Chief: Senior Assistant Professor Members of the Gynecologic Cancer Group“Come on and join us!”HE staining of GASMembers of the Placenta GroupCell cultures are a basic experimental technique that is indispensable for functional analyses. Obstetrics and GynecologyGynecologic Cancer GroupChief: Assoc. Prof. Tsutomu MiyamotoObstetrics and GynecologyPlacenta GroupSGI-1776(Pim1 inhibitor) significantly reduced the proliferation of USC cells. (red line).Dr. David H. Mvunta was a foreign graduate student from Tanzania (from 2013 to 2017). He worked hard and obtained a Ph.D. here. Early placental tissue immunostainedby CK7, a marker for EVT, showed the infiltration of EVT. Our research results will hopefully contribute to the development of newprevention and treatment methods. Hence, we aim to reduce the incidence ofthese cancers and improve treatment outcomes.After obtaining a Ph.D. degree, you can study abroad at foreign countries suchas Johns Hopkins University in the US and we actively support your furthersuccess.・Investigation of the effects of LCN2 and LCN2-related factors on EVT・Research on the mechanisms responsible for placental aging・Investigation of the utility of NRG1 as a diagnostic marker for fetal lung maturation・Research on the therapeutic effects of macrolide antibiotics in preeclampsiaWe hope that our research results lead to the establishment of screening andprevention methods for high-risk cases of HDP and IUGR. Our research results maylead to improvements in neonatal prognoses by establishing preterm birth predictionand prevention methods and promoting fetal lung maturation.After graduating and obtaining a Ph.D. degree, foreign students have returned totheir own country or worked in the USA as postdoctoral fellows. We are conducting research on refractory gynecological cancers (ovarian clear cellcarcinoma OCCC, uterine serous carcinoma USC, and gastric type adenocarcinomaof the cervix GAS).New candidate genes associated with the pathogenesis of OCCC were detected andfound to be a potential target for therapy. We have established the world‘s firstmouse model that develops endometriosis-related cancer by knocking out ARID1Aand PTEN, and now analyzing the carcinogenic process of endometriosis with thismodel. Focusing on the proto-oncogene PIM1, which correlates with the prognosisof USC showing rapid progression and resistance to treatment, we havedemonstrated the efficacy of Pim1 inhibitors against USC in vitro and in vivo. Wehave extensive experience in GAS, which has a poor prognosis and is difficult todiagnose at an early stage, and in the similar benign lesion, lobular endocervicalgland hyperplasia (LEGH), and are leading the world in basic and clinical research.Our original preoperative analytical diagnosis method has been established, and weare working to develop new treatment methods.Research subjectOutlook for researchOutlook for students after graduationNorihiko Kikuchi The placenta is involved in not only the exchange of oxygen, nutrients, andwaste, but also in hormone production and immunity. These functions affectfetal growth and the maintenance of pregnancy, but have not yet beenelucidated in detail. The insufficient invasion of extravillous trophoblasts (EVT)to the myometrium during placental formation in early pregnancy is a majorcause of hypertensive disorders of pregnancy (HDP) and intrauterine growthrestriction (IUGR), which significantly impair maternal and fetal health.Therefore, we focus on factors that regulate the invasion of EVT. We previouslyreported that LCN2, an iron transporter, promoted the invasion of EVT.Furthermore, among various biologically active substances secreted from theplacenta, such as hormones, we have investigated NRG1 as a factor promotingfetal lung maturation. We also examined the senescence of trophoblastic cellsin the placenta, which may regulate gestational age in approximately 280 days.Research subjectOutlook for researchOutlook for students after graduation・Development of novel PIM1- or CCNA-targeted therapy for endometrial cancer・Elucidation of the pathogenesis of refractory ovarian cancer・Clarification of the carcinogenesis of GAS and development of specific therapies29Revealing and curing refractory gynecological cancersThe placenta is a mysterious organ信州大学医学部医学科発行年月：２０２４年７月 発行：信州大学医学部
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