proteins,andresearchofandAssociateProfessorAraijoinedShinshuUniversityin2007afterworkingasaresearcheratRIKENandPrincetonUniversityintheU.S.Hisareasofresearcharestructuralbiologytoanalyzethethree-dimensionalstructureandfunctionofproteinengineeringtodevelopusefulproteinsthroughtheirmodificationanddesign.ProfessorShiomitookhiscurrentpositionin2021afterservingintheFacultyofTextileScienceandTechnologyatShinshuUniversityasanassistantprofessor.Hisincludeareasmolecularenvironmentalentomologyappliedentomologywithafocusonthedormancy,metamorphosis,andseasonalmorphologyofinsects.UsefulgenesareclonedfrominsectsoftheorderLepidoptera.Anexperimentintheresearchlab(upperleft),productionofusefulproteinswithmicroorganisms(upperright),proteincrystalswhichshinelikeapreciousstone(lowerleft),andanX-raydiffractionexperimentatasynchrotronradiationfacility(lowerright)Self-assemblingnanoarchitecturesarecreatedfromaproteinnano-buildingblockbyfusingadimericdenovoproteinWA20andatrimericfoldondomainfromT4phage.(Kobayashi,N.etal.,J.Am.Chem.Soc.,137,11285-11293,2015)Astudentobservesculturedcellsintowhichinsectsensorgeneshavebeeninserted.Silkworm eggs. Non-diapause eggs hatched 9–10 d after oviposition (left), but diapause eggs never hatched 60 d after oviposition, and normal embryogenesis was arrested (right).nature,Iamcarryingoutresearchonthesensorscarriedbyinsectstomonitorthearrivaloftheseasonsviasensorproteinsthatrespondtotemperatureanddaylength.Myfindingscanbeappliedtotheexterminationofpestsandinvasivespeciesthroughsuchtechniquesascausingeggstohatchinwinterandmakingadultinsectswithoutwingsgrowthem.Thisapproachisgarneringattentionasapestexterminationmethodthatdoesnotharmnatureorhumans.38ProfessorARAIRyoichiProfessorSHIOMIKunihiroOutlook for researchOurgoalistoapplyproteinsinvariousfields,forexampleinbiotechnologyandpharmaceuticaldevelopment,inordertodevelopeco-friendlyhighlygreenchemistrycatalysts,high-sensitivitybiosensors,andeffectivevaccines.Intheseways,wehopetocontributetheachievementofasustainablesociety.nanomaterials,functionalOutlook for students after graduationGraduatesareemployedinnumerousfields,includingchemical,andbiochemicalcompanies.atfood,pharmaceutical,optics,Outlook for researchTheabilitytocontrolthedormantstageofinsectsisusefulnotonlyforexterminatingpests,butalsoforprotectingecosystems.Further,Ibelievethatexplainingtheecologyofinsectscancontributesolutionsforglobalenvironmental,food-related,andmedicalproblems.Outlook for students after graduationGraduatescanfindemploymentatfoodandpharmaceuticalenvironmentalcompaniesworkingwithcompaniesengagedingeneticanalysis,andeventrade-relatedinspectioncompanies.companies,Department ofApplied BiologyWearecarryingoutresearchtogainadeeperunderstandingofthestructureandfunctionofproteinsandtodesign,develop,andapplyusefulartificialandengineeredproteins.Inthefieldsofproteindesignandengineering,ourlabusescungedgetechnologytosee,analyze,create,andapplyusefulproteins.Department ofApplied BiologyDesigning and developing useful proteins by studying the structure and function of proteinsUsing insects’ high-performance sensors to develop methods for extermination
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