•• ••••Chief：Senior Lecture. We specialize in treating esophageal, gastric, and colorectal cancers,utilizing robot-assisted surgery for minimally invasive procedures. Ourapproach includes multidisciplinary treatments like preoperativechemotherapy and chemoradiotherapy. We also focus on basicresearch to develop noveltreatments targeting driver genes indigestive cancers, such as KRAS mutations in colorectal cancer andRhoA gene mutations in diffuse-type gastric cancer.Outlook for research• The first case of living donor liver transplantation in our institute was Outlook for researchMasato KitazawaResearch subjectOutlook for students after graduationperformed in 1990, and more than 300 cases have been experienced. We will continue to provide careful patient care to overcome life threatening problems, such as rejection, infection, and de novo cancer after transplantation. For clinical islet transplantation program, our institution is approved by Minister for HLW* to provide Class I Regenerative Medicine under the Act on the Safety of Regenerative Medicine in 2015.Research subjectOutlook for students after graduationTransplant and Pediatric SurgeryDigestive tract surgerySurgerySurgeryWe focus on preventing recurrent laryngeal nerve injury during esophagealcancer surgery and quantifying intestinal blood flow to prevent sutureinsufficiency. Additionally, we're developing therapies for KRAS-mutantcolorectal/pancreatic cancer and analyzing mutated RhoA in gastric cancer.Using gene editing technologies like CRISPR-Cas9, along with flow cytometryand cell imaging equipment (Operetta), we can swiftly assess the functionalityand drug resistance of various genetic mutations. Our goal is to leverage thesefindings to pioneer innovative treatment approaches for colorectal, stomach,pancreatic cancers, and beyond.Because you can learn a wide range of basic knowledge of cancer andresearch method using the latest equipment, in the case of getting involved incancer research and clinical work, the knowledge and technology obtained inthis study seems very useful.Chief: Asssociate Prof. Atsuyoshi MitaTo become a transplant surgeon having a deep knowledge of immune system,cell protection, and patient care.Analysis of resistance signals of KRAS G12C inhibitors (Sotrasib and Adagrasib) and G12D inhibitor (MRTX1133)The upper graph is Kaplan-Meier patient survival curve. Islets for islet transplantationIslets (stained on red) isolated from a donor’s pancreas aretransplanted into the liver through the portal vein. * Health, Labour and WelfareMultidisciplinary Treatment for Rectal Cancer Chemoradiotherapy → total pelvic exenteration combined sacral resectionTo solve perioperative and long-term problems associated with liver transplantationSimulation training to improve islet isolation techniques To investigate how to protect pancreatic isletsAppling knowledge of our over 20 years of practice to improve the outcomeafter liver transplantationTo promote islet transplantation therapy in Japan along with other institutions18From high quality surgery to gene therapy- New challenge to cancer treatment - Exploring perioperative and long-term problems associated with liver transplantation Promoting pancreatic islet cell transplantation
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