Afterreceivingadoctorate(inengineering)TokyoTechnology,InstituteAssociateProfessorTakashimaworkedasaresearchfellowattheUniversityofTokyobeforecomingKyotoUniversityasanassistantprofessor.Hisareasofresearchareregenerativemedicineandstemcellbiology.AfterreceivingadoctorateinTokyoMedicalandDentalUniversity,AssociateprofessorNegishiworkedasaJSPSpostbeforecomingADEKAasaresearchworker.Hisareasofresearcharebiologicalmaterials.GScells.Left:MouseGScellsgrowinginvitro.Center:SpermatogenesisinthetestistransplantedwithGScellsexpressinggreenfluorescentprotein(GFP).Right:MouseoffspringproducedfromspermderivedfromGScellsexpressingGFP.TheoffspringalsoexhibitedgreenfluorescenceunderUVlight.ThepluripotencypotentialofGScells.Left:mGScellsde-differentiated(rejuvenated)fromGScells.mGScellspossesspluripotencylikeiPScells.Right:mGScancontributetotheformationof“chimeramice.”mGS-derivedtissueinthechimaeramiceexhibitedGFPexpression.Promotion of neurite outgrowth of decellularized tissues.Cell introduction into a porous material by VPI.RegenerativemedicineusingiPScellsisexpectedtoserveasanovelapproachforcuringdisease.Mylabisfocusingongermlinestem(GS)cells,tissue-specificstemcellsintestis.AlthoughGScellshavealreadycommittedtogermcelllineage,theyalsohavepluripotencypotentialandoftende-differentiateintomultipotentGS(mGS)cellsthatpossesspluripotencylikeiPScells.ThegoalofourresearchistounderstandtheuniquenatureofGS/mGScellsandcontroltheirfate.Decellularizedtissueobtainedbyremovingcellsfromlivingtissueconsistsofextracellularmatrix(ECM)andisknowntohavetissue-specificfunctions.Inourlaboratory,wecreateandanalyzedecellularizedtissuefromvarioustissues,clarifythefactorsandcharacteristics,andaimtoapplyittotissueregeneration.Vacuumpressureimpregnationmethod(VPI)usedinmetalprocessingisatechnologythatenablestheefficientintroductionofsolutionsintomaterials.ByapplyingVPItobiomaterialresearch,weaimtodevelopporousmaterialsthatcontaincellsandcompositematerialswithnewproperties.fromofAssociateProfessorTAKASHIMASeijiAssociateProfessorNEGISHIJunOutlook for researchThespermatogenicpotentialofGScellsisexpectedtofindapplicationnotonlyintreatingmaleinfertility,butalsoinproducingsuperiorlivestock.Inaddition,mGScellsareexpectedtoserveasanothersourceofpluripotentstemcellssuchasiPScells.Inthiscontext,GScellsmightbecalledmultipotentstemcellswiththepotentialtocontributetoawiderangeoffields.Outlook for students after graduationThevalueofthemarketassociatedwithregenerativemedicineisexpectedtogrowto1trillionyenin2020(accordingtostatisticsfromtheMinistryofEconomy,TradeandIndustry).colleagueswillbeabletoplayaremarkableroleingrowthindustries,includinginregenerativemedicine.ItismyhopethatourfutureOutlook for researchDecellularizedtissueshavesubstance-specificfunctions,andbybindingtocells,theymaybeabletocreatecomplexbiologicaltissuesandorgansinsideandoutsidethebody.Wealsobelievethatwecandevelopmaterialswithunprecedentedcharacteristicsbymakingfulluseoftechnologiesinvariousfields.Outlook for students after graduationThroughresearch,Iwantyoutolearntothink,act,andworkasateam.Ihopethatyouwillmakeuseofyourexperienceinthelaboratoryandplayanactiveroleinvariousfields.Department ofApplied BiologyDepartment ofApplied Biology43Understanding the nature of stem cells and controlling their fateBiomaterials that take advantage of the characteristics of biological tissues
元のページ ../index.html#45