PediatricsProf. Yozo NakazawaDermatologyProf. Ryuhei OkuyamaDevelopment process for CAR T-cellSerious Game「First steps in the NICU」Graduate students actively experiment. We can use experimental equipments such as laminar flow cabinet in our laboratory.Administration of a virus that multiplies only in cancer cellsHSCT.・Assessment for melanoma patients using liquid biopsy・ICI effect predictors・Imaging diagnosis for melanoma using RGB values・Noninvasive diagnosis by measurement melanin in the nails.You can continue the research in our laboratory or study abroad. Because the ourresearch themes are linked to medical treatment, the knowledge obtained in theresearch is often usefulfor clinical practice. There are some members in ourlaboratory who continue both the research and clinical practice after the graduationWe are advancing basic, translational, and clinical development ofCAR (Chimeric Antigen Receptor) T-cell therapy, a gene therapythat strengthens the anti-cancer response of patients' T cells.Three investigator-initiated trials for CAR T-cells developed by ourteam are now active.Research subjectOutlook for researchOutlook for students after graduationOur main projects are the diagnostic method, evaluation method ofdisease status and new treatment method of malignant melanoma.Because progressed melanoma is difficult to cure, early diagnosis andtotreatment are very importantdistinguish the early melanoma from the benign pigmented nevus. We aimto establish the new diagnosis methods using photographs and anoninvasive method using the nail pieces.Today, immune checkpoint inhibitors （ICI） and molecular target therapyare often used for the patients suffered from progressed melanoma. Wesearch forICI effect predictors. We also develop virotherapy againtmelanoma in collaboration with the Institute of Medical Scinence, TheUniversity of Tokyo.Research subjectOutlook for researchSince malignant melanoma is one of the aggressive cancers, once it progress,complete remission is difficult. Even using immune checkpoint blockade, objectiveresponse rate is up to 30%. We hope that outcomes of our study contribute forimprovement both of early diagnosis and treatment of advanced melanoma.Outlook for students after graduationfor patients. Sometimes,is difficultitAll for children Nevus or Melanoma ? Can you diagnose ?・Development and clinical application of CAR T-cell cancer immunotherapy.・Development of tumor-tropic liposomes for the treatment of cancers.・Development of novel diagnostic and therapeutic strategies for EBV-HLH.・Evaluation of capsule endoscopy and renal function in patients undergoing・Promotion of interprofessional collaboration through serious games.Our basic research seeks curative and safer therapies for children by understanding diseases and applying treatments. Our clinical studies provide evidence to advance pediatric care. We are all in on research for a better tomorrow.Our lab researches the core of diseases, building true understanding beyond textbooks. This critical thinking helps clinicians and researchers make significant strides. 15Research for Children's TomorrowChallenging for next generation of melanoma treatment
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