3AnatomyProf. Nanae FukushimaMolecularPathophysiologyProf. Tatsuya SawamuraHypoglossal nucleus in the rat brain (upper). Nissl-stained (lower left) and tracer-labelled (lower right) hypoglossal motor neurons.Skull suture. Hematoxylin-eosin (left) andMasson's trichrome (right) staining.LOX-1 promotes each stage of arteriosclerotic disease. the lectures and practicalcan acquire the knowledge ofIn ourlaboratory,techniques for histochemical study.neuroanatomy and skills ofAdditionally, they will acquire the problem-solving ability that is usefulafter graduation.Ligament of the ankle joint.(Masson's trichrome staining)We are responsible fortrainings ofneuroanatomy and gross anatomy for medical school students. Anatomyis the study of the structure and function of the human body, but thereare still many things that have not been studied. We aim to elucidate thestructure and function ofthe nervous system and joint using acombination of micro and macro experiments.Research subjectOutlook for researchOutlook for students after graduationOur goal is to elucidate the physiological, and pathophysiological mechanisms of vascular function and its disruption through investigating the biology of endothelial cells. In the process, we have found a key molecule, LOX-1, which mightillustrate the pathophysiology of atherothrombotic disease. Since thevascular function is closely related to ageing-related malfunctioningof organs,the finding opened a new avenue for understandingageing-related diseases. Based on the clues, we are developingnovel diagnostic, preventive and therapeutic methods.Research subjectOutlook for researchOutlook for students after graduation・Functionally essential neuronal population・Functional regeneration of the nervous system・Estimation of the total number of neurons・Joint structure and function・Skull suturesBody functions are impaired due to various factors. Elucidation of thestructure and function will lead to advances in diagnosis and treatmentof disease and injury.students・Biological significance of LOX-1 gene family・Screening of LOX-1 blocker to realize a novel therapeutics・Development of novel diagnostic technologies for clinical application of our research・Mechanism of ageing and ageing-related diseasesThe basic research has significance in itself, clarifying the mechanism ofnature. Besides, important as well is the application of the novel knowledgeand technologies to the future of medicine and people’s happiness.Our study is to contribute to medical diagnosis and therapeutics of lifestyle-related diseases, preventing ageing of vasculature and realizing healthy longevity. Participating in the research activity, students can learn what is to createmedical value. The experience would be beneficial to contribute to createinnovative products for medical diagnosis and therapeutics. Anatomical study of structure and function“A man is as old as his arteries”For prediction and prevention of atherosclerotic disease信州大学医学部医学科発行年月：２０２４年７月 発行：信州大学医学部
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