestigations,designs,experimentsandconsiderationsmanytimestodevelopnovelmaterials.I’maimingattrainingsothatstudentshavemanyexperiencesvialaboratoryactivitiesandtheywillplayactivepartsaftergraduation.Silkisusedasastructuralmaterialinnaturesuchasalifelineofspiderandashellofsilkworm.Thethicknessofspidersilkisapproximatelyonetenthofhuman’shair.Thespidersilkwith3-mmthicknesscansupportamanwith60kg.Silkseemsveryattractivewhenusedasstructuralmaterial,however,itisdifficulttosynthesizeanartificialsilkthathasbothstrengthandextensibilitylikenativesilk.Spidersandsilkwormsareknowntopossesssophisticatedspinningmechanism.Iwouldliketosharemysteriesinthenaturalspinningsystemsinspidersandsilkwormsandtakeadvantageofthesystemtosynthesizeartificialsilkforindustrialapplications.CellsculturedonasilkfibroinfilmAfunctionalpeptidewithbiologicalactivitySpiderstransformsilksolutionsintofibersintheirglands.Outlook for researchBiomaterialshavevariouspotentialtohelpbiologicalfunctions,improvetreatdiseases,healwounds,recoveries,andsoon.IbelievethatthedevelopmentofnovelbiomaterialsbringourimprovedQualityofLife.I’mcarryingoutthedevelopmentofnovelusefulbiomaterialsinordertoconstructthefuturewithhuman-friendlysociety.Outlook for students after graduationOutlook for researchMan-madefibersneedtobeprocessedathightemperature,whilespidersandsilkwormssynthesizetheirsilkinamildcondition.Wecansynthesizetheartificialsilkbymimickingthenaturalspinningsystemandcontributetousesilkasastructuralmaterialinourdailylife.Outlook for students after graduationIwouldliketosharetheexcitementoftacklingthescienceofnature,fromthestudyofspiderandsilkwormsilk.Youwillmakehypothesisandperformexperimentstoproofthehypothesis.Hopefully,youwillexertyourselfinsocietyfromyourresearchexperimentatShinshuUniversity.AssociateProfessorHASHIMOTOTomokoAssociateProfessorYAZAWA KenjiroDepartment ofApplied BiologyDepartment ofApplied BiologyAssociateTomokoProfessorHashimotoworkedasaresearchInstituteoffellowatNationalAgrobiological(nowNationalAgricultureandFoodResearchOrganization)beforecomingNaraWomen’sUniversityasanassistantprofessor.Shetookhercurrentpositionin2021,andspecializationisherareaofpolymericbiomaterials.AssociateProfessorYazawagothisph.DatTokyoTech.andcametohiscurrentpositionafterworkingasapostdoctoralresearcheratYamagatauniversityandRIKENinJapan.Hespecializesmolecularbiologyandpolymerscience.Hisfinalaimistorevealthemechanismofspinningsystemofspidersandsilkworms.Spidersarefixedbetweenspongeswiththeirlegsinsidethespongestoextracttheirsilks.Wefeelthatthesilkisshinyandtough.SciencesSilkfibroinhasusedastheluxurymaterialsforlongtime.Recently,theyarefocusedonashuman-friendlynaturematerials.However,wedon’tunderstandwhysilkfibroinshows“human-friendly”propertiesscientifically.Inourlaboratory,wearestudyingtoelucidateandcontrolvariouspropertiesofsilkfibroinformedicalapplications.Additionally,wearetryingtoimmobilizebiologicalfunctionalmoleculesontobiomaterialsbyhumanandeco-friendlymethodsforfurtherapplicationsanddevelopments.45Elucidating the influence of silk fibroin on our tissues and creating novel biomaterialsHow can spider and silkworm spin such a tough silk?
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