Barrel6-merS form modelTetrahedron12-merM form modelFusion41ProfessorARAI RyoichiProfessorKAJIURA ZentaOutlook for researchOur goal is to apply proteins in various fields, forexample in biotechnology and pharmaceuticaldevelopment, in order to develop eco-friendlyhighlygreenchemistry catalysts, high-sensitivity biosensors,and effective vaccines. In these ways, we hopeto contribute the achievement of a sustainablesociety.nanomaterials,functionalOutlook for students after graduationGraduates are employed in numerous fields,includingfood, pharmaceutical, optics,chemical, and biochemical companies.atOutlook for researchMy goal is to train new talent that can carry onthe tradition of cultivating and producing naturalsilk. This willcreate a future, where theproduction of silk and other agricultural productsis reinvigorated through a collaboration betweenagriculture, business, and industry.Outlook for students after graduationGraduates go on to graduate school or work attextile and food companies,localcompanies. Some serve as middle school teachersand public officials in agricultural studies.Department ofApplied BiologyWe are carrying out research to gain a deeper understandingof the structure and function of proteins and to design,develop, and apply useful artificial and engineered proteins.In the fields of protein design and engineering, our lab usescutting edge technology to see, analyze, create, and applyuseful proteins.Department ofApplied BiologyAssociate Professor AraijoinedShinshu University in 2007 afterworking as a researcher at RIKENand Princeton University in the U.S.His areas of research are structuralbiologyto analyze the three-dimensional structure and functionproteinofengineeringusefulproteins through their modificationand design.ProfessoracademicKajiura'scredentials are in agriculture,and his areas of specializationinclude agriculture and appliedentomology, molecular genetics.Keywords:DNA, bio-resources, breedingAn experiment in the research lab (upper left), production of usefulproteins with microorganisms (upper right), protein crystals whichshine like a precious stone (lower left), and an X-ray diffractionexperiment at a synchrotron radiation facility (lower right)WA20dimerFoldontrimerSelf-assemblyWA20-foldonProtein Nano-building Block(PN-Block)Self-assembling nanoarchitectures are created from a protein nano-building block by fusing a dimeric de novo protein WA20 and atrimeric foldon domain from T4 phage. (Kobayashi, N. et al., J. Am.Chem. Soc., 137, 11285-11293, 2015)Cocoons and silk from natural silkworms. The cocoons take on a beautiful green color that is unique to Japanese cocoons.I succeeded in breeding the large wild silkworm. Standard wildsilkworms are shown in the top row. The large wild silkworm isshown in the bottom row. I usually need more than 3000 cocoons ofthe standard wild silkworm to get 1 kg raw silk. However, I onlyneed approximately 2000 cocoons if I use the large size wildsilkworm.I am carrying out research into genetic breeding, ecdysisand metamorphosis, and the genetic relationship of thesilkworm (naturalsilkworm to its relative,silkworm). My lab cultivates excellent strains of naturalsilkwormsin order to reinvigorate Japan‘s silk industry.This is done by supporting the raising of natural silkwormsin silk-producing regions.JA, orproteins,toanddevelopthe giantDesigning and developing useful proteins by studying the structure and function of proteinsDeveloping the genetic resources of domestic and wild silkworms to make a brand of silk
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