Sports Medical SciencesProf. Shizue MasukiHistology & EmbryologyAssociate Prof. Kohei JohkuraParticipants perform interval walking training (IWT) around their homesand visit a community office once a month to transfer their walking recordto a sever computer via an internet. According to a trend graph sent backby the sever, they are instructed how to perform IWT by trainers etc.Recently, we have developed smartphone application for this system.Measurements of esophagealtemperature, skin blood flowand sweat rate during cyclingexercise.Ureteric buds induced from a mesonephric duct by growth factorsExercise causes methylation (inactivation) of proinflammatory genes to prevent lifestyle-related diseases.Human embryonic stem cells-derived cardiomyocytes characterized with specific structure and protein expressionCSC-like colony reprogrammed from retinoblastoma cancer cells (RBC51)Our goalis to provide evidence-based information to solve thecurrent social problems; global warming and advanced aging.Human beings have lived broadly on the earth by their high ability toadapt the hot/ cold environments by nature. However, the amenityincluding food and medical conditions, hasthatdeteriorated their ability and the waste of natural resources to attainthe amenity has accelerated the depletion of the resources to causethe viscous circle, we would like tothe global warming. To cutpropose to reactivate their genetic resources to adapttheenvironments.By using pluripotent stem cells which can create almost any cell type, it is possible tocure injuries and diseases that could not be treated before. For example, stem cellsare differentiated into specialized cells with unique functions and transplanted whendamaged cells are no longer able to heal themselves. Alternatively, tissues or organsare created from stem cells and transplanted to replace damaged parts. We arepromoting stem cell research to elucidate the causes of intractable diseases andcontribute to their treatment.they acquired,Research subjectOutlook for researchOutlook for students after graduationResearch subject Outlook for researchOutlook for students after graduationof physical fitness with agingTo study the mechanism of carcinogenesis and develop therapeutic methods by reprogramming cancer cells into cancer stem cells.To study the mechanisms that support the developmental competence of kidney germ tissues with the use of animal embryos.To elucidate the pathogenesis of Ehlers-Danlos syndrome, a kind of heterogeneous connective tissue disorder.1) To provide the strategy to prevent heat illness during exercise2) To provide the strategy to prevent lifestyle-related diseases with deterioration3) To provide the epigenetic mechanisms for the effects of exercise trainingWe have developed e-Health Promotion System, composed ofIntervalWalking Training (IWT), portable calorimeter, and IoT system. By using thesystem, we have accumulated the database (DB) on the effects of 5-mo IWTin several thousand of middle-aged and older people. By using the DB, weare developing a program to predict the effects of IWT for each person. Theprogram will encourage people to perform IWT, decrease healthcare costs,and achieve a healthy longevity society.Researchers to major exercise and applied physiology. Medical staff workingfor preventive and rehabilitation medicine. Researchers in private companiestreating with health promotion food or device.・Creating Cancer Stem Cells by Reprogramming Technology・Development and Regeneration of Kidney・Establishment of Disease Model with Patient Specific iPS Cells・Functional Analysis of Epigenetic Factors in Pluripotent Stem CellsTo study why various cells in the body maintain their different state of differentiation, even though they have the same genetic information.The promising field of regenerative medicine is to restore structure andfunction of damaged tissues and organs. It is also possible to find ways tocure cancer and genetic disorders.Many graduates are doing research works in medical fields in Universities orprivate institutions.Differentiation, Regeneration and OncogenesisExercise physiology to solve the current social problems ! 22024-2025 医学科研 究 紹 介
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